Guidelines on the Diagnosis and Treatment of Hypertrophic Cardiomyopathy – 2024

1. Introduction

Scientific knowledge of hypertrophic cardiomyopathy (HCM) has significantly improved in the past decades. A better understanding of its pathogenesis, significant advances in the use of imaging methods, and the more common application of genetic analysis, in addition to a better characterization of the natural history of this myocardial disease, have profoundly reformulated its clinical and prognostic significance. Conversely, these processes were accompanied by the development of new medications addressing molecular mechanisms intrinsically linked to the pathophysiology and pathogenesis of the disease and its manifestations, representing an enormous achievement of science and a milestone in the history of cardiology and myocardial diseases.

Therefore, in light of so much new knowledge, whose incorporation into clinical practice is necessary and urgent, these Guidelines aim to present the most current recommendations for the diagnosis, prognostic staging, and treatment of HCM based on a critical review of the current scientific literature.

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