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  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">abc</journal-id>
      <journal-title-group>
        <journal-title>Arquivos Brasileiros de Cardiologia</journal-title>
        <abbrev-journal-title abbrev-type="publisher">Arq. Bras. Cardiol.</abbrev-journal-title>
      </journal-title-group>
      <issn pub-type="ppub">0066-782X</issn>
      <issn pub-type="epub">1678-4170</issn>
      <publisher>
        <publisher-name>Sociedade Brasileira de Cardiologia - SBC</publisher-name>
        <publisher-loc>S&#227;o Paulo, SP, Brazil</publisher-loc>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id" specific-use="scielo-v3">wfXz4PDhdFxb3cg49cvLGct</article-id>
      <article-id pub-id-type="publisher-id" specific-use="scielo-v2">S0066-782X2012000400008</article-id>
      <article-id pub-id-type="publisher-id" specific-use="scielo-v1">S0066-782X(12)09800408</article-id>
      <article-id pub-id-type="doi">10.1590/S0066-782X2012005000020</article-id>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Artigos Originais</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>A variedade da dieta &#233; fator protetor para a press&#227;o arterial sist&#243;lica elevada</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <name>
            <surname>Oliveira</surname>
            <given-names>Erick Prado de</given-names>
          </name>
          <xref ref-type="aff" rid="aff01"/>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Camargo</surname>
            <given-names>Karina Fernandes de</given-names>
          </name>
          <xref ref-type="aff" rid="aff01"/>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Castanho</surname>
            <given-names>Gabriela Kaiser Fullin</given-names>
          </name>
          <xref ref-type="aff" rid="aff01"/>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Nicola</surname>
            <given-names>Marina</given-names>
          </name>
          <xref ref-type="aff" rid="aff01"/>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Portero-McLellan</surname>
            <given-names>K&#225;tia Cristina</given-names>
          </name>
          <xref ref-type="aff" rid="aff01"/>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Burini</surname>
            <given-names>Roberto Carlos</given-names>
          </name>
          <xref ref-type="aff" rid="aff01"/>
        </contrib>
      </contrib-group>
      <aff id="aff01">
        <addr-line>
          <named-content content-type="city">Botucatu</named-content>
          <named-content content-type="state">S&#227;o Paulo</named-content>
        </addr-line>
        <institution content-type="orgname">Universidade Estadual Paulista</institution>
        <institution content-type="orgdiv1">Faculdade de Medicina de Botucatu </institution>
        <institution content-type="orgdiv2">Departamento de Patologia</institution>
        <country country="BR">Brazil</country>
      </aff>
      <pub-date date-type="collection" publication-format="electronic">
        <month>04</month>
        <year>2012</year>
      </pub-date>
      <volume>98</volume>
      <issue>4</issue>
      <fpage>338</fpage>
      <lpage>343</lpage>
      <history>
        <date date-type="received">
          <day>09</day>
          <month>08</month>
          <year>2011</year>
        </date>
        <date date-type="accepted">
          <day>01</day>
          <month>12</month>
          <year>2011</year>
        </date>
        <date date-type="rev-recd">
          <day>09</day>
          <month>08</month>
          <year>2011</year>
        </date>
      </history>
      <permissions>
        <license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc/4.0/" xml:lang="en">
          <license-p>This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.</license-p>
        </license>
      </permissions>
      <abstract>
        <p>FUNDAMENTO: A dieta influencia diretamente a hipertens&#227;o arterial (HAS), que &#233; um dos principais fatores de risco da doen&#231;a cardiovascular. OBJETIVO: Associar a HAS com fatores diet&#233;ticos de adultos clinicamente selecionados para programa de mudan&#231;a de estilo de vida. M&#201;TODOS: Estudo transversal composto por 335 indiv&#237;duos, com idade entre 44 e 65 anos, clinicamente selecionados para um programa de mudan&#231;a de estilo de vida. Foram avaliados os dados antropom&#233;tricos (IMC, % de gordura e circunfer&#234;ncia abdominal), os componentes bioqu&#237;micos (concentra&#231;&#245;es plasm&#225;ticas de glicose, triglicer&#237;deos, colesterol total, HDL-c e LDL-c) e a dieta, por meio do recordat&#243;rio de 24 horas. A qualidade da dieta foi avaliada pelo &#205;ndice de Alimenta&#231;&#227;o Saud&#225;vel. A press&#227;o arterial foi mensurada de acordo com a V Diretriz Brasileira de Hipertens&#227;o Arterial e classificada de acordo com o NCEP-ATPIII. A regress&#227;o log&#237;stica foi realizada para determinar a probabilidade de altera&#231;&#245;es na PAS e PAD de acordo com a ingest&#227;o diet&#233;tica. Adotou-se como significante o valor de p &lt; 0,05. RESULTADOS: Observou-se correla&#231;&#227;o positiva da press&#227;o arterial diast&#243;lica com o consumo de colesterol e a&#231;&#250;car; e negativa com a ingest&#227;o de fibras, por&#231;&#245;es de &#243;leo e qualidade da dieta. A variedade da dieta &#8805; 8 itens alimentares apresentou efeito protetor para altera&#231;&#245;es da press&#227;o arterial sist&#243;lica; OR = 0,361 (0,148-0,878). CONCLUS&#195;O: A maior variedade da dieta ofereceu efeito protetor para altera&#231;&#227;o da press&#227;o arterial sist&#243;lica.</p>
      </abstract>
      <kwd-group xml:lang="pt" kwd-group-type="author-generated">
        <kwd>Hipertens&#227;o</kwd>
        <kwd>press&#227;o arterial</kwd>
        <kwd>dieta hiposs&#243;dica</kwd>
        <kwd>qualidade dos alimentos</kwd>
      </kwd-group>
      <pub-date publication-format="electronic" date-type="pub">
        <day>15</day>
        <month>03</month>
        <year>2012</year>
      </pub-date>
    </article-meta>
  </front>
  <body>
    <p>A variedade da dieta &#233; fator protetor para a press&#227;o arterial sist&#243;lica elevada</p>
    <p>
      <bold>Erick Prado de Oliveira; Karina Fernandes de Camargo; Gabriela Kaiser Fullin Castanho; Marina Nicola; K&#225;tia Cristina Portero-McLellan; Roberto Carlos Burini</bold>
    </p>
    <p> Centro de Metabolismo em Exerc&#237;cio e Nutri&#231;&#227;o (CeMENutri) - Departamento de Sa&#250;de P&#250;blica - Faculdade de Medicina de Botucatu (UNESP); Departamento de Patologia - Faculdade de Medicina de Botucatu (UNESP), Botucatu, SP - Brasil</p>
    <p>
      <xref ref-type="corresp" rid="end">Correspond&#234;ncia</xref>
    </p>
    <p>
      <bold>RESUMO</bold>
    </p>
    <p><bold>FUNDAMENTO:</bold> A dieta influencia diretamente a hipertens&#227;o arterial (HAS), que &#233; um dos principais fatores de risco da doen&#231;a cardiovascular. </p>
    <p><bold>OBJETIVO:</bold> Associar a HAS com fatores diet&#233;ticos de adultos clinicamente selecionados para programa de mudan&#231;a de estilo de vida. </p>
    <p><bold>M&#201;TODOS:</bold> Estudo transversal composto por 335 indiv&#237;duos, com idade entre 44 e 65 anos, clinicamente selecionados para um programa de mudan&#231;a de estilo de vida. Foram avaliados os dados antropom&#233;tricos (IMC, % de gordura e circunfer&#234;ncia abdominal), os componentes bioqu&#237;micos (concentra&#231;&#245;es plasm&#225;ticas de glicose, triglicer&#237;deos, colesterol total, HDL-c e LDL-c) e a dieta, por meio do recordat&#243;rio de 24 horas. A qualidade da dieta foi avaliada pelo &#205;ndice de Alimenta&#231;&#227;o Saud&#225;vel. A press&#227;o arterial foi mensurada de acordo com a V Diretriz Brasileira de Hipertens&#227;o Arterial e classificada de acordo com o NCEP-ATPIII. A regress&#227;o log&#237;stica foi realizada para determinar a probabilidade de altera&#231;&#245;es na PAS e PAD de acordo com a ingest&#227;o diet&#233;tica. Adotou-se como significante o valor de p &lt; 0,05. </p>
    <p><bold>RESULTADOS:</bold> Observou-se correla&#231;&#227;o positiva da press&#227;o arterial diast&#243;lica com o consumo de colesterol e a&#231;&#250;car; e negativa com a ingest&#227;o de fibras, por&#231;&#245;es de &#243;leo e qualidade da dieta. A variedade da dieta &#8805; 8 itens alimentares apresentou efeito protetor para altera&#231;&#245;es da press&#227;o arterial sist&#243;lica; OR = 0,361 (0,148-0,878). </p>
    <p><bold>CONCLUS&#195;O:</bold> A maior variedade da dieta ofereceu efeito protetor para altera&#231;&#227;o da press&#227;o arterial sist&#243;lica.  </p>
    <p><bold>Palavras-chave:</bold> Hipertens&#227;o, press&#227;o arterial, dieta hiposs&#243;dica, qualidade dos alimentos.</p>
    <p>
      <bold>Introdu&#231;&#227;o</bold>
    </p>
    <p>A hipertens&#227;o arterial &#233; o principal fator de risco de mortalidade por doen&#231;as cardiovasculares, estando relacionado ao aumento de sua incid&#234;ncia<sup>1,2</sup>. Representa maior influ&#234;ncia sobre o risco de doen&#231;as cardiovasculares do que tabagismo, hipercolesterolemia, hiperglicemia e obesidade<sup>3</sup>. </p>
    <p>De acordo com estudos populacionais, a preval&#234;ncia de hipertens&#227;o arterial no Brasil varia de 25,2% a 41,1%<sup>4-6</sup>, sendo mais prevalente em mulheres, especialmente ap&#243;s a menopausa<sup>7</sup>. A pesquisa mais recente de Indicadores de Dados B&#225;sicos (IBD) revela que a preval&#234;ncia de HAS na popula&#231;&#227;o brasileira &#233; de 23,9% nos adultos, e quando considerada por g&#234;nero, 21% do total de homens e 26,3% das mulheres apresentam a doen&#231;a<sup>8</sup>. A HAS apresenta custos m&#233;dicos e socioecon&#244;micos elevados decorrentes, especialmente, das suas complica&#231;&#245;es, como: doen&#231;a cerebrovascular, doen&#231;a arterial coronariana, insufici&#234;ncia card&#237;aca, insufici&#234;ncia renal cr&#244;nica e doen&#231;a vascular de extremidades<sup>2</sup>. </p>
    <p>Dentre os fatores de risco associados mais importantes, alguns s&#227;o considerados n&#227;o modific&#225;veis, como idade, g&#234;nero, etnia, fatores socioecon&#244;micos e gen&#233;tica. Dentre os modific&#225;veis, o estilo de vida inadequado est&#225; relacionado a maior preval&#234;ncia de hipertens&#227;o e menor a prote&#231;&#227;o contra a doen&#231;a9. Portanto, um componente fundamental para preven&#231;&#227;o e tratamento da HAS &#233; a mudan&#231;a de estilo de vida, como ado&#231;&#227;o de dieta hipocal&#243;rica, redu&#231;&#227;o do peso, pr&#225;tica de atividade f&#237;sica, redu&#231;&#227;o da ingest&#227;o de &#225;lcool e/ou sal2, sendo a maneira mais efetiva e menos dispendiosa em termos de sa&#250;de p&#250;blica10. </p>
    <p>Os efeitos ben&#233;ficos de uma dieta saud&#225;vel (rica em frutas e vegetais; pobre em gorduras) sobre o comportamento dos n&#237;veis press&#243;ricos s&#227;o conhecidos<sup>11</sup>. Dentre os fatores nutricionais que se associam &#224; elevada preval&#234;ncia de HAS est&#227;o o elevado consumo de &#225;lcool e s&#243;dio e excesso de peso. Recentemente, v&#234;m sendo, tamb&#233;m, associados o consumo de pot&#225;ssio, c&#225;lcio e magn&#233;sio, os quais atenuariam o progressivo aumento dos n&#237;veis press&#243;ricos com a idade<sup>12</sup>. </p>
    <p>A Sociedade Brasileira de Hipertens&#227;o Arterial, nas suas diretrizes, passou a recomendar a ado&#231;&#227;o da dieta DASH (Dietary Approaches to Stop Hypertension) no tratamento n&#227;o farmacol&#243;gico da hipertens&#227;o arterial<sup>2</sup>. A dieta DASH enfatiza o aumento do consumo de frutas, vegetais e produtos l&#225;cteos desnatados; inclus&#227;o de gr&#227;os integrais, aves, peixes e castanhas; e consumo reduzido em gorduras, carne vermelha, doces e refrigerantes. Em estudo realizado em indiv&#237;duos com hipertens&#227;o arterial foi observado que a dieta DASH reduziu substancialmente a press&#227;o sangu&#237;nea (sist&#243;lica: 5,5 mmHg) no per&#237;odo de dois meses e, quando combinada com a redu&#231;&#227;o do s&#243;dio, houve queda adicional da press&#227;o arterial (sist&#243;lica: 8,9 mmHg)<sup>13</sup>.</p>
    <p>No nosso conhecimento, nenhum estudo nacional avaliou a influ&#234;ncia da qualidade da dieta e do consumo das por&#231;&#245;es da pir&#226;mide alimentar sobre a hipertens&#227;o arterial e/ou altera&#231;&#245;es da press&#227;o sist&#243;lica e diast&#243;lica. Nosso grupo j&#225; mostrou a influ&#234;ncia da dieta sobre alguns fatores de risco de doen&#231;a cardiovascular<sup>14-16</sup>, entretanto ainda n&#227;o foi demonstrada essa rela&#231;&#227;o com a hipertens&#227;o. Nesse sentido, pretende-se estudar a associa&#231;&#227;o da dieta sobre a hipertens&#227;o arterial em adultos clinicamente selecionados para programa de mudan&#231;a de estilo de vida. </p>
    <p>
      <bold>M&#233;todos</bold>
    </p>
    <p>
      <bold>Amostra</bold>
    </p>
    <p>Foi efetuado estudo descritivo de corte transversal realizado em subgrupo de ingressantes de projeto de mudan&#231;a de estilo de vida "Mexa-se Pr&#243;-Sa&#250;de", Botucatu, SP, no per&#237;odo de 2004 a 2008. Os indiv&#237;duos foram recrutados para o estudo de maneira volunt&#225;ria (amostra de conveni&#234;ncia). Foram avaliados 335 indiv&#237;duos, portadores ou n&#227;o de hipertens&#227;o arterial sist&#234;mica, de ambos os sexos (76,4% mulheres), com idade entre 44 e 65 anos, selecionados para projeto de mudan&#231;a de estilo de vida. </p>
    <p>Todos os indiv&#237;duos assinaram o termo de consentimento livre e esclarecido, o qual, juntamente com o projeto, foi aprovado pelo Comit&#234; de &#201;tica em Pesquisa (Of. n&#186; 3271-2009) da Faculdade de Medicina de Botucatu (FMB - UNESP). </p>
    <p>
      <bold>An&#225;lises bioqu&#237;micas</bold>
    </p>
    <p>Para realiza&#231;&#227;o das an&#225;lises bioqu&#237;micas, os indiv&#237;duos foram submetidos a coleta sangu&#237;nea ap&#243;s jejum noturno (8 a 12 horas), por meio de pun&#231;&#227;o venosa padr&#227;o a v&#225;cuo. Foram analisadas as concentra&#231;&#245;es de glicose, triglicer&#237;deos (TG), colesterol total (CT) e HDL colesterol (HDL-C), quantificados no soro pelo m&#233;todo de Qu&#237;mica Seca (Sistema Vitros, Johnson &amp; Johnson), enquanto as concentra&#231;&#245;es de LDL colesterol (LDL-C) foram estimadas pela f&#243;rmula de Friedewald<sup>17</sup> [LDL-C = CT - (HDL-C + TG/5]). A classifica&#231;&#227;o dos valores de normalidade obedeceu a NCEP-ATPIII<sup>18</sup>. </p>
    <p>
      <bold>Avalia&#231;&#227;o antropom&#233;trica </bold>
    </p>
    <p>A avalia&#231;&#227;o antropom&#233;trica foi composta pelas medidas de peso corporal e estatura, de acordo com os procedimentos descritos por Heyward e Stolarczyk<sup>19</sup>, com posterior c&#225;lculo do &#205;ndice de Massa Corporal (IMC). O IMC foi classificado segundo a Organiza&#231;&#227;o Mundial da Sa&#250;de<sup>20</sup>.</p>
    <p>A Circunfer&#234;ncia Abdominal (CA) foi mensurada com fita milim&#233;trica inextens&#237;vel e inel&#225;stica, realizando-se a medida no ponto m&#233;dio entre o &#250;ltimo arco intercostal e a crista il&#237;aca<sup>18</sup>.</p>
    <p>O c&#225;lculo da composi&#231;&#227;o corporal, percentual de gordura corporal (%G) e Massa Livre de Gordura (MLG), foi obtido por meio do exame da Imped&#226;ncia Bioel&#233;trica (BIA) em aparelho da marca Biodin&#226;mics<sup>&#210;</sup> (modelo 450, <italic>USA</italic>). A partir da resist&#234;ncia em ohm obtida pela BIA e do c&#225;lculo pelo IMC, foi aplicada a equa&#231;&#227;o de Segal e cols. para se obter a massa livre de gordura<sup>21</sup>. A partir dos valores da MLG estimou-se a Gordura Absoluta (GA) pela subtra&#231;&#227;o do peso corporal menos a MLG e calculado o %G. </p>
    <p>
      <bold>Avalia&#231;&#227;o do consumo alimentar</bold>
    </p>
    <p>O consumo alimentar foi avaliado por meio de anamnese nutricional com o recordat&#243;rio de 24 horas. O recordat&#243;rio foi aplicado de ter&#231;a a sexta-feira e os dados referentes ao final de semana n&#227;o foram coletados. Os dados diet&#233;ticos estavam em medidas caseiras e foram convertidos para grama e mililitro a fim de possibilitar a an&#225;lise qu&#237;mica do consumo alimentar. As prepara&#231;&#245;es culin&#225;rias elaboradas com mais de um grupo alimentar tiveram seus ingredientes distinguidos e classificados nos respectivos grupos, procedimento esse que segue as recomenda&#231;&#245;es da Pir&#226;mide Alimentar Brasileira Adaptada<sup>22</sup>.</p>
    <p>Posteriormente, as informa&#231;&#245;es foram processadas por meio do programa de an&#225;lise nutricional NutWin (2002), vers&#227;o 1.5<sup>23</sup>. A qualidade da dieta foi avaliada pelo &#205;ndice de Alimenta&#231;&#227;o Saud&#225;vel (IAS)<sup>24</sup>, com base na Pir&#226;mide Alimentar Brasileira Adaptada<sup>22</sup>.</p>
    <p>O IAS &#233; um m&#233;todo de an&#225;lise da alimenta&#231;&#227;o de indiv&#237;duos com a finalidade de determinar a qualidade da dieta. Foram considerados os oito grupos alimentares da pir&#226;mide alimentar, a porcentagem de gordura total, gordura saturada, quantidade de colesterol diet&#233;tico e a variedade da dieta para sua pontua&#231;&#227;o. A variedade da dieta foi definida como a quantidade de diferentes itens alimentares presentes na dieta.</p>
    <p>
      <bold>Avalia&#231;&#227;o cl&#237;nica da press&#227;o arterial </bold>
    </p>
    <p>Foi avaliada a press&#227;o arterial sist&#243;lica e a diast&#243;lica dos indiv&#237;duos na posi&#231;&#227;o sentada de acordo com os procedimentos descritos pela VI Diretriz Brasileira de Hipertens&#227;o Arterial<sup>2</sup>, com manguitos de tamanho adequado &#224; circunfer&#234;ncia do bra&#231;o, respeitando a propor&#231;&#227;o largura/comprimento de 1:2, a largura da bolsa de borracha do manguito que deve corresponder a 40% da circunfer&#234;ncia do bra&#231;o, e seu comprimento, a pelo menos 80%. O intervalo de tempo entre as medidas de PA foi de 1 a 2 minutos. Os indiv&#237;duos foram diagnosticados como portadores de hipertens&#227;o arterial de acordo com "The Adult Treatment Panel III of the National Cholesterol Education Program" (NCEP-ATP III)<sup>18</sup>.</p>
    <p>
      <bold> An&#225;lise estat&#237;stica </bold>
    </p>
    <p>Os testes foram realizados utilizando o programa SAS vers&#227;o 9.1 e o STATISTICA 6.0. Os dados foram descritos em m&#233;dia &#177; DP. Para compara&#231;&#227;o dos indiv&#237;duos com ou sem HAS foi utilizado teste t para as vari&#225;veis cont&#237;nuas. Testou-se a normalidade da amostra por meio do teste Shapiro-Wilk. Para correlacionar as vari&#225;veis diet&#233;ticas com a press&#227;o arterial sist&#243;lica e diast&#243;lica foi utilizada a correla&#231;&#227;o parcial de Pearson ajustada para sexo, idade, valor cal&#243;rico total (VCT) e IMC. Foi realizada an&#225;lise de regress&#227;o linear, com intervalo de confian&#231;a (IC) de 95%, para observar a raz&#227;o de chance (<italic>odds ratio</italic>) dos indiv&#237;duos pesquisados apresentarem HAS e altera&#231;&#245;es na PAS e PAD de acordo com a ingest&#227;o diet&#233;tica. Foi realizado ajuste para sexo, idade, VCT e IMC. Os resultados foram discutidos com base no n&#237;vel de signific&#226;ncia de p &lt; 0,05.</p>
    <p>
      <bold>Resultados</bold>
    </p>
    <p>Observou-se que os indiv&#237;duos hipertensos apresentaram maior IMC, % G e CA. N&#227;o houve diferen&#231;a significativa entre os grupos quando avaliados os par&#226;metros diet&#233;ticos. Em rela&#231;&#227;o aos dados bioqu&#237;micos, o grupo de hipertensos apresentou maiores concentra&#231;&#245;es plasm&#225;ticas de glicemia de jejum, colesterol total, LDL-c e triglicer&#237;deo quando comparado ao grupo de n&#227;o hipertensos (<xref ref-type="table" rid="tab01">tab. 1</xref>).</p>
    <table-wrap id="tab01">
      <graphic xlink:href="1678-4170-abc-98-04-0338-00020-gt01.jpg"/></table-wrap>
    <p>A <xref ref-type="table" rid="tab02">tabela 2</xref> mostra a correla&#231;&#227;o de Pearson entre os grupos alimentares e os valores de PAS e PAD. Observou-se correla&#231;&#227;o positiva da PAD com o consumo de colesterol e a&#231;&#250;car; e negativa com a ingest&#227;o de fibras, por&#231;&#245;es de &#243;leo e IAS. </p>
    <table-wrap id="tab02">
      <graphic xlink:href="1678-4170-abc-98-04-0338-00020-gt02.jpg"/></table-wrap>
    <p>De acordo com a <xref ref-type="table" rid="a02312tab03">tabela 3</xref>, a variedade da dieta maior ou igual a 8 itens alimentares apresentou efeito protetor para altera&#231;&#245;es da PAS. N&#227;o houve associa&#231;&#227;o entre dieta e HAS e PAD.</p>
    <p content-type="asset">
      <table-wrap id="a02312tab03">
        <graphic xlink:href="1678-4170-abc-98-04-0338-00020-gt03.jpg"/></table-wrap>
    </p>
    <p>Para justificar a associa&#231;&#227;o inversa entre variedade da dieta e PAS, foi realizada a correla&#231;&#227;o da variedade da dieta com todos os componentes alimentares, a fim de caracterizar o consumo dos indiv&#237;duos que mais variavam a alimenta&#231;&#227;o. Foi observada correla&#231;&#227;o positiva entre variedade da dieta com ingest&#227;o de hortali&#231;as (r = 0,34; p &lt; 0,05), frutas (r = 0,32; p &lt; 0,05), fibras (r = 0,22; p &lt; 0,05), latic&#237;nios (r = 0,20; p &lt; 0,05) e IAS (r = 0,20; p &lt; 0,05) e negativa para o consumo de leguminosas (r = -0,11; p &lt; 0,05), carnes (r = -0,15; p &lt; 0,05) e cereais (r = -0,19; p &lt; 0,05). N&#227;o houve correla&#231;&#227;o significativa para ingest&#227;o dos macronutrientes, por&#231;&#245;es de &#243;leo e a&#231;&#250;car (dados n&#227;o demonstrados).</p>
    <p>
      <bold>Discuss&#227;o </bold>
    </p>
    <p>O principal resultado do presente estudo foi que a variedade da dieta (&#8805; 8 itens alimentares) ofereceu efeito protetor para altera&#231;&#245;es da PAS independentemente do sexo, idade, IMC e VCT. Al&#233;m disso, foi observada correla&#231;&#227;o positiva entre variedade da dieta e alimentos fontes de pot&#225;ssio, fibras e c&#225;lcio (hortali&#231;as, frutas, latic&#237;nios) e negativa com alimentos ricos em gordura saturada, s&#243;dio e carboidrato refinado (carnes e % de carboidrato). </p>
    <p>O consumo de pot&#225;ssio, c&#225;lcio e magn&#233;sio vem sendo associado com atenua&#231;&#227;o do aumento progressivo dos n&#237;veis press&#243;ricos<sup>12</sup>. O pot&#225;ssio &#233; respons&#225;vel pela redu&#231;&#227;o do s&#243;dio intracelular atrav&#233;s da bomba de s&#243;dio e pot&#225;ssio e induz a queda da Press&#227;o Arterial (PA) por meio do aumento da natriurese, diminui&#231;&#227;o da renina e norepinefrina e aumento de secre&#231;&#227;o de prostaglandinas. O c&#225;lcio auxilia na regula&#231;&#227;o dos batimentos card&#237;acos e reduz os n&#237;veis de s&#243;dio quando em altas concentra&#231;&#245;es e o magn&#233;sio inibe a contra&#231;&#227;o de musculatura lisa vascular podendo desempenhar um papel na regula&#231;&#227;o da PA como vasodilatador<sup>25,26</sup>.</p>
    <p>Um trabalho realizado recentemente no Jap&#227;o investigou as associa&#231;&#245;es do consumo de frutas, vegetais e seus micronutrientes com a redu&#231;&#227;o do risco de HAS. O consumo elevado de frutas e vegetais foi relacionado com menor risco de desenvolver HAS, sugerindo que a queda dos n&#237;veis press&#243;ricos se deu pela presen&#231;a do pot&#225;ssio e vitamina C nos alimentos<sup>27</sup>. Em estudo com adolescentes australianos observou-se que o consumo de frutas, verduras, cereais e peixe estava inversamente associado &#224; PAD<sup>28</sup>.</p>
    <p>N&#227;o foi observado efeito direto do consumo de frutas e hortali&#231;as em nosso estudo, provavelmente pelo fato de que tanto os indiv&#237;duos hipertensos quanto os n&#227;o hipertensos apresentaram baixo consumo desse tipo de alimento; al&#233;m disso, n&#227;o houve diferen&#231;a do consumo desses grupos alimentares entre os grupos. </p>
    <p>O consumo de fibras alimentares se relacionou negativamente com a queda da PA, por&#233;m de maneira fraca. Fato esse que tamb&#233;m pode ser justificado pelo baixo consumo de fibras em ambos os grupos. Sabe-se que indiv&#237;duos com ingest&#227;o elevada de fibra diet&#233;tica pode ter risco significativamente mais baixo para o desenvolvimento de doen&#231;a coronariana, infarto, hipertens&#227;o, diabetes e obesidade<sup>29,30</sup>.</p>
    <p>Observamos correla&#231;&#227;o positiva entre consumo de a&#231;&#250;car e PAD. O consumo inadequado desse tipo de alimento est&#225; associado &#224; maior produ&#231;&#227;o de insulina, podendo exercer efeito direto no aumento da reabsor&#231;&#227;o renal de s&#243;dio e, consequentemente, elevar a PA<sup>31</sup>. Al&#233;m disso, a resist&#234;ncia a insulina e a hiperinsulinemia podem ter papel na g&#234;nese da HAS associada &#224; obesidade, devido ao aumento de marcadores inflamat&#243;rios<sup>32,33</sup>. A hiperinsulinemia provoca aumento da atividade do sistema nervoso simp&#225;tico e da reabsor&#231;&#227;o tubular de s&#243;dio, a&#231;&#245;es que contribuem para o aumento da PA<sup>34-36</sup> .</p>
    <p>Maiores valores de IMC, %G e CA foram observados entre os indiv&#237;duos hipertensos, o que j&#225; era esperado<sup>37</sup>. A gordura visceral pode mediar a eleva&#231;&#227;o da press&#227;o arterial atrav&#233;s da diminui&#231;&#227;o da natriurese. A maior reten&#231;&#227;o de s&#243;dio seria provocada por ativa&#231;&#227;o do sistema renina-angiotensina, por ativa&#231;&#227;o do sistema nervoso aut&#244;nomo simp&#225;tico e ainda por altera&#231;&#245;es da hemodin&#226;mica intrarrenal, consequente &#224; compress&#227;o da medula renal<sup>38</sup>. Isso mostra a import&#226;ncia de ajustar os dados para adiposidade (IMC) quando analisamos a influ&#234;ncia da dieta sobre a HAS, pois dessa forma neutralizamos esses efeitos.</p>
    <p>Observou-se que os indiv&#237;duos hipertensos apresentaram maiores valores plasm&#225;ticos de glicose glicemia, colesterol total, triglicer&#237;deo e LDL-C, o que aumenta o risco de doen&#231;as cardiovasculares<sup>30</sup>. Segundo Schaan e cols.<sup>39</sup>, os indiv&#237;duos com algum grau de anormalidade na homeostase glic&#234;mica apresentaram maior preval&#234;ncia de HAS. </p>
    <p>
      <bold>Limita&#231;&#245;es do estudo </bold>
    </p>
    <p>O estudo foi do tipo transversal, dessa maneira n&#227;o podemos definir os mecanismos de causa-efeito. Em segundo lugar, foi realizado recordat&#243;rio de 24h de um dia, o que pode n&#227;o refletir exatamente o h&#225;bito dos indiv&#237;duos avaliados. Al&#233;m disso, n&#227;o foi avaliado o consumo de s&#243;dio e &#225;lcool, que podem influenciar a press&#227;o arterial.</p>
    <p>
      <bold>Conclus&#227;o</bold>
    </p>
    <p>O presente estudo mostrou que a maior variedade da dieta (oito ou mais tipos de alimentos diferentes) ofereceu efeito protetor para altera&#231;&#245;es da PAS. As demais vari&#225;veis diet&#233;ticas estudadas n&#227;o apresentaram associa&#231;&#227;o significativa com a PA. </p>
    <p>
      <fn id="end" fn-type="corresp">
        <p>Correspond&#234;ncia:</p>
        <p> Erick Prado de Oliveira </p>
        <p> CeMENutri - Faculdade de Medicina, Depto de Sa&#250;de P&#250;blica (FMBUNESP) </p>
        <p> Distrito de Rubi&#227;o Jr, s/n&#186; </p>
        <p> 18618-970 </p>
        <p> Botucatu, SP - Brasil </p>
        <p> E-mail: </p>
        <p>
          <email xlink:href="erick_po@yahoo.com.br">erick_po@yahoo.com.br</email>
        </p>
      </fn>
    </p>
    <p>Artigo recebido em 09/08/11; recebido revisado em 09/08/11; aceito em 01/12/11.</p>
  </body>
  <back>
    <ref-list>
      <ref id="B1">
        <mixed-citation>1. Kearney PM, Whelton M, Reynolds   K, Whelton PK, He J. Worldwide prevalence of hypertension: a systematic review.</mixed-citation>
        <element-citation publication-type="book">
          <source>Worldwide prevalence of hypertension: a systematic review</source>
          <person-group person-group-type="author">
            <name>
              <surname>Kearney</surname>
              <given-names>PM</given-names>
            </name>
            <name>
              <surname>Whelton</surname>
              <given-names>M</given-names>
            </name>
            <name>
              <surname>Reynolds</surname>
              <given-names>K</given-names>
            </name>
            <name>
              <surname>Whelton</surname>
              <given-names>PK</given-names>
            </name>
            <name>
              <surname>He</surname>
              <given-names>J</given-names>
            </name>
          </person-group>
        </element-citation>
      </ref>
      <ref id="B2">
        <mixed-citation>2. Sociedade   Brasileira de Cardiologia / Sociedade Brasileira de Hipertens&#227;o / Sociedade   Brasileira de Nefrologia. VI Diretrizes brasileiras de hipertens&#227;o. Arq Bras   Cardiol. 2010;95(1 supl. 1):1-51.</mixed-citation>
        <element-citation publication-type="journal">
          <article-title>VI Diretrizes brasileiras de hipertens&#227;o</article-title>
          <source>Arq Bras Cardiol</source>
          <date>
            <year>2010</year>
          </date>
          <fpage>1</fpage>
          <lpage>51</lpage>
          <issue>1 supl. 1</issue>
          <volume>95</volume>
        </element-citation>
      </ref>
      <ref id="B3">
        <mixed-citation>3. Grundy   SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH, Franklin BA, et al. Diagnosis   and management of the metabolic syndrome: an American Heart   Association/National Heart, Lung, and Blood Institute Scientific Statement.   Circulation. 2005;112(17):2735-52.</mixed-citation>
        <element-citation publication-type="journal">
          <article-title>Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement</article-title>
          <source>Circulation</source>
          <date>
            <year>2005</year>
          </date>
          <fpage>2735</fpage>
          <lpage>52</lpage>
          <issue>17</issue>
          <volume>112</volume>
          <person-group person-group-type="author">
            <name>
              <surname>Grundy</surname>
              <given-names>SM</given-names>
            </name>
            <name>
              <surname>Cleeman</surname>
              <given-names>JI</given-names>
            </name>
            <name>
              <surname>Daniels</surname>
              <given-names>SR</given-names>
            </name>
            <name>
              <surname>Donato</surname>
              <given-names>KA</given-names>
            </name>
            <name>
              <surname>Eckel</surname>
              <given-names>RH</given-names>
            </name>
            <name>
              <surname>Franklin</surname>
              <given-names>BA</given-names>
            </name>
          </person-group>
        </element-citation>
      </ref>
      <ref id="B4">
        <mixed-citation>4. Cipullo JP, Martin JF,   Ciorlia LA, Godoy MR, Ca&#231;&#227;o JC, Loureiro AA, et al. Preval&#234;ncia e fatores de   risco para hipertens&#227;o em uma popula&#231;&#227;o urbana brasileira. Arq Bras Cardiol.   2010;94(4):519-26.</mixed-citation>
        <element-citation publication-type="journal">
          <article-title>Preval&#234;ncia e fatores de risco para hipertens&#227;o em uma popula&#231;&#227;o urbana brasileira</article-title>
          <source>Arq Bras Cardiol</source>
          <date>
            <year>2010</year>
          </date>
          <fpage>519</fpage>
          <lpage>26</lpage>
          <issue>4</issue>
          <volume>94</volume>
          <person-group person-group-type="author">
            <name>
              <surname>Cipullo</surname>
              <given-names>JP</given-names>
            </name>
            <name>
              <surname>Martin</surname>
              <given-names>JF</given-names>
            </name>
            <name>
              <surname>Ciorlia</surname>
              <given-names>LA</given-names>
            </name>
            <name>
              <surname>Godoy</surname>
              <given-names>MR</given-names>
            </name>
            <name>
              <surname>Ca&#231;&#227;o</surname>
              <given-names>JC</given-names>
            </name>
            <name>
              <surname>Loureiro</surname>
              <given-names>AA</given-names>
            </name>
          </person-group>
        </element-citation>
      </ref>
      <ref id="B5">
        <mixed-citation>5. de Souza AR, Costa A,   Nakamura D, Mocheti LN, Stevanato Filho PR, Ovando LA. Um estudo sobre   hipertens&#227;o arterial sist&#234;mica na cidade de Campo Grande, MS. Arq Bras Cardiol.   2007;88(4):441-6.</mixed-citation>
        <element-citation publication-type="journal">
          <article-title>Um estudo sobre hipertens&#227;o arterial sist&#234;mica na cidade de Campo Grande, MS</article-title>
          <source>Arq Bras Cardiol</source>
          <date>
            <year>2007</year>
          </date>
          <fpage>441</fpage>
          <lpage>6</lpage>
          <issue>4</issue>
          <volume>88</volume>
          <person-group person-group-type="author">
            <name>
              <surname>de Souza</surname>
              <given-names>AR</given-names>
            </name>
            <name>
              <surname>Costa</surname>
              <given-names>A</given-names>
            </name>
            <name>
              <surname>Nakamura</surname>
              <given-names>D</given-names>
            </name>
            <name>
              <surname>Mocheti</surname>
              <given-names>LN</given-names>
            </name>
            <name>
              <surname>Stevanato Filho</surname>
              <given-names>PR</given-names>
            </name>
            <name>
              <surname>Ovando</surname>
              <given-names>LA</given-names>
            </name>
          </person-group>
        </element-citation>
      </ref>
      <ref id="B6">
        <mixed-citation>6. Castro RA, Moncau JE,   Marcopito LF. Hypertension prevalence in the city of Formiga, MG (Brazil). Arq   Bras Cardiol. 2007;88(3):334-9.</mixed-citation>
        <element-citation publication-type="journal">
          <article-title>Hypertension prevalence in the city of Formiga, MG (Brazil)</article-title>
          <source>Arq Bras Cardiol</source>
          <date>
            <year>2007</year>
          </date>
          <fpage>334</fpage>
          <lpage>9</lpage>
          <issue>3</issue>
          <volume>88</volume>
          <person-group person-group-type="author">
            <name>
              <surname>Castro</surname>
              <given-names>RA</given-names>
            </name>
            <name>
              <surname>Moncau</surname>
              <given-names>JE</given-names>
            </name>
            <name>
              <surname>Marcopito</surname>
              <given-names>LF</given-names>
            </name>
          </person-group>
        </element-citation>
      </ref>
      <ref id="B7">
        <mixed-citation>7. Barton M, Meyer MR.   Postmenopausal hypertension: mechanisms and therapy. Hypertension.   2009;54(1):11-8.</mixed-citation>
        <element-citation publication-type="journal">
          <article-title>Postmenopausal hypertension: mechanisms and therapy</article-title>
          <source>Hypertension</source>
          <date>
            <year>2009</year>
          </date>
          <fpage>11</fpage>
          <lpage>8</lpage>
          <issue>1</issue>
          <volume>54</volume>
          <person-group person-group-type="author">
            <name>
              <surname>Barton</surname>
              <given-names>M</given-names>
            </name>
            <name>
              <surname>Meyer</surname>
              <given-names>MR</given-names>
            </name>
          </person-group>
        </element-citation>
      </ref>
      <ref id="B8">
        <mixed-citation>8. Minist&#233;rio da Sa&#250;de.   Datasus. Pesquisa e indicadores de dados b&#225;sicos do Brasil. [Acesso em 2011   maio 16]. Dispon&#237;vel em <ext-link ext-link-type="uri" xlink:href="http://www.tabnet.datasus.gov.br/cgi/idb2009/matriz.htm">http://tabnet.datasus.gov.br/cgi/idb2009/matriz.htm</ext-link></mixed-citation>
        <element-citation publication-type="book">
          <source>Datasus. Pesquisa e indicadores de dados b&#225;sicos do Brasil</source>
        </element-citation>
      </ref>
      <ref id="B9">
        <mixed-citation>9. Greenlund KJ, Daviglus ML,   Croft JB. Differences in healthy lifestyle characteristics between adults with   prehypertension and normal blood pressure. J Hypertens. 2009;27(5):955-62.</mixed-citation>
        <element-citation publication-type="journal">
          <article-title>Differences in healthy lifestyle characteristics between adults with prehypertension and normal blood pressure</article-title>
          <source>J Hypertens</source>
          <date>
            <year>2009</year>
          </date>
          <fpage>955</fpage>
          <lpage>62</lpage>
          <issue>5</issue>
          <volume>27</volume>
          <person-group person-group-type="author">
            <name>
              <surname>Greenlund</surname>
              <given-names>KJ</given-names>
            </name>
            <name>
              <surname>Daviglus</surname>
              <given-names>ML</given-names>
            </name>
            <name>
              <surname>Croft</surname>
              <given-names>JB</given-names>
            </name>
          </person-group>
        </element-citation>
      </ref>
      <ref id="B10">
        <mixed-citation>10. Mensah GA, Bakris G.   Treatment and control of high blood pressure in adults. Cardiol Clin.   2010;28(4):609-22.</mixed-citation>
        <element-citation publication-type="journal">
          <article-title>Treatment and control of high blood pressure in adults</article-title>
          <source>Cardiol Clin</source>
          <date>
            <year>2010</year>
          </date>
          <fpage>609</fpage>
          <lpage>22</lpage>
          <issue>4</issue>
          <volume>28</volume>
          <person-group person-group-type="author">
            <name>
              <surname>Mensah</surname>
              <given-names>GA</given-names>
            </name>
            <name>
              <surname>Bakris</surname>
              <given-names>G</given-names>
            </name>
          </person-group>
        </element-citation>
      </ref>
      <ref id="B11">
        <mixed-citation>11. Parikh A, Lipsitz SR,   Natarajan S. Association between a DASH-like diet and mortality in adults with   hypertension: findings from a population-based follow-up study. Am J Hypertens.   2009;22(4):409-16.</mixed-citation>
        <element-citation publication-type="journal">
          <article-title>Association between a DASH-like diet and mortality in adults with hypertension: findings from a population-based follow-up study</article-title>
          <source>Am J Hypertens</source>
          <date>
            <year>2009</year>
          </date>
          <fpage>409</fpage>
          <lpage>16</lpage>
          <issue>4</issue>
          <volume>22</volume>
          <person-group person-group-type="author">
            <name>
              <surname>Parikh</surname>
              <given-names>A</given-names>
            </name>
            <name>
              <surname>Lipsitz</surname>
              <given-names>SR</given-names>
            </name>
            <name>
              <surname>Natarajan</surname>
              <given-names>S</given-names>
            </name>
          </person-group>
        </element-citation>
      </ref>
      <ref id="B12">
        <mixed-citation>12. Molina MDCB, Cunha RS,   Herkenhoff LF, Mill JG. Hipertens&#227;o arterial e consumo de sal em popula&#231;&#227;o   urbana. Rev Sa&#250;de P&#250;blica. 2003;37(6):743-50.</mixed-citation>
        <element-citation publication-type="journal">
          <article-title>Hipertens&#227;o arterial e consumo de sal em popula&#231;&#227;o urbana</article-title>
          <source>Rev Sa&#250;de P&#250;blica</source>
          <date>
            <year>2003</year>
          </date>
          <fpage>743</fpage>
          <lpage>50</lpage>
          <issue>6</issue>
          <volume>37</volume>
          <person-group person-group-type="author">
            <name>
              <surname>Molina</surname>
              <given-names>MDCB</given-names>
            </name>
            <name>
              <surname>Cunha</surname>
              <given-names>RS</given-names>
            </name>
            <name>
              <surname>Herkenhoff</surname>
              <given-names>LF</given-names>
            </name>
            <name>
              <surname>Mill</surname>
              <given-names>JG</given-names>
            </name>
          </person-group>
        </element-citation>
      </ref>
      <ref id="B13">
        <mixed-citation>13. Folsom AR, Parker ED,   Harnack LJ. Degree of concordance with DASH diet guidelines and incidence of   hypertension and fatal cardiovascular disease. Am J Hypertens.   2007;20(3):225-32.</mixed-citation>
        <element-citation publication-type="journal">
          <article-title>Degree of concordance with DASH diet guidelines and incidence of hypertension and fatal cardiovascular disease</article-title>
          <source>Am J Hypertens</source>
          <date>
            <year>2007</year>
          </date>
          <fpage>225</fpage>
          <lpage>32</lpage>
          <issue>3</issue>
          <volume>20</volume>
          <person-group person-group-type="author">
            <name>
              <surname>Folsom</surname>
              <given-names>AR</given-names>
            </name>
            <name>
              <surname>Parker</surname>
              <given-names>ED</given-names>
            </name>
            <name>
              <surname>Harnack</surname>
              <given-names>LJ</given-names>
            </name>
          </person-group>
        </element-citation>
      </ref>
      <ref id="B14">
        <mixed-citation>14. de Oliveira EP, Manda RM,   Torezan GA, Corrente JE, Burini RC. Dietary, anthropometric, and biochemical   determinants of plasma high-density lipoprotein-cholesterol in free-living   adults. Cholesterol. 2011;2011:851750. Epub 2010 Dec 15.</mixed-citation>
        <element-citation publication-type="journal">
          <article-title>Dietary, anthropometric, and biochemical determinants of plasma high-density lipoprotein-cholesterol in free-living adults</article-title>
          <source>Cholesterol</source>
          <date>
            <year>2011</year>
          </date>
          <fpage>851750</fpage>
          <volume>2011</volume>
          <person-group person-group-type="author">
            <name>
              <surname>de Oliveira</surname>
              <given-names>EP</given-names>
            </name>
            <name>
              <surname>Manda</surname>
              <given-names>RM</given-names>
            </name>
            <name>
              <surname>Torezan</surname>
              <given-names>GA</given-names>
            </name>
            <name>
              <surname>Corrente</surname>
              <given-names>JE</given-names>
            </name>
            <name>
              <surname>Burini</surname>
              <given-names>RC</given-names>
            </name>
          </person-group>
        </element-citation>
      </ref>
      <ref id="B15">
        <mixed-citation>15. Pimentel GD,   Portero-McLellan KC, de Oliveira EP, Spada AP, Oshiiwa M, Zemdegs JC, et al.   Long-term nutrition education reduces several risk factors for type 2 diabetes   mellitus in Brazilians with impaired glucose tolerance. Nutr Res.   2010;30(3):186-90.</mixed-citation>
        <element-citation publication-type="journal">
          <article-title>Long-term nutrition education reduces several risk factors for type 2 diabetes mellitus in Brazilians with impaired glucose tolerance</article-title>
          <source>Nutr Res</source>
          <date>
            <year>2010</year>
          </date>
          <fpage>186</fpage>
          <lpage>90</lpage>
          <issue>3</issue>
          <volume>30</volume>
          <person-group person-group-type="author">
            <name>
              <surname>Pimentel</surname>
              <given-names>GD</given-names>
            </name>
            <name>
              <surname>Portero-McLellan</surname>
              <given-names>KC</given-names>
            </name>
            <name>
              <surname>de Oliveira</surname>
              <given-names>EP</given-names>
            </name>
            <name>
              <surname>Spada</surname>
              <given-names>AP</given-names>
            </name>
            <name>
              <surname>Oshiiwa</surname>
              <given-names>M</given-names>
            </name>
            <name>
              <surname>Zemdegs</surname>
              <given-names>JC</given-names>
            </name>
          </person-group>
        </element-citation>
      </ref>
      <ref id="B16">
        <mixed-citation>16. Takahashi MM, de Oliveira EP,   Moreto F, Portero-McLellan KC, Burini RC. Association of dyslipidemia with   intakes of fruit and vegetables and the body fat content of adults clinically   selected for a lifestyle modification program. Arch Latinoam Nutr.   2010;60(2):148-54.</mixed-citation>
        <element-citation publication-type="journal">
          <article-title>Association of dyslipidemia with intakes of fruit and vegetables and the body fat content of adults clinically selected for a lifestyle modification program</article-title>
          <source>Arch Latinoam Nutr</source>
          <date>
            <year>2010</year>
          </date>
          <fpage>148</fpage>
          <lpage>54</lpage>
          <issue>2</issue>
          <volume>60</volume>
          <person-group person-group-type="author">
            <name>
              <surname>Takahashi</surname>
              <given-names>MM</given-names>
            </name>
            <name>
              <surname>de Oliveira</surname>
              <given-names>EP</given-names>
            </name>
            <name>
              <surname>Moreto</surname>
              <given-names>F</given-names>
            </name>
            <name>
              <surname>Portero-McLellan</surname>
              <given-names>KC</given-names>
            </name>
            <name>
              <surname>Burini</surname>
              <given-names>RC</given-names>
            </name>
          </person-group>
        </element-citation>
      </ref>
      <ref id="B17">
        <mixed-citation>17. Friedewald WT, Levy RI,   Fredrickson DS. Estimation of the concentration of low-density lipoprotein   cholesterol in plasma, without use of the preparative ultracentrifuge. Clin   Chem. 1972;18(6):499-502.</mixed-citation>
        <element-citation publication-type="journal">
          <article-title>Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge</article-title>
          <source>Clin Chem</source>
          <date>
            <year>1972</year>
          </date>
          <fpage>499</fpage>
          <lpage>502</lpage>
          <issue>6</issue>
          <volume>18</volume>
          <person-group person-group-type="author">
            <name>
              <surname>Friedewald</surname>
              <given-names>WT</given-names>
            </name>
            <name>
              <surname>Levy</surname>
              <given-names>RI</given-names>
            </name>
            <name>
              <surname>Fredrickson</surname>
              <given-names>DS</given-names>
            </name>
          </person-group>
        </element-citation>
      </ref>
      <ref id="B18">
        <mixed-citation>18. de Lemos AS, Wolfe ML, Long   CJ, Sivapackianathan R, Rader DJ. Identification of genetic variants in   endothelial lipase in persons with elevated high-density lipoprotein   cholesterol. Circulation. 2002;106(11):1321-6.</mixed-citation>
        <element-citation publication-type="journal">
          <article-title>Identification of genetic variants in endothelial lipase in persons with elevated high-density lipoprotein cholesterol</article-title>
          <source>Circulation</source>
          <date>
            <year>2002</year>
          </date>
          <fpage>1321</fpage>
          <lpage>6</lpage>
          <issue>11</issue>
          <volume>106</volume>
          <person-group person-group-type="author">
            <name>
              <surname>de Lemos</surname>
              <given-names>AS</given-names>
            </name>
            <name>
              <surname>Wolfe</surname>
              <given-names>ML</given-names>
            </name>
            <name>
              <surname>Long</surname>
              <given-names>CJ</given-names>
            </name>
            <name>
              <surname>Sivapackianathan</surname>
              <given-names>R</given-names>
            </name>
            <name>
              <surname>Rader</surname>
              <given-names>DJ</given-names>
            </name>
          </person-group>
        </element-citation>
      </ref>
      <ref id="B19">
        <mixed-citation>19. Heyward VH, Stolarczyk LM.   Avalia&#231;&#227;o da composi&#231;&#227;o corporal aplicada. S&#227;o Paulo: Manole; 2000.</mixed-citation>
        <element-citation publication-type="book">
          <source>Avalia&#231;&#227;o da composi&#231;&#227;o corporal aplicada</source>
          <date>
            <year>2000</year>
          </date>
          <person-group person-group-type="author">
            <name>
              <surname>Heyward</surname>
              <given-names>VH</given-names>
            </name>
            <name>
              <surname>Stolarczyk</surname>
              <given-names>LM</given-names>
            </name>
          </person-group>
        </element-citation>
      </ref>
      <ref id="B20">
        <label>20</label>
        <mixed-citation>20. World Health Organization (WHO). The World Health Report 2002: reducing risks, promoting healthy lifestyles. Geneva; 2002.</mixed-citation>
        <element-citation publication-type="book">
          <source>The World Health Report 2002: reducing risks, promoting healthy lifestyles</source>
          <date>
            <year>2002</year>
          </date>
        </element-citation>
      </ref>
      <ref id="B21">
        <mixed-citation>21. Segal KR, Van Loan M,   Fitzgerald PI, Hodgdon JA, Van Itallie TB. Lean body mass estimation by   bioelectrical impedance analysis: a four-site cross-validation study. Am J Clin   Nutr. 1988;47(1):7-14.</mixed-citation>
        <element-citation publication-type="journal">
          <article-title>Lean body mass estimation by bioelectrical impedance analysis: a four-site cross-validation study</article-title>
          <source>Am J Clin Nutr</source>
          <date>
            <year>1988</year>
          </date>
          <fpage>7</fpage>
          <lpage>14</lpage>
          <issue>1</issue>
          <volume>47</volume>
          <person-group person-group-type="author">
            <name>
              <surname>Segal</surname>
              <given-names>KR</given-names>
            </name>
            <name>
              <surname>Van Loan</surname>
              <given-names>M</given-names>
            </name>
            <name>
              <surname>Fitzgerald</surname>
              <given-names>PI</given-names>
            </name>
            <name>
              <surname>Hodgdon</surname>
              <given-names>JA</given-names>
            </name>
            <name>
              <surname>Van Itallie</surname>
              <given-names>TB</given-names>
            </name>
          </person-group>
        </element-citation>
      </ref>
      <ref id="B22">
        <mixed-citation>22. Philippi ST, Latterza AR,   Cruz AT, Ribeiro LC. Adapted food pyramid: a guide for a right food choice. Rev   Nutr. 1999;12(1):65-80.</mixed-citation>
        <element-citation publication-type="journal">
          <article-title>Adapted food pyramid: a guide for a right food choice</article-title>
          <source>Rev Nutr</source>
          <date>
            <year>1999</year>
          </date>
          <fpage>65</fpage>
          <lpage>80</lpage>
          <issue>1</issue>
          <volume>12</volume>
          <person-group person-group-type="author">
            <name>
              <surname>Philippi</surname>
              <given-names>ST</given-names>
            </name>
            <name>
              <surname>Latterza</surname>
              <given-names>AR</given-names>
            </name>
            <name>
              <surname>Cruz</surname>
              <given-names>AT</given-names>
            </name>
            <name>
              <surname>Ribeiro</surname>
              <given-names>LC</given-names>
            </name>
          </person-group>
        </element-citation>
      </ref>
      <ref id="B23">
        <mixed-citation>23. Navab M, Ananthramaiah GM,   Reddy ST, Van Lenten BJ, Ansell BJ, Hama S, et al. The double jeopardy of HDL.   Ann Med. 2005;37(3):173-8.</mixed-citation>
        <element-citation publication-type="journal">
          <article-title>The double jeopardy of HDL</article-title>
          <source>Ann Med</source>
          <date>
            <year>2005</year>
          </date>
          <fpage>173</fpage>
          <lpage>8</lpage>
          <issue>3</issue>
          <volume>37</volume>
          <person-group person-group-type="author">
            <name>
              <surname>Navab</surname>
              <given-names>M</given-names>
            </name>
            <name>
              <surname>Ananthramaiah</surname>
              <given-names>GM</given-names>
            </name>
            <name>
              <surname>Reddy</surname>
              <given-names>ST</given-names>
            </name>
            <name>
              <surname>Van Lenten</surname>
              <given-names>BJ</given-names>
            </name>
            <name>
              <surname>Ansell</surname>
              <given-names>BJ</given-names>
            </name>
            <name>
              <surname>Hama</surname>
              <given-names>S</given-names>
            </name>
          </person-group>
        </element-citation>
      </ref>
      <ref id="B24">
        <mixed-citation>24. Mota JF, Rinaldi AEM,   Pereira AF, Maest&#225; N, Scarpin MM, Burini RC. Adaptation of the healthy eating   index to the food guide of the Brazilian population. Rev Nutr. 2008;21(5):545-52.</mixed-citation>
        <element-citation publication-type="journal">
          <article-title>Adaptation of the healthy eating index to the food guide of the Brazilian population</article-title>
          <source>Rev Nutr</source>
          <date>
            <year>2008</year>
          </date>
          <fpage>545</fpage>
          <lpage>52</lpage>
          <issue>5</issue>
          <volume>21</volume>
          <person-group person-group-type="author">
            <name>
              <surname>Mota</surname>
              <given-names>JF</given-names>
            </name>
            <name>
              <surname>Rinaldi</surname>
              <given-names>AEM</given-names>
            </name>
            <name>
              <surname>Pereira</surname>
              <given-names>AF</given-names>
            </name>
            <name>
              <surname>Maest&#225;</surname>
              <given-names>N</given-names>
            </name>
            <name>
              <surname>Scarpin</surname>
              <given-names>MM</given-names>
            </name>
            <name>
              <surname>Burini</surname>
              <given-names>RC</given-names>
            </name>
          </person-group>
        </element-citation>
      </ref>
      <ref id="B25">
        <mixed-citation>25. Franceschini SCC, Priore SE,   Euclydes MP. Necessidades e recomenda&#231;&#245;es de nutrientes. In: Cupari L. Guias de   medicina ambulatorial e hospitalar. UNIFESP/ Escola Paulista de Medicina. 2&#170;   ed. S&#227;o Paulo: Manole; 2002. p. 3-26.</mixed-citation>
        <element-citation publication-type="book">
          <source>Guias de medicina ambulatorial e hospitalar.UNIFESP/ Escola Paulista de Medicina</source>
          <date>
            <year>2002</year>
          </date>
          <fpage>3</fpage>
          <lpage>26</lpage>
          <person-group person-group-type="author">
            <name>
              <surname>Franceschini</surname>
              <given-names>SCC</given-names>
            </name>
            <name>
              <surname>Priore</surname>
              <given-names>SE</given-names>
            </name>
            <name>
              <surname>Euclydes</surname>
              <given-names>MP</given-names>
            </name>
            <name>
              <surname>Cupari</surname>
              <given-names>L</given-names>
            </name>
          </person-group>
        </element-citation>
      </ref>
      <ref id="B26">
        <mixed-citation>26. Davis MM, Jones DW. The role   of lifestyle management in the overall treatment plan for prevention and   management of hypertension. Semin Nephrol. 2002;35(2):35-43.</mixed-citation>
        <element-citation publication-type="journal">
          <article-title>The role of lifestyle management in the overall treatment plan for prevention and management of hypertension</article-title>
          <source>Semin Nephrol</source>
          <date>
            <year>2002</year>
          </date>
          <fpage>35</fpage>
          <lpage>43</lpage>
          <issue>2</issue>
          <volume>35</volume>
          <person-group person-group-type="author">
            <name>
              <surname>Davis</surname>
              <given-names>MM</given-names>
            </name>
            <name>
              <surname>Jones</surname>
              <given-names>DW</given-names>
            </name>
          </person-group>
        </element-citation>
      </ref>
      <ref id="B27">
        <mixed-citation>27. Utsugi MT, Ohkubo T, Kikuya   M, Kurimoto A, Sato RI, Suzuki K, et al. Fruit and vegetable consumption and   the risk of hypertension determined by self measurement of blood pressure at   home: the Ohasama study. Hypertens Res. 2008;31(7):1435-43.</mixed-citation>
        <element-citation publication-type="journal">
          <article-title>Fruit and vegetable consumption and the risk of hypertension determined by self measurement of blood pressure at home: the Ohasama study</article-title>
          <source>Hypertens Res</source>
          <date>
            <year>2008</year>
          </date>
          <fpage>1435</fpage>
          <lpage>43</lpage>
          <issue>7</issue>
          <volume>31</volume>
          <person-group person-group-type="author">
            <name>
              <surname>Utsugi</surname>
              <given-names>MT</given-names>
            </name>
            <name>
              <surname>Ohkubo</surname>
              <given-names>T</given-names>
            </name>
            <name>
              <surname>Kikuya</surname>
              <given-names>M</given-names>
            </name>
            <name>
              <surname>Kurimoto</surname>
              <given-names>A</given-names>
            </name>
            <name>
              <surname>Sato</surname>
              <given-names>RI</given-names>
            </name>
            <name>
              <surname>Suzuki</surname>
              <given-names>K</given-names>
            </name>
          </person-group>
        </element-citation>
      </ref>
      <ref id="B28">
        <mixed-citation>28. McNaughton SA, Ball K,   Mishra GD, Crawford DA. Dietary patterns of adolescents and risk of obesity and   hypertension. J Nutr. 2008;138(2):364-70.</mixed-citation>
        <element-citation publication-type="journal">
          <article-title>Dietary patterns of adolescents and risk of obesity and hypertension</article-title>
          <source>J Nutr</source>
          <date>
            <year>2008</year>
          </date>
          <fpage>364</fpage>
          <lpage>70</lpage>
          <issue>2</issue>
          <volume>138</volume>
          <person-group person-group-type="author">
            <name>
              <surname>McNaughton</surname>
              <given-names>SA</given-names>
            </name>
            <name>
              <surname>Ball</surname>
              <given-names>K</given-names>
            </name>
            <name>
              <surname>Mishra</surname>
              <given-names>GD</given-names>
            </name>
            <name>
              <surname>Crawford</surname>
              <given-names>DA</given-names>
            </name>
          </person-group>
        </element-citation>
      </ref>
      <ref id="B29">
        <mixed-citation>29. Anderson JW, Baird P, Davis   RH Jr, Ferreri S, Knudtson M, Koraym A, et al. Health benefits of dietary   fiber. Nutr Rev. 2009;67(4):188-205.</mixed-citation>
        <element-citation publication-type="journal">
          <article-title>Health benefits of dietary fiber</article-title>
          <source>Nutr Rev</source>
          <date>
            <year>2009</year>
          </date>
          <fpage>188</fpage>
          <lpage>205</lpage>
          <issue>4</issue>
          <volume>67</volume>
          <person-group person-group-type="author">
            <name>
              <surname>Anderson</surname>
              <given-names>JW</given-names>
            </name>
            <name>
              <surname>Baird</surname>
              <given-names>P</given-names>
            </name>
            <name>
              <surname>Davis Jr</surname>
              <given-names>RH</given-names>
            </name>
            <name>
              <surname>Ferreri</surname>
              <given-names>S</given-names>
            </name>
            <name>
              <surname>Knudtson</surname>
              <given-names>M</given-names>
            </name>
            <name>
              <surname>Koraym</surname>
              <given-names>A</given-names>
            </name>
          </person-group>
        </element-citation>
      </ref>
      <ref id="B30">
        <mixed-citation>30. Takahashi MM, de Oliveira   EP, de Carvalho AL, Dantas LA, Burini FH, Portero-McLellan KC, et al. Metabolic   syndrome and dietary components are associated with coronary artery disease   risk score in free-living adults: a cross-sectional study. Diabetol Metab   Syndr. 2011;3:7.</mixed-citation>
        <element-citation publication-type="journal">
          <article-title>Metabolic syndrome and dietary components are associated with coronary artery disease risk score in free-living adults: a cross-sectional study</article-title>
          <source>Diabetol Metab Syndr</source>
          <date>
            <year>2011</year>
          </date>
          <fpage>7</fpage>
          <volume>3</volume>
          <person-group person-group-type="author">
            <name>
              <surname>Takahashi</surname>
              <given-names>MM</given-names>
            </name>
            <name>
              <surname>de Oliveira</surname>
              <given-names>EP</given-names>
            </name>
            <name>
              <surname>de Carvalho</surname>
              <given-names>AL</given-names>
            </name>
            <name>
              <surname>Dantas</surname>
              <given-names>LA</given-names>
            </name>
            <name>
              <surname>Burini</surname>
              <given-names>FH</given-names>
            </name>
            <name>
              <surname>Portero-McLellan</surname>
              <given-names>KC</given-names>
            </name>
          </person-group>
        </element-citation>
      </ref>
      <ref id="B31">
        <mixed-citation>31. Carvalho MHC, Cola&#231;o AL,   Fortes ZB. Citocinas, disfun&#231;&#227;o endotelial e resist&#234;ncia &#224; insulina. Arq Bras   Endocrinol Metab. 2006;50(2):304-12.</mixed-citation>
        <element-citation publication-type="journal">
          <article-title>Citocinas, disfun&#231;&#227;o endotelial e resist&#234;ncia &#224; insulina</article-title>
          <source>Arq Bras Endocrinol Metab</source>
          <date>
            <year>2006</year>
          </date>
          <fpage>304</fpage>
          <lpage>12</lpage>
          <issue>2</issue>
          <volume>50</volume>
          <person-group person-group-type="author">
            <name>
              <surname>Carvalho</surname>
              <given-names>MHC</given-names>
            </name>
            <name>
              <surname>Cola&#231;o</surname>
              <given-names>AL</given-names>
            </name>
            <name>
              <surname>Fortes</surname>
              <given-names>ZB</given-names>
            </name>
          </person-group>
        </element-citation>
      </ref>
      <ref id="B32">
        <mixed-citation>32. Orsatti FL, Nahas EA,   Orsatti CL, de Oliveira EP, Nahas-Neto J, da Mota GR, et al. Muscle mass gain   after resistance training is inversely correlated with trunk adiposity gain in   postmenopausal women. J Strength Cond Res. 2011 Oct 7. [Epub ahead of print]</mixed-citation>
        <element-citation publication-type="journal">
          <article-title>Muscle mass gain after resistance training is inversely correlated with trunk adiposity gain in postmenopausal women</article-title>
          <source>J Strength Cond Res</source>
          <date>
            <year>2011</year>
            <day>07</day>
            <month>10</month>
          </date>
          <person-group person-group-type="author">
            <name>
              <surname>Orsatti</surname>
              <given-names>FL</given-names>
            </name>
            <name>
              <surname>Nahas</surname>
              <given-names>EA</given-names>
            </name>
            <name>
              <surname>Orsatti</surname>
              <given-names>CL</given-names>
            </name>
            <name>
              <surname>de Oliveira</surname>
              <given-names>EP</given-names>
            </name>
            <name>
              <surname>Nahas-Neto</surname>
              <given-names>J</given-names>
            </name>
            <name>
              <surname>da Mota</surname>
              <given-names>GR</given-names>
            </name>
          </person-group>
        </element-citation>
      </ref>
      <ref id="B33">
        <mixed-citation>33. Hotamisligil GS.   Inflammation and metabolic disorders. Nature. 2006;444(7121):860-7.</mixed-citation>
        <element-citation publication-type="journal">
          <article-title>Inflammation and metabolic disorders</article-title>
          <source>Nature</source>
          <date>
            <year>2006</year>
          </date>
          <fpage>860</fpage>
          <lpage>7</lpage>
          <issue>7121</issue>
          <volume>444</volume>
          <person-group person-group-type="author">
            <name>
              <surname>Hotamisligil</surname>
              <given-names>GS</given-names>
            </name>
          </person-group>
        </element-citation>
      </ref>
      <ref id="B34">
        <mixed-citation>34. DeFronzo RA, Ferrannini E.   Insulin resistance. a multifaceted syndrome responsible for NIDDM, obesity,   hypertension, dyslipidemia, and atherosclerotic cardiovascular disease.   Diabetes Care. 1991;14(3):173-94.</mixed-citation>
        <element-citation publication-type="journal">
          <article-title>Insulin resistance: a multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease</article-title>
          <source>Diabetes Care</source>
          <date>
            <year>1991</year>
          </date>
          <fpage>173</fpage>
          <lpage>94</lpage>
          <issue>3</issue>
          <volume>14</volume>
          <person-group person-group-type="author">
            <name>
              <surname>DeFronzo</surname>
              <given-names>RA</given-names>
            </name>
            <name>
              <surname>Ferrannini</surname>
              <given-names>E</given-names>
            </name>
          </person-group>
        </element-citation>
      </ref>
      <ref id="B35">
        <mixed-citation>35. Rosa EC, Zanella MT, Ribeiro   AB, Junior OK. Obesidade visceral, hipertens&#227;o arterial e risco c&#225;rdio-renal:   uma revis&#227;o. Arq Bras Endocrinol Metab. 2005;49(2):196-204.</mixed-citation>
        <element-citation publication-type="journal">
          <article-title>Obesidade visceral, hipertens&#227;o arterial e risco c&#225;rdio-renal: uma revis&#227;o</article-title>
          <source>Arq Bras Endocrinol Metab</source>
          <date>
            <year>2005</year>
          </date>
          <fpage>196</fpage>
          <lpage>204</lpage>
          <issue>2</issue>
          <volume>49</volume>
          <person-group person-group-type="author">
            <name>
              <surname>Rosa</surname>
              <given-names>EC</given-names>
            </name>
            <name>
              <surname>Zanella</surname>
              <given-names>MT</given-names>
            </name>
            <name>
              <surname>Ribeiro</surname>
              <given-names>AB</given-names>
            </name>
            <name>
              <surname>Junior</surname>
              <given-names>OK</given-names>
            </name>
          </person-group>
        </element-citation>
      </ref>
      <ref id="B36">
        <mixed-citation>36. Lopes HF. Hipertens&#227;o e   inflama&#231;&#227;o: papel da obesidade. Rev Bras Hipertens. 2007;14(4):239-44.</mixed-citation>
        <element-citation publication-type="journal">
          <article-title>Hipertens&#227;o e inflama&#231;&#227;o: papel da obesidade</article-title>
          <source>Rev Bras Hipertens</source>
          <date>
            <year>2007</year>
          </date>
          <fpage>239</fpage>
          <lpage>44</lpage>
          <issue>4</issue>
          <volume>14</volume>
          <person-group person-group-type="author">
            <name>
              <surname>Lopes</surname>
              <given-names>HF</given-names>
            </name>
          </person-group>
        </element-citation>
      </ref>
      <ref id="B37">
        <mixed-citation>37. Huang Z, Willett WC, Manson   JE, Rosner B, Stampfer MJ, Speizer FE, et al. Body weight, weight change, and   risk for hypertension in women. Ann Intern Med. 1998;128(2):81-8.</mixed-citation>
        <element-citation publication-type="journal">
          <article-title>Body weight, weight change, and risk for hypertension in women</article-title>
          <source>Ann Intern Med</source>
          <date>
            <year>1998</year>
          </date>
          <fpage>81</fpage>
          <lpage>8</lpage>
          <issue>2</issue>
          <volume>128</volume>
          <person-group person-group-type="author">
            <name>
              <surname>Huang</surname>
              <given-names>Z</given-names>
            </name>
            <name>
              <surname>Willett</surname>
              <given-names>WC</given-names>
            </name>
            <name>
              <surname>Manson</surname>
              <given-names>JE</given-names>
            </name>
            <name>
              <surname>Rosner</surname>
              <given-names>B</given-names>
            </name>
            <name>
              <surname>Stampfer</surname>
              <given-names>MJ</given-names>
            </name>
            <name>
              <surname>Speizer</surname>
              <given-names>FE</given-names>
            </name>
          </person-group>
        </element-citation>
      </ref>
      <ref id="B38">
        <mixed-citation>38. Manrique C, Lastra G,   Gardner M, Sowers JR. The renin angiotensin aldosterone system in hypertension:   roles of insulin resistance and oxidative stress. Med Clin North Am.   2009;93(3):569-82.</mixed-citation>
        <element-citation publication-type="journal">
          <article-title>The renin angiotensin aldosterone system in hypertension: roles of insulin resistance and oxidative stress</article-title>
          <source>Med Clin North Am</source>
          <date>
            <year>2009</year>
          </date>
          <fpage>569</fpage>
          <lpage>82</lpage>
          <issue>3</issue>
          <volume>93</volume>
          <person-group person-group-type="author">
            <name>
              <surname>Manrique</surname>
              <given-names>C</given-names>
            </name>
            <name>
              <surname>Lastra</surname>
              <given-names>G</given-names>
            </name>
            <name>
              <surname>Gardner</surname>
              <given-names>M</given-names>
            </name>
            <name>
              <surname>Sowers</surname>
              <given-names>JR</given-names>
            </name>
          </person-group>
        </element-citation>
      </ref>
      <ref id="B39">
        <mixed-citation>39. Schann BDA, Harzheim E, Gus   I. Perfil de risco card&#237;aco no diabetes mellitus e na glicemia de jejum   alterada. Rev Sa&#250;de P&#250;blica. 2004;38(4):529-36.</mixed-citation>
        <element-citation publication-type="journal">
          <article-title>Perfil de risco card&#237;aco no diabetes mellitus e na glicemia de jejum alterada</article-title>
          <source>Rev Sa&#250;de P&#250;blica</source>
          <date>
            <year>2004</year>
          </date>
          <fpage>529</fpage>
          <lpage>36</lpage>
          <issue>4</issue>
          <volume>38</volume>
          <person-group person-group-type="author">
            <name>
              <surname>Schann</surname>
              <given-names>BDA</given-names>
            </name>
            <name>
              <surname>Harzheim</surname>
              <given-names>E</given-names>
            </name>
            <name>
              <surname>Gus</surname>
              <given-names>I</given-names>
            </name>
          </person-group>
        </element-citation>
      </ref>
    </ref-list>
  </back>
  <sub-article article-type="translation" id="TRen" xml:lang="en">
    <front-stub>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Original Articles</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title xml:lang="en">Dietary variety is a protective factor for elevated systolic blood pressure</article-title>
      </title-group>
      <abstract xml:lang="en">
        <p>BACKGROUND: Diet directly influences systemic arterial hypertension (SAH), which is one of the main risk factors for cardiovascular disease. OBJECTIVE: To associate hypertension with dietary factors in adults clinically selected for a change-of-lifestyle program. METHODS: Cross-sectional study comprising 335 individuals, aged between 44 and 65 years, clinically selected for a change-of-lifestyle program. We evaluated anthropometric data (BMI, %body fat and waist circumference), biochemical components (plasma glucose, triglycerides, total cholesterol, HDL-C and LDL-c) and diet, through the 24-hour recall method. The quality of the diet was assessed by the Healthy Eating Index. Blood pressure was measured according to the V Brazilian Guidelines on Hypertension and classified according to NCEP-ATPIII. Logistic regression was performed to determine the likelihood of changes in SBP and DBP according to dietary intake. The level of significance was set at p &lt;0.05. RESULTS: There was a positive correlation between diastolic blood pressure and sugar and cholesterol intake, and a negative one with intake of fiber, portions of oil and fats and diet quality. Dietary variety with &#8805; 8 food items showed a protective effect for alterations in systolic blood pressure, OR = 0.361 (0.148 to 0.878). CONCLUSION: A greater dietary variety had a protective effect on the systolic blood pressure.</p>
      </abstract>
      <kwd-group xml:lang="en">
        <kwd>Hypertension</kwd>
        <kwd>blood pressure</kwd>
        <kwd>diet, sodium-restricted</kwd>
        <kwd>food quality</kwd>
      </kwd-group>
    </front-stub>
    <body>
      <p><undefined id="top-body2"/>Dietary variety is a protective factor for elevated systolic blood pressure</p>
      <p>
        <bold>Erick Prado de Oliveira; Karina Fernandes de Camargo; Gabriela Kaiser Fullin Castanho; Marina Nicola; K&#225;tia Cristina Portero-McLellan; Roberto Carlos Burini</bold>
      </p>
      <p> Centro de Metabolismo em Exerc&#237;cio e Nutri&#231;&#227;o (CeMENutri) - Departamento de Sa&#250;de P&#250;blica - Faculdade de Medicina de Botucatu (UNESP); Departamento de Patologia - Faculdade de Medicina de Botucatu (UNESP), Botucatu, SP - Brasil</p>
      <p>Mailing Address</p>
      <p>
        <bold>ABSTRACT</bold>
      </p>
      <p><bold>BACKGROUND:</bold> Diet directly influences systemic arterial hypertension (SAH), which is one of the main risk factors for cardiovascular disease.</p>
      <p><bold>OBJECTIVE:</bold> To associate hypertension with dietary factors in adults clinically selected for a change-of-lifestyle program.</p>
      <p><bold>METHODS:</bold> Cross-sectional study comprising 335 individuals, aged between 44 and 65 years, clinically selected for a change-of-lifestyle program. We evaluated anthropometric data (BMI, %body fat and waist circumference), biochemical components (plasma glucose, triglycerides, total cholesterol, HDL-C and LDL-c) and diet, through the 24-hour recall method. The quality of the diet was assessed by the Healthy Eating Index. Blood pressure was measured according to the V Brazilian Guidelines on Hypertension and classified according to NCEP-ATPIII. Logistic regression was performed to determine the likelihood of changes in SBP and DBP according to dietary intake. The level of significance was set at p &lt;0.05.</p>
      <p><bold>RESULTS:</bold> There was a positive correlation between diastolic blood pressure and sugar and cholesterol intake, and a negative one with intake of fiber, portions of oil and fats and diet quality. Dietary variety with &#8805; 8 food items showed a protective effect for alterations in systolic blood pressure, OR = 0.361 (0.148 to 0.878).</p>
      <p><bold>CONCLUSION:</bold> A greater dietary variety had a protective effect on the systolic blood pressure. </p>
      <p><bold>Keywords:</bold> Hypertension; blood pressure; diet, sodium-restricted; food quality.</p>
      <p>
        <bold>Introduction</bold>
      </p>
      <p>Systemic arterial hypertension (SAH) is a major risk factor for cardiovascular mortality, being related to the increase of its incidence<sup>1,2</sup>. It has a greater influence on the risk of cardiovascular disease than smoking, hypercholesterolemia, hyperglycemia and obesity<sup>3</sup>. </p>
      <p>According to population studies, the prevalence of hypertension in Brazil varies from 25.2% to 41.1%<sup>4-6</sup>, being more prevalent in women, especially after menopause<sup>7</sup>. The most recent Basic Data Indicators (BDI) survey shows that the prevalence of hypertension in the Brazilian population is 23.9% in adults, and when considered by gender, 21% of men and 26.3% of women have the disease<sup>8</sup>. SAH has high medical and socioeconomic costs arising mainly from its complications, such as cerebrovascular disease, coronary artery disease, heart failure, chronic renal failure and lower extremity vascular disease<sup>2</sup>. </p>
      <p>Among the most important associated risk factors, some are considered not modifiable such as age, gender, ethnicity, socioeconomic factors and genetics. Among the modifiable ones, the inadequate lifestyle is related to higher prevalence of hypertension and reduced protection against the disease<sup>9</sup>. Therefore, a key component for the prevention and treatment of hypertension is the change in lifestyle, such as adopting a low-calorie diet, weight reduction, physical activity, decrease alcohol and/or salt intake<sup>2</sup>, which is the most effective and less costly way in terms of public health<sup>10</sup>. </p>
      <p>The beneficial effects of a healthy diet (rich in fruits and vegetables, low on fat) on the behavior of blood pressure are well known<sup>11</sup>. Among the nutritional factors that are associated with high prevalence of hypertension are the high consumption of alcohol and sodium and excess weight. Recently, the consumption of potassium, calcium and magnesium has also been associated, which would attenuate the progressive increase in blood pressure with age<sup>12</sup>. </p>
      <p>The Brazilian Society of Hypertension, in its guidelines, has started to recommend the DASH (Dietary Approaches to Stop Hypertension) diet in the non-pharmacological treatment of hypertension <sup>2</sup>. The DASH diet emphasizes increased consumption of fruits, vegetables and low-fat dairy products, as well as whole grains, poultry, fish and nuts, and reduced consumption of fats, red meat, sweets and soft drinks. In a study carried out in patients with hypertension it has been observed that DASH substantially reduced blood pressure (systolic: 5.5 mmHg) in a period of two months, and, when combined with reduction in sodium intake, there was an additional decrease in blood pressure (systolic: 8.9 mm Hg)<sup>13</sup>. </p>
      <p>To our knowledge, no national study has evaluated the influence of diet quality and consumption of servings of the food pyramid on hypertension and/or alterations in systolic (SBP) and diastolic blood pressure (DBP). Our group has shown the influence of diet on some risk factors for cardiovascular disease<sup>14-16</sup>; however, an association with hypertension has yet to be demonstrated. Accordingly, we intend to study the association of diet on hypertension in adults clinically selected for a change-of-lifestyle program. </p>
      <p>
        <bold>Methods</bold>
      </p>
      <p>
        <bold>Sample</bold>
      </p>
      <p>A cross-sectional study was carried out in a subgroup of individuals referred to a change-of-lifestyle program, called "Move Pro-Health", in the city of Botucatu, state of S&#227;o Paulo, Brazil, from 2004 to 2008. Individuals were voluntarily recruited for the study (convenience sample).</p>
      <p>We evaluated 335 individuals, with or without systemic hypertension of both sexes (76.4% women), aged between 44 and 65, selected for the change-of-lifestyle program.</p>
      <p>All subjects signed an informed consent form, which, together with the project, was approved by the Ethics in Research Committee (protocol # 3271-2009) from Faculdade de Medicina de Botucatu (FMB - UNESP). </p>
      <p>
        <bold> Biochemical Assessment </bold>
      </p>
      <p>To perform the biochemical analyses, subjects underwent blood collection after an overnight fast (8-12 hours), via standard venipuncture procedure. Blood was analyzed for glucose, triglycerides (TG), total cholesterol (TC) and HDL cholesterol (HDL-C) measurements, quantified in serum by the dry-chemistry method (Sistema Vitros, Johnson &amp; Johnson), while the concentrations of LDL cholesterol (LDL-C) was estimated using Friedewald formula<sup>17</sup> [LDL-C = TC - (HDL-C + TG / 5]). The classification of normal values &#8203;&#8203;followed those established by NCEP-ATPIII<sup>18</sup>.</p>
      <p>
        <bold>Anthropometric Assessment</bold>
      </p>
      <p>The anthropometric assessment consisted of measurements of body weight and height, according to the procedures described by Heyward and Stolarczyk<sup>19</sup>, with subsequent calculation of Body Mass Index (BMI). BMI was classified according to the World Health Organization<sup>20</sup>.</p>
      <p>The Abdominal Circumference (AC) was measured using an inextensible, inelastic, measuring tape and the measurement was performed at midpoint between the lower margin of the last palpable rib and the iliac crest<sup>18</sup>. </p>
      <p>The calculation of body composition, body fat percentage (BF%) and Fat Free Mass (FFM) was carried out by bioelectrical impedance (BIA) in a Biodynamics<sup>&#210;</sup> device (model 450, USA). Based on the resistance in ohms obtained by BIA and the calculation of BMI, the equation of Segal et al. was applied to obtain the fat-free mass<sup>21</sup>. Based on the values &#8203;&#8203;of FFM, we estimated the Absolute Fat Mass (AFM) by subtracting the body weight minus FFM and calculating the % BF. </p>
      <p>
        <bold>Dietary Intake Assessment </bold>
      </p>
      <p>Dietary intake was assessed by nutritional history with the 24-hour recall method. The recall was applied from Tuesday to Friday and the data related to the weekend were not collected. Dietary data were in household measures and were converted to grams and milliliters to enable chemical analysis of food consumption. Culinary preparations made &#8203;&#8203;with more than one food group had their ingredients distinguished and classified in their respective groups, a procedure that follows the adapted Brazilian Food Pyramid Guide recommendations<sup>22</sup>. </p>
      <p>Subsequently, the data were processed using the nutritional analysis software NutWin (2002), release 1.5<sup>23</sup>. The quality of the diet was assessed by the Healthy Eating Index (HEI)<sup>24</sup>, based on Adapted Brazilian Food Pyramid<sup>22</sup>. </p>
      <p>HEI is a dietary analysis method used to determine the individual's quality of diet. We considered the eight food groups of the food pyramid, the percentage of total fat, saturated fat, amount of dietary cholesterol and dietary variety for the score. The variety of diet was defined as the amount of different food items present in the diet. </p>
      <p>
        <bold>Clinical assessment of blood pressure </bold>
      </p>
      <p>We evaluated the systolic and diastolic blood pressure of subjects in the sitting position, according to the procedures described by the VI Brazilian Guidelines on Arterial Hypertension<sup>2</sup>, with cuffs of adequate size for arm circumference, respecting the width / length ratio of 1:2, the width on the rubber cuff that must correspond to 40% of arm circumference, and its length, of at least 80%. The time interval between blood pressure measurements was 1-2 minutes. The subjects were diagnosed as having hypertension according to "The Adult Treatment Panel III of the National Cholesterol Education Program" (NCEP-ATP III)<sup>18</sup>. </p>
      <p>
        <bold>Statistical Analysis</bold>
      </p>
      <p>The tests were performed using SAS software release 9.1 and STATISTICA 6.0. Data were presented as mean &#177; SD. For comparison of individuals with or without hypertension, the <italic>t </italic>test was used for continuous variables.. Normality of the sample was tested through the Shapiro-Wilk test. Pearson's partial correlation was used to correlate the dietary variables with systolic and diastolic blood pressure, adjusted for sex, age, total caloric intake (TCI), and BMI. A linear regression analysis was performed with 95% confidence interval (95%CI) to observe the odds ratio of the studied individuals to present hypertension and alterations in SBP and DBP according to dietary intake. Data were adjusted for sex, age, BMI, and TCI. The results were discussed based on the significance level of p &lt;0.05. </p>
      <p>
        <bold>Results</bold>
      </p>
      <p>It was observed that individuals with hypertension had higher BMI, %BF and WC. There was no significant difference between groups when dietary parameters were assessed. Regarding the biochemical data, the group of hypertensive patients had higher plasma concentrations of fasting glucose, total cholesterol, LDL-C and triglycerides when compared to the nonhypertensive group (<xref ref-type="table" rid="tab01-body2">Table 1</xref>).</p>
      <table-wrap id="tab01-body2">
        <graphic xlink:href="1678-4170-abc-98-04-0338-00020-gt01-en.jpg"/></table-wrap>
      <p><xref ref-type="table" rid="tab02-body2">Table 2</xref> shows Pearson's correlation between the food groups and the values &#8203;&#8203;of SBP and DBP. There was a positive correlation between DBP and the consumption of cholesterol and sugar, and a negative one with the consumption of fibers, servings of oil/fats and HEI.</p>
      <table-wrap id="tab02-body2">
        <graphic xlink:href="1678-4170-abc-98-04-0338-00020-gt02-en.jpg"/></table-wrap>
      <p>According to <xref ref-type="table" rid="en_a02312tab03-body2">Table 3</xref>, a dietary variety &#8805; 8 food items showed a protective effect for alterations in SBP. There was no association between diet and hypertension and DBP. </p>
      <p content-type="asset">
        <table-wrap id="en_a02312tab03-body2">
          <graphic xlink:href="1678-4170-abc-98-04-0338-00020-gt03-en.jpg"/></table-wrap>
      </p>
      <p>To explain the inverse relationship between dietary variety and SBP, a correlation was performed between diet variety with all food components in order to characterize the consumption of individuals who had more varied diets. A positive correlation was observed between dietary variety with intake of vegetables (r = 0.34, p &lt;0.05), fruit (r = 0.32, p &lt;0.05), fibers (r = 0.22, p &lt;0.05), dairy products (r = 0.20, p &lt;0.05) and HEI (r = 0.20, p &lt;0.05) and a negative one for legume consumption (r = -0.11; p &lt;0.05), meats (r = -0.15, p &lt;0.05) and cereals (r = -0.19, p &lt;0.05). There was no significant correlation for intake of macronutrients, servings of oil/fats and sugar (data not shown). </p>
      <p>
        <bold>Discussion</bold>
      </p>
      <p>The main result of this study was that dietary variety (food items &#8805; 8) offered a protective effect for alterations in SBP regardless of gender, age, BMI, and TCI. Furthermore, we observed a positive correlation between dietary variety and food sources of potassium, calcium and fibers (vegetables, fruit, dairy products) and a negative one with foods high in saturated fat, sodium and refined carbohydrates (meat and % of carbohydrate). </p>
      <p>The consumption of potassium, calcium and magnesium has been associated with attenuation of the progressive increase in blood pressure levels<sup>12</sup>. Potassium is responsible for the reduction in intracellular sodium through the sodium-potassium pump and induces the decrease in blood pressure (BP) by increasing the natriuresis, reducing renin and norepinephrine and increasing prostaglandin secretion. Calcium helps regulate the heartbeat and reduces sodium levels when in high concentrations and magnesium inhibits the contraction of vascular smooth muscle and may play a role in regulating BP as a vasodilator<sup>25,26</sup>. </p>
      <p>A study carried out recently in Japan investigated the associations of consumption of fruit, vegetables and their micronutrients with a reduced risk of SAH. The high consumption of fruit and vegetables was associated with a lower risk of developing hypertension, suggesting that the decrease in blood pressure was due to the presence of potassium and vitamin C in the foods<sup>27</sup>. A study with Australian adolescents showed that the consumption of fruit, vegetables, grains and fish was inversely associated with DBP<sup>28</sup>. </p>
      <p>No direct effect of fruit and vegetable consumption was observed in our study, probably due to the fact that both hypertensive and nonhypertensive patients showed low consumption of this type food; moreover, there was no difference regarding the consumption of these food groups between the groups. </p>
      <p>The consumption of fibers was negatively correlated with the decrease in BP, albeit weakly. This fact can also be explained by the low fiber consumption in both groups. It is known that individuals with high intake of dietary fiber may have significantly lower risk for developing coronary heart disease, infarction, hypertension, diabetes and obesity<sup>29,30</sup>.</p>
      <p>We observed a positive correlation between sugar consumption and DBP. Inadequate consumption of this type of food is associated with increased insulin production, and may have a direct effect on the increase in renal reabsorption of sodium and thus, increase BP<sup>31</sup>. Moreover, insulin resistance and hyperinsulinemia may play a role in the pathogenesis of hypertension associated with obesity, due to the increase in inflammatory markers<sup>32,33</sup>. Hyperinsulinemia causes increased activity of the sympathetic nervous system and tubular reabsorption of sodium, actions that contribute to the increase in BP<sup>34-36</sup>. </p>
      <p>Higher BMI, %BF and WC were observed among individuals with hypertension, which was expected<sup>37</sup>. Visceral fat can mediate the increase in blood pressure by reducing the natriuresis. The higher sodium retention would be caused by the activation of the renin-angiotensin system, activation of the sympathetic nervous system and also by changes in intrarenal hemodynamics, consequent to the compression of the renal medulla<sup>38</sup>. This shows the importance of adjusting the data for adiposity (BMI) when we analyze the influence of diet on hypertension, because then, these effects can be neutralized.</p>
      <p>It was observed that hypertensive individuals showed higher plasma glucose, glycemia, total cholesterol, triglycerides and LDL-C levels, which increases the risk of cardiovascular diseases<sup>30</sup>. According to Schaan et al<sup>39</sup>, individuals with some degree of abnormal glucose homeostasis had a higher prevalence of hypertension. </p>
      <p>
        <bold>Study limitations</bold>
      </p>
      <p>This was a cross-sectional study, and, therefore, the cause-effect mechanisms cannot be defined. Secondly, 24-hour recall was conducted in a single a day, which may not accurately reflect the habits of the evaluated individuals. Moreover, the consumption of sodium and alcohol was not evaluated, which may influence blood pressure. </p>
      <p>
        <bold>Conclusion</bold>
      </p>
      <p>The present study showed that the greater the dietary variety (eight or more different types of food) offered a protective effect for alterations in SBP. The other dietary variables studied were not significantly associated with BP.</p>
      <p>
        <bold>References</bold>
      </p>
    </body>
  </sub-article>
</article>
