Hypokalemic Periodic Paralysis

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Letter to the Editor

Possible Brugada Phenocopy Induced by Hypokalemia in a Patient with Congenital Hypokalemic Periodic Paralysis

Daniel D. Anselm et al. Natalia Rodriguez Genaro Adrian Baranchuk

Dear Editor,

We read with great interest the case report by Gazzoni et al regarding a Brugada ECG pattern induced by hypokalemia. This paper is important because it contributes to the growing body of literature describing Brugada Phenocopies (BrP)^–.

Briefly, BrP are characterized by ECG patterns that are identical to type-1 or type-2 Brugada ECG patterns despite the absence of true congenital Brugada Syndrome (BrS). BrP are induced by various clinical circumstances including: hypokalemia, hyperkalemia, hypothermia, myocardial ischemia, and pulmonary embolism. We have established six etiological categories of BrP^– along with a systematic approach to diagnose BrP by excluding sodium channel dysfunction in the myocardium. The presented case by Gazzoni et al would possibly qualify under category (i) metabolic conditions; however, further analysis of this case report is required.

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Possible Brugada Phenocopy Induced by Hypokalemia in a Patient with Congenital Hypokalemic Periodic Paralysis

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