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  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">dic</journal-id>
      <journal-title-group>
        <journal-title>Arquivos Brasileiros de Cardiologia Imagem cardiovascular</journal-title>
        
        <abbrev-journal-title abbrev-type="publisher">Arq Bras Cardiol: Imagem cardiovasc</abbrev-journal-title>
      </journal-title-group>
      <issn pub-type="epub">2675-312X</issn>
      <publisher>
        <publisher-name>Sociedade Brasileira de Cardiologia</publisher-name>
        
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">2318-8219.20170033</article-id>
      <article-id pub-id-type="doi">10.5935/2318-8219.20170033</article-id>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Original Article</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Analysis of Right Ventricular Function in Patients with Hypothyroidism</article-title>
        <trans-title-group xml:lang="pt">
          <trans-title>Análise da Função Ventricular Direita em Portadores de Hipotireoidismo</trans-title>
        </trans-title-group>
        <trans-title-group xml:lang="es">
          <trans-title>Análisis de la Función Ventricular Derecha en Portadores de Hipotiroidismo</trans-title>
        </trans-title-group>
      </title-group>
      <contrib-group><contrib contrib-type="author"><name><surname>Macedo</surname><given-names>Gustavo Demasi Quadros de</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Macedo</surname><given-names>Mario Jorge Quadros de</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Souza</surname><given-names>Jean Jorge Silva de</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Gazzana</surname><given-names>Maria Luiza</given-names></name><xref ref-type="aff" rid="aff4"><sup>4</sup></xref><xref ref-type="aff" rid="aff5"><sup>5</sup></xref></contrib></contrib-group>
      <aff id="aff1"><label>1</label><institution content-type="normalized"/><institution content-type="orgname">Universidade Federal do Amazonas</institution><country country="BR"/><institution content-type="original">Universidade Federal do Amazonas;</institution></aff>
      <aff id="aff2"><label>2</label><institution content-type="normalized"/><institution content-type="orgname">Secretaria Estadual de Saúde do Amazonas</institution><country country="BR"/><institution content-type="original">Secretaria Estadual de Saúde do Amazonas;</institution></aff>
      <aff id="aff3"><label>3</label><institution content-type="normalized"/><institution content-type="orgname">Universidade Nilton Lins</institution><country country="BR"/><institution content-type="original">Universidade Nilton Lins;</institution></aff>
      <aff id="aff4"><label>4</label><institution content-type="normalized"/><institution content-type="orgname">Hospital Universitário Francisca Mendes</institution><country country="BR"/><institution content-type="original">Hospital Universitário Francisca Mendes;</institution></aff>
      <aff id="aff5"><label>5</label><institution content-type="normalized"/><institution content-type="orgname">Universidade do Estado do Amazonas</institution><addr-line><named-content content-type="city">Manaus</named-content><named-content content-type="state">Amazonas</named-content></addr-line><country country="BR">Brazil</country><institution content-type="original">Universidade do Estado do Amazonas, Manaus, Amazonas – Brazil</institution></aff>
      <author-notes> <corresp id="c01"> Mailing Address: Escola Superior de Ciências da Saúde - ESA - UEA • Av. Carvalho Leal, 1777. Postal Code 69065-001, Cachoeirinha, Manaus, AM – Brazil E-mail: <email>luizagazzana@yahoo.com.br</email> </corresp> <fn fn-type="con"> <p>Authors’ contributions</p> <p>Research creation and design: Souza JJS, Gazzana ML; Data acquisition: Macedo GDQ, Macedo MJQ; Data analysis and interpretation: Macedo GDQ, Macedo MJQ, Souza JJS, Gazzana ML; Statistical analysis: Macedo GDQ, Souza JJS; Funding: Souza JJS; Manuscript drafting: Macedo GDQ, Macedo MJQ, Souza JJS, Gazzana ML; Critical revision of the manuscript as for important intellectual content: Souza JJS, Gazzana ML.</p></fn><fn fn-type="conflict"> <p>Potential Conflicts of Interest</p> <p>There are no relevant conflicts of interest.</p></fn> </author-notes>
      <pub-date date-type="pub" publication-format="electronic">
				<day>20</day>
				<month>01</month>
				<year>2022</year>
			</pub-date>
			<pub-date date-type="collection" publication-format="electronic">
        <season>Oct-Dec</season>
        <year>2017</year>
      </pub-date>
      <volume>30</volume>
      <issue>4</issue>
      <fpage>126</fpage>
      <lpage>131</lpage>
      <history><date date-type="received"><day>29</day><month>05</month><year>2017</year></date><date date-type="rev-recd"><day>12</day><month>06</month><year>2017</year></date><date date-type="accepted"><day>12</day><month>07</month><year>2017</year></date></history>
      <permissions>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc/3.0/">
<license-p>
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
</license-p>
</license>
</permissions>
      <abstract><title>Summary</title><sec><title>Background</title><p> After many studies about the left ventricle (LV), little is known about the effect of thyroid hormones deprivation at the right ventricle (RV).</p></sec><sec><title>Objective</title><p> This study was aimed to evaluate the right ventricular function in patients who had hypothyroidism in different degrees of disease severity.</p></sec><sec><title>Methods</title><p> Eighteen patients with primary hypothyroidism were submitted to two-dimensional echocardiography evaluation, of which 10 (55,6%) had TSH &lt; 12 mIU/L (less high TSH group) and 8 (44,4%) had TSH &gt; 12 mIU/L (highest TSH group).</p></sec><sec><title>Results</title><p> By comparing the two groups, there were no differences in respect of LV global systolic function or diastolic function. There was neither difference related to right atrium or RV dimensions. About the right ventricular function, it was shown a difference in the myocardial performance index (Tei index), which was higher in patients who had TSH &gt; 12 compared with patients who had TSH &lt; 12 (0.52 ± 0.13 vs. 0.39 ± 0.08; p &lt; 0.05), indicating worse right ventricular global function in those patients with the highest TSH levels. No differences were observed between these groups related to other variables, which are: percentage of systolic change in the VD area, TAPSE and peak systolic velocity. Variables of RV diastolic function (E/A tricuspid ratio and E/E’ tricuspid ratio), as well as pulmonary vascular resistance and pulmonary artery systolic pressure were not different between groups.</p></sec><sec><title>Conclusion</title><p> Patients with hypothyroidism who had the highest TSH levels, as compared to those with less high TSH, presented with a reduction at the overall right ventricular function, evaluated by myocardial performance index, not observed in other parameters of RV function evaluation. (Arq Bras Cardiol: Imagem cardiovasc. 2017;30(4):126-131)</p></sec></abstract>
      <trans-abstract xml:lang="pt"><title>Resumo</title><sec><title>Fundamentos</title><p> Os hormônios da tireoide exercem ações diretas e indiretas sobre o sistema cardiovascular. Após vários estudos sobre o ventrículo esquerdo, indaga-se quais seriam os efeitos do hipotireoidismo no ventrículo direito.</p></sec><sec><title>Objetivo</title><p> Avaliar, através de ecoDopplercardiograma, a função ventricular direita de portadores de hipotireoidismo em diferentes graus da doença.</p></sec><sec><title>Métodos</title><p> Foram avaliados pacientes com diagnóstico de hipotireoidismo primário, que foram divididos em dois grupos: com TSH pouco elevado – até 12 mcUI/mL – e TSH muito elevado – TSH acima de 12 mcUI/mL. Os pacientes foram submetidos a exames clínico e laboratorial e ecocardiograma transtorácico.</p></sec><sec><title>Resultados</title><p> Dos 18 pacientes submetidos à Ecocardiografia, 10 (55,6%) tinham TSH &lt; 12 mcUI/mL e 8 (44,4%) tinham TSH &gt; 12 mcUI/mL. Não houve diferença entre os dois grupos quanto à função global do ventrículo esquerdo (VE), nem quanto às dimensões das câmaras cardíacas direitas. Quanto às variáveis de função ventricular direita, houve diferença apenas no índice de desempenho miocárdico do VD (IDMVD), que foi mais elevado nos pacientes com TSH &gt; 12 do que nos pacientes com TSH &lt; 12 (0,52 ± 0,13 vs. 0,39 ± 0,08; p &lt; 0,05), indicando uma pior função sistólica global do VD naquele grupo. Não houve diferença entre os grupos em relação às demais variáveis de função sistólica ou diastólica do VD. A resistência vascular pulmonar e a pressão sistólica da artéria pulmonar não diferiram entre os dois grupos.</p></sec><sec><title>Conclusões</title><p> Pacientes com hipotireoidismo com TSH mais elevado apresentaram redução da função ventricular direita global, avaliada pelo IDMVD, mas que não foi observada nos demais parâmetros de função deste ventrículo. (Arq Bras Cardiol: Imagem cardiovasc. 2017;30(4):126-131)</p></sec></trans-abstract>
      <trans-abstract xml:lang="es"><title>Resumen</title><sec><title>Fundamentos</title><p> Las hormonas de la tiroides ejercen acciones directas e indirectas sobre el sistema cardiovascular. Después de varios estudios sobre el ventrículo izquierdo, se indaga cuáles serían los efectos del hipotiroidismo en el ventrículo derecho.</p></sec><sec><title>Objetivo</title><p> Evaluar, por medio de ecoDopplercardiograma, la función ventricular derecha de portadores de hipotiroidismo en diferentes grados de la enfermedad.</p></sec><sec><title>Métodos</title><p> Fueron evaluados pacientes con diagnóstico de hipotiroidismo primario, que fueron divididos en dos grupos:con TSH poco elevado – hasta 12 mcUI/mL – y TSH muy elevado – TSH encima de 12 mcUI/mL. Los pacientes fueron sometidos a exámenes clínicos y de laboratorio y ecocardiograma transtorácico.</p></sec><sec><title>Resultados</title><p> De los 18 pacientes sometidos a Ecocardiografía, 10 (55,6%) tenían TSH &lt; 12 mcUI/mL y 8 (44,4%) tenían TSH &gt; 12 mcUI/mL. No hubo diferencia entre los dos grupos respecto a la función global del ventrículo izquierdo (VI), ni respecto a las dimensiones de las cámaras cardíacas derechas. Respecto a las variables de función ventricular derecha, hubo diferencia apenas en el índice de desempeño miocárdico del VD (IDMVD), que fue más elevado en los pacientes con TSH &gt; 12 que en los pacientes con TSH &lt; 12 (0,52 ± 0,13 vs. 0,39 ± 0,08; p &lt; 0,05), indicando una peor función sistólica global del VD en aquel grupo. No hubo diferencia entre los grupos en relación a las demás variables de función sistólica o diastólica del VD. La resistencia vascular pulmonar y la presión sistólica de la arteria pulmonar no difirieron entre los dos grupos.</p></sec><sec><title>Conclusiones</title><p> Pacientes con hipotiroidismo con TSH más elevado presentaron reducción de la función ventricular derecha global, evaluada por el IDMVD, pero que no fue observada en los demás parámetros de función de este ventrículo. (Arq Bras Cardiol: Imagem cardiovasc. 2017;30(4):126-131)</p></sec></trans-abstract>
      <kwd-group xml:lang="en"><kwd>Ventricular Function, Right/physiology</kwd><kwd>Thyroid Hormones</kwd><kwd>Echocardiography</kwd></kwd-group>
      <kwd-group xml:lang="pt"><kwd>Função Ventricular Direita/fisiologia</kwd><kwd>Hipotireoidismo, Hormônios Tireóideos</kwd><kwd>Ecocardiografia</kwd></kwd-group>
      <kwd-group xml:lang="es"><kwd>Función Ventricular Derecha/fisiología</kwd><kwd>Hipotiroidismo, Hormonas Tiroideas</kwd><kwd>Ecocardiografía</kwd></kwd-group>
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