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  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">ijcs</journal-id>
      <journal-title-group>
        <journal-title>International Journal of Cardiovascular Sciences</journal-title>
        <abbrev-journal-title abbrev-type="publisher">Int. J. Cardiovasc. Sci.</abbrev-journal-title>
      </journal-title-group>
      <issn pub-type="ppub">2359-4802</issn>
      <issn pub-type="epub">2359-5647</issn>
      <publisher>
        <publisher-name>Sociedade Brasileira de Cardiologia</publisher-name>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id" specific-use="scielo-v3">ZjBCLYwzf73cQPWpQRtsHPz</article-id>
      <article-id pub-id-type="publisher-id" specific-use="scielo-v2">S2359-56472019000200190</article-id>
      <article-id pub-id-type="doi">10.5935/2359-4802.20180077</article-id>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>VIEWPOINT</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Effect of <italic>A&#231;a&#237;</italic> (<italic>Euterpe Oleracea</italic>) Intake on Vascular Function and Lipid Profile: What is the Recommendation?</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <contrib-id contrib-id-type="orcid">0000-0003-4317-9365</contrib-id>
          <name>
            <surname>Santos</surname>
            <given-names>Heitor Oliveira</given-names>
          </name>
          <xref ref-type="aff" rid="aff1"/>
          <xref ref-type="corresp" rid="c1"/>
        </contrib>
        <aff id="aff1">
          <institution content-type="orgname">Universidade Federal de Uberl&#226;ndia</institution>
          <addr-line>
            <city>Uberl&#226;ndia</city>
            <state>MG</state>
          </addr-line>
          <country country="BR">Brazil</country>
          <institution content-type="original">Universidade Federal de Uberl&#226;ndia, Uberl&#226;ndia, MG - Brazil</institution>
        </aff>
      </contrib-group>
      <author-notes>
        <corresp id="c1"><bold>Mailing Address: Heitor Oliveira Santos,</bold> Av. Par&#225;, 1720. Postal Code: 38400-902, Umuarama, Uberl&#226;ncia, Minas Gerais, MG - Brazil. E-mail: <email>heitoroliveirasantos@gmail.com</email>, <email>heitor13cam@hotmail.com</email>
				</corresp>
        <fn fn-type="con">
          <p>
            <bold>Author contributions</bold>
          </p>
          <p>Conception and design of the research: Santos HO. Acquisition of data: Santos HO. Analysis and interpretation of the data: Santos HO. Writing of the manuscript: Santos HO. Critical revision of the manuscript for intellectual content: Santos HO.</p>
        </fn>
        <fn fn-type="conflict">
          <p>
            <bold>Potential Conflict of Interest</bold>
          </p>
          <p>No potential conflict of interest relevant to this article was reported.</p>
        </fn>
      </author-notes>
      <pub-date pub-type="epub-ppub">
        <season>Mar-Apr</season>
        <year>2019</year>
      </pub-date>
      <volume>32</volume>
      <issue>2</issue>
      <fpage>190</fpage>
      <lpage>192</lpage>
      <history>
        <date date-type="received">
          <day>27</day>
          <month>12</month>
          <year>2017</year>
        </date>
        <date date-type="rev-recd">
          <day>14</day>
          <month>04</month>
          <year>2018</year>
        </date>
        <date date-type="accepted">
          <day>30</day>
          <month>04</month>
          <year>2018</year>
        </date>
      </history>
      <permissions>
        <license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/" xml:lang="en">
          <license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
        </license>
      </permissions>
      <kwd-group xml:lang="pt">
        <title>Keywords</title>
        <kwd>Euterpe</kwd>
        <kwd>Hypertension</kwd>
        <kwd>Phytochemicals</kwd>
        <kwd>Lipids</kwd>
        <kwd>Cholesterol, HDL</kwd>
        <kwd>Flavonoids</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <body>
    <sec sec-type="intro">
      <title>Introduction</title>
      <p>The <italic>a&#231;a&#237;</italic> palm tree (<italic>Euterpe oleracea</italic> Mart.) is mostly native to Brazil, and its fruit, <italic>a&#231;a&#237;</italic> berry, is very popular among physically active individuals. The <italic>a&#231;a&#237;</italic> berry pulp, very pleasing to the taste buds, has gained adepts in Brazil, Europe and USA in recent years, being even considered a "superfruit".<xref ref-type="bibr" rid="B1">1</xref>
			</p>
      <p>The <italic>a&#231;a&#237;</italic> berry pulp is rich in anthocyanins, which is reflected on its deep purple color, in addition to other bioactive substances, such as phenolic compounds and flavonoids. Because of its content of such substances, the <italic>a&#231;a&#237;</italic> fruit has been claimed to have a significant pharmacodynamic effect, mainly on the cardiovascular physiology, affecting dyslipidemia and arterial hypertension.</p>
      <p>Thus, considering the pharmacodynamic substances and nutritional composition of the <italic>a&#231;a&#237;</italic> berry, understanding the impact of its intake on the lipid profile and blood pressure is necessary.</p>
    </sec>
    <sec>
      <title>Development</title>
      <sec>
        <title>Nutrition facts</title>
        <p>The pulp of the Brazilian <italic>a&#231;a&#237;</italic> has a considerable amount of fats and dietary fibers. When compared to popularly consumed foods, whose cardiovascular benefits have been well established, vitamin E is the nutrient of <italic>a&#231;a&#237;</italic> that stands out. The amount of carbohydrates in the <italic>a&#231;a&#237;</italic> pulp alone, without syrup or any dietary item added, is low (<xref ref-type="table" rid="t1">Table 1</xref>).</p>
        <table-wrap id="t1">
          <label>Table 1</label>
          <caption>
            <title>Comparison of the nutrition facts of the a&#231;a&#237; pulp with servings of foods which display cardiovascular protection</title>
          </caption>
          <table frame="hsides" rules="groups">
            <colgroup>
              <col width="14%"/>
              <col width="14%"/>
              <col width="14%"/>
              <col width="14%"/>
              <col width="14%"/>
              <col width="14%"/>
              <col width="14%"/>
            </colgroup>
            <thead>
              <tr>
                <th align="left" style="background-color:#C5C6C8">Dietary item <break/> (homemade amount)</th>
                <th align="center" style="background-color:#C5C6C8">Calories</th>
                <th align="center" style="background-color:#C5C6C8">Protein(g)</th>
                <th align="center" style="background-color:#C5C6C8">Total fat (g)</th>
                <th align="center" style="background-color:#C5C6C8">Carbohydrate available (g)</th>
                <th align="center" style="background-color:#C5C6C8">Total fibers (g)</th>
                <th align="center" style="background-color:#C5C6C8">Vitamin E (mg)</th>
              </tr>
            </thead>
            <tbody>
              <tr>
                <td align="left"><italic>A&#231;a&#237;</italic> pulp (100 g)</td>
                <td align="center">72</td>
                <td align="center">1</td>
                <td align="center">4.9</td>
                <td align="center">5.8</td>
                <td align="center">5.3</td>
                <td align="center">14.8</td>
              </tr>
              <tr>
                <td align="left">Avocado (100 g) </td>
                <td align="center">167</td>
                <td align="center">2</td>
                <td align="center">15.4</td>
                <td align="center">8.6</td>
                <td align="center">6.8</td>
                <td align="center">2</td>
              </tr>
              <tr>
                <td align="left">Powder cocoa (30 g)</td>
                <td align="center">123</td>
                <td align="center">6</td>
                <td align="center">3</td>
                <td align="center">18</td>
                <td align="center">6</td>
                <td align="center">0.1</td>
              </tr>
              <tr>
                <td align="left">Mix of oilseeds (28.5 g)</td>
                <td align="center">172</td>
                <td align="center">5.5</td>
                <td align="center">15.2</td>
                <td align="center">6.4</td>
                <td align="center">1.8</td>
                <td align="center">1.7</td>
              </tr>
              <tr>
                <td align="left">Extra virgin olive oil (14 mL)</td>
                <td align="center">120</td>
                <td align="center">0</td>
                <td align="center">14</td>
                <td align="center">0</td>
                <td align="center">0</td>
                <td align="center">1.9</td>
              </tr>
            </tbody>
          </table>
          <table-wrap-foot>
            <fn id="TFN1">
              <p>Adapted from the United States Department of Agriculture (USDA).<xref ref-type="bibr" rid="B2">2</xref>
							</p>
            </fn>
          </table-wrap-foot>
        </table-wrap>
        <p>The lipid composition of the Brazilian <italic>a&#231;a&#237;</italic> berry is as follows: polyunsaturated fatty acids, 11.1%; monounsaturated fatty acids, 60.2%; and saturated fatty acids, 28.7%.<xref ref-type="bibr" rid="B3">3</xref> Of the monounsaturated fatty acids of the <italic>a&#231;a&#237;</italic> berry, 53.9% are oleic acid,<xref ref-type="bibr" rid="B3">3</xref> a substance found in avocado and olive oil and that can improve the lipid profile.<xref ref-type="bibr" rid="B4">4</xref>
				</p>
      </sec>
      <sec>
        <title>Bioactive substances of cardiovascular importance</title>
        <p>A significant amount of anthocyanins is present in the <italic>a&#231;a&#237;</italic> berry, which also contains other antioxidant phytochemicals important to the cardiovascular system, such as sterols, mainly beta-sitosterol,<xref ref-type="bibr" rid="B3">3</xref> which, similarly to monounsaturated fats, is also found in olive oil and avocado.<xref ref-type="bibr" rid="B4">4</xref> Beta-sitosterol acts mainly on lipid modulation,<xref ref-type="bibr" rid="B4">4</xref> while anthocyanins act mainly by reducing blood pressure.<xref ref-type="bibr" rid="B5">5</xref>
				</p>
      </sec>
      <sec>
        <title>Impact of a&#231;a&#237; intake on vascular function</title>
        <p>The most important effect of the <italic>a&#231;a&#237;</italic> berry on vascular function is vasodilation, mainly via the anthocyanins. An easily accessible clinical parameter to monitor the <italic>a&#231;a&#237;</italic> effect on vascular function is blood pressure. Despite the expectations, Aqurashi et al.,<xref ref-type="bibr" rid="B6">6</xref> and Udani et al.,<xref ref-type="bibr" rid="B7">7</xref> have not found any improvement in blood pressure deriving from the <italic>a&#231;a&#237;</italic> intake, but their sample was formed by normotensive individuals. However, Aqurashi et al.,<xref ref-type="bibr" rid="B6">6</xref> have reported a 1.4% increase in the flow-mediated dilation of the brachial artery resulting from the intake of 150 g of <italic>a&#231;a&#237;</italic> pulp in an acute test, which reflects a significant improvement in vascular function.</p>
      </sec>
      <sec>
        <title>Effect of a&#231;a&#237; intake on lipid profile</title>
        <p>Despite not finding any improvement in blood pressure, Udani et al. have shown a reduction in total cholesterol from 159 to 142 mg/dL (p &lt; 0.030) in overweight patients consuming 100 g of <italic>a&#231;a&#237;</italic> pulp twice a day for one month, but the other lipid profile parameters showed no change.<xref ref-type="bibr" rid="B7">7</xref> Surprisingly, Sadowska-Kr&#281;pa et al.,<xref ref-type="bibr" rid="B8">8</xref> have reported an increase in HDL-C levels from 50 to 60 mg/dL in young athletes following the intake of 100 mL/day of <italic>a&#231;a&#237;</italic> juice for six weeks, in addition to a decrease in total cholesterol from 159 to 134 mg/dL, in LDL-C from 90 to 60 mg/dL, and in triglycerides from 94 to 72 mg/dL.</p>
        <p>However, a new study has reported that the intake of 200 g/day of <italic>a&#231;a&#237;</italic> pulp for four weeks did not improve the traditional lipid profile parameters of healthy women. Nevertheless, <italic>a&#231;a&#237;</italic> consumption elevated the serum levels of apolipoprotein A1 and the activity of paraoxonase-1, whose molecules are HDL-C precursors. The consumption of <italic>a&#231;a&#237;</italic> improved the transfer of cholesteryl esters to HDL-C, a beneficial biochemical process, because that is an HDL-C function, which captures cholesteryl esters from VLDL-C (reverse cholesterol transport).<xref ref-type="bibr" rid="B9">9</xref>
				</p>
      </sec>
    </sec>
    <sec sec-type="conclusions">
      <title>Conclusions/Dietary Management</title>
      <p>The <italic>a&#231;a&#237;</italic> intake can be encouraged to patients already adept to its consumption or those who are willing to. However, one should be cautious about overvaluing its claimed effects on lipid profile and vascular function.</p>
      <p>Regarding nutrition facts of the <italic>a&#231;a&#237;</italic>, shown in <xref ref-type="table" rid="t1">Table 1</xref>, ensures its usual use in dietary plans. However, attention should be paid to the foods added to <italic>a&#231;a&#237;</italic> preparations, such as sugar, honey, powder milk, peanut powder.</p>
      <p>The <italic>a&#231;a&#237;</italic> pulp is popularly consumed combined with other foods, and some dietary items that can enhance the claimed cardiovascular effects of <italic>a&#231;a&#237;</italic> are cocoa or dark chocolate and oilseeds, such as almonds, chestnuts and walnuts.</p>
    </sec>
  </body>
  <back>
    <fn-group>
      <fn fn-type="financial-disclosure">
        <p>
          <bold>Sources of Funding</bold>
        </p>
        <p>There were no external funding sources for this study.</p>
      </fn>
      <fn fn-type="other">
        <p>
          <bold>Study Association</bold>
        </p>
        <p>This study is not associated with any thesis or dissertation work.</p>
      </fn>
      <fn fn-type="other">
        <p>
          <bold>Ethics approval and consent to participate</bold>
        </p>
        <p>This article does not contain any studies with human participants or animals performed by any of the authors.</p>
      </fn>
    </fn-group>
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