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Research Letter

Theophylline for Attenuating Ticagrelor-Related Dyspnea

Marcelo Sanmartin-Fernandez et al. Jose Luis Zamorano

Introduction

Dyspnea is one of the most frequent adverse reaction of ticagrelor, leading to premature discontinuation in 15-20% of the patients. The mechanism is unclear, but it is thought to be related to increased tissue adenosine concentrations or to the direct reversible inhibition of P2Y₁₂ receptors on sensory neurons.

Theophylline has been used as a bronchodilator since 1922, and its effects seem to be partly mediated through nonselective adenosine receptors blockade.

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Acute coronary syndrome
Theophylline
Ticagrelor

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Theophylline for Attenuating Ticagrelor-Related Dyspnea

Introduction

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