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  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">abc</journal-id>
      <journal-title-group>
        <journal-title>Arquivos Brasileiros de Cardiologia</journal-title>
        <abbrev-journal-title abbrev-type="publisher">Arq. Bras. Cardiol.</abbrev-journal-title>
      </journal-title-group>
      <issn pub-type="ppub">0066-782X</issn>
      <issn pub-type="epub">1678-4170</issn>
      <publisher>
        <publisher-name>Sociedade Brasileira de Cardiologia - SBC</publisher-name>
        <publisher-loc>S&#227;o Paulo, SP, Brazil</publisher-loc>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id" specific-use="scielo-v3">vpqhfvtpVzZmTMmNvK5cpHz</article-id>
      <article-id pub-id-type="other">00014</article-id>
      <article-id pub-id-type="publisher-id" specific-use="scielo-v2">S0066-782X2011000600014</article-id>
      <article-id pub-id-type="publisher-id" specific-use="scielo-v1">S0066-782X(11)09600614</article-id>
      <article-id pub-id-type="doi">10.1590/S0066-782X2011000600014</article-id>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Carta ao Editor</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Estatina na preven&#231;&#227;o de fibrila&#231;&#227;o atrial p&#243;s-cirurgia card&#237;aca</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <name>
            <surname>Zen</surname>
            <given-names>B&#225;rbara</given-names>
          </name>
          <xref ref-type="aff" rid="aff01"/>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Rossi</surname>
            <given-names>Luiza</given-names>
          </name>
          <xref ref-type="aff" rid="aff01"/>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Rosa</surname>
            <given-names>Eduardo Maffini da</given-names>
          </name>
          <xref ref-type="aff" rid="aff01"/>
        </contrib>
      </contrib-group>
      <aff id="aff01">
        <addr-line>
          <named-content content-type="city">Caxias do Sul</named-content>
          <named-content content-type="state">Rio Grande do Sul</named-content>
        </addr-line>
        <institution content-type="orgname">Universidade de Caxias do Sul</institution>
        <country country="BR">Brazil</country>
      </aff>
      <pub-date date-type="collection" publication-format="electronic">
        <month>06</month>
        <year>2011</year>
      </pub-date>
      <volume>96</volume>
      <issue>6</issue>
      <fpage>516</fpage>
      <lpage>516</lpage>
      <permissions>
        <license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc/4.0/" xml:lang="en">
          <license-p>This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.</license-p>
        </license>
      </permissions>
      <pub-date publication-format="electronic" date-type="pub">
        <day>03</day>
        <month>10</month>
        <year>2011</year>
      </pub-date>
    </article-meta>
  </front>
  <body>
    <p>
      <bold>CARTA AO EDITOR</bold>
    </p>
    <p>
      <bold>Estatina na preven&#231;&#227;o de fibrila&#231;&#227;o atrial p&#243;s-cirurgia card&#237;aca</bold>
    </p>
    <p>
      <bold>B&#225;rbara Zen; Luiza Rossi; Eduardo Maffini da Rosa</bold>
    </p>
    <p>Universidade de Caxias do Sul - UCS, Caxias do Sul, RS - Brasil</p>
    <p>
      <xref ref-type="corresp" rid="end">Correspond&#234;ncia</xref>
    </p>
    <p><bold>Palavras-chave:</bold> Inibidores de hidroximetilglutaril CoA edutases/uso terap&#234;utico, fibrila&#231;&#227;o atrial/preven&#231;&#227;o &amp; controle, per&#237;odo p&#243;s-operat&#243;rio.</p>
    <p>Nosso grupo de estudos em coronariopatias gostaria de parabenizar os autores pelo artigo escrito por Alves e cols.<sup>1</sup> em rela&#231;&#227;o ao pertinente assunto abordado. Queremos relatar nossa opini&#227;o em rela&#231;&#227;o ao uso cr&#244;nico de estatina pr&#233;-operat&#243;ria e &#224; ocorr&#234;ncia de fibrila&#231;&#227;o atrial no p&#243;s-operat&#243;rio.</p>
    <p>O aparecimento de fibrila&#231;&#227;o atrial frequentemente ocorre em pacientes ap&#243;s cirurgia card&#237;aca<sup>2</sup>. E a presen&#231;a de tr&#234;s ou mais fatores de risco aumenta significativamente a incid&#234;ncia dessa arritmia no per&#237;odo p&#243;s-operat&#243;rio de cirurgia card&#237;aca<sup>3</sup>.</p>
    <p>Concordamos com a exist&#234;ncia do efeito anti-inflamat&#243;rio atribu&#237;do &#224;s estatinas, por&#233;m acreditamos que a redu&#231;&#227;o da ocorr&#234;ncia da fibrila&#231;&#227;o atrial no p&#243;s-operat&#243;rio card&#237;aco se deva &#224; menor manipula&#231;&#227;o do peric&#225;rdio em pacientes usu&#225;rios de estatina, em raz&#227;o da maior estabiliza&#231;&#227;o do quadro isqu&#234;mico ateroscler&#243;tico e at&#233; menor extens&#227;o de doen&#231;a coronariana. A fibrila&#231;&#227;o atrial p&#243;s-operat&#243;ria tem uma forte rela&#231;&#227;o com o grau de inflama&#231;&#227;o peric&#225;rdica, e essa com a quantidade de manipula&#231;&#227;o do peric&#225;rdio.</p>
    <p>Gostar&#237;amos de saber dos autores qual foi a ocorr&#234;ncia de pericardite aguda p&#243;s-operat&#243;ria e qual foi a ocorr&#234;ncia de fibrila&#231;&#227;o atrial nesse grupo.</p>
    <p>
      <bold>Carta-resposta</bold>
    </p>
    <p>Agradecemos imensamente a aten&#231;&#227;o e nos sentimos honrados com os coment&#225;rios feitos ao nosso trabalho, os quais servir&#227;o de est&#237;mulo e, tamb&#233;m, para futuras observa&#231;&#245;es.</p>
    <p>Sem d&#250;vida, pericardite &#233; um dos fatores de risco para o desenvolvimento de fibrila&#231;&#227;o atrial no p&#243;s-operat&#243;rio de cirurgia card&#237;aca, bem como a presen&#231;a de tr&#234;s ou mais fatores de risco<sup>1,2</sup>. Por isso, j&#225; inclu&#237;mos esse fator de risco em nossas atuais pesquisas.</p>
    <p>No atual estudo<sup>3</sup>, contudo, n&#227;o se verificou quadro cl&#237;nico de pericardite aguda no p&#243;s-operat&#243;rio. O que pudemos observar nos pacientes foi apenas a presen&#231;a de atrito peric&#225;rdico entre o per&#237;odo de p&#243;s-operat&#243;rio imediato e o primeiro dia de p&#243;s-operat&#243;rio. O quadro apresentou resolu&#231;&#227;o espont&#226;nea e n&#227;o se observou rela&#231;&#227;o com o aparecimento de fibrila&#231;&#227;o atrial.</p>
    <p>Atenciosamente,</p>
    <p>
      <bold>Dr. Renato J. Alves</bold>
    </p>
    <p>
      <bold>Refer&#234;ncias (Respostas)</bold>
    </p>
    <p>2. Geovanini GR, Alves RJ, Brito G, Miguel AS, Glauser VA, Nakiri K. Fibrila&#231;&#227;o atrial no p&#243;s-operat&#243;rio de cirurgia card&#237;aca: quem deve receber quimioprofilaxia? Arq Bras Cardiol. 2009;92(4):326-30.</p>
    <p>3. Alves RJ, Campos RN, Nakiri K. Chronic and regular use of statin prevents atrial fibrillation in period after cardiac surgery. Arq Bras Cardiol. 2010;95(5):614-20.</p>
    <p>
      <fn id="end" fn-type="corresp">
        <label>
          <bold>Correspond&#234;ncia:</bold>
        </label>
        <p> Luiza Rossi </p>
        <p> Rua Francisco Get&#250;lio Vargas, 1130 </p>
        <p> Petr&#243;polis - 95070-560 - Caxias do Sul, RS - Brasil </p>
        <p> E-mail: </p>
        <p><email xlink:href="rossiluiza@hotmail.com">rossiluiza@hotmail.com</email>, </p>
        <p>
          <email xlink:href="lrossi5@ucs.br">lrossi5@ucs.br</email>
        </p>
      </fn>
    </p>
    <p>Artigo recebido em 13/12/10; revisado recebido em 21/12/10; aceito em 21/12/10.</p>
  </body>
  <back>
    <ref-list>
      <ref id="B1">
        <mixed-citation>1. Alves RJ, Campos RN, Nakiri K. Chronic and regular use of statin prevents atrial fibrillation in period after cardiac surgery. Arq Bras Cardiol. 2010;95(5):614-20.</mixed-citation>
        <element-citation publication-type="journal">
          <article-title>Chronic and regular use of statin prevents atrial fibrillation in period after cardiac surgery</article-title>
          <source>Arq Bras Cardiol</source>
          <date>
            <year>2010</year>
          </date>
          <fpage>614</fpage>
          <lpage>20</lpage>
          <issue>5</issue>
          <volume>95</volume>
          <person-group person-group-type="author">
            <name>
              <surname>Alves</surname>
              <given-names>RJ</given-names>
            </name>
            <name>
              <surname>Campos</surname>
              <given-names>RN</given-names>
            </name>
            <name>
              <surname>Nakiri</surname>
              <given-names>K</given-names>
            </name>
          </person-group>
        </element-citation>
      </ref>
      <ref id="B2">
        <mixed-citation>2. Bradley D, Creswell LL, Hogue CW Jr, Epstein AE, Prystowsky EN, Daoud EG / (American College of Chest Physicians). Pharmacologic prophylaxis: American College of Chest Physicians guidelines for the prevention and management of postoperative atrial fibrillation after cardiac surgery. Chest. 2005;128(2 Suppl.):39-47.</mixed-citation>
        <element-citation publication-type="journal">
          <article-title>Pharmacologic prophylaxis: American College of Chest Physicians guidelines for the prevention and management of postoperative atrial fibrillation after cardiac surgery</article-title>
          <source>Chest</source>
          <date>
            <year>2005</year>
          </date>
          <fpage>39</fpage>
          <lpage>47</lpage>
          <issue>2</issue>
          <volume>128</volume>
          <person-group person-group-type="author">
            <name>
              <surname>Bradley</surname>
              <given-names>D</given-names>
            </name>
            <name>
              <surname>Creswell</surname>
              <given-names>LL</given-names>
            </name>
            <name>
              <surname>Hogue</surname>
              <given-names>CW Jr</given-names>
            </name>
            <name>
              <surname>Epstein</surname>
              <given-names>AE</given-names>
            </name>
            <name>
              <surname>Prystowsky</surname>
              <given-names>EN</given-names>
            </name>
            <name>
              <surname>Daoud</surname>
              <given-names>EG</given-names>
            </name>
          </person-group>
        </element-citation>
      </ref>
      <ref id="B3">
        <mixed-citation>3. Geovanini GR, Alves RJ, Brito G, Miguel AS, Glauser VA, Nakiri K. Fibrila&#231;&#227;o atrial no p&#243;s-operat&#243;rio de cirurgia card&#237;aca: quem deve receber quimioprofilaxia? Arq Bras Cardiol. 2009;92(4):326-30.</mixed-citation>
        <element-citation publication-type="journal">
          <article-title>Fibrila&#231;&#227;o atrial no p&#243;s-operat&#243;rio de cirurgia card&#237;aca: quem deve receber quimioprofilaxia?</article-title>
          <source>Arq Bras Cardiol</source>
          <date>
            <year>2009</year>
          </date>
          <fpage>326</fpage>
          <lpage>30</lpage>
          <issue>4</issue>
          <volume>92</volume>
          <person-group person-group-type="author">
            <name>
              <surname>Geovanini</surname>
              <given-names>GR</given-names>
            </name>
            <name>
              <surname>Alves</surname>
              <given-names>RJ</given-names>
            </name>
            <name>
              <surname>Brito</surname>
              <given-names>G</given-names>
            </name>
            <name>
              <surname>Miguel</surname>
              <given-names>AS</given-names>
            </name>
            <name>
              <surname>Glauser</surname>
              <given-names>VA</given-names>
            </name>
            <name>
              <surname>Nakiri</surname>
              <given-names>K</given-names>
            </name>
          </person-group>
        </element-citation>
      </ref>
      <ref id="B4">
        <mixed-citation>1. Alves RJ, Geovannini GR, Brito G, Miguel GAS, Glauser VA, Nakiri K. Amiodarona em moderada dosagem previne fibrila&#231;&#227;o atrial aguda em pacientes com fatores de risco arritmog&#234;nicos no p&#243;s-operat&#243;rio de cirurgia card&#237;aca. Arq Bras Cardiol. 2007;89(1):22-7.</mixed-citation>
        <element-citation publication-type="journal">
          <article-title>Amiodarona em moderada dosagem previne fibrila&#231;&#227;o atrial aguda em pacientes com fatores de risco arritmog&#234;nicos no p&#243;s-operat&#243;rio de cirurgia card&#237;aca</article-title>
          <source>Arq Bras Cardiol</source>
          <date>
            <year>2007</year>
          </date>
          <fpage>22</fpage>
          <lpage>7</lpage>
          <issue>1</issue>
          <volume>89</volume>
          <person-group person-group-type="author">
            <name>
              <surname>Alves</surname>
              <given-names>RJ</given-names>
            </name>
            <name>
              <surname>Geovannini</surname>
              <given-names>GR</given-names>
            </name>
            <name>
              <surname>Brito</surname>
              <given-names>G</given-names>
            </name>
            <name>
              <surname>Miguel</surname>
              <given-names>GAS</given-names>
            </name>
            <name>
              <surname>Glauser</surname>
              <given-names>VA</given-names>
            </name>
            <name>
              <surname>Nakiri</surname>
              <given-names>K</given-names>
            </name>
          </person-group>
        </element-citation>
      </ref>
    </ref-list>
  </back>
  <sub-article article-type="translation" id="TRes" xml:lang="es">
    <front-stub>
      <article-categories/>
      <title-group>
        <article-title xml:lang="es">Estatina en prevenci&#243;n de fibrilaci&#243;n atrial post cirug&#237;a card&#237;aca</article-title>
      </title-group>
    </front-stub>
    <body>
      <p>
        <bold>CARTA AL EDITOR</bold>
      </p>
      <p>
        <fn id="ab-body2">
          <label>
            <bold>Estatina en prevenci&#243;n de fibrilaci&#243;n atrial post cirug&#237;a card&#237;aca</bold>
          </label>
          <p>
            <bold>B&#225;rbara Zen; Luiza Rossi; Eduardo Maffini da Rosa</bold>
          </p>
        </fn>
      </p>
      <p>Universidade de Caxias do Sul - UCS, Caxias do Sul, RS - Brasil</p>
      <p>Correspondencia</p>
      <p><bold>Palabras clave:</bold> Inhibidores de hidroximetilglutaril CoA reductasas/uso terap&#233;utico, fibrilaci&#243;n atrial/prevenci&#243;n &amp; control, per&#237;odo post operatorio.</p>
      <p>A nuestro grupo de estudios en coronariopat&#237;as le gustar&#237;a felicitar a los autores por el art&#237;culo escrito por Alves et al<sup>1</sup> en relaci&#243;n al pertinente asunto abordado. Queremos relatar nuestra opini&#243;n en relaci&#243;n al uso cr&#243;nico de estatina preoperatoria y a la ocurrencia de fibrilaci&#243;n atrial en el postoperatorio.</p>
      <p>La aparici&#243;n de fibrilaci&#243;n atrial frecuentemente ocurre en pacientes despu&#233;s de cirug&#237;a card&#237;aca<sup>2</sup>. Y la presencia de tres o m&#225;s factores de riesgo aumenta significativamente la incidencia de esa arritmia en el per&#237;odo postoperatorio de cirug&#237;a card&#237;aca<sup>3</sup>.</p>
      <p>Concordamos con la existencia del efecto antiinflamatorio atribuido a las estatinas, sin embargo creemos que la reducci&#243;n de la ocurrencia de la fibrilaci&#243;n atrial en el postoperatorio card&#237;aco se deba a menor manipulaci&#243;n del pericardio en pacientes usuarios de estatina, en raz&#243;n de la mayor estabilizaci&#243;n del cuadro isqu&#233;mico ateroscler&#243;tico y hasta menor extensi&#243;n de enfermedad coronaria. La fibrilaci&#243;n atrial post-operatoria tiene una forte relaci&#243;n con el grado de inflamaci&#243;n peric&#225;rdica, y esa con la cantidad de manipulaci&#243;n del pericardio.</p>
      <p>Nos gustar&#237;a saber de los autores cual fue la ocurrencia de pericarditis aguda postoperatoria y cual fue la ocurrencia de fibrilaci&#243;n atrial en ese grupo.</p>
      <p>
        <bold>Carta respuesta</bold>
      </p>
      <p>Agradecemos inmensamente la atenci&#243;n y nos sentimos honrados con los comentarios hechos a nuestro trabajo, los cuales servir&#225;n de est&#237;mulo y, tambi&#233;n, para futuras observaciones.</p>
      <p>Sin duda, pericarditis es uno de los factores de riesgo para el desarrollo de fibrilaci&#243;n atrial en el postoperatorio de cirug&#237;a card&#237;aca, as&#237; como la presencia de tres o m&#225;s factores de riesgo<sup>1,2</sup>. Por eso, ya incluimos ese factor de riesgo en nuestras actuales investigaciones.</p>
      <p>En el actual estudio<sup>3</sup>, con todo, no se verific&#243; cuadro cl&#237;nico de pericarditis aguda en el postoperatorio. Lo que pudimos observar en los pacientes fue apenas la presencia de fricci&#243;n peric&#225;rdica entre el per&#237;odo de postoperatorio inmediato y el primer d&#237;a de postoperatorio. El cuadro present&#243; resoluci&#243;n espont&#225;nea y no se observ&#243; relaci&#243;n con la aparici&#243;n de fibrilaci&#243;n atrial.</p>
      <p>Atentamente,</p>
      <p>
        <bold>Dr. Renato J. Alves</bold>
      </p>
      <p>
        <bold>Referencias</bold>
      </p>
      <p>
        <bold>Refer&#234;ncias (Respostas)</bold>
      </p>
    </body>
  </sub-article>
  <sub-article article-type="translation" id="TRen" xml:lang="en">
    <front-stub>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Letter to the Editor</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title xml:lang="en">Statin in prevention of atrial fibrillation after cardiac surgery</article-title>
      </title-group>
    </front-stub>
    <body>
      <p>
        <bold>LETTER TO THE EDITOR</bold>
      </p>
      <p>
        <fn id="top1-body3">
          <label>
            <bold>Statin in prevention of atrial fibrillation after cardiac surgery</bold>
          </label>
          <p>
            <bold>B&#225;rbara Zen; Luiza Rossi; Eduardo Maffini da Rosa</bold>
          </p>
        </fn>
      </p>
      <p>Universidade de Caxias do Sul - UCS, Caxias do Sul, RS - Brazil</p>
      <p>Mailing address</p>
      <p><bold>Keywords:</bold> Hydroxymethylglutaril-CoA reductase inhibitors/therapeutic use; atrial fibrillation/prevention &amp; control; postoperative period.</p>
      <p>Our group of studies on coronary heart diseases would like to congratulate the authors for the article by Alves et al<sup>1</sup> for this relevant subject matter. We wished to report our opinion regarding the chronic use of preoperative statin and atrial fibrillation in the postoperative period.</p>
      <p>The onset of atrial fibrillation often occurs in patients after cardiac surgery<sup>2</sup>. And the presence of three or more risk factors significantly increases the incidence of arrhythmia after cardiac surgery<sup>3</sup>.</p>
      <p>We agree with the existence of an anti-inflammatory effect attributed to statins, but we believe that reducing the occurrence of atrial fibrillation in the postoperative period is due to a smaller manipulation of the pericardium in patients taking statins, due to a greater stabilization of atherosclerotic ischemia and smaller extension of coronary disease. Postoperative atrial fibrillation has a strong relationship with the degree of pericardial inflammation, which is turn related to the amount of pericardial manipulation.</p>
      <p>We would like to ask the authors about the occurrence of acute postoperative pericarditis and the occurrence of atrial fibrillation in this group.</p>
      <p>
        <bold>Reply</bold>
      </p>
      <p>We greatly appreciate your attention and we are honored with the comments made to our study, which will serve as an encouragement, and for future observations.</p>
      <p>Undoubtedly, pericarditis is a risk factor for developing atrial fibrillation after cardiac surgery, as well as the presence of three or more risk factors<sup>1,2</sup>. Therefore, we have already included this risk factor in our current research.</p>
      <p>However, in the study at hand<sup>3</sup>, there was no clinical sign of acute pericarditis in the postoperative period. We have observed in patients only the presence of pericardial friction between the immediate postoperative period and the first day after the surgery. This picture was spontaneously solved and we did not associate it with the onset of atrial fibrillation.</p>
      <p>Sincerely,</p>
      <p>
        <bold>Dr. Renato J. Alves</bold>
      </p>
      <p>
        <bold>References</bold>
      </p>
      <p>
        <bold>Refer&#234;ncias (Respostas)</bold>
      </p>
    </body>
  </sub-article>
</article>
