Inflamação – ABC CARDIOL

ABCHF

Letter to the Editor

Impacts of Post-COVID-19 Syndrome on Cardiovascular Autonomic Changes

Dear Editor,

The article by Davanço et al., entitled “Post-COVID-19 Syndrome and Autonomic Repercussions on Cardiovascular Variables” (ABC Heart Fail Cardiomyop. 2023; 3(3): e20230056), makes an important contribution to understanding the autonomic repercussions of COVID-19 on cardiovascular modulation. This study stands out for addressing an emerging and highly relevant clinical topic by investigating heart rate variability (HRV) parameters in patients with post-COVID-19 syndrome, using robust temporal and spectral domain measures. The methodological rigor, adherence to STROBE guidelines, and adequate characterization of the comparison groups are noteworthy, lending solidity to the conclusions presented.

The correlation between increased parasympathetic indices (RMSSD, HF) and reduced global variability parameters suggests a complex autonomic adaptation, possibly mediated by persistent inflammatory mechanisms— a hypothesis of great pathophysiological value.

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Original Article

Transcriptome High-Throughput Sequencing Analysis of lncRNA and mRNA Expression in Patients with Coronary Slow Flow

Haibing Jiang et al. Yi Yang Xueqin Zhai Lijing Zhang Aerziya Kahaerjiang

Abstract

Background

Long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) are believed to play key roles in the pathophysiology of coronary slow flow (CSF).

Objectives

This study aimed to explore the complex biological networks involved in CSF using whole-transcriptome sequencing, with the goal of identifying potential diagnostic biomarkers and therapeutic targets.

Methods

Whole-transcriptome sequencing was performed on samples from three patients with CSF and three matched control subjects. A p-value < 0.05 was considered statistically significant.

Results

A total of 854 lncRNAs were differentially expressed, with 425 downregulated and 429 upregulated. KEGG pathway analysis showed significant enrichment of lncRNAs in pathways associated with cardiovascular diseases, endocrine and metabolic disorders, and neurodegenerative disease progression. Additionally, 1,999 mRNAs were differentially expressed, including 990 downregulated and 1,009 upregulated. Molecular function analysis identified roles in protein binding, regulation of kinase activity, ubiquitin-protein transferase activity, and RNA binding. KEGG analysis indicated that the differentially expressed mRNAs were primarily involved in autophagy, measles, ubiquitin-mediated proteolysis, the NOD-like receptor signaling pathway, the tumor necrosis factor (TNF) signaling pathway, the toll-like receptor (TLR) signaling pathway, and the NF-κB signaling pathway.

Conclusions

Differentially expressed mRNAs were significantly enriched in KEGG pathways related to autophagy, measles, and ubiquitin-mediated degradation, as well as in signaling cascades involving NOD-like receptors, TNF, TLR, and NF-κB. Further studies are required to validate these findings.