Uncompacted Myocardium: A Disease or a Phenotype?

Introduction

Non-compacted myocardium (NCM) remains controversial between those who consider it a genetic cardiomyopathy and those who believe that excessive trabeculation is a characteristic morphological condition shared by distinct pathological processes and, therefore, not a single disease.

The hallmark of this phenotype is the presence of prominent trabeculae in the left ventricle (LV) and deep intertrabecular recesses, continuous with the LV cavity and separated from the epicardial coronary arteries.^, Such abnormalities are identified through imaging exams and may affect the LV, the right ventricle (RV), or both, and do not by themselves define cardiomyopathy.

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