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  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">dic</journal-id>
      <journal-title-group>
        <journal-title>Arquivos Brasileiros de Cardiologia Imagem cardiovascular</journal-title>
        
        <abbrev-journal-title abbrev-type="publisher">Arq Bras Cardiol: Imagem cardiovasc</abbrev-journal-title>
      </journal-title-group>
      <issn pub-type="epub">2675-312X</issn>
      <publisher>
        <publisher-name>Sociedade Brasileira de Cardiologia</publisher-name>
        
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">2318-8219.20170004</article-id>
      <article-id pub-id-type="doi">10.5935/2318-8219.20170004</article-id>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Review Article</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Application of Echocardiography in the Early Detection of Cardiotoxicity by Chemotherapy</article-title>
        <trans-title-group xml:lang="pt">
          <trans-title>Aplicação da Ecocardiografia na Detecção Precoce de Cardiotoxicidade por Quimioterapia</trans-title>
        </trans-title-group>
        <trans-title-group xml:lang="es">
          <trans-title>Aplicación de la Ecocardiografia en la Detección Temprana de Cardiotoxicidad por Quimioterapia</trans-title>
        </trans-title-group>
      </title-group>
      <contrib-group><contrib contrib-type="author"><name><surname>Fassio</surname><given-names>Rafael Carlos Castilla</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Del Castillo</surname><given-names>José Maria</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib></contrib-group>
      <aff id="aff1"><label>1</label><institution content-type="normalized"/><institution content-type="orgname">Hospital Alcívar</institution><addr-line><named-content content-type="city">Guayaquil</named-content></addr-line><country country="EC">Ecuador</country><institution content-type="original">Hospital Alcívar, Guayaquil - Ecuador;</institution></aff>
      <aff id="aff2"><label>2</label><institution content-type="normalized"/><institution content-type="orgname">Escola de Ecografia de Pernambuco</institution><addr-line><named-content content-type="city">Recife</named-content><named-content content-type="state">PE</named-content></addr-line><country country="BR">Brazil</country><institution content-type="original">Escola de Ecografia de Pernambuco – ECOPE, Recife, PE – Brazil</institution></aff>
      <author-notes> <corresp id="c01"> Mailing Address: Rafael Carlos Castilla Fassio • Centro Médico Alcívar número 4, Coronel 2207, Guayaquil, Ecuador. E-mail: <email>castillarafael4@gmail.com</email> </corresp> <fn fn-type="con"> <p>Authors’ contributions</p> <p>Concept and design of the research: Castilla RC; Data collection: Castilla RC; Data analysis and interpretation: Castilla RC; Writing the manuscript: Castilla RC; Critical review of the manuscript regarding the important intellectual content: Castilla RC, Del Castillo JM.</p> </fn><fn fn-type="conflict"><p>Potential Conflict of Interest</p> <p>I declare there is no relevant conflict of interest.</p></fn> </author-notes>
      <pub-date date-type="pub" publication-format="electronic">
				<day>20</day>
				<month>01</month>
				<year>2022</year>
			</pub-date>
			<pub-date date-type="collection" publication-format="electronic">
        <season>Jan-Mar</season>
        <year>2017</year>
      </pub-date>
      <volume>30</volume>
      <issue>1</issue>
      <fpage>8</fpage>
      <lpage>12</lpage>
      <history><date date-type="received"><day>10</day><month>10</month><year>2016</year></date><date date-type="rev-recd"><day>30</day><month>10</month><year>2016</year></date><date date-type="accepted"><day>30</day><month>11</month><year>2016</year></date></history>
      <permissions>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc/3.0/">
<license-p>
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
</license-p>
</license>
</permissions>
      <abstract><title>Abstract</title><p>The cardiotoxicity produced by chemotherapeutic agents, mainly to treat breast cancer, presents a significant incidence, often requiring specific treatment and / or forcing the reduction or suspension of the chemotherapeutic treatment. Cardiotoxicity is characterized by causing cell damage, reversible or not, leading to heart failure. The main indicators of these alterations can be detected by conventional echocardiography, through the left ventricular ejection fraction and techniques that evaluate myocardial deformation, such as the global longitudinal strain, which are now considered essential markers for this analysis. The cardiotoxicity produced by anthracyclines, monoclonal antibodies and their association is analyzed, the latter showing an alarming incidence, mainly in elderly patients.</p></abstract>
      <trans-abstract xml:lang="pt"><title>Resumo</title><p>A cardiotoxicidade produzida por agentes quimioterápicos, especialmente para tratar câncer de mama, presenta significativa incidência, muitas vezes necessitando tratamento específico e/ou obrigando a redução ou suspensão do tratamento quimioterápico. A cardiotoxicidade se caracteriza por provocar dano celular, reversível ou não, que conduz à insuficiência cardíaca. Os principais indicadores dessas alterações podem ser detectados pela ecocardiografia convencional, por meio da fração de ejeção do ventrículo esquerdo e pelas técnicas que avaliam a deformação miocárdica, como o strain longitudinal global, hoje considerados marcadores essenciais para essa análise. Analisa-se a cardiotoxicidade produzida por antraciclinas, anticorpos monoclonais e sua associação, mostrando esta última alarmante incidência, especialmente em pacientes idosas.</p></trans-abstract>
      <trans-abstract xml:lang="es"><title>Resumen</title><p>La cardiotoxicidad producida por agentes quimioterápicos, principalmente los usados para tratar cáncer de mama, presenta significativa incidencia, necesitando muchas veces tratamiento específico y/u obligando a la reducción o suspensión del tratamiento quimioterápico. La cardiotoxicidad se caracteriza por provocar daño celular, reversible o no, que conduce a la insuficiencia cardíaca. Los principales indicadores de estas alteraciones pueden ser detectados por la ecocardiografia convencional, por medio de la fracción de eyección del ventrículo izquierdo y por las técnicas que evalúan la deformación miocárdica, como el strain longitudinal global, hoy considerados marcadores esenciales para este análisis. Se analiza la cardiotoxicidad producida por antraciclinas, anticuerpos monoclonales y su asociación, mostrando esta última alarmante incidencia, principalmente en pacientes añosas.</p></trans-abstract>
      <kwd-group xml:lang="en"><kwd>Echocardiography</kwd><kwd>Neoplasms/drug therapy</kwd><kwd>Cardiotoxicity</kwd><kwd>Heart Failure</kwd></kwd-group>
      <kwd-group xml:lang="pt"><kwd>Ecocardiografia</kwd><kwd>Neoplasias/quimioterapia</kwd><kwd>Cardiotoxicidade</kwd><kwd>Insuficiência Cardíaca</kwd></kwd-group>
      <kwd-group xml:lang="es"><kwd>Ecocardiografía</kwd><kwd>Neoplasias/quimioterapia</kwd><kwd>Cardiotoxicidad</kwd><kwd>Insuficiencia Cardíaca</kwd></kwd-group>
      <counts><fig-count count="0"/><table-count count="0"/><equation-count count="0"/><ref-count count="0"/><page-count count="5"/></counts>
    </article-meta>
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