Ischemia-reperfusion injury

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Editorial

Challenges of Translational Science

Leonardo R. Garcia et al. Bertha F. Polegato Leonardo A. M. Zornoff

The introduction of standardized therapies for the treatment of major cardiovascular diseases, such as heart failure and myocardial infarction, significantly reduced mortality. However, cardiovascular diseases are still one of the main causes of morbidity and mortality worldwide. Consequently, a large number of experimental studies are published regarding this subject. These studies investigate, in addition to the mechanisms involved in the genesis of cardiovascular disease, potential therapeutic targets, as well as interventions that are beneficial in reducing the size of the ischemic lesion and the progression of cardiac dysfunction and, consequently, decrease mortality.

In some situations, the results of preclinical research are reproducible in clinical studies. As an example, we could cite the influence of obesity on the process of cardiac remodeling. It is accepted that the remodeling process plays a critical role in the onset and progression of cardiac dysfunction secondary to different stimuli. Experimental studies have shown that obesity induces ventricular remodeling, since it has been confirmed in clinical studies.^,

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Challenges of Translational Science

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