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  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">abcic</journal-id>
      <journal-title-group>
        <journal-title>ABC Imagem Cardiovascular</journal-title>
        <abbrev-journal-title abbrev-type="publisher">ABC Imagem Cardiovasc.</abbrev-journal-title>
      </journal-title-group>
      <issn pub-type="epub">2675-312X</issn>
      <issn pub-type="ppub">2318-8219</issn>
      <publisher>
        <publisher-name>Departamento de Imagem Cardiovascular da Sociedade Brasileira de Cardiolodia (DIC/SBC)</publisher-name>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id specific-use="scielo-v3" pub-id-type="publisher-id">VjwXyZKsgtJwjDdJxS7CWGq</article-id>
      <article-id specific-use="scielo-v2" pub-id-type="publisher-id">S2675-312X2026000102204</article-id>
      <article-id pub-id-type="other">02204</article-id>
      <article-id pub-id-type="doi">10.36660/abcimg.20250055i</article-id>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Case Report</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Aneurysm of the Suprahepatic Inferior Vena Cava: A Case Report</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <contrib-id contrib-id-type="orcid">0009-0006-8082-7578</contrib-id>
          <name>
            <surname>Mariano</surname>
            <given-names>Gabriella Ghattas</given-names>
          </name>
          <xref ref-type="aff" rid="aff1">
            <sup>1</sup>
          </xref>
          <role>Conception and design of the research</role>
          <role>acquisition of data</role>
          <role>analysis and interpretation of the data and writing of the manuscript</role>
        </contrib>
        <contrib contrib-type="author">
          <contrib-id contrib-id-type="orcid">0009-0008-9064-3072</contrib-id>
          <name>
            <surname>Thaines</surname>
            <given-names>Calina Araujo</given-names>
          </name>
          <xref ref-type="aff" rid="aff1">
            <sup>1</sup>
          </xref>
          <role>Conception and design of the research</role>
          <role>acquisition of data</role>
          <role>analysis and interpretation of the data and writing of the manuscript</role>
        </contrib>
        <contrib contrib-type="author">
          <contrib-id contrib-id-type="orcid">0009-0003-9078-184X</contrib-id>
          <name>
            <surname>Desani</surname>
            <given-names>Gabrielle Silva</given-names>
          </name>
          <xref ref-type="aff" rid="aff1">
            <sup>1</sup>
          </xref>
          <role>Conception and design of the research</role>
          <role>acquisition of data</role>
          <role>analysis and interpretation of the data and writing of the manuscript</role>
        </contrib>
        <contrib contrib-type="author">
          <contrib-id contrib-id-type="orcid">0009-0004-8795-4778</contrib-id>
          <name>
            <surname>Gouv&#234;a</surname>
            <given-names>Let&#237;cia de Castro</given-names>
          </name>
          <xref ref-type="aff" rid="aff1">
            <sup>1</sup>
          </xref>
          <role>Conception and design of the research</role>
          <role>acquisition of data</role>
          <role>analysis and interpretation of the data and writing of the manuscript</role>
        </contrib>
        <contrib contrib-type="author">
          <contrib-id contrib-id-type="orcid">0009-0001-2397-206X</contrib-id>
          <name>
            <surname>Covilo</surname>
            <given-names>Paulo V&#237;tor Cabral</given-names>
          </name>
          <xref ref-type="aff" rid="aff1">
            <sup>1</sup>
          </xref>
          <role>Conception and design of the research</role>
          <role>acquisition of data</role>
          <role>analysis and interpretation of the data and writing of the manuscript</role>
        </contrib>
        <contrib contrib-type="author">
          <contrib-id contrib-id-type="orcid">0009-0001-0384-4335</contrib-id>
          <name>
            <surname>Caravante</surname>
            <given-names>Rog&#233;rio de Paula Garcia</given-names>
          </name>
          <xref ref-type="aff" rid="aff1">
            <sup>1</sup>
          </xref>
          <xref ref-type="corresp" rid="c1"/>
          <role>Conception and design of the research</role>
          <role>acquisition of data</role>
          <role>analysis and interpretation of the data and writing of the manuscript</role>
          <role>critical revision of the manuscript for intellectual content</role>
        </contrib>
        <aff id="aff1">
          <label>1</label>
          <institution content-type="orgname">Centro Universit&#225;rio Cat&#243;lico Salesiano Auxilium</institution>
          <addr-line>
            <named-content content-type="city">Ara&#231;atuba</named-content>
            <named-content content-type="state">SP</named-content>
          </addr-line>
          <country country="BR">Brazil</country>
          <institution content-type="original">Centro Universit&#225;rio Cat&#243;lico Salesiano Auxilium, Ara&#231;atuba, SP &#8211; Brazil</institution>
        </aff>
      </contrib-group>
      <author-notes>
        <corresp id="c1"><label>Mailing Address:</label><bold>Rog&#233;rio de Paula Garcia Caravante&#8226;</bold> Centro Universit&#225;rio Cat&#243;lico Salesiano Auxilium. Rodovia Teotonio Vilela, 3821. Postal code: <postal-code>16016-500</postal-code>. Ara&#231;atuba, SP &#8211; Brazil E-mail: <email>rpgcaravante2011@gmail.com</email> </corresp>
        <fn fn-type="coi-statement">
          <label>Potential Conflict of Interest</label>
          <p>No potential conflict of interest relevant to this article was reported.</p>
        </fn>
        <fn fn-type="edited-by">
          <label>Editor responsible for the review:</label>
          <p>Tiago Magalh&#227;es</p>
        </fn>
      </author-notes>
      <pub-date date-type="pub" publication-format="electronic">
        <day>11</day>
        <month>05</month>
        <year>2026</year>
      </pub-date>
      <pub-date date-type="collection" publication-format="electronic">
        <year>2026</year>
      </pub-date>
      <volume>39</volume>
      <issue>1</issue>
      <elocation-id>e20250055</elocation-id>
      <history>
        <date date-type="received">
          <day>04</day>
          <month>08</month>
          <year>2025</year>
        </date>
        <date date-type="rev-recd">
          <day>29</day>
          <month>10</month>
          <year>2025</year>
        </date>
        <date date-type="accepted">
          <day>25</day>
          <month>02</month>
          <year>2026</year>
        </date>
      </history>
      <permissions>
        <license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/" xml:lang="en">
          <license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution License</license-p>
        </license>
      </permissions>
      <kwd-group xml:lang="en">
        <title>Keywords</title>
        <kwd>Aneurysm</kwd>
        <kwd>Inferior Vena Cava</kwd>
        <kwd>Cardiovascular Diseases</kwd>
        <kwd>Case Reports</kwd>
      </kwd-group>
      <funding-group>
        <funding-statement><bold>Sources of Funding</bold>: There were no external funding sources for this study.</funding-statement>
      </funding-group>
      <counts>
        <fig-count count="6"/>
        <table-count count="0"/>
        <equation-count count="0"/>
        <ref-count count="9"/>
      </counts>
    </article-meta>
  </front>
  <body>
    <sec sec-type="intro">
      <title>Introduction</title>
      <p>Aneurysms of the inferior vena cava (IVC) are a rare occurrence in the cardiovascular system and can present with a variety of signs and symptoms. In many cases, patients remain asymptomatic, which makes diagnosis difficult.<sup><xref ref-type="bibr" rid="B1">1</xref></sup> Venous aneurysms are defined as an abnormal and persistent dilation of a vein in a specific area, with a diameter at least twice that considered normal. An IVC aneurysm is a specific type of venous aneurysm.<sup><xref ref-type="bibr" rid="B2">2</xref></sup> This case report is relevant because this condition is rare; by 2021, only around 70 cases had been described in literature.<sup><xref ref-type="bibr" rid="B3">3</xref></sup></p>
      <p>Aneurysms may arise due to fragility in the vessel wall and can be triggered by various factors, including hypertension, trauma, infection, and genetic conditions. Smoking, atherosclerosis, and chronic obstructive pulmonary disease are also considered risk factors for aneurysm development. Although they can occur in different regions of the body, they most frequently affect the cerebral arteries, the aorta, and the peripheral arteries.<sup><xref ref-type="bibr" rid="B4">4</xref></sup></p>
      <p>The clinical manifestations of aneurysms vary according to the size, location, and stability of the vascular dilation. They may even remain asymptomatic. However, in more severe cases, the vessel may rupture, resulting in hemorrhage, embolism, or thrombosis. These events may progress to fatal outcomes.<sup><xref ref-type="bibr" rid="B5">5</xref></sup> Among symptomatic patients with IVC aneurysm, the most frequently reported clinical findings include abdominal pain, lower limb edema (LLE), and dyspnea. Associated complications may include vena cava thrombosis, deep vein thrombosis (DVT), and pulmonary embolism, conditions that represent a significant risk to patients&#8217; lives.<sup><xref ref-type="bibr" rid="B6">6</xref></sup></p>
      <p>The objective of this study is to report a case of IVC aneurysm diagnosed in a private clinic in the city of Ara&#231;atuba, state of S&#227;o Paulo, Brazil, classified as Type I because it is located in the suprahepatic portion of the IVC.<sup><xref ref-type="bibr" rid="B7">7</xref></sup> The clinical presentation, characterized by nonspecific manifestations as well as the diagnostic process and the follow-up strategy adopted, are highlighted.</p>
    </sec>
    <sec sec-type="cases">
      <title>Case report</title>
      <p>A 75-year-old White female patient sought care from a pulmonologist due to diffuse pain in the dorsal region and cough. Due to initial suspicions of a respiratory condition, a contrast-enhanced chest CT scan was requested. During the scan, a protruding sacular formation was identified in the upper quadrant of the abdomen.</p>
      <p>The imaging examination demonstrated the presence of an IVC aneurysm in a suprahepatic location, classified as Type I according to the Gradman &amp; Steinberg classification,<sup><xref ref-type="bibr" rid="B7">7</xref></sup> adjacent to the right atrium, without evidence of venous obstruction, measuring 4.2 cm at its greatest diameter. The cardiac silhouette was also observed to be of normal size, and the mediastinal vessels were centered, without other relevant abnormalities. These findings are illustrated in <xref ref-type="fig" rid="f1">Figures 1</xref> and <xref ref-type="fig" rid="f2">2</xref>.</p>
      <fig id="f1">
        <label>Figure 1</label>
        <caption>
          <title>Chest CT. A) Chest CT with IV contrast administration, sagittal section, showing an IVC aneurysm (white circle); B) Chest CT with IV contrast administration, coronal section, demonstrating a suprahepatic IVC aneurysm adjacent to the right atrium (white arrow). CT: computed tomography; IVC: inferior vena cava.</title>
        </caption>
        <graphic xlink:href="2675-312X-abcic-39-01-e20250055-0055i-gf01.tif"/></fig>
      <fig id="f2">
        <label>Figure 2</label>
        <caption>
          <title>Chest computed tomography with IV contrast administration, axial section, showing an inferior vena cava aneurysm measuring 42.24 mm in the largest diameter and 31.58 mm in the smallest diameter (white lines).</title>
        </caption>
        <graphic xlink:href="2675-312X-abcic-39-01-e20250055-0055i-gf02.tif"/></fig>
      <p>According to the clinical history, the patient maintains a healthy lifestyle, with regular physical activity and a balanced diet, denying alcohol consumption and smoking. She was recently diagnosed with type 2 diabetes mellitus and is currently undergoing treatment. She reports a history of seizures during childhood and two vaginal deliveries in the second decade of life. Her surgical history includes appendectomy, gastroesophageal hiatoplasty, cholecystectomy, hysterectomy, oophorectomy, arthroplasty, and uterine curettage after an episode of ectopic pregnancy. In addition, she reports recurrent episodes of discomfort associated with palpitations throughout her life.</p>
      <p>After the incidental finding, the patient was referred for cardiological evaluation and subsequently for consultation with a cardiovascular surgeon to undergo a more detailed investigation. At the time of the specialized evaluation, she was oligosymptomatic, presenting only persistent dorsal pain, which worsened with movement and improved with rest. On physical examination, slight abdominal prominence was observed, without pain on palpation, a finding consistent with the results of the previously performed imaging examination.</p>
      <p>During follow-up, the patient presented significant improvement in pain after symptomatic treatment and remains under conservative clinical follow-up due to the stability of the condition. Currently, she undergoes periodic follow-up with a cardiovascular surgeon, with semiannual consultations and serial imaging examinations, with the objective of monitoring possible changes in the dimensions or characteristics of the IVC aneurysm.</p>
    </sec>
    <sec sec-type="discussion">
      <title>Discussion</title>
      <p>According to the classification proposed for IVC aneurysms, there are four forms of presentation (<xref ref-type="fig" rid="f3">Figure 3</xref>). Type I corresponds to an aneurysm located in the suprahepatic portion of the IVC, without venous obstruction. Type II is associated with interruption of the IVC. Type III refers to an aneurysm located in the infrarenal portion of the IVC. Finally, Type IV corresponds to an aneurysm involving the iliac vein, associated with the presence of a left-sided IVC.<sup><xref ref-type="bibr" rid="B7">7</xref></sup> Based on this classification, the case presented was characterized as a Type I IVC aneurysm due to its suprahepatic location.</p>
      <fig id="f3">
        <label>Figure 3</label>
        <caption>
          <title>Schematic representation of the four types of IVC aneurysm. A) Type I: aneurysm located in the suprahepatic portion of the IVC, without obstruction of venous flow; B) Type II: infrarenal aneurysm associated with interruption of the suprahepatic segment of the IVC; C) Type III: aneurysmal dilation in the infrarenal region, without obstruction; D) Type IV: aneurysm involving the iliac vein, with the IVC positioned on the left side. Image adapted from Gradman &amp; Steinberg.<sup><xref ref-type="bibr" rid="B7">7</xref></sup> IVC: inferior vena cava.</title>
        </caption>
        <graphic xlink:href="2675-312X-abcic-39-01-e20250055-0055i-gf03.tif"/></fig>
      <p>In the present report, the patient is female, 75 years old, and remained oligosymptomatic throughout her clinical history. Previous studies describe that most patients diagnosed with IVC aneurysm are male, with a mean age of 63.5 years among cases classified as Type I, with a large proportion of them being asymptomatic.<sup><xref ref-type="bibr" rid="B6">6</xref></sup> These data demonstrate that there may be variation in the epidemiological profile of individuals affected by this condition.</p>
      <p>In this case, the diagnosis of IVC aneurysm was established after a chest CT scan. For the identification of this condition, imaging examinations constitute the main diagnostic method, particularly CT, magnetic resonance angiography, and venography, as they allow detailed evaluation of the morphology and characteristics of the venous aneurysm.<sup><xref ref-type="bibr" rid="B8">8</xref></sup> In the reported case, CT enabled precise visualization of the location, shape, and dimensions of the lesion.</p>
      <p>Among the main complications associated with IVC aneurysm are rupture, DVT, pulmonary embolism, and IVC syndrome. Rupture occurs more frequently in aneurysms classified as Types II and III and may manifest with intense abdominal pain, dorsal pain, and LLE, leading to more severe clinical conditions.<sup><xref ref-type="bibr" rid="B9">9</xref></sup> Considering the classification of the aneurysm described in this report, Type I, as well as the patient's clinical history, no complications have been observed to date.</p>
      <p>The literature describes abdominal pain, dyspnea, dorsalgia, LLE, and a sensation of heaviness in the lower limbs as the most common clinical manifestations in patients with IVC aneurysm. However, in aneurysms classified as Type I, asymptomatic or oligosymptomatic cases are more frequent.<sup><xref ref-type="bibr" rid="B6">6</xref></sup> In agreement with these findings, the patient in this report presented dorsalgia as the main clinical manifestation, which may be related to the identified aneurysm.</p>
      <p>The treatment adopted in this case was conservative, with periodic clinical follow-up through physical examination and imaging studies, including CT performed every 6 months. This approach is consistent with the therapeutic algorithm proposed by Baker et al.,<sup><xref ref-type="bibr" rid="B5">5</xref></sup> which recommends conservative management with regular monitoring for IVC aneurysms classified as Type I. For Types II, III, and IV, the literature often indicates surgical intervention, such as embolization or resection, due to the higher risk of complications.<sup><xref ref-type="bibr" rid="B5">5</xref></sup></p>
    </sec>
    <sec sec-type="conclusions">
      <title>Conclusion</title>
      <p>Due to the scarcity of studies on the topic, the particularities described in this case may contribute to improving diagnosis and management in patients presenting with similar clinical features and symptoms. As a cardiovascular condition with possible systemic repercussions and often without evident clinical manifestations, IVC aneurysm may progress silently. Early identification is therefore essential for appropriate clinical management and follow-up.</p>
    </sec>
  </body>
  <back>
    <fn-group>
      <fn fn-type="financial-disclosure" id="fn1">
        <label>Sources of Funding</label>
        <p>There were no external funding sources for this study.</p>
      </fn>
      <fn fn-type="other" id="fn2">
        <label>Study Association</label>
        <p>This study is not associated with any thesis or dissertation work.</p>
      </fn>
      <fn fn-type="other" id="fn3">
        <label>Ethics Approval and Consent to Participate</label>
        <p>This study was approved by the Ethics Committee of the Miss&#227;o Salesiana De Mato Grosso under the protocol number 7.053.378 (CAAE 79880624.0.0000.5379). All the procedures in this study were in accordance with the 1975 Helsinki Declaration, updated in 2013. Informed consent was obtained from all participants included in the study.</p>
      </fn>
      <fn fn-type="other" id="fn4">
        <label>Use of Artificial Intelligence</label>
        <p>The authors did not use any artificial intelligence tools in the development of this work.</p>
      </fn>
    </fn-group>
    <ack>
      <title>Acknowledgments</title>
      <p>We thank everyone who contributed, directly or indirectly, to the completion of this case report.</p>
    </ack>
    <sec sec-type="data-availability" specific-use="data-in-article">
      <title>Availability of Research Data</title>
      <p>The underlying content of the research text is contained within the manuscript.</p>
    </sec>
    <ref-list>
      <title>References</title>
      <ref id="B1">
        <label>1</label>
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>Marsafi</surname>
              <given-names>O</given-names>
            </name>
            <name>
              <surname>Ibenyahia</surname>
              <given-names>A</given-names>
            </name>
            <name>
              <surname>Moussaoui</surname>
              <given-names>A</given-names>
            </name>
            <name>
              <surname>Belmekia</surname>
              <given-names>A</given-names>
            </name>
            <name>
              <surname>Wakrim</surname>
              <given-names>S</given-names>
            </name>
          </person-group>
          <article-title>Aneurysm of the Inferior Vena Cava : A Case Report</article-title>
          <source>Ann Cardiol Angeiol</source>
          <year>2022</year>
          <volume>71</volume>
          <issue>4</issue>
          <fpage>235</fpage>
          <lpage>239</lpage>
          <pub-id pub-id-type="doi">10.1016/j.ancard.2022.05.002</pub-id>
        </element-citation>
        <mixed-citation>1 Marsafi O, Ibenyahia A, Moussaoui A, Belmekia A, Wakrim S. Aneurysm of the Inferior Vena Cava : A Case Report. Ann Cardiol Angeiol. 2022;71(4):235-9. doi: 10.1016/j.ancard.2022.05.002.</mixed-citation>
      </ref>
      <ref id="B2">
        <label>2</label>
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>Hai</surname>
              <given-names>TD</given-names>
            </name>
            <name>
              <surname>Minh</surname>
              <given-names>LN</given-names>
            </name>
            <name>
              <surname>Dung</surname>
              <given-names>NT</given-names>
            </name>
            <name>
              <surname>Van Dung</surname>
              <given-names>L</given-names>
            </name>
            <name>
              <surname>Tuong</surname>
              <given-names>CT</given-names>
            </name>
            <name>
              <surname>Van Phuoc</surname>
              <given-names>L</given-names>
            </name>
          </person-group>
          <article-title>Large Intra-Abdominal Venous Malformations in Associated with Inferior Vena Cava Aneurysm</article-title>
          <source>Radiol Case Rep</source>
          <year>2023</year>
          <volume>18</volume>
          <issue>5</issue>
          <fpage>1733</fpage>
          <lpage>1737</lpage>
          <pub-id pub-id-type="doi">10.1016/j.radcr.2023.01.085</pub-id>
        </element-citation>
        <mixed-citation>2 Hai TD, Minh LN, Dung NT, Van Dung L, Tuong CT, Van Phuoc L. Large Intra-Abdominal Venous Malformations in Associated with Inferior Vena Cava Aneurysm. Radiol Case Rep. 2023;18(5):1733-7. doi: 10.1016/j.radcr.2023.01.085.</mixed-citation>
      </ref>
      <ref id="B3">
        <label>3</label>
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>Chang</surname>
              <given-names>H</given-names>
            </name>
            <name>
              <surname>Bae</surname>
              <given-names>J</given-names>
            </name>
            <name>
              <surname>Chung</surname>
              <given-names>TN</given-names>
            </name>
          </person-group>
          <article-title>A Unique Case of Inferior Vena Cava Aneurysm Complicated with Pulmonary Embolism and Cerebral Infarction</article-title>
          <source>J Cardiovasc Dev Dis</source>
          <year>2021</year>
          <volume>8</volume>
          <issue>11</issue>
          <fpage>147</fpage>
          <lpage>147</lpage>
          <pub-id pub-id-type="doi">10.3390/jcdd8110147</pub-id>
        </element-citation>
        <mixed-citation>3 Chang H, Bae J, Chung TN. A Unique Case of Inferior Vena Cava Aneurysm Complicated with Pulmonary Embolism and Cerebral Infarction. J Cardiovasc Dev Dis. 2021;8(11):147. doi: 10.3390/jcdd8110147.</mixed-citation>
      </ref>
      <ref id="B4">
        <label>4</label>
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>Brito</surname>
              <given-names>CJ</given-names>
            </name>
            <name>
              <surname>Silva</surname>
              <given-names>RM</given-names>
            </name>
            <name>
              <surname>Loureiro</surname>
              <given-names>E</given-names>
            </name>
          </person-group>
          <source>Cirurgia Vascular: Cirurgia Endovascular e Angiologia</source>
          <edition>4th ed.</edition>
          <publisher-loc>Rio de Janeiro</publisher-loc>
          <publisher-name>Thieme</publisher-name>
          <year>2020</year>
        </element-citation>
        <mixed-citation>4 Brito CJ, Silva RM, Loureiro E. Cirurgia Vascular: Cirurgia Endovascular e Angiologia. 4th ed. Rio de Janeiro: Thieme; 2020.</mixed-citation>
      </ref>
      <ref id="B5">
        <label>5</label>
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>Montero-Baker</surname>
              <given-names>MF</given-names>
            </name>
            <name>
              <surname>Branco</surname>
              <given-names>BC</given-names>
            </name>
            <name>
              <surname>Leon</surname>
              <given-names>LL</given-names>
              <suffix>Jr</suffix>
            </name>
            <name>
              <surname>Labropoulos</surname>
              <given-names>N</given-names>
            </name>
            <name>
              <surname>Echeverria</surname>
              <given-names>A</given-names>
            </name>
            <name>
              <surname>Mills</surname>
              <given-names>JL</given-names>
              <suffix>Sr</suffix>
            </name>
          </person-group>
          <article-title>Management of Inferior Vena Cava Aneurysm</article-title>
          <source>J Cardiovasc Surg</source>
          <year>2015</year>
          <volume>56</volume>
          <issue>5</issue>
          <fpage>769</fpage>
          <lpage>774</lpage>
        </element-citation>
        <mixed-citation>5 Montero-Baker MF, Branco BC, Leon LL Jr, Labropoulos N, Echeverria A, Mills JL Sr. Management of Inferior Vena Cava Aneurysm. J Cardiovasc Surg. 2015;56(5):769-74.</mixed-citation>
      </ref>
      <ref id="B6">
        <label>6</label>
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>Wang</surname>
              <given-names>M</given-names>
            </name>
            <name>
              <surname>Wang</surname>
              <given-names>H</given-names>
            </name>
            <name>
              <surname>Liao</surname>
              <given-names>B</given-names>
            </name>
            <name>
              <surname>Peng</surname>
              <given-names>G</given-names>
            </name>
            <name>
              <surname>Chang</surname>
              <given-names>G</given-names>
            </name>
          </person-group>
          <article-title>Treatment Strategies for Inferior Vena Cava Aneurysms</article-title>
          <source>J Vasc Surg Venous Lymphat Disord</source>
          <year>2021</year>
          <volume>9</volume>
          <issue>6</issue>
          <fpage>1588</fpage>
          <lpage>1596</lpage>
          <pub-id pub-id-type="doi">10.1016/j.jvsv.2021.03.017</pub-id>
        </element-citation>
        <mixed-citation>6 Wang M, Wang H, Liao B, Peng G, Chang G. Treatment Strategies for Inferior Vena Cava Aneurysms. J Vasc Surg Venous Lymphat Disord. 2021;9(6):1588-96. doi: 10.1016/j.jvsv.2021.03.017.</mixed-citation>
      </ref>
      <ref id="B7">
        <label>7</label>
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>Gradman</surname>
              <given-names>WS</given-names>
            </name>
            <name>
              <surname>Steinberg</surname>
              <given-names>F</given-names>
            </name>
          </person-group>
          <article-title>Aneurysm of the Inferior Vena Cava: Case Report and Review of the Literature</article-title>
          <source>Ann Vasc Surg</source>
          <year>1993</year>
          <volume>7</volume>
          <issue>4</issue>
          <fpage>347</fpage>
          <lpage>353</lpage>
          <pub-id pub-id-type="doi">10.1007/BF02002888</pub-id>
        </element-citation>
        <mixed-citation>7 Gradman WS, Steinberg F. Aneurysm of the Inferior Vena Cava: Case Report and Review of the Literature. Ann Vasc Surg. 1993;7(4):347-53. doi: 10.1007/BF02002888.</mixed-citation>
      </ref>
      <ref id="B8">
        <label>8</label>
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>Duarte</surname>
              <given-names>ML</given-names>
            </name>
            <name>
              <surname>Abreu</surname>
              <given-names>BFBB</given-names>
            </name>
            <name>
              <surname>Silva</surname>
              <given-names>AQPD</given-names>
            </name>
            <name>
              <surname>Prado</surname>
              <given-names>JLMA</given-names>
            </name>
            <name>
              <surname>Silva</surname>
              <given-names>MQPD</given-names>
            </name>
          </person-group>
          <article-title>Idiopathic Inferior Vena Cava Aneurysm - Tomographic Diagnosis</article-title>
          <source>Rev Port Cardiol</source>
          <year>2017</year>
          <volume>36</volume>
          <issue>10</issue>
          <fpage>7812</fpage>
          <lpage>7812</lpage>
          <pub-id pub-id-type="doi">10.1016/j.repc.2016.11.014</pub-id>
        </element-citation>
        <mixed-citation>8 Duarte ML, Abreu BFBB, Silva AQPD, Prado JLMA, Silva MQPD. Idiopathic Inferior Vena Cava Aneurysm - Tomographic Diagnosis. Rev Port Cardiol. 2017;36(10):7812. doi: 10.1016/j.repc.2016.11.014.</mixed-citation>
      </ref>
      <ref id="B9">
        <label>9</label>
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>Momeni</surname>
              <given-names>M</given-names>
            </name>
            <name>
              <surname>Momeni</surname>
              <given-names>F</given-names>
            </name>
          </person-group>
          <article-title>Ruptured Inferior Vena Cava Aneurysm in the Setting of Mural Vascular Malformation: A Case Report</article-title>
          <source>J Clin Ultrasound</source>
          <year>2019</year>
          <volume>47</volume>
          <issue>7</issue>
          <fpage>423</fpage>
          <lpage>425</lpage>
          <pub-id pub-id-type="doi">10.1002/jcu.22708</pub-id>
        </element-citation>
        <mixed-citation>9 Momeni M, Momeni F. Ruptured Inferior Vena Cava Aneurysm in the Setting of Mural Vascular Malformation: A Case Report. J Clin Ultrasound. 2019;47(7):423-5. doi: 10.1002/jcu.22708.</mixed-citation>
      </ref>
    </ref-list>
  </back>
  <sub-article article-type="translation" id="S1" xml:lang="pt">
    <front-stub>
      <article-id pub-id-type="doi">10.36660/abcimg.20250055</article-id>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Relato de Caso</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Aneurisma da Por&#231;&#227;o Supra-Hep&#225;tica da Veia Cava Inferior: Relato de Caso</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <contrib-id contrib-id-type="orcid">0009-0006-8082-7578</contrib-id>
          <name>
            <surname>Mariano</surname>
            <given-names>Gabriella Ghattas</given-names>
          </name>
          <xref ref-type="aff" rid="aff2">
            <sup>1</sup>
          </xref>
          <role>Concep&#231;&#227;o e desenho da pesquisa</role>
          <role>obten&#231;&#227;o de dados</role>
          <role>an&#225;lise e interpreta&#231;&#227;o dos dados e reda&#231;&#227;o do manuscrito</role>
        </contrib>
        <contrib contrib-type="author">
          <contrib-id contrib-id-type="orcid">0009-0008-9064-3072</contrib-id>
          <name>
            <surname>Thaines</surname>
            <given-names>Calina Araujo</given-names>
          </name>
          <xref ref-type="aff" rid="aff2">
            <sup>1</sup>
          </xref>
          <role>Concep&#231;&#227;o e desenho da pesquisa</role>
          <role>obten&#231;&#227;o de dados</role>
          <role>an&#225;lise e interpreta&#231;&#227;o dos dados e reda&#231;&#227;o do manuscrito</role>
        </contrib>
        <contrib contrib-type="author">
          <contrib-id contrib-id-type="orcid">0009-0003-9078-184X</contrib-id>
          <name>
            <surname>Desani</surname>
            <given-names>Gabrielle Silva</given-names>
          </name>
          <xref ref-type="aff" rid="aff2">
            <sup>1</sup>
          </xref>
          <role>Concep&#231;&#227;o e desenho da pesquisa</role>
          <role>obten&#231;&#227;o de dados</role>
          <role>an&#225;lise e interpreta&#231;&#227;o dos dados e reda&#231;&#227;o do manuscrito</role>
        </contrib>
        <contrib contrib-type="author">
          <contrib-id contrib-id-type="orcid">0009-0004-8795-4778</contrib-id>
          <name>
            <surname>Gouv&#234;a</surname>
            <given-names>Let&#237;cia de Castro</given-names>
          </name>
          <xref ref-type="aff" rid="aff2">
            <sup>1</sup>
          </xref>
          <role>Concep&#231;&#227;o e desenho da pesquisa</role>
          <role>obten&#231;&#227;o de dados</role>
          <role>an&#225;lise e interpreta&#231;&#227;o dos dados e reda&#231;&#227;o do manuscrito</role>
        </contrib>
        <contrib contrib-type="author">
          <contrib-id contrib-id-type="orcid">0009-0001-2397-206X</contrib-id>
          <name>
            <surname>Covilo</surname>
            <given-names>Paulo V&#237;tor Cabral</given-names>
          </name>
          <xref ref-type="aff" rid="aff2">
            <sup>1</sup>
          </xref>
          <role>Concep&#231;&#227;o e desenho da pesquisa</role>
          <role>obten&#231;&#227;o de dados</role>
          <role>an&#225;lise e interpreta&#231;&#227;o dos dados e reda&#231;&#227;o do manuscrito</role>
        </contrib>
        <contrib contrib-type="author">
          <contrib-id contrib-id-type="orcid">0009-0001-0384-4335</contrib-id>
          <name>
            <surname>Caravante</surname>
            <given-names>Rog&#233;rio de Paula Garcia</given-names>
          </name>
          <xref ref-type="aff" rid="aff2">
            <sup>1</sup>
          </xref>
          <xref ref-type="corresp" rid="c2"/>
          <role>Concep&#231;&#227;o e desenho da pesquisa</role>
          <role>obten&#231;&#227;o de dados</role>
          <role>an&#225;lise e interpreta&#231;&#227;o dos dados e reda&#231;&#227;o do manuscrito</role>
          <role>revis&#227;o cr&#237;tica do manuscrito quanto ao conte&#250;do intelectual importante</role>
        </contrib>
        <aff id="aff2">
          <label>1</label>
          <addr-line>
            <named-content content-type="city">Ara&#231;atuba</named-content>
            <named-content content-type="state">SP</named-content>
          </addr-line>
          <country country="BR">Brasil</country>
          <institution content-type="original">Centro Universit&#225;rio Cat&#243;lico Salesiano Auxilium, Ara&#231;atuba, SP &#8211; Brasil</institution>
        </aff>
      </contrib-group>
      <author-notes>
        <corresp id="c2"><bold>Correspond&#234;ncia: Rog&#233;rio de Paula Garcia Caravante &#8226;</bold> Centro Universit&#225;rio Cat&#243;lico Salesiano Auxilium. Rodovia Teotonio Vilela, 3821. CEP: <postal-code>16016-500</postal-code>. Ara&#231;atuba, SP &#8211; Brasil E-mail: <email>rpgcaravante2011@gmail.com</email> </corresp>
        <fn fn-type="coi-statement">
          <label>Potencial Conflito de Interesse</label>
          <p>Declaro n&#227;o haver conflito de interesses pertinentes.</p>
        </fn>
        <fn fn-type="edited-by">
          <label>Editor respons&#225;vel pela revis&#227;o:</label>
          <p>Tiago Magalh&#227;es</p>
        </fn>
      </author-notes>
      <kwd-group xml:lang="pt">
        <title>Palavras-chave</title>
        <kwd>Aneurisma</kwd>
        <kwd>Veia Cava Inferior</kwd>
        <kwd>Doen&#231;as Cardiovasculares</kwd>
        <kwd>Relatos de Casos</kwd>
      </kwd-group>
      <funding-group>
        <funding-statement><bold>Fontes de Financiamento</bold> O presente estudo n&#227;o teve fontes de financiamento externas.</funding-statement>
      </funding-group>
    </front-stub>
    <body>
      <sec sec-type="intro">
        <title>Introdu&#231;&#227;o</title>
        <p>Os aneurismas da veia cava inferior (VCI) constituem achados raros no sistema cardiovascular e podem manifestar-se com sinais e sintomas variados. Em muitos casos, os pacientes permanecem assintom&#225;ticos, o que contribui para a dificuldade no estabelecimento do diagn&#243;stico.<sup><xref ref-type="bibr" rid="B1">1</xref></sup> Aneurismas venosos s&#227;o definidos como uma dilata&#231;&#227;o anormal e persistente de uma veia em uma regi&#227;o focal, apresentando di&#226;metro pelo menos duas vezes maior que o considerado normal. Nesse contexto, o aneurisma da VCI representa uma forma espec&#237;fica de aneurisma venoso.<sup><xref ref-type="bibr" rid="B2">2</xref></sup> A relev&#226;ncia do presente relato de caso &#233; evidenciada pela raridade dessa condi&#231;&#227;o, visto que, at&#233; 2021, aproximadamente 70 casos haviam sido descritos na literatura.<sup><xref ref-type="bibr" rid="B3">3</xref></sup></p>
        <p>Essa condi&#231;&#227;o pode surgir em decorr&#234;ncia de fragilidade na parede do vaso, podendo ser desencadeada por diferentes fatores, como hipertens&#227;o, traumas, infec&#231;&#245;es ou condi&#231;&#245;es gen&#233;ticas. Al&#233;m desses fatores, tabagismo, aterosclerose e doen&#231;a pulmonar obstrutiva cr&#244;nica tamb&#233;m s&#227;o considerados fatores de risco para o desenvolvimento de aneurismas. Embora possam ocorrer em diferentes regi&#245;es do corpo, os locais mais frequentemente acometidos s&#227;o as art&#233;rias cerebrais, a aorta e as art&#233;rias perif&#233;ricas.<sup><xref ref-type="bibr" rid="B4">4</xref></sup></p>
        <p>As manifesta&#231;&#245;es cl&#237;nicas associadas aos aneurismas variam de acordo com o tamanho, a localiza&#231;&#227;o e a estabilidade da dilata&#231;&#227;o vascular, podendo inclusive permanecer assintom&#225;ticas. Entretanto, em situa&#231;&#245;es mais graves, pode ocorrer ruptura do vaso acometido, resultando em hemorragias, embolias ou trombose, eventos que podem evoluir para desfechos fatais.<sup><xref ref-type="bibr" rid="B5">5</xref></sup> Entre os pacientes sintom&#225;ticos com aneurisma de VCI, os achados cl&#237;nicos mais frequentemente descritos incluem dor abdominal, edema de membros inferiores (MMII) e dispneia. As complica&#231;&#245;es associadas podem incluir trombose da veia cava, trombose venosa profunda (TVP) e embolia pulmonar, condi&#231;&#245;es que representam risco significativo &#224; vida dos pacientes.<sup><xref ref-type="bibr" rid="B6">6</xref></sup></p>
        <p>O objetivo deste estudo &#233; relatar um caso de aneurisma de VCI diagnosticado em consult&#243;rio particular na cidade de Ara&#231;atuba, estado de S&#227;o Paulo, Brasil, classificado como Tipo I por localizar-se na por&#231;&#227;o supra-hep&#225;tica do vaso.<sup><xref ref-type="bibr" rid="B7">7</xref></sup> Destacam-se a apresenta&#231;&#227;o cl&#237;nica, caracterizada por manifesta&#231;&#245;es inespec&#237;ficas, bem como o processo diagn&#243;stico e a estrat&#233;gia de acompanhamento adotada.</p>
      </sec>
      <sec sec-type="cases">
        <title>Relato de caso</title>
        <p>Paciente do sexo feminino, 75 anos, branca, procurou atendimento com m&#233;dico pneumologista ap&#243;s apresentar dor difusa na regi&#227;o dorsal associada a tosse. Diante da suspeita inicial de quadro respirat&#243;rio, foi solicitada tomografia computadorizada (TC) de t&#243;rax com contraste, na qual se identificou, incidentalmente, uma forma&#231;&#227;o protuberante de aspecto sacular no quadrante superior do abdome.</p>
        <p>O exame de imagem evidenciou a presen&#231;a de aneurisma da VCI em localiza&#231;&#227;o supra-hep&#225;tica, classificado como Tipo I segundo a classifica&#231;&#227;o de Gradman e Steinberg,<sup><xref ref-type="bibr" rid="B7">7</xref></sup> adjacente ao &#225;trio direito, sem evid&#234;ncias de obstru&#231;&#227;o venosa, medindo 4,2 cm em seu maior di&#226;metro. Observou-se, ainda, &#225;rea card&#237;aca de dimens&#245;es normais e vasos mediastinais centrados, sem outras altera&#231;&#245;es relevantes. Esses achados est&#227;o ilustrados nas <xref ref-type="fig" rid="f4">Figuras 1</xref> e <xref ref-type="fig" rid="f5">2</xref>.</p>
        <fig id="f4">
          <label>Figura 1</label>
          <caption>
            <title>TC de t&#243;rax. A) TC de t&#243;rax com administra&#231;&#227;o de contraste intravenoso, em corte sagital, evidenciando aneurisma da VCI (c&#237;rculo branco); B) TC de t&#243;rax com administra&#231;&#227;o de contraste intravenoso, em corte coronal, demonstrando aneurisma supra-hep&#225;tico da VCI adjacente ao &#225;trio direito (seta branca). TC: tomografia computadorizada; VCI: veia cava inferior.</title>
          </caption>
          <graphic xlink:href="2675-312X-abcic-39-01-e20250055-0055i-gf01-pt.tif"/></fig>
        <fig id="f5">
          <label>Figura 2</label>
          <caption>
            <title>Tomografia computadorizada de t&#243;rax com administra&#231;&#227;o de contraste intravenoso, em corte axial, evidenciando aneurisma da veia cava inferior com 42,24 mm de maior di&#226;metro e 31,58 mm de menor di&#226;metro (linhas brancas).</title>
          </caption>
          <graphic xlink:href="2675-312X-abcic-39-01-e20250055-0055i-gf02-pt.tif"/></fig>
        <p>De acordo com o hist&#243;rico cl&#237;nico, a paciente apresenta estilo de vida saud&#225;vel, com pr&#225;tica regular de atividade f&#237;sica e alimenta&#231;&#227;o equilibrada, negando etilismo e tabagismo. Foi recentemente diagnosticada com diabetes mellitus tipo 2, encontrando-se em tratamento. Relata antecedentes de crises convulsivas na inf&#226;ncia e dois partos vaginais na segunda d&#233;cada de vida. O hist&#243;rico cir&#250;rgico inclui apendicectomia, hiatoplastia gastroesof&#225;gica, colecistectomia, histerectomia, ooforectomia, artroplastia e curetagem uterina ap&#243;s epis&#243;dio de gravidez ect&#243;pica. Al&#233;m disso, refere epis&#243;dios recorrentes de desconforto associados a palpita&#231;&#245;es ao longo da vida.</p>
        <p>Ap&#243;s o achado incidental, a paciente foi encaminhada para avalia&#231;&#227;o cardiol&#243;gica e, posteriormente, para consulta com cirurgi&#227;o cardiovascular, a fim de realizar investiga&#231;&#227;o mais detalhada. No momento da avalia&#231;&#227;o especializada, encontrava-se oligossintom&#225;tica, apresentando apenas dor dorsal persistente, que se intensificava com o movimento e apresentava melhora com o repouso. Ao exame f&#237;sico, observou-se discreta proemin&#234;ncia abdominal, sem dor &#224; palpa&#231;&#227;o, achado compat&#237;vel com os resultados do exame de imagem previamente realizado.</p>
        <p>Durante o acompanhamento, a paciente apresentou melhora significativa da dor ap&#243;s tratamento sintom&#225;tico e permanece em seguimento cl&#237;nico conservador, em virtude da estabilidade do quadro. Atualmente, realiza acompanhamento peri&#243;dico com cirurgi&#227;o cardiovascular, com consultas semestrais e exames de imagem seriados, com o objetivo de monitorar poss&#237;veis altera&#231;&#245;es nas dimens&#245;es ou caracter&#237;sticas do aneurisma da VCI.</p>
      </sec>
      <sec sec-type="discussion">
        <title>Discuss&#227;o</title>
        <p>De acordo com a classifica&#231;&#227;o proposta para os aneurismas da VCI, existem quatro formas de apresenta&#231;&#227;o (<xref ref-type="fig" rid="f6">Figura 3</xref>). O Tipo I corresponde ao aneurisma localizado na por&#231;&#227;o supra-hep&#225;tica da VCI, sem obstru&#231;&#227;o venosa. O Tipo II est&#225; associado &#224; interrup&#231;&#227;o da VCI. O Tipo III refere-se ao aneurisma localizado na por&#231;&#227;o infrarrenal da VCI. Por fim, o Tipo IV corresponde ao aneurisma envolvendo a veia il&#237;aca, associado &#224; presen&#231;a de VCI &#224; esquerda.<sup><xref ref-type="bibr" rid="B7">7</xref></sup> Com base nessa classifica&#231;&#227;o, o caso apresentado foi caracterizado como aneurisma da VCI do Tipo I, em raz&#227;o de sua localiza&#231;&#227;o supra-hep&#225;tica.</p>
        <fig id="f6">
          <label>Figura 3</label>
          <caption>
            <title>Representa&#231;&#227;o esquem&#225;tica dos quatro tipos de aneurisma da VCI. A) Tipo I: aneurisma localizado na por&#231;&#227;o supra-hep&#225;tica da VCI, sem obstru&#231;&#227;o do fluxo venoso; B) Tipo II: aneurisma infrarrenal associado &#224; interrup&#231;&#227;o do segmento supra-hep&#225;tico da VCI; C) Tipo III: dilata&#231;&#227;o aneurism&#225;tica na regi&#227;o infrarrenal, sem obstru&#231;&#227;o; D) Tipo IV: aneurisma envolvendo a veia il&#237;aca, com posicionamento da VCI &#224; esquerda. Imagem adaptada de Gradman e Steinberg.<sup><xref ref-type="bibr" rid="B7">7</xref></sup> VCI: veia cava inferior.</title>
          </caption>
          <graphic xlink:href="2675-312X-abcic-39-01-e20250055-0055i-gf03-pt.tif"/></fig>
        <p>No presente relato, a paciente, do sexo feminino, possui 75 anos e manteve-se oligossintom&#225;tica ao longo de sua hist&#243;ria cl&#237;nica. Estudos pr&#233;vios descrevem que a maioria dos pacientes diagnosticados com aneurisma de VCI &#233; do sexo masculino, com idade m&#233;dia de 63,5 anos entre os casos classificados como Tipo I, sendo grande parte deles assintom&#225;tica.<sup><xref ref-type="bibr" rid="B6">6</xref></sup> Esses dados demonstram que pode haver varia&#231;&#227;o no perfil epidemiol&#243;gico dos indiv&#237;duos acometidos por essa condi&#231;&#227;o.</p>
        <p>Neste caso, o diagn&#243;stico de aneurisma de VCI foi estabelecido ap&#243;s a realiza&#231;&#227;o de TC de t&#243;rax. Para a identifica&#231;&#227;o dessa condi&#231;&#227;o, os exames de imagem constituem o principal m&#233;todo diagn&#243;stico, destacando-se a TC, a angiorresson&#226;ncia magn&#233;tica e a venografia, pois permitem a avalia&#231;&#227;o detalhada da morfologia e das caracter&#237;sticas do aneurisma venoso.<sup><xref ref-type="bibr" rid="B8">8</xref></sup> No caso relatado, a TC possibilitou a visualiza&#231;&#227;o precisa da localiza&#231;&#227;o, do formato e das dimens&#245;es da les&#227;o.</p>
        <p>Entre as principais complica&#231;&#245;es associadas ao aneurisma da VCI destacam-se ruptura, TVP, embolia pulmonar e s&#237;ndrome da VCI. A ruptura ocorre com maior frequ&#234;ncia nos aneurismas classificados como Tipos II e III, podendo manifestar-se com dor abdominal intensa, dor dorsal e edema de MMII, levando a quadros cl&#237;nicos mais graves.<sup><xref ref-type="bibr" rid="B9">9</xref></sup> Considerando a classifica&#231;&#227;o do aneurisma descrito neste relato, do Tipo I, bem como a hist&#243;ria cl&#237;nica da paciente, n&#227;o foram observadas complica&#231;&#245;es at&#233; o momento.</p>
        <p>A literatura descreve como manifesta&#231;&#245;es cl&#237;nicas mais comuns em pacientes com aneurisma de VCI dor abdominal, dispneia, dorsalgia, edema de MMII e sensa&#231;&#227;o de peso nos MMII. Entretanto, nos aneurismas classificados como Tipo I, os casos assintom&#225;ticos ou oligossintom&#225;ticos s&#227;o mais frequentes.<sup><xref ref-type="bibr" rid="B6">6</xref></sup> Em concord&#226;ncia com esses achados, a paciente deste relato apresentou como principal manifesta&#231;&#227;o cl&#237;nica a dorsalgia, que pode estar relacionada ao aneurisma identificado.</p>
        <p>O tratamento adotado neste caso foi conservador, com acompanhamento cl&#237;nico peri&#243;dico por meio de exame f&#237;sico e exames de imagem, incluindo TC realizada a cada 6 meses. Essa conduta est&#225; em concord&#226;ncia com o algoritmo terap&#234;utico proposto por Montero-Baker et al.,<sup><xref ref-type="bibr" rid="B5">5</xref></sup> que recomenda manejo conservador com monitoramento regular para aneurismas da VCI classificados como Tipo I. Para os Tipos II, III e IV a literatura frequentemente indica interven&#231;&#227;o cir&#250;rgica, como emboliza&#231;&#227;o ou ressec&#231;&#227;o, em raz&#227;o do maior risco de complica&#231;&#245;es.<sup><xref ref-type="bibr" rid="B5">5</xref></sup></p>
      </sec>
      <sec sec-type="conclusions">
        <title>Conclus&#227;o</title>
        <p>Devido &#224; escassez de estudos sobre o tema, as particularidades descritas neste caso podem contribuir para aprimorar o diagn&#243;stico e a conduta em pacientes que apresentem quadro cl&#237;nico e sintomatologia semelhantes. Por se tratar de uma altera&#231;&#227;o cardiovascular com poss&#237;veis repercuss&#245;es sist&#234;micas e, frequentemente, sem manifesta&#231;&#245;es cl&#237;nicas evidentes, o aneurisma da VCI pode evoluir de forma silenciosa. Nesse contexto, a identifica&#231;&#227;o precoce &#233; fundamental para o adequado manejo cl&#237;nico e acompanhamento do paciente.</p>
      </sec>
    </body>
    <back>
      <fn-group>
        <fn fn-type="financial-disclosure" id="fn5">
          <label>Fontes de Financiamento</label>
          <p>O presente estudo n&#227;o teve fontes de financiamento externas.</p>
        </fn>
        <fn fn-type="other" id="fn6">
          <label>Vincula&#231;&#227;o Acad&#234;mica </label>
          <p>N&#227;o h&#225; vincula&#231;&#227;o deste estudo a programas de p&#243;s-gradua&#231;&#227;o.</p>
        </fn>
        <fn fn-type="other" id="fn7">
          <label>Aprova&#231;&#227;o &#201;tica e Consentimento Informado </label>
          <p>Este estudo foi aprovado pelo Comit&#234; de &#201;tica do(a) Miss&#227;o Salesiana De Mato Grosso sob o n&#250;mero de protocolo 7.053.378 (CAAE 79880624.0.0000.5379). Todos os procedimentos envolvidos nesse estudo est&#227;o de acordo com a Declara&#231;&#227;o de Helsinki de 1975, atualizada em 2013. O consentimento informado foi obtido de todos os participantes inclu&#237;dos no estudo.</p>
        </fn>
        <fn fn-type="other" id="fn8">
          <label>Uso de Intelig&#234;ncia Artificial</label>
          <p>Os autores n&#227;o utilizaram ferramentas de intelig&#234;ncia artificial no desenvolvimento deste trabalho.</p>
        </fn>
      </fn-group>
      <ack>
        <title>Agradecimentos</title>
        <p>Agradecemos a todos que contribu&#237;ram, direta ou indiretamente, para a realiza&#231;&#227;o deste relato de caso.</p>
      </ack>
      <sec sec-type="data-availability" specific-use="data-in-article">
        <title>Disponibilidade de Dados</title>
        <p>Os conte&#250;dos subjacentes ao texto da pesquisa est&#227;o contidos no manuscrito.</p>
      </sec>
    </back>
  </sub-article>
</article>
