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  2. Keyword: alpha-smooth muscle actin
Myocardial repair with long-term and low-dose administration of a nitric oxide synthesis inhibitor. Myofibroblasts, type III collagen and fibronectin
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Original Article

Myocardial repair with long-term and low-dose administration of a nitric oxide synthesis inhibitor. Myofibroblasts, type III collagen and fibronectin

Mônica Gomes Pessanha et al. Myriam Dumas Hahn Carlos Alberto Mandarim-de-Lacerda

OBJECTIVE: To study the healing process of the myocardium in hypertensive rats undergoing inhibition of nitric oxide synthesis. METHODS: Two groups of animals were studied: one received L-NAME, 12mg/kg/day, and the other was a control group. The presence of type III collagen, fibronectin, and alpha-smooth muscle actin-positive cells was assessed by immunohistochemistry. RESULTS: Fibronectin was seen in both early and late lesions, while type III collagen was seen mainly in areas of incomplete healing, situated among myocytes and around the intramyocardial branches of the coronary arteries. Areas representing early and late lesions showed a population of spindle-shaped cells. Immunohistochemistry showed that these cells were positive for alpha-smooth muscle actin. CONCLUSION: In the myocardium of hypertensive rats, the alpha-smooth muscle actin-positive cells are related to the accumulation of type III collagen and fibronectin in the areas of myocardial damage.

  • alpha-smooth muscle actin
  • myocardial remodeling
  • myofibroblasts
  • Nitric Oxide
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Creative Commons Attribution (CC BY) Creative Commons license
24/10/2000 DOI: 10.1590/S0066-782X1999000700008 Views 2

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EndNote RIS

Electronic Document Format (Vancouver)

Pessanha MG, Hahn MD, Mandarim-de-Lacerda CA. Myocardial repair with long-term and low-dose administration of a nitric oxide synthesis inhibitor. Myofibroblasts, type III collagen and fibronectin. Arquivos Brasileiros de Cardiologia 2000;73(1):92-6.

Electronic Document Format (ABNT)

Pessanha, Mônica Gomes; Hahn, Myriam Dumas; Mandarim-de-Lacerda, Carlos Alberto. Myocardial repair with long-term and low-dose administration of a nitric oxide synthesis inhibitor. Myofibroblasts, type III collagen and fibronectin. Arquivos Brasileiros de Cardiologia, v. 73, n. 1, p. 92-96, Oct. 2000.

Electronic Document Format (APA)

Pessanha, M. G., Hahn, M. D., & Mandarim-de-Lacerda, C. A. (2000). Myocardial repair with long-term and low-dose administration of a nitric oxide synthesis inhibitor. Myofibroblasts, type III collagen and fibronectin. Arquivos Brasileiros de Cardiologia, 73(1), 92-96.

Electronic Document Format (ISO)

Pessanha, Mônica Gomes and Hahn, Myriam Dumas and Mandarim-de-Lacerda, Carlos Alberto. Myocardial repair with long-term and low-dose administration of a nitric oxide synthesis inhibitor. Myofibroblasts, type III collagen and fibronectin. Arquivos Brasileiros de Cardiologia [online]. 2000, vol. 73, n. 1, [cited 2026-10-15], pp. 92-96. Available from: <https://journals.cardiol.br/article/myocardial-repair-with-long-term-and-low-dose-administration-of-a-nitric-oxide-synthesis-inhibitor-myofibroblasts-type-iii-collagen-and-fibronectin/>. ISSN 0066-782X

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