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  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">ijcs</journal-id>
      <journal-title-group>
        <journal-title>International Journal of Cardiovascular Sciences</journal-title>
        <abbrev-journal-title abbrev-type="publisher">Int. J. Cardiovasc. Sci.</abbrev-journal-title>
      </journal-title-group>
      <issn pub-type="ppub">2359-4802</issn>
      <issn pub-type="epub">2359-5647</issn>
      <publisher>
        <publisher-name>Sociedade Brasileira de Cardiologia</publisher-name>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id specific-use="scielo-v3" pub-id-type="publisher-id">G6vxNWwczFSVd6rsNWFtKJf</article-id>
      <article-id specific-use="scielo-v2" pub-id-type="publisher-id">S2359-56472023000100402</article-id>
      <article-id pub-id-type="other">00402</article-id>
      <article-id pub-id-type="doi">10.36660/ijcs.20230083</article-id>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Viewpoint</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Value-based Health Care Impact on Cardiovascular and Metabolic Diseases</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <contrib-id contrib-id-type="orcid">0000-0002-6411-3480</contrib-id>
          <name>
            <surname>Etges</surname>
            <given-names>Ana Paula Beck da Silva</given-names>
          </name>
          <xref ref-type="aff" rid="aff1">
            <sup>1</sup>
          </xref>
          <xref ref-type="aff" rid="aff2">
            <sup>2</sup>
          </xref>
          <xref ref-type="aff" rid="aff3">
            <sup>3</sup>
          </xref>
          <role content-type="http://credit.niso.org/contributor-roles/conception-and-design-of-the-research/">Conception and design of the research</role>
          <role content-type="http://credit.niso.org/contributor-roles/acquisition-of-data/">acquisition of data</role>
          <role content-type="http://credit.niso.org/contributor-roles/analysis-and-interpretation-of-the-data/">analysis and interpretation of the data</role>
          <role content-type="http://credit.niso.org/contributor-roles/writing-of-the-manuscript/">writing of the manuscript</role>
          <role content-type="http://credit.niso.org/contributor-roles/critical-revision-of-the-manuscript-for-intellectual-content/">critical revision of the manuscript for intellectual content</role>
        </contrib>
        <contrib contrib-type="author">
          <contrib-id contrib-id-type="orcid">0009-0002-7941-1218</contrib-id>
          <name>
            <surname>Comiran</surname>
            <given-names>Gabriela Boff</given-names>
          </name>
          <xref ref-type="aff" rid="aff3">
            <sup>3</sup>
          </xref>
          <xref ref-type="corresp" rid="c1"/>
          <role content-type="http://credit.niso.org/contributor-roles/acquisition-of-data/">acquisition of data</role>
          <role content-type="http://credit.niso.org/contributor-roles/analysis-and-interpretation-of-the-data/">analysis and interpretation of the data</role>
          <role content-type="http://credit.niso.org/contributor-roles/writing-of-the-manuscript/">writing of the manuscript</role>
          <role content-type="http://credit.niso.org/contributor-roles/critical-revision-of-the-manuscript-for-intellectual-content/">critical revision of the manuscript for intellectual content</role>
        </contrib>
        <contrib contrib-type="author">
          <contrib-id contrib-id-type="orcid">0009-0006-3915-7138</contrib-id>
          <name>
            <surname>Ferreira</surname>
            <given-names>Anna Luiza Reinehr</given-names>
          </name>
          <xref ref-type="aff" rid="aff3">
            <sup>3</sup>
          </xref>
          <role content-type="http://credit.niso.org/contributor-roles/acquisition-of-data/">acquisition of data</role>
          <role content-type="http://credit.niso.org/contributor-roles/analysis-and-interpretation-of-the-data/">analysis and interpretation of the data</role>
          <role content-type="http://credit.niso.org/contributor-roles/writing-of-the-manuscript/">writing of the manuscript</role>
          <role content-type="http://credit.niso.org/contributor-roles/critical-revision-of-the-manuscript-for-intellectual-content/">critical revision of the manuscript for intellectual content</role>
        </contrib>
        <contrib contrib-type="author">
          <contrib-id contrib-id-type="orcid">0000-0002-2447-2577</contrib-id>
          <name>
            <surname>Polanczyk</surname>
            <given-names>Carisi Anne</given-names>
          </name>
          <xref ref-type="aff" rid="aff1">
            <sup>1</sup>
          </xref>
          <xref ref-type="aff" rid="aff2">
            <sup>2</sup>
          </xref>
          <xref ref-type="aff" rid="aff4">
            <sup>4</sup>
          </xref>
          <role content-type="http://credit.niso.org/contributor-roles/conception-and-design-of-the-research/">Conception and design of the research</role>
          <role content-type="http://credit.niso.org/contributor-roles/acquisition-of-data/">acquisition of data</role>
          <role content-type="http://credit.niso.org/contributor-roles/analysis-and-interpretation-of-the-data/">analysis and interpretation of the data</role>
          <role content-type="http://credit.niso.org/contributor-roles/writing-of-the-manuscript/">writing of the manuscript</role>
          <role content-type="http://credit.niso.org/contributor-roles/critical-revision-of-the-manuscript-for-intellectual-content/">critical revision of the manuscript for intellectual content</role>
        </contrib>
        <aff id="aff1">
          <label>1</label>
          <institution content-type="orgname">National Institute of Science and Technology for Health Technology Assessment</institution>
          <addr-line>
            <named-content content-type="city">Porto Alegre</named-content>
            <named-content content-type="state">RS</named-content>
          </addr-line>
          <country country="BR">Brazil</country>
          <institution content-type="original">National Institute of Science and Technology for Health Technology Assessment (IATS), Porto Alegre, RS &#8211; Brazil</institution>
        </aff>
        <aff id="aff2">
          <label>2</label>
          <institution content-type="orgname">Universidade Federal do Rio Grande do Sul</institution>
          <addr-line>
            <named-content content-type="city">Porto Alegre</named-content>
            <named-content content-type="state">RS</named-content>
          </addr-line>
          <country country="BR">Brazil</country>
          <institution content-type="original">Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS &#8211; Brazil</institution>
        </aff>
        <aff id="aff3">
          <label>3</label>
          <institution content-type="orgname">Pontif&#237;cia Universidade Cat&#243;lica do Rio Grande do Sul</institution>
          <addr-line>
            <named-content content-type="city">Porto Alegre</named-content>
            <named-content content-type="state">RS</named-content>
          </addr-line>
          <country country="BR">Brazil</country>
          <institution content-type="original">Pontif&#237;cia Universidade Cat&#243;lica do Rio Grande do Sul (PUCRS), Porto Alegre, RS &#8211; Brazil</institution>
        </aff>
        <aff id="aff4">
          <label>4</label>
          <institution content-type="orgname">Hospital Moinhos de Vento</institution>
          <addr-line>
            <named-content content-type="city">Porto Alegre</named-content>
            <named-content content-type="state">RS</named-content>
          </addr-line>
          <country country="BR">Brazil</country>
          <institution content-type="original">Hospital Moinhos de Vento, Porto Alegre, RS &#8211; Brazil</institution>
        </aff>
      </contrib-group>
      <author-notes>
        <corresp id="c1"><bold>Mailing Address: Gabriela Boff Comiran</bold> Pontif&#237;cia Universidade Cat&#243;lica do Rio Grande do Sul (PUCRS). Av. Ipiranga, 6681. Postal code: <postal-code>90619-900</postal-code>. Porto Alegre, RS &#8211; Brazil. E-mail: <email>G.Boff@edu.pucrs.br</email></corresp>
        <fn fn-type="conflict">
          <p>
            <bold>Potential Conflict of Interest</bold>
          </p>
          <p>No potential conflict of interest relevant to this article was reported.</p>
        </fn>
      </author-notes>
      <pub-date publication-format="electronic" date-type="pub">
        <day>28</day>
        <month>08</month>
        <year>2023</year>
      </pub-date>
      <pub-date publication-format="electronic" date-type="collection">
        <year>2023</year>
      </pub-date>
      <volume>36</volume>
      <elocation-id>e20230083</elocation-id>
      <history>
        <date date-type="received">
          <day>07</day>
          <month>06</month>
          <year>2023</year>
        </date>
        <date date-type="rev-recd">
          <day>14</day>
          <month>06</month>
          <year>2023</year>
        </date>
        <date date-type="accepted">
          <day>23</day>
          <month>06</month>
          <year>2023</year>
        </date>
      </history>
      <permissions>
        <license license-type="open-access" xml:lang="en" xlink:href="https://creativecommons.org/licenses/by/4.0/">
          <license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
        </license>
      </permissions>
      <kwd-group xml:lang="en">
        <title>Keywords</title>
        <kwd>Value-based health care</kwd>
        <kwd>Program Evaluation</kwd>
        <kwd>Telemedicine</kwd>
        <kwd>Heart diseases</kwd>
      </kwd-group>
      <counts>
        <fig-count count="1"/>
        <table-count count="1"/>
        <equation-count count="0"/>
        <ref-count count="21"/>
      </counts>
    </article-meta>
  </front>
  <body>
    <fig id="f1">
      <graphic xlink:href="2359-5647-ijcs-36-e20230083-30083-gf01.tif"/></fig>
    <p>Cardiometabolic diseases include conditions of metabolic changes starting with insulin resistance, dyslipidemia, hypertension, and obesity that affect the cardiovascular system. In Brazil, cardiovascular diseases were the leading cause of death in 2019, with coronary disease and stroke being on top, with a population prevalence of 6.1%.<sup><xref ref-type="bibr" rid="B1">1</xref></sup> It is estimated that more than 17 million Brazilians have diabetes, 46% of whom are unaware of the disease. Associated illnesses such as ischemic disease, stroke, and diabetes represent a high economic burden on health systems, justified by their high incidence, population aging, and increasing incorporation of more expensive technologies.</p>
    <p>Increased health spending without evidence of population health improvements has led to major changes in how health systems are defined and managed. In the search for strategies to contribute to the system&#8217;s capacity to stimulate the generation of better results with existing resources, the concept of value-based health care has emerged. It consists of converting available investments into better healthcare results for the population.<sup><xref ref-type="bibr" rid="B2">2</xref></sup> The concept was introduced just over a decade ago,<sup><xref ref-type="bibr" rid="B3">3</xref></sup> in which primary health care (PHC) and education about population health and prevention are considered the pillars for the establishment of a value-based health system.<sup><xref ref-type="bibr" rid="B4">4</xref>,<xref ref-type="bibr" rid="B5">5</xref></sup></p>
    <p>PHC ensures cardiometabolic diseases are tracked, prevented and managed at a non-advanced stage or after an intervention in specialized care, and best practices for implementing specific programs have already been developed.<sup><xref ref-type="bibr" rid="B6">6</xref></sup> For PHC to perform its duty, however, it is important to encourage prevention, self-care, and healthy habits, which can be done through remuneration models.<sup><xref ref-type="bibr" rid="B7">7</xref></sup> Remuneration strategies that include health outcome measures are required for implementing value-based healthcare<sup><xref ref-type="bibr" rid="B8">8</xref></sup> and, when it comes to PHC, it also refers to measuring whether prevention, tracking and education activities are being delivered to the assisted population in each unit.<sup><xref ref-type="bibr" rid="B9">9</xref></sup> However, the implementation of strategies and programs that reward the achievement of better health results and promote prevention and self-care initiatives require an accurate ability to organize measurement at the individual level.<sup><xref ref-type="bibr" rid="B10">10</xref></sup></p>
    <p>Technological advances facilitates measurement, especially of diseases that allow tracking and monitoring by the individuals themselves. As an example, the HEARTS application was implemented by Latin American countries to collaborate in the identification of patients with cardiovascular risk in the PHC.<sup><xref ref-type="bibr" rid="B11">11</xref></sup> Based on variables answered by the patients when arriving at the PHC, the application suggests the level of cardiovascular risk, facilitating medical conduct within alternatives available in public and supplementary health. It collaborates with patient-centered care, particularly when established lines of care exist. They describe patient routines, including information on actions and activities towards promotion, prevention, treatment, and rehabilitation, to be developed in health care units, while defining the role of each member of the process and, therefore, reducing waste and increasing guidance assertiveness in the health care system.<sup><xref ref-type="bibr" rid="B12">12</xref></sup></p>
    <p>When considering the behavioral and self-care factors in the prevention and screening of cardiometabolic diseases, the establishment of value-based management models for this care pathway can achieve better results with the adoption of technologies used by patients. From educational solutions to self-monitoring of blood glucose levels, examples with positive results are widely known and summarized in systematic reviews of the literature on diabetes, obesity and post-infarction conditions. <xref ref-type="table" rid="t1">Table 1</xref> describes the main contributions of these systematic reviews.</p>
    <table-wrap id="t1">
      <label>Table 1</label>
      <caption>
        <title>Systematic reviews on the incorporation of self-care technologies with a focus on cardiometabolic diseases.</title>
      </caption>
      <table frame="hsides" rules="rows">
        <colgroup width="20%">
          <col/>
          <col/>
          <col/>
          <col/>
          <col/>
        </colgroup>
        <thead style="border-top: thin solid; border-bottom: thin solid; border-color: #000000">
          <tr style="background-color:#BCBDC0">
            <th align="left" valign="middle">Title</th>
            <th align="center" valign="middle">Country</th>
            <th align="center" valign="middle">Disease</th>
            <th align="center" valign="middle">Technology employed</th>
            <th align="left" valign="middle">Impact and results generated by the digitization of data.</th>
          </tr>
        </thead>
        <tbody style="border-bottom: thin solid; border-color: #000000">
          <tr>
            <td align="left" valign="middle">Considerations for the Development of Mobile Phone Apps to Support Diabetes Self-Management: Systematic Review<sup><xref ref-type="bibr" rid="B13">13</xref></sup></td>
            <td align="center" valign="middle">USA</td>
            <td align="center" valign="middle">Diabetes</td>
            <td align="center" valign="middle">Mobile apps</td>
            <td align="left" valign="middle">Shared decision-making between diabetes patients, healthcare professionals, and application developers. Data security and privacy must be ensured, in addition to the integration of the main functions that support self-care as indicated by diabetes melitus guidelines. Therefore, the specific needs of diabetic patients can be addressed in the application, thus improving self-management and clinical outcomes.</td>
          </tr>
          <tr>
            <td align="left" valign="middle">Effectiveness of Mobile Health Interventions on Diabetes and Obesity Treatment and Management: Systematic Review of Systematic Reviews<sup><xref ref-type="bibr" rid="B14">14</xref></sup></td>
            <td align="center" valign="middle">USA</td>
            <td align="center" valign="middle">Diabetes and obesity</td>
            <td align="center" valign="middle">Mobile apps, text messages, self-monitoring, and mHealth Program Management</td>
            <td align="left" valign="middle">mHealth interventions are promising, but evidence is limited about their effectiveness in glycemic control and weight reduction. In order to improve effectiveness, future studies are required to determine optimal formats and frequency, better adaptation of messages and improved usability, emphasizing maintenance of effectiveness over time.</td>
          </tr>
          <tr>
            <td align="left" valign="middle">The Use of DASH Mobile Apps for Supporting a Healthy Diet and Controlling Hypertension in Adults: Systematic Review<sup><xref ref-type="bibr" rid="B15">15</xref></sup></td>
            <td align="center" valign="middle">USA</td>
            <td align="center" valign="middle">Hypertension</td>
            <td align="center" valign="middle">Mobile apps</td>
            <td align="left" valign="middle">There is weak emerging evidence of the positive effect of using DASH smartphone apps in supporting self-management to improve adherence to the DASH diet and consequently reduce BP.</td>
          </tr>
          <tr>
            <td align="left" valign="middle">A Systematic Review of Application and Effectiveness of mHealth Interventions for Obesity and Diabetes Treatment and Self-Management<sup><xref ref-type="bibr" rid="B16">16</xref></sup></td>
            <td align="center" valign="middle">United States</td>
            <td align="center" valign="middle">Diabetes and Obesity</td>
            <td align="center" valign="middle">mHealth. Text messaging, wearable or handheld devices, and smartphone applications</td>
            <td align="left" valign="middle">Primary outcomes included weight loss or maintenance, in addition to glucose maintenance (mean decrease in glycated hemoglobin from -0.4% at 10 months to -1.9% at 12 months); secondary outcomes included changes in patient behavior and perceptions such as self-efficacy and program acceptability. Over 50% of studies reported positive effects of interventions based on primary outcomes. Most studies included small sample sizes, short intervention periods, and no rigorous data collection or analytical approaches. While some studies have suggested that mHealth interventions are effective and promising, most of them are pilot studies or have design limitations.</td>
          </tr>
          <tr>
            <td align="left" valign="middle">mHealth Interventions for Self-management of Hypertension: Framework and Systematic Review on Engagement, Interactivity, and Tailoring<sup><xref ref-type="bibr" rid="B17">17</xref></sup></td>
            <td align="center" valign="middle">United States</td>
            <td align="center" valign="middle">Hypertension</td>
            <td align="center" valign="middle">Mobile app interventions for hypertension self-monitoring</td>
            <td align="left" valign="middle">mHealth app interventions for managing hypertension have implemented engagement, interactivity, and adaptation, as shown by the 21 studies in this review. A patient-centered engagement framework for hypertension self-management with mHealth technology was proposed, aiming to facilitate intervention design and disease self-management by using this technology in the future.</td>
          </tr>
          <tr>
            <td align="left" valign="middle">Mobile Apps to Support the Self-Management of Hypertension: Systematic Review of Effectiveness, Usability, and User Satisfaction<sup><xref ref-type="bibr" rid="B18">18</xref></sup></td>
            <td align="center" valign="middle">United States</td>
            <td align="center" valign="middle">Hypertension</td>
            <td align="center" valign="middle">Mobile app interventions for hypertension self-monitoring</td>
            <td align="left" valign="middle">Twenty-one (21) studies with 3,112 participants were included in the review. Of the 14 studies that evaluated the effectiveness of mobile applications in lowering blood pressure, ten (71.4%) reported significant reductions in blood pressure and appeared to be effective in controlling hypertension. Of these ten, only two (20%) RCTs and three (30%) non-randomized studies had low to moderate risk of bias. Results were inconclusive and combinations of features would be more effective in lowering blood pressure due to variation in trial quality. Data suggests that apps that incorporate more comprehensive functionality will be more effective.</td>
          </tr>
          <tr>
            <td align="left" valign="middle">The Effectiveness of Self-Management of Hypertension in Adults Using Mobile Health: Systematic Review and Meta-Analysis<sup><xref ref-type="bibr" rid="B19">19</xref></sup></td>
            <td align="center" valign="middle">United States</td>
            <td align="center" valign="middle">Hypertension</td>
            <td align="center" valign="middle">Mobile and wearable devices</td>
            <td align="left" valign="middle">Twenty-four (24) studies with 8,933 participants were included. Twenty-three (23) studies reported clinical BP outcome, 12 provided blood pressure data, and 16 focused on change in self-management behavior and medication adherence. A greater reduction in SBP and DBP was observed in the mHealth intervention groups compared with the control groups. Subgroup analyses showed consistent reductions in blood pressure levels across different reminder frequencies, interactive patterns, intervention functions, and study duration subgroups. Sixteen (16) studies reported better medication adherence and behavioral change in the intervention groups, while eight showed no significant change.</td>
          </tr>
        </tbody>
      </table>
      <table-wrap-foot>
        <fn id="TFN1">
          <p>DAH: Dietary Approaches to Stop Hypertension; mHealth: mobile technologies and wearable devices; RCTs: random clinical trialS; SBP: systolic blood pressure; DBP: diastolic blood pressure.</p>
        </fn>
      </table-wrap-foot>
    </table-wrap>
    <p>Consolidated evidence in systematic reviews indicates that the use of technologies by individuals favors the centralization of self-care, patient involvement in health-related decisions, early diagnosis and, consequently, greater adherence to the care pathway. These are the expected results of strategies aimed at generating value, as implemented in the context of PHC and cardiometabolic diseases. In the United States, the Centers of Medicare &amp; Medicaid Services (CMS) launched a Bundled Payments Initiative, with a fixed portion for the delivery of a service and a variable portion for the outcome. Performance evaluation is based on measures of process results and assisted individuals related to monitoring cardiometabolic diseases, such as blood pressure and diabetes control, cancer screening, individual care planning, and patient experience.<sup><xref ref-type="bibr" rid="B5">5</xref></sup> In addition, the American Heart Association has also launched initiatives to better integrate primary and specialized care for diseases such as heart failure.<sup><xref ref-type="bibr" rid="B20">20</xref></sup></p>
    <p>In Brazil, existing projects incorporate these concepts, such as the Previne Brasil program, instituted by Ordinance No. 2979, of November 12, 2019.<sup><xref ref-type="bibr" rid="B9">9</xref></sup> The new funding model for PHC by SUS (Brazilian public health system) alters some forms of transferring funds to municipalities, which are now distributed based on four criteria: weighted capitation, payment for performance, incentives for strategic actions and financial incentives based on population criteria. For the pay-for-performance indicators, seven indicators are considered, two of which related to chronic conditions, such as the proportion of people with hypertension and blood pressure measured in the last semester and people with diabetes with glycated hemoglobin measured. This proposal is based on structuring a financing model focused on increasing people&#8217;s access to PHC services and the link between population and HC team, based on mechanisms that induce managers and professionals to be responsible for the people assisted. An analysis of the Program in the State of Minas Gerais units showed an important increase in hypertension and diabetes indicators, from 2% in 2019 to 11% in 2021 and 5% to 23%, respectively.<sup><xref ref-type="bibr" rid="B21">21</xref></sup> This still preliminary and focal data corroborate the concepts of the importance of relating the care provided to chronic conditions with metrics and payment models leading to better results for both patients and overall population health in the future. Central illustration elucidates new technological alternatives to monitor/deal with cardiovascular diseases.</p>
    <sec sec-type="conclusions">
      <title>Final considerations</title>
      <p>The development of a value-based health system that is centered around individual needs and scaled to deliver the best health outcomes within a budget constraint is possible and favored by structural changes to the system, such as payment methods and a technology base that enables real-life data-driven management. PHC centralization and the interconnection with data shared between the assisted population and specialized care systems seem to be a requirement for greater capacity for tracking, diagnosing, and managing cardiometabolic diseases in the health system. For Brazil&#8217;s current scenario, the challenges start with the precarious measurement culture and remuneration strategies that are centered on payment for the service delivery rather than the impact they have on population health.</p>
      <p>As primary steps to establish a value-based health model for cardiometabolic diseases in Brazil, seeking inspiration from existing evidence, the following are recommended: start by disseminating mobile technologies that provide education and self-care and can be easily accessed by the population; advance towards implementing a measurement culture in PHC, sharing results with specialized care institutions and funding sources; and establish a better capacity for longitudinal monitoring of individuals in the care pathways, which can be driven by a change in the specific reimbursement strategy for each of care pathways.</p>
    </sec>
  </body>
  <back>
    <fn-group>
      <fn fn-type="supported-by" id="fn1">
        <p>
          <bold>Sources of Funding</bold>
        </p>
        <p>There were no external funding sources for this study.</p>
      </fn>
      <fn fn-type="other" id="fn2">
        <p>
          <bold>Study Association</bold>
        </p>
        <p>This study is not associated with any thesis or dissertation work.</p>
      </fn>
      <fn fn-type="other" id="fn3">
        <p>
          <bold>Ethics Approval and Consent to Participate</bold>
        </p>
        <p>This article does not contain any studies with human participants or animals performed by any of the authors.</p>
      </fn>
    </fn-group>
    <ref-list>
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            <name>
              <surname>Soares</surname>
              <given-names>CS</given-names>
            </name>
          </person-group>
          <article-title>Programa Previne Brasil: An&#225;lise da Mudan&#231;a do Modelo de Financiamento Federal da Aten&#231;&#227;o Prim&#225;ria &#224; Sa&#250;de em Munic&#237;pios do Estado de Minas Gerais. Belo Horizonte</article-title>
          <source>Disserta&#231;&#227;o [Mestrado em Gest&#227;o de Servi&#231;os de Sa&#250;de]. Universidade Federal de Minas Gerais</source>
          <year>2022</year>
        </element-citation>
        <mixed-citation>21 Soares CS. Programa Previne Brasil: An&#225;lise da Mudan&#231;a do Modelo de Financiamento Federal da Aten&#231;&#227;o Prim&#225;ria &#224; Sa&#250;de em Munic&#237;pios do Estado de Minas Gerais. Belo Horizonte. Disserta&#231;&#227;o [Mestrado em Gest&#227;o de Servi&#231;os de Sa&#250;de]. Universidade Federal de Minas Gerais; 2022.</mixed-citation>
      </ref>
    </ref-list>
  </back>
</article>
