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Família ABC

  • Família ABC
  • Arquivos Brasileiros de Cardiologia
  • International Journal of Cardiovascular Sciences
  • ABC Heart Failure & Cardiomyopathy
  • ABC Imagem Cardiovascular
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  2. Palavra-chave: Heart Defects
IJCS
Original Article

Prevalence of Critical Congenital Heart Disease Detected in the Pulse Oximetry Test in Asymptomatic Newborns, ≥35 Gestational Weeks, in a Maternity in Southern Brazil

Sandra Mara Witkowski et al. Rafael Bertoldi Torres Aline Fernanda Pereira Carolina Marchi Guerra … Marco Otílio Rodrigues Wilde Leonardo Fonseca Sene Marcelo França Soares Thor Ferreira da Cruz

Abstract

Background

Congenital heart diseases (CHD) are one of the most prevalent malformations, and the screening tests to identify critical congenital heart disease (CCHD) is the pulse oximetry test, with subsequent investigation and treatment.

Objective

To quantify positive pulse oximetry tests and verify the prevalence of CCHD detected by it in asymptomatic newborns, ≥35 gestational weeks, in a Brazilian maternity hospital.

Methodology

This is an observational, retrospective, quantitative, analytical and cross-sectional study, conducted from October 2020 to May 2022, in a maternity hospital in southern Brazil, through the collection of records of positive oximetry pulse tests, following the norms of screening CCHD test of the Brazilian Society of Pediatrics (SBP), after they were evaluated with echocardiography for confirmation or exclusion of CHD.

Results

A total of 5,667 newborns were evaluated in this study, according to the inclusion criteria; 0.17% (n = 10) had a positive pulse oximetry test. Regarding the results of the echocardiography of the neonates with a positive test, two were normal, seven were cases of patent foramen ovale (PFO), and one was a case (0,017%) with interatrial communication (IAC) diagnosis. In the same period, five neonates with CCHD were born, symptomatic, diagnosed by physical examination, and referred to neonatal intensive care units (NICU) before taking the neonatal cardiac screening (< 24 hours of life).

Conclusion

The prevalence of positive pulse oximetry tests was 0.17% and none CCHD was detected. Five cases of CCHD were born in this period, but they were diagnosed before the recommend time to perform the screening test.

  • Congenital
  • Echocardiography/methods
  • Heart Defects
  • Infant
  • Neonatology
  • Newborn
  • Oximetry/methods
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Creative Commons Attribution (CC BY) Creative Commons license
04/03/2024 DOI: 10.36660/ijcs.20230065 Visualizações 1
IJCS
Original Article

HDL-Cholesterol in Children and Adolescents with Congenital Heart Disease

Matheus Alves Pacheco et al. Silvia Meyer Cardoso Michele Honicky Yara Maria Franco Moreno … Luiz Rodrigo Augustemak de Lima Camila Souza Marcos Isabela de Carlos Back

Abstract

Background

Children and adolescents with congenital heart disease may be more likely to develop atherogenic cardiovascular diseases in adulthood. Therefore, the early identification of risk factors and intervention in childhood may be crucial for a good quality of life and longevity.

Objectives

To describe the distribution of high-density lipoprotein-cholesterol (HDL-c) levels and its association with socioeconomic, clinical and cardiovascular risk factors in children and adolescents with congenital heart disease.

Methods

Cross-sectional study with children and adolescents aged between 5 and 18 years, with congenital heart disease. Socioeconomic, clinical and cardiovascular risk factors were evaluated. HDL-c concentrations were evaluated by the direct method and categorized as desirable (>45 mg/dL), borderline (40-45 mg/dL) and low (<40 mg/dL). We also assessed the “undesirable” levels, consisting of the sum of “borderline” and “low” values for comparative purposes. The multivariate logistic regression analysis was used to evaluate the factor associated with undesirable HDL-c levels. A p<0.05 value was adopted as statistically significant.

Results

Mean HDL-c was 51.2 mg/dL (SD 12.6), with a prevalence of 33.2% of undesirable HDL-c. In the multivariate analysis, C-reactive protein levels ≥ 3mg/dL (OR 3.26; 95% CI 1.32-8.04), age ≥ 10 years old (OR: 2.11; 95% CI 1.12-3.99) and undesirable levels of triglycerides (OR 2.21; 95% CI 1.13-4.75) were associated with undesirable HDL-c.

Conclusion

In this sample of children and adolescents with congenital heart disease, almost one third presented low or borderline HDL-c levels. Age ≥10 years, C-reactive protein and triglycerides were associated with undesirable HDL-c levels. These factors should be considered in the prevention of cerebrovascular diseases in adulthood in this population.

  • Adolescent
  • Atherosclerosis
  • Child
  • cholesterol
  • Congenital/genetics
  • Dyslipidemia
  • HDL-Cholesterol/genetics
  • Heart Defects
  • Risk Factors
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Creative Commons Attribution (CC BY) Creative Commons license
19/08/2022 DOI: 10.36660/ijcs.20210106

Como citar este artigo

EndNote RIS

Formato de Documento Eletrônico (Vancouver)

Witkowski SM, Torres RB, Pereira AF, Guerra CM, Wilde MOR, Sene LF, Soares MF, et al. Prevalence of Critical Congenital Heart Disease Detected in the Pulse Oximetry Test in Asymptomatic Newborns, ≥35 Gestational Weeks, in a Maternity in Southern Brazil. International Journal of Cardiovascular Sciences 2024;37:e20230065.

Formato de Documento Eletrônico (ABNT)

Witkowski, Sandra Mara; Torres, Rafael Bertoldi; Pereira, Aline Fernanda; Guerra, Carolina Marchi; Wilde, Marco Otílio Rodrigues; Sene, Leonardo Fonseca; Soares, Marcelo França; Cruz, Thor Ferreira da. Prevalence of Critical Congenital Heart Disease Detected in the Pulse Oximetry Test in Asymptomatic Newborns, ≥35 Gestational Weeks, in a Maternity in Southern Brazil. International Journal of Cardiovascular Sciences, v. 37, e20230065, mar. 2024.

Formato de Documento Eletrônico (APA)

Witkowski, S. M., Torres, R. B., Pereira, A. F., Guerra, C. M., Wilde, M. O. R., Sene, L. F., Soares, M. F., & Cruz, T. F. (2024). Prevalence of Critical Congenital Heart Disease Detected in the Pulse Oximetry Test in Asymptomatic Newborns, ≥35 Gestational Weeks, in a Maternity in Southern Brazil. International Journal of Cardiovascular Sciences, 37, e20230065.

Formato de Documento Eletrônico (ISO)

Witkowski, Sandra Mara and Torres, Rafael Bertoldi and Pereira, Aline Fernanda and Guerra, Carolina Marchi and Wilde, Marco Otílio Rodrigues and Sene, Leonardo Fonseca and Soares, Marcelo França and Cruz, Thor Ferreira da. Prevalence of Critical Congenital Heart Disease Detected in the Pulse Oximetry Test in Asymptomatic Newborns, ≥35 Gestational Weeks, in a Maternity in Southern Brazil. International Journal of Cardiovascular Sciences [online]. 2024, vol. 37, [citado 2026-10-14], e20230065. Disponível em: <https://journals.cardiol.br/article/prevalence-of-critical-congenital-heart-disease-detected-in-the-pulse-oximetry-test-in-asymptomatic-newborns-%e2%89%a535-gestational-weeks-in-a-maternity-in-southern-brazil-2/>. ISSN 2359-4802

EndNote RIS

Formato de Documento Eletrônico (Vancouver)

Pacheco MA, Cardoso SM, Honicky M, Moreno YMF, Lima LRA, Marcos CS, Back IC, et al. HDL-Cholesterol in Children and Adolescents with Congenital Heart Disease. International Journal of Cardiovascular Sciences 2022;35(6):784-93.

Formato de Documento Eletrônico (ABNT)

Pacheco, Matheus Alves; Cardoso, Silvia Meyer; Honicky, Michele; Moreno, Yara Maria Franco; Lima, Luiz Rodrigo Augustemak de; Marcos, Camila Souza; Back, Isabela de Carlos. HDL-Cholesterol in Children and Adolescents with Congenital Heart Disease. International Journal of Cardiovascular Sciences, v. 35, n. 6, p. 784-793, ago. 2022.

Formato de Documento Eletrônico (APA)

Pacheco, M. A., Cardoso, S. M., Honicky, M., Moreno, Y. M. F., Lima, L. R. A. , Marcos, C. S., & Back, I. C. (2022). HDL-Cholesterol in Children and Adolescents with Congenital Heart Disease. International Journal of Cardiovascular Sciences, 35(6), 784-793.

Formato de Documento Eletrônico (ISO)

Pacheco, Matheus Alves and Cardoso, Silvia Meyer and Honicky, Michele and Moreno, Yara Maria Franco and Lima, Luiz Rodrigo Augustemak de and Marcos, Camila Souza and Back, Isabela de Carlos. HDL-Cholesterol in Children and Adolescents with Congenital Heart Disease. International Journal of Cardiovascular Sciences [online]. 2022, vol. 35, n. 6, [citado 2026-10-14], pp. 784-793. Disponível em: <https://journals.cardiol.br/article/hdl-cholesterol-in-children-and-adolescents-with-congenital-heart-disease-2/>. ISSN 2359-4802

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