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  2. Palavra-chave: Neoplasms
IJCS
Case Report

High-Grade Pleomorphic Sarcoma of the Left Atrium after Incomplete Resection and Adjuvant Chemotherapy

Ricardo J. Razera et al. Amanda Mendonça de Araújo Viviane Pereira Bernardes Fernanda Miranda Moisés … Leonardo Santos Mundim Rogério A. Araújo

Introduction

Primary cardiac tumors are extremely rare, found in only 0.02% of all autopsies. These tumors are malignant in only 25% of the cases, 75% of which are sarcomas, frequently affecting young people with no risk factors.² The median overall survival is less than 1 year,³ ranging from 9 to 16 months,, with rapid proliferation and deaths caused by arrhythmias, thrombosis, pulmonary embolism, and, most importantly, heart failure. Due to its rarity, reports in the literature about the best treatment are scarce, especially in malignant tumors.¹ The aim of the present work is to report a case of an undifferentiated pleomorphic sarcoma (UPS) in the left atrium in which surgical treatment was associated with chemotherapy, with an overall and progression-free survival of neoplastic disease higher than the median described in previous manuscripts.

[…]

  • Atrial Function
  • cardiovascular diseases
  • Drug Therapy
  • Heart Atria/surgery
  • Neoplasms
  • Sarcoma/complications
  • Sarcoma/surgery
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Creative Commons Attribution (CC BY) Creative Commons license
16/04/2021 DOI: 10.36660/ijcs.20200140 Visualizações 1
IJCS
Original Article

Elderly Mortality from Cerebrovascular Disease in Alagoas, 2000-2016: Spatial-Temporal Analysis

Luiz Carlos Francelino Silva Junior et al. Euclides José Oliveira Da Cunha Carlos Dornels Freire de Souza Alysson Wagner Fernandes Duarte

Abstract

Background

Cerebrovascular diseases (CVDs) are the second leading cause of death in Brazil.

Objective

This study aimed to describe the epidemiological profile and to analyze the spatiotemporal dynamics of mortality from cerebrovascular disease in the elderly in Alagoas from 2000-2016.

Methods

This is a multilevel ecological study of all deaths from CVD in individuals aged 60 years or older. Data were collected from the Mortality Information System. The variables were submitted to descriptive analysis, trend analysis by Joinpoint Regression method and spatial analysis with Global Moran’s and local statistics; 95% confidence interval and significance of 5% were considered in the analysis.

Results

There were 21,440 deaths in the study period, 50.4% (n=10,797) male, 40.5% (n=8,670) aged ≥ 80 years, 44.5% (n=9,465) of “brown” race, 30.1% (n=6,448) married and 36.5% (n=7,828) with less than four years of schooling. Female and male mortality rates were 460.24/100,000 and 602.23 / 100,000, respectively. An annual decreasing trend of -1.4% (p<0.001) in overall and male mortality was observed from 2007 on. The highest mortality rates were concentrated in the eastern region of Alagoas (Moran’s I =0.766288; p=0.01). Twenty-two municipalities were in quadrant Q1 of Moran’s scattering diagram and considered priorities.

Conclusion

Death from CVD in Alagoas occurred equally in men and women in the study period, mostly in individuals of mixed race, married, and with low education attainment. The highest rates were observed in the eastern region of the state . The results highlight the need for public policies aimed at healthy aging in the state. (Int J Cardiovasc Sci. 2020; [online].ahead print, PP.0-0)

  • cardiovascular diseases
  • Cerebrovascular Disorders
  • Diabetes mellitus
  • Ecological Studies
  • Epidemiology
  • Ethnic Inequality
  • Mortality
  • Neoplasms
  • Respiratory Tract Diseases
  • Social Class
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Creative Commons Attribution (CC BY) Creative Commons license
23/11/2020 DOI: 10.36660/ijcs.2019-0208
IJCS
Original Article

Intestinal Microbiota and Cardiovascular Diseases

Protásio L. da Luz et al. Elisa Alberton Haas Desiderio Favarato

Abstract

Recently, gut microbiota has emerged as an important mediator of several diseases such as diabetes, atherosclerosis, arterial hypertension, obesity, cancers and neuropsychiatric diseases including Alzheimer, autism and depression. Intestinal microbiota is formed by bacteria, fungi and viruses and its main function is to facilitate the absorption and metabolism of foods (protein, fat and carbohydrate). One example of the multiple actions of the gut microbiota is the bidirectional relationship between the intestine and the brain, the so-called “gut/brain axis”. Furthermore, metabolites produced by gut microbiota can induce effects locally or at distance, which suggests that the intestine is an endocrine organ. Given the participation of the gut microbiota in several diseases, there is great interest in strategies that may positively affect the gut flora and prevent or even treat diseases. Among these strategies, lifestyle change, but specially diet modulation has gained importance. In this article, we review the mechanisms through which intestinal microbiota participates in cardiovascular diseases and possible therapeutic interventions.

  • Alzheimer Disease
  • Atherosclerosis
  • cardiovascular diseases
  • Diabetes mellitus
  • Diet, Mediterranean
  • Gastrointestinal Microbiome/physiology
  • Hypertension
  • Metabolism
  • Neoplasms
  • Obesity
  • Risk Factors
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Creative Commons Attribution (CC BY) Creative Commons license
17/07/2020 DOI: 10.36660/ijcs.20200043

Como citar este artigo

EndNote RIS

Formato de Documento Eletrônico (Vancouver)

Razera RJ, Araújo AM, Bernardes VP, Moisés FM, Mundim LS, Araújo RA. High-Grade Pleomorphic Sarcoma of the Left Atrium after Incomplete Resection and Adjuvant Chemotherapy. International Journal of Cardiovascular Sciences 2021;34(5 Supl 1):158-63.

Formato de Documento Eletrônico (ABNT)

Razera, Ricardo J.; Araújo, Amanda Mendonça de; Bernardes, Viviane Pereira; Moisés, Fernanda Miranda; Mundim, Leonardo Santos; Araújo, Rogério A.. High-Grade Pleomorphic Sarcoma of the Left Atrium after Incomplete Resection and Adjuvant Chemotherapy. International Journal of Cardiovascular Sciences, v. 34, n. 5 Supl 1, p. 158-163, abr. 2021.

Formato de Documento Eletrônico (APA)

Razera, R. J., Araújo, A. M. , Bernardes, V. P., Moisés, F. M., Mundim, L. S., & Araújo, R. A. (2021). High-Grade Pleomorphic Sarcoma of the Left Atrium after Incomplete Resection and Adjuvant Chemotherapy. International Journal of Cardiovascular Sciences, 34(5 Supl 1), 158-163.

Formato de Documento Eletrônico (ISO)

Razera, Ricardo J. and Araújo, Amanda Mendonça de and Bernardes, Viviane Pereira and Moisés, Fernanda Miranda and Mundim, Leonardo Santos and Araújo, Rogério A.. High-Grade Pleomorphic Sarcoma of the Left Atrium after Incomplete Resection and Adjuvant Chemotherapy. International Journal of Cardiovascular Sciences [online]. 2021, vol. 34, n. 5 Supl 1, [citado 2026-10-14], pp. 158-163. Disponível em: <https://journals.cardiol.br/article/high-grade-pleomorphic-sarcoma-of-the-left-atrium-after-incomplete-resection-and-adjuvant-chemotherapy-2/>. ISSN 2359-4802

EndNote RIS

Formato de Documento Eletrônico (Vancouver)

Silva Junior LCF, Cunha EJOD, Souza CDF, Duarte AWF. Elderly Mortality from Cerebrovascular Disease in Alagoas, 2000-2016: Spatial-Temporal Analysis. International Journal of Cardiovascular Sciences 2020;34(2):159-67.

Formato de Documento Eletrônico (ABNT)

Silva Junior, Luiz Carlos Francelino; Cunha, Euclides José Oliveira Da; Souza, Carlos Dornels Freire de; Duarte, Alysson Wagner Fernandes. Elderly Mortality from Cerebrovascular Disease in Alagoas, 2000-2016: Spatial-Temporal Analysis. International Journal of Cardiovascular Sciences, v. 34, n. 2, p. 159-167, nov. 2020.

Formato de Documento Eletrônico (APA)

Silva Junior, L. C. F., Cunha, E. J. O. D., Souza, C. D. F. , & Duarte, A. W. F. (2020). Elderly Mortality from Cerebrovascular Disease in Alagoas, 2000-2016: Spatial-Temporal Analysis. International Journal of Cardiovascular Sciences, 34(2), 159-167.

Formato de Documento Eletrônico (ISO)

Silva Junior, Luiz Carlos Francelino and Cunha, Euclides José Oliveira Da and Souza, Carlos Dornels Freire de and Duarte, Alysson Wagner Fernandes. Elderly Mortality from Cerebrovascular Disease in Alagoas, 2000-2016: Spatial-Temporal Analysis. International Journal of Cardiovascular Sciences [online]. 2020, vol. 34, n. 2, [citado 2026-10-14], pp. 159-167. Disponível em: <https://journals.cardiol.br/article/elderly-mortality-from-cerebrovascular-disease-in-alagoas-2000-2016-spatial-temporal-analysis-2/>. ISSN 2359-4802

EndNote RIS

Formato de Documento Eletrônico (Vancouver)

Luz PL, Haas EA, Favarato D. Intestinal Microbiota and Cardiovascular Diseases. International Journal of Cardiovascular Sciences 2020;33(5):462-71.

Formato de Documento Eletrônico (ABNT)

Luz, Protásio L. da; Haas, Elisa Alberton; Favarato, Desiderio. Intestinal Microbiota and Cardiovascular Diseases. International Journal of Cardiovascular Sciences, v. 33, n. 5, p. 462-471, jul. 2020.

Formato de Documento Eletrônico (APA)

Luz, P. L. , Haas, E. A., & Favarato, D. (2020). Intestinal Microbiota and Cardiovascular Diseases. International Journal of Cardiovascular Sciences, 33(5), 462-471.

Formato de Documento Eletrônico (ISO)

Luz, Protásio L. da and Haas, Elisa Alberton and Favarato, Desiderio. Intestinal Microbiota and Cardiovascular Diseases. International Journal of Cardiovascular Sciences [online]. 2020, vol. 33, n. 5, [citado 2026-10-14], pp. 462-471. Disponível em: <https://journals.cardiol.br/article/intestinal-microbiota-and-cardiovascular-diseases-2/>. ISSN 2359-4802

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