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  2. Keyword: Gastrointestinal Hemorrhage / complications
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Editorial

Should Patients with Heyde’s Syndrome Undergo Early Valve Intervention?

Marcelo Dantas Tavares de Melo et al. Jose Luiz Barros Pena Jorge de Oliveira Júnior Vera Maria Cury Salemi

The epidemiological profile of patients with aortic stenosis has changed with the aging of the population, characterized by an increase in associated comorbidities. Thanks to the revolution in percutaneous aortic valve treatment, many patients who previously would have limited survival and quality of life have benefited from the possibility of curative treatment. On the other hand, the clinical challenges that arise in this population reinforce not only the consolidated relevance of the heart team but also of other specialties such as oncology and hematology.

The interesting study published in the current issue reinforces the importance of the association between Heyde’s syndrome and aortic stenosis, with increased bleeding in this population. However, it is important to highlight in this context the frequently associated comorbidities that may contribute to eventual digestive bleeding, such as the association between aortic stenosis and neoplasm, since both share the same risk factors, particularly colon cancer neoplasm. This one presents with cardinal clinical signs: anemia and low gastrointestinal bleeding. In this context, the exclusion of neoplasm is mandatory, even in the suspicion of Heyde’s Syndrome. We can also describe other frequently associated comorbidities that add bleeding risk due to the therapy used, such as coronary artery disease, which usually uses antiplatelet therapy, or dual anti-aggregation after percutaneous coronary intervention with a drug-eluting stent.

[…]

  • Aortic Valve Stenosis
  • Comorbidities
  • Gastrointestinal Hemorrhage / complications
  • Mortality
  • Percutaneous Coronary Intervention
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Creative Commons Attribution (CC BY) Creative Commons license
20/09/2021 DOI: 10.36660/abc.20210734
Figure 1
ABC
Case Report

Heyde's Syndrome and Transcatheter Aortic Valve Implantation

Conrado Pedroso Balbo et al. Luciana Paula Seabra Victor Gualda Galoro Guido Caputi … José Honório Palma Ênio Buffolo

Introduction

Aortic Stenosis (AoS) is the valvular pathology most frequently acquired in developed countries, present in 4% of individuals over 85 years of age. Patients with severe AoS may have comorbidities, presenting greater risk of thrombotic and bleeding events.

Heyde’s Syndrome was described in 1958 by E. C. Heyde as he observed the relation between aortic valve stenosis and gastrointestinal bleeding. In 1992, Warkentin et al. observed the loss of the largest Willebrand factor multimers, characterizing the Acquired type 2A, von Willebrand syndrome. Von Willebrand Factor (vWF) is a multimeric protein, secreted by endothelial cells and platelets. It promotes adherence of platelets to vascular lesion sites through glycoprotein Ib-vWF interactions. A change in the shape of vWF occurs in AoS, making such protein more susceptible to proteolytic cleavage. As a consequence, vWF is degraded specifically by protease ADAMTS13, hindering vWF-mediated platelet adhesion, thus generating a lack of these multimers and causing bleeding, especially in pre-existing lesions such as gastrointestinal angiodysplasia.–

[…]

  • Angiodysplasia
  • Gastrointestinal Hemorrhage / complications
  • Prosthesis Implantation of Aortic Valve
  • Stenosis Valve Aortic / therapy
  • von Willebrand Diseases / therapy
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Creative Commons Attribution (CC BY) Creative Commons license
01/04/2017 DOI: 10.5935/abc.20160193 Views 1

How to cite this article

EndNote RIS

Electronic Document Format (Vancouver)

Melo MDT, Pena JLB, Oliveira Júnior J, Salemi VMC. Should Patients with Heyde’s Syndrome Undergo Early Valve Intervention?. Arquivos Brasileiros de Cardiologia 2021;117(3):518-9.

Electronic Document Format (ABNT)

Melo, Marcelo Dantas Tavares de; Pena, Jose Luiz Barros; Oliveira Júnior, Jorge de; Salemi, Vera Maria Cury. Should Patients with Heyde’s Syndrome Undergo Early Valve Intervention?. Arquivos Brasileiros de Cardiologia, v. 117, n. 3, p. 518-519, Sep. 2021.

Electronic Document Format (APA)

Melo, M. D. T. , Pena, J. L. B., Oliveira Júnior, J. , & Salemi, V. M. C. (2021). Should Patients with Heyde’s Syndrome Undergo Early Valve Intervention?. Arquivos Brasileiros de Cardiologia, 117(3), 518-519.

Electronic Document Format (ISO)

Melo, Marcelo Dantas Tavares de and Pena, Jose Luiz Barros and Oliveira Júnior, Jorge de and Salemi, Vera Maria Cury. Should Patients with Heyde’s Syndrome Undergo Early Valve Intervention?. Arquivos Brasileiros de Cardiologia [online]. 2021, vol. 117, n. 3, [cited 2026-10-14], pp. 518-519. Available from: <https://journals.cardiol.br/en/article/should-patients-with-heydes-syndrome-undergo-early-valve-intervention/>. ISSN 0066-782X

EndNote RIS

Electronic Document Format (Vancouver)

Balbo CP, Seabra LP, Galoro VG, Caputi G, Palma JH, Buffolo . Heyde’s Syndrome and Transcatheter Aortic Valve Implantation. Arquivos Brasileiros de Cardiologia 2017;108(4):378-80.

Electronic Document Format (ABNT)

Balbo, Conrado Pedroso; Seabra, Luciana Paula; Galoro, Victor Gualda; Caputi, Guido; Palma, José Honório; Buffolo, Ênio. Heyde’s Syndrome and Transcatheter Aortic Valve Implantation. Arquivos Brasileiros de Cardiologia, v. 108, n. 4, p. 378-380, Mar. 2017.

Electronic Document Format (APA)

Balbo, C. P., Seabra, L. P., Galoro, V. G., Caputi, G., Palma, J. H., & Buffolo, (2017). Heyde’s Syndrome and Transcatheter Aortic Valve Implantation. Arquivos Brasileiros de Cardiologia, 108(4), 378-380.

Electronic Document Format (ISO)

Balbo, Conrado Pedroso and Seabra, Luciana Paula and Galoro, Victor Gualda and Caputi, Guido and Palma, José Honório and Buffolo, Ênio. Heyde’s Syndrome and Transcatheter Aortic Valve Implantation. Arquivos Brasileiros de Cardiologia [online]. 2017, vol. 108, n. 4, [cited 2026-10-14], pp. 378-380. Available from: <https://journals.cardiol.br/en/article/heydes-syndrome-and-transcatheter-aortic-valve-implantation/>. ISSN 0066-782X

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