A Practical Approach to Differential Diagnosis of Cardiomyopathies with Infiltrative Phenotypes

Introduction

Heart failure (HF) affects approximately 2% of the world population; heart failure with preserved ejection fraction (HFpEF) is responsible for approximately 50% of cases, and it has shown a progressive increase in prevalence with the aging of the population.

HFpEF is associated with high morbidity and mortality, and it is responsible for frequent hospitalizations, especially in the most elderly population. It has a complex pathophysiology and a diversified group of risk factors and etiologies. To date, few therapies have been shown to be effective in reducing cardiovascular outcomes in HFpEF; however, for specific etiologies, the possibility of disease-modifying therapeutic strategies exists. ^–

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