According to the recently published “Cardiovascular Statistics – Brazil 2020”,¹ mortality from cardiovascular diseases (CVD) is proportionally higher in women compared to men. The INTERHEART study demonstrated that the population attributable risk for myocardial infarction associated with modifiable risk factors of smoking, alcohol use, high-risk diet, and physical inactivity, was significantly higher among women than men.² Evidence from the VIRGO study (Variation in Recovery: Role of Gender on Outcomes of Young Acute Myocardial Infarction [AMI] Patients) indicates that both health professionals and women are unaware or neglect the development of cardiovascular heart disease (CHD) and the presence of cardiovascular risk factors in women.

Women are underrepresented in cardiovascular disease trials despite known sex differences across a broad range of risk, prevention, treatment, and outcome parameters. Gender influences many aspects of disease like its pathophysiology and clinical presentation, response to treatment, clinicians' behavior, and access to health care,^{3 , 4} and now it is clear that research must consider this to promote better diagnosis and treatment, and gender equity in health care.

How can scientific journals strengthen sex and gender equity in research and publishing? In many ways, like promoting research in the field. Recently the International Journal of Cardiovascular Sciences made a call for articles about cardiovascular diseases in women and published an entire edition dedicated to subject. In that edition, Meira Ferreira et al.,⁴ published a review article about closing the gender gap in ischemic heart disease (IHD) and myocardial infarction. These authors showed that the prevalence of IHD increased in both sexes from 1990 to 2017 in Brazil, with differences in sex distribution among geographical regions. For example, there were 22% more IHD cases in women in the southeast region than in women in the northeast region.⁴ In the same edition, Gazzilli⁵ highlighted the increase in annual proportional mortality from IHD in women in recent years, with an age-standardized incidence of 104 per 100,000 population for males and 58 per 100,000 population for females.⁵

Another important step in the promotion of gender equity is the adoption of guidelines to improve the reporting of sex and gender in research across disciplines. A panel of 13 experts developed the SAGER (Sex and Gender Equity in Research) guidelines to guide authors in preparing manuscripts and editors in assessing the inclusion of sex and gender into manuscripts as an integral part of the editorial process.⁶Table 1 lists a summary of recommendations from the SAGER guidelines that may be easily adopted by authors. The International Journal of Cardiovascular Sciences is including the SAGER guidelines in its policy and will encourage the submitting authors to follow these recommendations. We will make progressive changes in the Scholar One submission system to increase the compliance to these guidelines and promote educational activities to revisors and authors to facilitate the adherence to the SAGER guidelines.

Table 1

General principles
Use the words sex and gender carefully. Use the term sex in animal studies. Where subjects can be differentiated by gender, research should take this into account.
Recommendations per section of the article
Title and Abstract	the title and the abstract of articles should specify the sex /gender of research subjects specify the sex of cells and tissues in cell biological, molecular biological, and biochemical studies
Introduction	authors should report if sex/gender differences may be expected.
Methods	authors should describe how sex/gender was determined (self-report, examination, genetic testing) in medical device testing, explain whether the device will be used by all genders and if it has been tested with this in mind
Results	data should be routinely presented disaggregated by sex sex- and gender-based analyses should be carried out, if appropriate, and reported regardless of positive or negative outcome.
Discussion	implications of sex and gender on study results and analysis should be discussed. If a sex and gender analysis was not conducted, the rationale should be given, and authors should discuss the implications of the lack of such analysis in interpreting the results.

Adapted from Heidari ,et al.⁶

There is a lot yet to be done to close the gap of sex and gender equity in research, publication, and in many other aspects of life. Women need to be included, respected, empowered, and adequately represented in many aspects of the scientific community.^{7 , 8} Men and women publish a comparable number of papers per year and have equivalent career impact for the same total number of publications. The decrease in productivity observed in women can be largely explained by different publishing career length and dropout rates.⁹

We must use our knowledge and wisdom to offer opportunities to close the gender gap to researchers and to our patients. The International Journal of Cardiovascular Sciences is making this call to the cardiovascular scientific community.