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  2. Keyword: echocardiographic contrast
Study of Coronary Flow Reserve with Intravenous Use of Microbubbles (Contrast Echocardiography) and Adenosine: Protocol for Clinical Application in Patients Suspected of Having Coronary Heart Disease
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Original Article

Study of Coronary Flow Reserve with Intravenous Use of Microbubbles (Contrast Echocardiography) and Adenosine: Protocol for Clinical Application in Patients Suspected of Having Coronary Heart Disease

Fernando Morcerf et al. Alvaro Moraes Marcia Carrinho Hans J. F. Dohmann

OBJECTIVE: To test the feasibility, safety and accuracy of the adenosine protocol in the study of myocardial perfusion with microbubbles contrast echocardiography. METHODS: 81 pts (64 male, 60+11 years) were submitted to contrast echocardiography with PESDA (sonicated solution of albumin 20%-1ml, dextrose 5%-12ml and deca-fluorobutane gas-8ml) to study the myocardial perfusion at rest and after bolus injection of adenosine (6 to 18mg) and to coronary angiography within 1 month each other. For each patient 3 left ventricle perfusion beds were considered (total of 243 territories). 208 territories were analyzed and 35 territories were excluded. PESDA was continuously infused (1-2ml/min), titrated for best myocardial contrast. Triggered (1:1) second harmonic imaging was used. RESULTS: Coronary angiography showed 70 flow limiting (> 75%) lesions and 138 no flow limiting lesions. At rest an obvious myocardium contrast enhancement was seen in at least 1 segment of a territory in all patients. After adenosine injection an unquestionable further increase in myocardial contrast was observed in 136 territories (99%) related to no flow limiting lesions, lasting < 10 s, and a myocardial perfusion defect was detected in 68 territories (97%) related to flow limiting lesions. It was observed only 4 false results. There were no serious complications. CONCLUSION: Myocardial perfusion study with PESDA and adenosine protocol is a practical, safe and accurate method to analyze the coronary flow reserve.

  • Coronary Disease
  • echocardiographic contrast
  • myocardial perfusion
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Creative Commons Attribution (CC BY) Creative Commons license
19/04/2002 DOI: 10.1590/S0066-782X2002000300004 Views 1

How to cite this article

EndNote RIS

Electronic Document Format (Vancouver)

Morcerf F, Moraes A, Carrinho M, Dohmann HJF. Study of Coronary Flow Reserve with Intravenous Use of Microbubbles (Contrast Echocardiography) and Adenosine: Protocol for Clinical Application in Patients Suspected of Having Coronary Heart Disease. Arquivos Brasileiros de Cardiologia 2002;78(3):290-8.

Electronic Document Format (ABNT)

Morcerf, Fernando; Moraes, Alvaro; Carrinho, Marcia; Dohmann, Hans J. F.. Study of Coronary Flow Reserve with Intravenous Use of Microbubbles (Contrast Echocardiography) and Adenosine: Protocol for Clinical Application in Patients Suspected of Having Coronary Heart Disease. Arquivos Brasileiros de Cardiologia, v. 78, n. 3, p. 290-298, Apr. 2002.

Electronic Document Format (APA)

Morcerf, F., Moraes, A., Carrinho, M., & Dohmann, H. J. F. (2002). Study of Coronary Flow Reserve with Intravenous Use of Microbubbles (Contrast Echocardiography) and Adenosine: Protocol for Clinical Application in Patients Suspected of Having Coronary Heart Disease. Arquivos Brasileiros de Cardiologia, 78(3), 290-298.

Electronic Document Format (ISO)

Morcerf, Fernando and Moraes, Alvaro and Carrinho, Marcia and Dohmann, Hans J. F.. Study of Coronary Flow Reserve with Intravenous Use of Microbubbles (Contrast Echocardiography) and Adenosine: Protocol for Clinical Application in Patients Suspected of Having Coronary Heart Disease. Arquivos Brasileiros de Cardiologia [online]. 2002, vol. 78, n. 3, [cited 2026-10-14], pp. 290-298. Available from: <https://journals.cardiol.br/en/article/study-of-coronary-flow-reserve-with-intravenous-use-of-microbubbles-contrast-echocardiography-and-adenosine-protocol-for-clinical-application-in-patients-suspected-of-having-coronary-heart-disease/>. ISSN 0066-782X

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