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  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">dic</journal-id>
      <journal-title-group>
        <journal-title>Arquivos Brasileiros de Cardiologia Imagem cardiovascular</journal-title>
        
        <abbrev-journal-title abbrev-type="publisher">Arq Bras Cardiol: Imagem cardiovasc</abbrev-journal-title>
      </journal-title-group>
      <issn pub-type="epub">2675-312X</issn>
      <publisher>
        <publisher-name>Sociedade Brasileira de Cardiologia</publisher-name>
        
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">2318-8219.20180025</article-id>
      <article-id pub-id-type="doi">10.5935/2318-8219.20180025</article-id>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Original Article</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Analyzing the Safety and Predictors of Arrhythmias during Dobutamine-Atropine Stress Echocardiography in a Non-Hospital Setting</article-title>
        <trans-title-group xml:lang="pt">
          <trans-title>Análise da Segurança e dos Preditores de Arritmias Durante o Ecocardiograma Sob Estresse com Dobutamina em um Ambiente Não Hospitalar</trans-title>
        </trans-title-group>
      </title-group>
      <contrib-group><contrib contrib-type="author"><name><surname>Rassi</surname><given-names>Daniela do Carmo</given-names></name><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name><surname>Furtado</surname><given-names>Rogério Gomes</given-names></name><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name><surname>Turco</surname><given-names>Fabio de Paula</given-names></name><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name><surname>Melato</surname><given-names>Luciano Henrique</given-names></name><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name><surname>Oliveira</surname><given-names>Ana Caroline Reinaldo de</given-names></name><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name><surname>Dourado</surname><given-names>Colandy Nunes</given-names></name><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name><surname>Rassi</surname><given-names>Luiz</given-names><suffix>Jr</suffix></name><xref ref-type="aff" rid="aff1"/></contrib></contrib-group>
      <aff id="aff1"><institution content-type="normalized"/><institution content-type="orgname">CDI - Centro de Diagnóstico por Imagem</institution><addr-line><named-content content-type="city">Goiânia</named-content><named-content content-type="state">Goiás</named-content></addr-line><country country="BR">Brazil</country><institution content-type="original">CDI - Centro de Diagnóstico por Imagem, Goiânia, Goiás – Brazil</institution></aff>
      <author-notes>
        <corresp id="c01"> Mailing Address: Daniela do Carmo Rassi • Rua T34, 1999, Setor Bueno. Postal Code 74223-220, Goiânia, Goiás – Brazil E-mail: <email>dani.rassi@hotmail.com</email> </corresp>
        <fn fn-type="con">
	<p>Authors’ contributions</p>
	<p>Research creation and design: Rassi DC, Furtado RG, Turco FP, Melato LH, Dourado CN, Rassi Jr. L; Data acquisition: Rassi DC, Furtado RG, Turco FP, Melato LH, Dourado CN, Rassi Jr. L; Data analysis and interpretation: Rassi DC, Furtado RG, Turco FP, Melato LH, Dourado CN, Rassi Jr. L; Statistical analysis: Rassi DC, Furtado RG; Funding: Rassi DC, Furtado RG, Turco FP, Melato LH, Dourado CN, Rassi Jr. L; Manuscript drafting: Rassi DC, Furtado RG, Turco FP, Melato LH, Oliveira ACR, Dourado CN, Rassi Jr. L; Critical revision of the manuscript as for important intellectual content: Rassi DC, Furtado RG, Turco FP, Melato LH, Oliveira ACR, Dourado CN, Rassi Jr. L.</p></fn><fn fn-type="conflict">
	<p>Potential Conflicts of Interest</p>
	<p>There are no relevant conflicts of interest.</p></fn>
      </author-notes>
      <pub-date date-type="pub" publication-format="electronic">
				<day>20</day>
				<month>01</month>
				<year>2022</year>
			</pub-date>
			<pub-date date-type="collection" publication-format="electronic">
        <season>Jul-Sept</season>
        <year>2018</year>
      </pub-date>
      <volume>31</volume>
      <issue>3</issue>
      <fpage>168</fpage>
      <lpage>174</lpage>
      <history><date date-type="received"><day>9</day><month>12</month><year>2017</year></date><date date-type="rev-recd"><day>23</day><month>12</month><year>2017</year></date><date date-type="accepted"><day>6</day><month>03</month><year>2018</year></date></history>
      <permissions>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc/3.0/">
<license-p>
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
</license-p>
</license>
</permissions>
      <abstract><title>Abstract</title><sec><title>Background</title><p> Dobutamine-atropine stress echocardiography (DASE) is an accessible and important test, especially in patients under investigation for coronary artery disease. However, it is necessary to evaluate its safety, as it is used in patients with increasingly complex and serious conditions and in seniors.</p></sec><sec><title>Objective</title><p> To confirm the safety of DASE and evaluate the predictors of arrhythmias in a non-hospital setting.</p></sec><sec><title>Methods</title><p> DASE was performed to evaluate ischemia using the standard protocol of dobutamine infusion of 5 to 40 mcg/kg/min associated with atropine.</p></sec><sec><title>Results</title><p> From September to November 2010, 227 patients were evaluated prospectively. The mean age was 60.7 +/- 12.5 years old and 60.8% were females. Mean ejection fraction was 67.9 +/- 9. Among the adverse events, 12 patients presented hypertensive response, 466 had arrhythmia, 58 had headaches and 57 had precordial pain. No patient had acute myocardial infarction, ventricular fibrillation, cardiac rupture, asystole or death. As for the onset of significant arrhythmia, three patients had atrial fibrillation, 16 had sustained supraventricular tachycardia, 19 had non-sustained ventricular tachycardia and 2 had sustained ventricular tachycardia. In these patients, age (OR = 1.0559, p = 0.0002) and segmental contractility index at rest (SCIr) &gt; 1 (OR 2.5039, p = 0.0354) were independent predictors for the onset significant arrhythmia during the test.</p></sec><sec><title>Conclusion</title><p> DASE was proven safe in this group of patients in a non-hospital setting. Age and SCIr &gt; 1 were independent predictors for the onset of significant arrhythmia during the test. (Arq Bras Cardiol: Imagem cardiovasc. 2018;31(3):168-174)</p></sec></abstract>
      <trans-abstract xml:lang="pt"><title>Resumo</title><sec><title>Fundamento</title><p> O ecocardiograma sob estresse com dobutamina-atropina (EEDA) é um exame acessível e importante, principalmente em pacientes sob investigação de doença coronariana. Contudo, faz-se necessário a avaliação de sua segurança, devido ao seu emprego em pacientes com patologias cada vez mais complexas, graves e idosos.</p></sec><sec><title>Objetivo</title><p> Confirmar segurança do EEDA e avaliar os preditores de arritmias em ambiente não hospitalar.</p></sec><sec><title>Métodos</title><p> EEDA foi realizado com o objetivo de avaliar isquemia utilizando o protocolo padrão de infusão de dobutamina de 5 a 40 mcg/kg/min associado a atropina.</p></sec><sec><title>Resultados</title><p> Foram avaliados de forma prospectiva 2227 pacientes no período de setembro a novembro de 2010. Idade média foi de 60,7 +/- 12,5 anos e 60,8% eram mulheres. A fração de ejeção média foi de 67,9% +/- 9. Dentre dos eventos adversos,12 pacientes apresentaram resposta hipertensiva, 466 arritmias, 58 cefaleias e 57 dores precordial. Nenhum paciente apresentou infarto agudo do miocárdio, fibrilação ventricular, ruptura cardíaca, assistolia ou morte. Quanto ao surgimento das arritmias significativas, 3 pacientes apresentaram fibrilação atrial,16 taquicardias supraventricular sustentada,19 taquicardias ventricular não sustentada e 2 taquicardias ventricular sustentada. Nestes pacientes, idade (OR = 1,0559, p = 0,0002) e o índice de escore de contração segmentar (IECS) em repouso &gt; 1 (OR 2,5039, p = 0,0354) foram preditores independentes para o surgimento de arritmias significativas durante o exame.</p></sec><sec><title>Conclusão</title><p> O EEDA mostrou-se seguro nesse grupo de pacientes em ambiente não hospitalar. Idade e IECS em repouso &gt; 1 foram preditores independentes para o surgimento de arritmias significativas durante o exame. (Arq Bras Cardiol:Imagem cardiovasc. 2018;31(3):168-174)</p></sec></trans-abstract>
      <kwd-group xml:lang="en"><kwd>Echocardiography, Stress/adverse effects</kwd><kwd>Safety</kwd><kwd>Dobutamine</kwd><kwd>Heart Failure</kwd><kwd>Arrhythmias, Cardiac</kwd></kwd-group>
      <kwd-group xml:lang="pt"><kwd>Ecocardografia sob Estresse/efeitos adversos</kwd><kwd>Segurança</kwd><kwd>Dobutamina</kwd><kwd>Insuficiência Coronária</kwd><kwd>Arritmias cardíacas</kwd></kwd-group>
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