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  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">dic</journal-id>
      <journal-title-group>
        <journal-title>Arquivos Brasileiros de Cardiologia Imagem cardiovascular</journal-title>
        
        <abbrev-journal-title abbrev-type="publisher">Arq Bras Cardiol: Imagem cardiovasc</abbrev-journal-title>
      </journal-title-group>
      <issn pub-type="epub">2675-312X</issn>
      <publisher>
        <publisher-name>Sociedade Brasileira de Cardiologia</publisher-name>
        
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">2318-8219.20180027</article-id>
      <article-id pub-id-type="doi">10.5935/2318-8219.20180027</article-id>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Original Article</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Echocardiographic Evaluation of Late Cardiac Abnormalities Caused by the Chikungunya Fever</article-title>
        <trans-title-group xml:lang="pt">
          <trans-title>Avaliação Ecocardiográfica das Alterações Cardíacas Tardias Provocadas pela Febre Chikungunya</trans-title>
        </trans-title-group>
      </title-group>
      <contrib-group><contrib contrib-type="author"><name><surname>Del Castillo</surname><given-names>José Maria</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Alencar</surname><given-names>Gabriela Marques Pereira de</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Nóbrega</surname><given-names>Marcus Vinicius Dantas da</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Mazzarollo</surname><given-names>Carlos</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Diniz</surname><given-names>Jonny Vitor</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Albuquerque</surname><given-names>Eugenio Soares de</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Sena</surname><given-names>Antônia Dulcineide Medeiros</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Silveira</surname><given-names>Carlos Antônio da Mota</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Osella</surname><given-names>Oscar Francisco Sanchez</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib></contrib-group>
      <aff id="aff1"><label>1</label><institution content-type="normalized"/><institution content-type="orgname">Escola de Ecografia de Pernambuco</institution><country country="BR"/><institution content-type="original">Escola de Ecografia de Pernambuco (Ecope);</institution></aff>
      <aff id="aff2"><label>2</label><institution content-type="normalized"/><institution content-type="orgname">Universidade Católica de Pernambuco</institution><country country="BR"/><institution content-type="original">Universidade Católica de Pernambuco (Unicap);</institution></aff>
      <aff id="aff3"><label>3</label><institution content-type="normalized"/><institution content-type="orgdiv1">Pronto-Socorro Cardiológico de Pernambuco</institution><institution content-type="orgname">Universidade de Pernambuco</institution><addr-line><named-content content-type="city">Recife</named-content><named-content content-type="state">Pernambuco</named-content></addr-line><country country="BR">Brazil</country><institution content-type="original">Pronto-Socorro Cardiológico de Pernambuco, Universidade de Pernambuco (UPE), Recife, Pernambuco - Brazil</institution></aff>
      <author-notes> <corresp id="c01"> Mailing Address: José Maria Del Castillo • Rua Jorge de Lima, 245, apto. 303, Salute. Postal Code 51160-070, Recife, PE – Brazil E-mail: <email>castillojmd@gmail.com</email> </corresp> <fn fn-type="con"> <p>Authors’ contributions</p> <p>Research creation and design: Del Castillo JM; Data acquisition: Del Castillo JM, Alencar GMP, Nóbrega MVD, Mazzarollo C, Diniz JV; Data analysis and interpretation: Del Castillo JM, Alencar GMP; Statistical analysis: Del Castillo JM, Sena ADM; Manuscript writing: Del Castillo JM; Critical revision of the manuscript as for important intellectual content: Del Castillo JM, Alencar GMP, Nóbrega MVD, Mazzarollo C, Diniz JV, Albuquerque ES, Sena ADM, , Silveira CAM, Osella OFS; Collection of references: Alencar GMP, Nóbrega MVD.</p> </fn><fn fn-type="conflict">
<p>Potential Conflicts of Interest</p> <p>There are no relevant conflicts of interest.</p></fn> </author-notes>
      <pub-date date-type="pub" publication-format="electronic">
				<day>20</day>
				<month>01</month>
				<year>2022</year>
			</pub-date>
			<pub-date date-type="collection" publication-format="electronic">
        <season>Jul-Sept</season>
        <year>2018</year>
      </pub-date>
      <volume>31</volume>
      <issue>3</issue>
      <fpage>183</fpage>
      <lpage>190</lpage>
      <history><date date-type="received"><day>21</day><month>01</month><year>2018</year></date><date date-type="rev-recd"><day>1</day><month>02</month><year>2018</year></date><date date-type="accepted"><day>4</day><month>06</month><year>2018</year></date></history>
      <permissions>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc/3.0/">
<license-p>
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
</license-p>
</license>
</permissions>
      <abstract><title>Abstract</title><sec><title>Background</title><p> Chicungunya fever causes highly debilitating joint pains. Complications are rare and may affect the cardiovascular system.</p></sec><sec><title>Objective</title><p> To evaluate, with echocardiography and two-dimensional strain, the cardiovascular changes in the chronic phase of the Chikungunya infection.</p></sec><sec><title>Methods</title><p> The study included 32 patients, mean age 56 ± 14 years divided into Group A, with &lt; 12 months evolution (12 patients) and Group B, with ≥ 12 months evolution (20 patients). The cardiac dimensions, left ventricular end-diastolic volume indexed to body surface, left ventricular ejection fraction, left ventricular global longitudinal strain and left atrial longitudinal strain were determined. The groups were compared using unpaired analysis. The p significance was &lt; 0.05.</p></sec><sec><title>Results</title><p> Most Group A patients presented diffuse hypocontratility and decreased left ventricular ejection fraction (45.5 ± 10.4%) with normal left ventricular diastolic indexed volume (58.7 ± 24.9 mL/m<sup>2</sup>). Most Group B patients presented diffuse hypocontratility (ejection fraction 38.2 ± 6.4%) and increased left ventricular diastolic indexed volume (88.3 ± 26.4 mL/m<sup>2</sup>). There was segmental changes in 22% of the patients, and hypertrophy or remodelling in seven cases of each Group. There was decreased global longitudinal strain in both Groups (-11.9 ± 4.4% in Group A and -10.3 ± 3.8% in Group B). Lef atrial longitudinal strain were 37.9 ± 17.3% in Group A and 27.5 ± 15.2% in Group B. Patients with pericarditis had normal left ventricular dimensions and function.</p></sec><sec><title>Conclusion</title><p> The cardiac complications of Chikungunya fever was diffuse hypocontratility with left ventricular normal size observed in the first year of chronic evolution and diffuse hypocontratility with left ventricular dilation observed in later evolution. Patients with pericardial thickening did not present myocardial issues. Echocardiography can be used as an important tool in patients with Chikungunya fever, since it can detects early abnormalities in the cardiovascular system. (Arq Bras Cardiol: Imagem cardiovasc. 2018;31(3):183-190)</p></sec></abstract>
      <trans-abstract xml:lang="pt"><title>Resumo</title><sec><title>Fundamento</title><p> A febre Chicungunya (CHIKV) provoca dores articulares altamente debilitantes. As complicações são raras, podendo afetar o sistema cardiovascular.</p></sec><sec><title>Objetivo</title><p> Avaliar, com ecocardiografia e strain bidimensional, as alterações cardiovasculares na fase crônica da infecção por CHIKV.</p></sec><sec><title>Métodos</title><p> Foram estudados 32 pacientes, média etária de 56 ± 14 anos, divididos em Grupo A, com evolução &lt; 12 meses (12 pacientes) e Grupo B, com evolução ≥12 meses (20 pacientes). Foram determinadas as dimensões cardíacas, o volume diastólico final do ventrículo esquerdo indexado para superfície corporal; a fração de ejeção do ventrículo esquerdo, o strain longitudinal global do ventrículo esquerdo e o strain longitudinal do átrio esquerdo. Os grupos foram comparados pela análise não pareada. A significância de p foi &lt; 0,05.</p></sec><sec><title>Resultados</title><p> A maioria dos pacientes do Grupo A apresentou hipocontratilidade difusa e diminuição da fração de ejeção do ventrículo esquerdo (45,5 ± 10,4%) com com volume diastólico do ventrículo esquerdo indexado normal (58,7 ± 24,9 mL/m²). A maioria dos pacientes do Grupo B apresentou hipocontratilidade difusa (fração de ejeção do ventrículo esquerdo de 38,2 ± 6,4%) e volume diastólico do ventrículo esquerdo indexado aumentado (88,3 ± 26,4 mL/m²). Foram observadas alterações segmentares em 22% dos pacientes e hipertrofia ou remodelamento em 7 casos de cada Grupo.O strain longitudinal global estava diminuído (-11,9 ± 4,4% no Grupo A e -10,3 ± 3,8% no Grupo B). O strain longitudinal do átrio esquerdo foi de 37,9 ± 17,3% no Grupo A e de 27,5 ± 15,2% no Grupo B. Os pacientes com pericardite apresentavam dimensões e função do VE normais.</p></sec><sec><title>Conclusão</title><p> Entre as complicações cardíacas da febre Chicungunya, a hipocontratilidade difusa com ventrículo esquerdo de dimensões normais foi observada no primeiro ano da evolução crônica e a hipocontratilidade difusa com dilatação do ventrículo esquerdo na evolução mais tardia. Pacientes com espessamento pericárdico não evidenciaram alterações miocárdicas.A ecocardiografia é uma importante ferramenta diagnóstica para os pacientes com infecção por vírus Chicungunya, pois detecta e quantifica as alterações do sistema cardiovascular. (Arq Bras Cardiol: Imagem cardiovasc. 2018;31(3):183-190)</p></sec></trans-abstract>
      <kwd-group xml:lang="en"><kwd>Echocardiography</kwd><kwd>Longitudinal Strain</kwd><kwd>Chikungunya fever</kwd></kwd-group>
      <kwd-group xml:lang="pt"><kwd>ecocardiografia</kwd><kwd>strain longitudinal</kwd><kwd>febre Chicungunya</kwd></kwd-group>
      <counts><fig-count count="0"/><table-count count="0"/><equation-count count="0"/><ref-count count="0"/><page-count count="8"/></counts>
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