Coronary Artery Disease/genetics

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Letter to the Editor

Paraoxonase-1 Genotype and Angiogram Positive Coronary Artery Disease

Rujittika Mungmunpuntipantip et al. Viroj Wiwanitkit

Dear Editor,

We would like to share ideas on the publication “Association of Paraoxonase-1 Genotype and Phenotype with Angiogram Positive Coronary Artery Disease”. Soflaei et al. noted that The presence of the G allele of the rs662 single nucleotide polymorphism is independently associated with an increased risk of coronary artery disease (CAD). The effect of polymorphism is investigated in this study. CAD might or might not be impacted by the hereditary component studied in this report. We both concur that CAD may be related to the underlying genetic component under research. However, CAD has been linked to numerous genetic variations. Examples of gene polymorphisms include the effect of polymorphisms (M235T and T174M) on the angiotensinogen gene (AGT), TGFB1 rs1800469, and BCMO1 rs6564851.^– Future research should examine the implications of unexpected, possibly perplexing genetic variants.

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ABC

Editorial

Genetic Risk in Coronary Artery Disease

Paula F. Martinez et al. Marina P. Okoshi

Coronary artery disease (CAD) is a leading cause of death worldwide. It is most commonly caused by atherosclerosis in coronary arteries. Coronary artery disease has a complex etiology, mainly a combination of traditional risk factors and genetic predisposition. Traditional risk factors include type 2 diabetes, dyslipidemia, arterial hypertension, and cigarette smoking. However, these are not sufficient to identify high risk asymptomatic individuals and do not explain all cases of CAD. In fact, hereditary influence on CAD susceptibility accounts for between 40% and 50% of cases.

Polymorphisms are common genetic variations, defined as being present in more than 1% of the population. A polymorphism is a nucleotide substitution that does not alter the primary amino acid structure of the resulting protein. A single-nucleotide polymorphism (SNP) is a variation in DNA in a single nucleotide that occurs at a specific position in the genome. An SNP may be a marker of disease susceptibility. Populations of healthy and affected individuals can be evaluated by genotyping SNP within a gene and its regulatory sequences. Genome-wide association studies (GWAS) have been used to create genetic risk scores to improve CAD risk prediction.^– However, their value as an independent risk predictor for CAD is not clear.

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Paraoxonase-1 Genotype and Angiogram Positive Coronary Artery Disease

Genetic Risk in Coronary Artery Disease

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