Six-Minute Walk Test in Patients with Cardiac Amyloidosis: Does it mean anything?

Cardiac amyloidosis (CA) is a restrictive cardiomyopathy characterized by the extracellular deposition of proteins in the myocardium. Transthyretin (TTR) protein is predominantly synthesized in the liver and normally transports thyroxine and retinol. When TTR is misfolded, it can form amyloid fibrils deposited in different organs, such as the heart.

TTR amyloidosis (ATTR) can be inherited as an autosomal dominant trait caused by variants in the TTR gene (TTRv), or by the deposition of wild-type TTR (TTRwt).

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