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<article article-type="editorial" dtd-version="1.1" specific-use="sps-1.9" xml:lang="pt" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">
	<front>
		<journal-meta>
			<journal-id journal-id-type="publisher-id">dic</journal-id>
			<journal-title-group>
				<journal-title>ABC Imagem Cardiovascular</journal-title>
				<abbrev-journal-title abbrev-type="publisher">Arq Bras Cardiol: Imagem cardiovasc.</abbrev-journal-title>
			</journal-title-group>
			<issn pub-type="epub">2675-312X</issn>
			<publisher>
				<publisher-name>Sociedade Brasileira de Cardiologia</publisher-name>
			</publisher>
		</journal-meta>
		<article-meta>
			<article-id pub-id-type="doi">10.47593/2675-312X/20223503eed24</article-id>
			<article-categories>
				<subj-group subj-group-type="heading">
					<subject>Editorial</subject>
				</subj-group>
			</article-categories>
			<title-group>
				<article-title>Papel da Ecocardiografia na Avaliação de Pacientes com Suspeita de Hipertensão Pulmonar: Além da Velocidade de Pico do Jato de Insuficiência Tricúspide</article-title>
			</title-group>
			<contrib-group>
				<contrib contrib-type="author">
					<contrib-id contrib-id-type="orcid">0000-0002-9236-3815</contrib-id>
					<name>
						<surname>Hotta</surname>
						<given-names>Viviane Tiemi</given-names>
					</name>
					<xref ref-type="aff" rid="aff1"><sup>1</sup></xref>
					<xref ref-type="aff" rid="aff2"><sup>2</sup></xref>
				</contrib>
			</contrib-group>
			<aff id="aff1">
				<label>1</label>
				<institution content-type="orgdiv2">Instituto do Coração</institution>
				<institution content-type="orgdiv1">Faculdade de Medicina</institution>
				<institution content-type="orgname">Universidade de São Paulo</institution>
				<addr-line>
					<named-content content-type="city">São Paulo</named-content>
					<named-content content-type="state">SP</named-content>
				</addr-line>
				<country country="BR">Brasil</country>
				<institution content-type="original">Instituto do Coração, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brasil.</institution>
			</aff>
			<aff id="aff2">
				<label>2</label>
				<institution content-type="orgname">Fleury Medicina e Saúde</institution>
				<addr-line>
					<named-content content-type="city">São Paulo</named-content>
					<named-content content-type="state">SP</named-content>
				</addr-line>
				<country country="BR">Brasil</country>
				<institution content-type="original">Fleury Medicina e Saúde, São Paulo, SP, Brasil.</institution>
			</aff>
			<author-notes>
				<corresp id="c01"> Correspondência: Viviane Tiemi Hotta • Instituto do Coração HC-FMUSP, Unidade Clínica de Miocardiopatias e Doenças da Aorta. Av. Dr Enéas Carvalho de Aguiar, 55. CEP 05403-900, São Paulo, SP – Brasil. E-mail: <email>viviane.hotta@gmail.com</email>
				</corresp>
				<fn fn-type="con">
					<p>Contribuição do autor</p>
					<p>VTH; redação do manuscrito: VTH; revisão crítica do manuscrito quanto ao conteúdo intelectual importante.</p>
				</fn>
				<fn fn-type="conflict">
					<p>Conflito de interesses</p>
					<p>A autora declara não ter conflitos de interesse.</p>
				</fn>
			</author-notes>
			<pub-date date-type="pub" publication-format="electronic">
				<day>23</day>
				<month>09</month>
				<year>2022</year>
			</pub-date>
			<pub-date date-type="collection" publication-format="electronic">
				<year>2022</year>
			</pub-date>
			<volume>35</volume>
			<issue>3</issue>
			<elocation-id>eed24</elocation-id>
			<history>
				<date date-type="received">
					<day>8</day>
					<month>10</month>
					<year>2022</year>
				</date>
				<date date-type="rev-recd">
					<day>8</day>
					<month>7</month>
					<year>2022</year>
				</date>
				<date date-type="accepted">
					<day>9</day>
					<month>5</month>
					<year>2022</year>
				</date>
			</history>
			<permissions>
				<license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by-nc/4.0/">
					<license-p> This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. </license-p>
				</license>
			</permissions>
			<kwd-group xml:lang="pt">
				<kwd>Hipertensão Pulmonar</kwd>
				<kwd>Ecocardiografia</kwd>
				<kwd>Átrio Direito</kwd>
				<kwd>Ventrículo Direito</kwd>
			</kwd-group>
			<counts>
				<fig-count count="0"/>
				<table-count count="0"/>
				<equation-count count="0"/>
				<ref-count count="6"/>
				<page-count count="2"/>
			</counts>
		</article-meta>
	</front>
	<body>
		<p>A hipertensão pulmonar (HP) consiste em uma condição que resulta em grande limitação clínica e funcional dos pacientes acometidos por essa doença, com significativo impacto na qualidade de vida e na sobrevida.<sup><xref ref-type="bibr" rid="B1">1</xref>,<xref ref-type="bibr" rid="B2">2</xref></sup> Atualmente, existem opções de tratamento farmacológico, como os inibidores de fosfodiesterase tipo 5, antagonistas dos receptores da endotelina e prostanoides para esses pacientes com resposta satisfatória. Porém, para melhores resultados, é fundamental o diagnóstico precoce dessa condição e de sua definição etiológica.<sup><xref ref-type="bibr" rid="B3">3</xref></sup></p>
		<p>O ecocardiograma transtorácico (ETT) é o exame de primeira linha para o rastreio e a suspeita diagnóstica inicial de HP, por se tratar de exame não invasivo, com ampla disponibilidade, relativo baixo custo e ausência de exposição à radiação com risco mínimo para os pacientes. No entanto, é importante ressaltar que o ETT apenas sugere o diagnóstico de HP, uma vez que o diagnóstico definitivo é baseado em medidas hemodinâmicas invasivas pelo cateterismo cardíaco direito.<sup><xref ref-type="bibr" rid="B4">4</xref></sup></p>
		<p>Ao ETT, além da medida da pressão sistólica de artéria pulmonar pela análise da velocidade de pico do jato de insuficiência tricúspide, é possível realizar a avaliação de variáveis não apenas diagnósticas, mas também prognósticas.<sup><xref ref-type="bibr" rid="B4">4</xref>,<xref ref-type="bibr" rid="B5">5</xref></sup></p>
		<p>Em estudo de Brito et al., os autores realizaram correlação de parâmetros avaliados pelo ETT com a avaliação invasiva, pelo estudo hemodinâmico, considerado padrão-ouro para o diagnóstico.<sup><xref ref-type="bibr" rid="B6">6</xref></sup> Apesar do n limitado, os autores realizaram um estudo com metodologia adequada e analisaram parâmetros como a área do átrio direito, a pressão média da artéria pulmonar, o <italic>strain</italic> de átrio direito, além de variáveis quantitativas convencionais e <italic>strain</italic> da parede livre para análise da função sistólica do ventrículo direito. Particularmente, estudos que realizam a correlação entre a deformação do átrio direito com medidas invasivas são bastante escassos na literatura, o que torna o estudo de Brito et al original e interessante. A análise da deformação miocárdica atrial apresenta o potencial de detectar precocemente sinais de disfunção diastólica, porém, ao contrário da análise do <italic>strain</italic> atrial esquerdo, que tem papel crescente em diversos cenários clínicos, a análise do <italic>strain</italic> atrial direito tem valor ainda incerto na prática clínica. O estudo de Brito et al. apresenta proposta pertinente ao incorporar novas variáveis da análise ecocardiográfica, como o <italic>strain</italic> atrial direito e o <italic>strain</italic> da parede livre do ventrículo direito, associada a medidas convencionais, como a área do átrio direito, com correlação moderada com dados invasivos. Talvez a análise do volume indexado do átrio direito e/ou associação das variáveis em um estudo com maior número de pacientes consiga melhorar a eficiência do ecocardiograma na avaliação inicial dos pacientes com suspeita de HP.</p>
		<p>Assim, apesar de atualmente o diagnóstico definitivo de HP ser feito de forma invasiva pelo cateterismo cardíaco direito, novas variáveis ecocardiográficas, como a análise da deformação (<italic>strain</italic>) atrial e ventricular direita, além dos índices tradicionais de avaliação do coração direito, têm papel promissor no refinamento da avaliação ecocardiográfica em pacientes com HP, não apenas para o diagnóstico, mas também fornecendo informações a respeito da classificação do grupo de HP, além do prognóstico.</p>
	</body>
	<back>
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	</back>
	<sub-article article-type="translation" id="TRen" xml:lang="en">
		<front-stub>
			<article-categories>
				<subj-group subj-group-type="heading">
					<subject>Editorial</subject>
				</subj-group>
			</article-categories>
			<title-group>
				<article-title>Role of Echocardiography in Assessment of Patients with Suspected Ph: Beyond the Peak Tricuspid Regurgitant Velocity</article-title>
			</title-group>
			<contrib-group>
				<contrib contrib-type="author">
					<contrib-id contrib-id-type="orcid">0000-0002-9236-3815</contrib-id>
					<name>
						<surname>Hotta</surname>
						<given-names>Viviane Tiemi</given-names>
					</name>
					<xref ref-type="aff" rid="aff1001"><sup>1</sup></xref>
					<xref ref-type="aff" rid="aff2001"><sup>2</sup></xref>
				</contrib>
			</contrib-group>
			<aff id="aff1001">
				<label>1</label>
				<country country="BR">Brazil</country>
				<institution content-type="original">Instituto do Coração, Faculdade de Medicina, Universidade de São Paulo,(InCor/FMUSP) São Paulo, SP, Brazil.</institution>
			</aff>
			<aff id="aff2001">
				<label>2</label>
				<country country="BR">Brazil</country>
				<institution content-type="original">Fleury Medicina e Saúde, São Paulo, SP, Brazil.</institution>
			</aff>
			<author-notes>
				<corresp id="c01001"> Mailing Address: Viviane Tiemi Hotta • Instituto do Coração HC-FMUSP, Unidade Clínica de Miocardiopatias e Doenças da Aorta. Av. Dr Enéas Carvalho de Aguiar, 55. CEP 05403-900, São Paulo, SP – Brazil. E-mail: viviane.hotta@gmail.com </corresp>
				<fn fn-type="con">
					<p>Author contributions</p>
					<p>Research conception and design: VTH; manuscript writing: VTH; Critical review of the manuscript for important intellectual content.</p>
				</fn>
				<fn fn-type="conflict">
					<p>Conflict of interest</p>
					<p>The author declares that he has no conflict of interest</p>
				</fn>
			</author-notes>
			<kwd-group xml:lang="en">
				<kwd>Pulmonary Hypretension</kwd>
				<kwd>Echocardiography</kwd>
				<kwd>Right Atrium</kwd>
				<kwd>Right Ventricle</kwd>
			</kwd-group>
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		<body>
			<p>Pulmonary hypertension (PH) causes great clinical and functional limitations and significantly impacts quality of life and survival.<sup><xref ref-type="bibr" rid="B1">1</xref>,<xref ref-type="bibr" rid="B2">2</xref></sup> Current pharmacological treatment options for PH include phosphodiesterase-5 inhibitors, endothelin receptor antagonists, and prostanoids. However, an early diagnosis and etiological definition are essential to improve prognosis.<sup><xref ref-type="bibr" rid="B3">3</xref></sup></p>
			<p>Transthoracic echocardiography (TTE) is the first-line test for suspected PH, as it is widely available, noninvasive, relatively low cost, does not involve radiation exposure, and carries minimal risk to patients. However, TTE can only suggest the diagnosis of PH since the definitive diagnosis requires invasive hemodynamic measurements via right heart catheterization.<sup><xref ref-type="bibr" rid="B4">4</xref></sup></p>
			<p>In addition to measuring pulmonary artery systolic pressure by analyzing the peak tricuspid regurgitant velocity, TTE evaluates diagnostic and prognostic variables.<sup><xref ref-type="bibr" rid="B4">4</xref>,<xref ref-type="bibr" rid="B5">5</xref></sup></p>
			<p>Brito et al. correlated parameters evaluated by TTE and invasive hemodynamic analysis, considered the diagnostic gold standard.<sup><xref ref-type="bibr" rid="B6">6</xref></sup> Despite the limited sample size, the study had adequate methodology and analyzed parameters such as right atrial area, mean pulmonary artery pressure, and right atrial strain in addition to conventional quantitative variables and free wall strain to analyze right ventricular systolic function.</p>
			<p>Studies correlating right atrial deformations using invasive measurements are quite scarce in the literature, which makes the study by Brito et al. original and interesting. The analysis of atrial myocardial deformation may detect early signs of diastolic dysfunction; however, unlike left atrial strain analysis, which has an increasing role in several clinical scenarios, the value of right atrial strain analysis in clinical practice remains uncertain. The Brito et al. study presented a relevant proposal by incorporating new echocardiographic variables such as right atrial strain and right ventricular free wall strain associated with conventional measurements such as right atrial area, with a moderate correlation with invasive data. The analysis of the indexed volume of the right atrium and/or the association of variables in a study with a larger number of patients may improve the efficiency of TTE in the initial evaluation of patients with suspected PH.</p>
			<p>Thus, although the definitive diagnosis of PH requires invasive right heart catheterization, new echocardiographic variables such as atrial and right ventricular strain analysis in addition to traditional right heart indices have a promising role in refining PH diagnosis, refining classification as well as improving prognosis.</p>
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