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  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">abc</journal-id>
      <journal-title-group>
        <journal-title>Arquivos Brasileiros de Cardiologia</journal-title>
        <abbrev-journal-title abbrev-type="publisher">Arq. Bras. Cardiol.</abbrev-journal-title>
      </journal-title-group>
      <issn pub-type="ppub">0066-782X</issn>
      <issn pub-type="epub">1678-4170</issn>
      <publisher>
        <publisher-name>Sociedade Brasileira de Cardiologia - SBC</publisher-name>
        <publisher-loc>S&#227;o Paulo, SP, Brazil</publisher-loc>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id" specific-use="scielo-v3">KjwyzdkDwLFp7sZkLXmGmgN</article-id>
      <article-id pub-id-type="other">00012</article-id>
      <article-id pub-id-type="publisher-id" specific-use="scielo-v2">S0066-782X2010001400012</article-id>
      <article-id pub-id-type="publisher-id" specific-use="scielo-v1">S0066-782X(10)09500412</article-id>
      <article-id pub-id-type="doi">10.1590/S0066-782X2010005000119</article-id>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Artigos Originais</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Respostas cardiovasculares ao exerc&#237;cio resistido s&#227;o afetadas pela carga e intervalos entre s&#233;ries</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <name>
            <surname>Castinheiras-Neto</surname>
            <given-names>Antonio Gil</given-names>
          </name>
          <xref ref-type="aff" rid="aff01"/>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Costa-Filho</surname>
            <given-names>Irineu Rodrigues da</given-names>
          </name>
          <xref ref-type="aff" rid="aff01"/>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Farinatti</surname>
            <given-names>Paulo Tarso Veras</given-names>
          </name>
          <xref ref-type="aff" rid="aff01"/>
          <xref ref-type="aff" rid="aff02"/>
        </contrib>
      </contrib-group>
      <aff id="aff01">
        <addr-line>
          <named-content content-type="city">Niter&#243;i</named-content>
          <named-content content-type="state">RJ</named-content>
        </addr-line>
        <institution content-type="orgname">Universidade Salgado de Oliveira</institution>
        <country country="BR">Brasil</country>
      </aff>
      <aff id="aff02">
        <addr-line>
          <named-content content-type="city">Rio de Janeiro</named-content>
          <named-content content-type="state">Rio de Janeiro</named-content>
        </addr-line>
        <institution content-type="orgname">Universidade do Estado do Rio de Janeiro</institution>
        <institution content-type="orgdiv1">Laborat&#243;rio de Atividade F&#237;sica e Promo&#231;&#227;o da Sa&#250;de </institution>
        <institution content-type="orgdiv2">Instituto de Educa&#231;&#227;o F&#237;sica e Desportos</institution>
        <country country="BR">Brazil</country>
      </aff>
      <pub-date date-type="collection" publication-format="electronic">
        <month>10</month>
        <year>2010</year>
      </pub-date>
      <volume>95</volume>
      <issue>4</issue>
      <fpage>493</fpage>
      <lpage>501</lpage>
      <history>
        <date date-type="rev-recd">
          <day>17</day>
          <month>03</month>
          <year>2010</year>
        </date>
        <date date-type="received">
          <day>01</day>
          <month>08</month>
          <year>2009</year>
        </date>
        <date date-type="accepted">
          <day>11</day>
          <month>05</month>
          <year>2010</year>
        </date>
      </history>
      <permissions>
        <license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc/4.0/" xml:lang="en">
          <license-p>This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.</license-p>
        </license>
      </permissions>
      <abstract>
        <p>FUNDAMENTO: O controle das respostas cardiovasculares durante exerc&#237;cio resistido (ER) &#233; importante para a seguran&#231;a do paciente. OBJETIVO: Investigar a influ&#234;ncia do n&#250;mero de repeti&#231;&#245;es m&#225;ximas (RM) e dos intervalos de recupera&#231;&#227;o entre s&#233;ries (IR) sobre a frequ&#234;ncia card&#237;aca (FC), press&#227;o arterial sist&#243;lica (PAS) e duplo produto (DP) durante ER. M&#201;TODOS: Vinte sujeitos saud&#225;veis (26 &#177; 5 anos) realizaram protocolos de ER envolvendo tr&#234;s s&#233;ries do leg press (6 e 12 RM) e IR proporcional ao tempo de contra&#231;&#227;o (1:3 e 1:5). Aferiu-se a FC continuamente com cardiofrequenc&#237;metro e a PAS foi verificada ao final das s&#233;ries, por meio de protocolo validado com m&#233;todo auscultat&#243;rio. RESULTADOS: A FC sofreu influ&#234;ncia da carga (p = 0,008) e das s&#233;ries (p &lt; 0,001), mas n&#227;o do IR (p = 0,087). A PAS sofreu efeito isolado do n&#250;mero de s&#233;ries (p &lt; 0,001) e do IR (p = 0,017), mas n&#227;o da carga (p = 0,95). O DP elevou-se em rela&#231;&#227;o direta com a carga (p = 0,036) e com as s&#233;ries (p &lt; 0,001), mas inversamente ao IR (p = 0,006). Nos protocolos de 6 RM, a varia&#231;&#227;o da FC foi maior para IR = 1:3 (&#916; = 11,2 &#177; 1,1 bpm) do que para IR = 1:5 (&#916; = 4,5 &#177; 0,2 bpm; p = 0,002), mas n&#227;o houve diferen&#231;a para 12 RM (&#916; 1:3 = 21,1 &#177; 2,2 bpm; &#916; 1:5 = 18,9 &#177; 2,0 bpm, p = 0,83). O IR influenciou a varia&#231;&#227;o da PAS em todas as cargas (6 RM - &#916; 1:3 = 10,6 &#177; 0,9 mmHg, &#916; 1:5 = 6,6 &#177; 0,7 mmHg; p = 0,02 e 12 RM - &#916; 1:3 = 15,2 &#177; 1,1 mmHg, &#916; 1:5 = 8,4 &#177; 0,7 mmHg; p = 0,04). O DP elevou-se proporcionalmente &#224; carga (p = 0,036) e para s&#233;ries (p &lt; 0,001), mas inversamente ao IR (p = 0,006). Com IR = 1:3, houve diferen&#231;a de DP para 6 RM (&#916; = 2.892 &#177; 189 mmHg.bpm) e 12 RM (&#916; = 4.587 &#177; 300 mmHg.bpm; p = 0,018), mas n&#227;o com IR = 1:5 (6 RM: &#916; = 1.224 &#177; 141 mmHg.bpm, 12 RM: &#916; = 2.332 &#177; 194 mmHg.bpm; p = 0,58). CONCLUS&#195;O: Independentemente da carga, um maior IR associou-se a menores respostas cardiovasculares durante ER, especialmente de PAS.</p>
      </abstract>
      <kwd-group xml:lang="pt" kwd-group-type="author-generated">
        <kwd>Exerc&#237;cio</kwd>
        <kwd>treinamento de resist&#234;ncia</kwd>
        <kwd>frequ&#234;ncia card&#237;aca</kwd>
        <kwd>press&#227;o arterial</kwd>
      </kwd-group>
      <pub-date publication-format="electronic" date-type="pub">
        <day>03</day>
        <month>09</month>
        <year>2010</year>
      </pub-date>
    </article-meta>
  </front>
  <body>
    <p>ARTIGO ORIGINAL </p>
    <p> FISIOLOGIA </p>
    <p>
      <bold>Respostas cardiovasculares ao exerc&#237;cio resistido s&#227;o afetadas pela carga e intervalos entre s&#233;ries</bold>
    </p>
    <p>
      <bold>Antonio Gil Castinheiras-Neto<sup>I</sup>; Irineu Rodrigues da Costa-Filho<sup>I</sup>; Paulo Tarso Veras Farinatti<sup>I, II</sup></bold>
    </p>
    <p><sup>I</sup>Programa de P&#243;s-Gradua&#231;&#227;o em Ci&#234;ncias da Atividade F&#237;sica - Universidade Salgado de Oliveira, Niter&#243;i, RJ - Brasil </p>
    <p><sup>II</sup>Instituto de Educa&#231;&#227;o F&#237;sica e Desportos - Laborat&#243;rio de Atividade F&#237;sica e Promo&#231;&#227;o da Sa&#250;de - Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ - Brasil</p>
    <p>
      <xref ref-type="corresp" rid="back">Correspond&#234;ncia</xref>
    </p>
    <p>
      <bold>RESUMO</bold>
    </p>
    <p><bold>FUNDAMENTO:</bold> O controle das respostas cardiovasculares durante exerc&#237;cio resistido (ER) &#233; importante para a seguran&#231;a do paciente. </p>
    <p><bold>OBJETIVO:</bold> Investigar a influ&#234;ncia do n&#250;mero de repeti&#231;&#245;es m&#225;ximas (RM) e dos intervalos de recupera&#231;&#227;o entre s&#233;ries (IR) sobre a frequ&#234;ncia card&#237;aca (FC), press&#227;o arterial sist&#243;lica (PAS) e duplo produto (DP) durante ER. </p>
    <p><bold>M&#201;TODOS:</bold> Vinte sujeitos saud&#225;veis (26 &#177; 5 anos) realizaram protocolos de ER envolvendo tr&#234;s s&#233;ries do leg press (6 e 12 RM) e IR proporcional ao tempo de contra&#231;&#227;o (1:3 e 1:5). Aferiu-se a FC continuamente com cardiofrequenc&#237;metro e a PAS foi verificada ao final das s&#233;ries, por meio de protocolo validado com m&#233;todo auscultat&#243;rio. </p>
    <p><bold>RESULTADOS:</bold> A FC sofreu influ&#234;ncia da carga (p = 0,008) e das s&#233;ries (p &lt; 0,001), mas n&#227;o do IR (p = 0,087). A PAS sofreu efeito isolado do n&#250;mero de s&#233;ries (p &lt; 0,001) e do IR (p = 0,017), mas n&#227;o da carga (p = 0,95). O DP elevou-se em rela&#231;&#227;o direta com a carga (p = 0,036) e com as s&#233;ries (p &lt; 0,001), mas inversamente ao IR (p = 0,006). Nos protocolos de 6 RM, a varia&#231;&#227;o da FC foi maior para IR = 1:3 (&#916; = 11,2 &#177; 1,1 bpm) do que para IR = 1:5 (&#916; = 4,5 &#177; 0,2 bpm; p = 0,002), mas n&#227;o houve diferen&#231;a para 12 RM (&#916; 1:3 = 21,1 &#177; 2,2 bpm; &#916; 1:5 = 18,9 &#177; 2,0 bpm, p = 0,83). O IR influenciou a varia&#231;&#227;o da PAS em todas as cargas (6 RM - &#916; 1:3 = 10,6 &#177; 0,9 mmHg, &#916; 1:5 = 6,6 &#177; 0,7 mmHg; p = 0,02 e 12 RM - &#916; 1:3 = 15,2 &#177; 1,1 mmHg, &#916; 1:5 = 8,4 &#177; 0,7 mmHg; p = 0,04). O DP elevou-se proporcionalmente &#224; carga (p = 0,036) e para s&#233;ries (p &lt; 0,001), mas inversamente ao IR (p = 0,006). Com IR = 1:3, houve diferen&#231;a de DP para 6 RM (&#916; = 2.892 &#177; 189 mmHg.bpm) e 12 RM (&#916; = 4.587 &#177; 300 mmHg.bpm; p = 0,018), mas n&#227;o com IR = 1:5 (6 RM: &#916; = 1.224 &#177; 141 mmHg.bpm, 12 RM: &#916; = 2.332 &#177; 194 mmHg.bpm; p = 0,58). </p>
    <p><bold>CONCLUS&#195;O:</bold> Independentemente da carga, um maior IR associou-se a menores respostas cardiovasculares durante ER, especialmente de PAS.</p>
    <p><bold>Palavras-chave:</bold> Exerc&#237;cio, treinamento de resist&#234;ncia; frequ&#234;ncia card&#237;aca, press&#227;o arterial.</p>
    <p>
      <bold>Introdu&#231;&#227;o</bold>
    </p>
    <p>O treinamento resistido acarreta eleva&#231;&#227;o importante da frequ&#234;ncia card&#237;aca (FC) e press&#227;o arterial (PA)<sup>1,2</sup>. A manipula&#231;&#227;o de vari&#225;veis do treinamento pode controlar essas respostas, modificando a sobrecarga cardiovascular durante os exerc&#237;cios<sup>2,3</sup>. Estudos pr&#233;vios investigaram a influ&#234;ncia de diversas vari&#225;veis, como a velocidade de movimento<sup>4</sup>, o n&#250;mero de s&#233;ries<sup>5</sup>, a intensidade e o n&#250;mero de repeti&#231;&#245;es<sup>2,6</sup>, a massa muscular envolvida<sup>2,7</sup>, os tipos de exerc&#237;cio<sup>1</sup> ou o estado de treinamento<sup>8</sup>.</p>
    <p>No entanto, s&#227;o escassas as informa&#231;&#245;es sobre a influ&#234;ncia do intervalo de recupera&#231;&#227;o entre s&#233;ries e exerc&#237;cios. Apenas um estudo investigou especificamente a influ&#234;ncia de tal vari&#225;vel sobre os valores de FC e PA<sup>9</sup>, identificando maior resposta press&#243;rica em sess&#245;es com intervalos mais curtos. Ratamess e cols.<sup>10</sup> n&#227;o mediram especificamente a PA, mas n&#227;o identificaram diferen&#231;as significativas nas respostas de FC a exerc&#237;cio feito com diferentes intervalos de recupera&#231;&#227;o. Todavia, o aumento progressivo da pulsa&#231;&#227;o ao longo das s&#233;ries foi mais evidente para intervalos mais curtos.</p>
    <p>Vale ressaltar que esses estudos<sup>9,10</sup> aplicaram intervalos de recupera&#231;&#227;o fixos. Assim, n&#227;o consideraram o efeito cumulativo da fadiga muscular no decorrer das s&#233;ries. Na pr&#225;tica, percebe-se que diferentes exerc&#237;cios necessitam de tempo de execu&#231;&#227;o vari&#225;vel, seja pela complexidade ou pela amplitude requerida do movimento. Pode-se cogitar, por exemplo, que, se o intervalo de recupera&#231;&#227;o fosse proporcional ao tempo de execu&#231;&#227;o do exerc&#237;cio, ocorreria uma menor raz&#227;o do decr&#233;scimo da carga em virtude de menor fadiga acumulada.</p>
    <p>Estrat&#233;gias de recupera&#231;&#227;o com tempo fixo podem n&#227;o permitir plena recupera&#231;&#227;o em s&#233;ries consecutivas, o que pode potencializar o aumento de PA e FC<sup>5,9,11</sup>. Fixar o intervalo de recupera&#231;&#227;o com base no tempo de execu&#231;&#227;o do exerc&#237;cio (ou tempo de tens&#227;o) pode ser mais adequado, dependendo da sobrecarga com que se trabalha. Infelizmente, n&#227;o foi poss&#237;vel localizar estudos que tenham confirmado essa hip&#243;tese, o que seria especialmente importante no &#226;mbito de programas de treinamento para pacientes com risco de intercorr&#234;ncia cardiovascular.</p>
    <p>Desse modo, o presente estudo investigou a influ&#234;ncia de dois intervalos de recupera&#231;&#227;o, estabelecidos com base no tempo de tens&#227;o, em s&#233;ries m&#250;ltiplas de exerc&#237;cio resistido, realizado com diferentes repeti&#231;&#245;es m&#225;ximas, por indiv&#237;duos normotensos, sobre as respostas agudas de FC e PA sist&#243;lica (PAS) e, consequentemente, do duplo-produto (DP).</p>
    <p>
      <bold>M&#233;todos</bold>
    </p>
    <p>
      <bold>Amostragem</bold>
    </p>
    <p>Vinte volunt&#225;rios (26 &#177; 5 anos; 70,9 &#177; 8,1 kg; 173,9 &#177; 7,0 cm), com experi&#234;ncia pr&#233;via de 6-12 meses em treinamento resistido, participaram do estudo.</p>
    <p>Os seguintes crit&#233;rios de exclus&#227;o foram observados: a) utiliza&#231;&#227;o de drogas que pudessem influenciar as respostas cardiovasculares no repouso ou exerc&#237;cio; b) limita&#231;&#245;es osteomioarticulares que contraindicassem a realiza&#231;&#227;o dos exerc&#237;cios; c) diagn&#243;stico de hipertens&#227;o, doen&#231;a card&#237;aca ou outro comprometimento cardiovascular que contraindicasse a realiza&#231;&#227;o dos exerc&#237;cios ou influenciasse nos resultados.</p>
    <p>O estudo foi aprovado por comit&#234; de &#233;tica institucional e todos os participantes assinaram termo de consentimento livre e esclarecido, conforme recomendado pelo Conselho Nacional de Sa&#250;de (Resolu&#231;&#227;o 196/96).</p>
    <p>
      <bold>Determina&#231;&#227;o das cargas - 6 e 12 repeti&#231;&#245;es m&#225;ximas (RM)</bold>
    </p>
    <p>Foram necess&#225;rias 4 visitas para a realiza&#231;&#227;o dos testes que estabeleceram as cargas associadas &#224; execu&#231;&#227;o de 6 RM e 12 RM no <italic>leg press</italic>, bem como verificar a confiabilidade dos resultados aferidos. A escolha do <italic>leg press</italic> horizontal foi motivada pelo fato de envolver grandes grupos musculares e, portanto, sugerir maior impacto sobre os valores de press&#227;o arterial. Al&#233;m disso, trata-se de um exerc&#237;cio de f&#225;cil execu&#231;&#227;o, frequentemente inclu&#237;do nas rotinas de prescri&#231;&#227;o de exerc&#237;cios para pacientes com doen&#231;a cardiovascular.</p>
    <p>Antes da realiza&#231;&#227;o dos testes de RM, foi realizado aquecimento espec&#237;fico, que consistiu na execu&#231;&#227;o de 12 repeti&#231;&#245;es com carga equivalente a 30% da carga m&#225;xima predita. Em cada dia, os sujeitos tiveram at&#233; 5 tentativas para concluir com &#234;xito os testes, com intervalo de 5 min entre cada tentativa.</p>
    <p>Os testes de 6 RM e 12 RM foram realizados em dias diferentes, espa&#231;ados por pelo menos 48 h. Est&#237;mulos verbais foram fornecidos para manter elevado o n&#237;vel de estimula&#231;&#227;o durante os exerc&#237;cios. Os pesos utilizados foram previamente aferidos em balan&#231;a de precis&#227;o. Caso n&#227;o fosse poss&#237;vel estabelecer a carga associada &#224;s 6 RM ou 12 RM at&#233; a 5&#170; tentativa, uma nova data era marcada, respeitando-se igualmente um intervalo de pelo menos 48 h. A reprodutibilidade dos testes de RM foi testada pelo coeficiente de correla&#231;&#227;o intraclasse, revelando-se satisfat&#243;ria (ICC 6 RM = 0,89; p &lt; 0,01 e ICC 12 RM = 0,85; p &lt; 0,01).</p>
    <p>
      <bold>Protocolo experimental</bold>
    </p>
    <p>Uma vez determinadas as cargas de 6 RM e 12 RM, os sujeitos realizaram 4 protocolos aleat&#243;rios de exerc&#237;cios, em ordem definida de forma contrabalanceada. Cada sess&#227;o teve lugar em dia espec&#237;fico, perfazendo-se um total de mais 4 visitas ao laborat&#243;rio, espa&#231;adas por intervalos de 48 horas. Todos os sujeitos executaram os seguintes procedimentos: a) tr&#234;s s&#233;ries de 6 RM com intervalo de 1:3; b) tr&#234;s s&#233;ries de 6 RM com intervalo de 1:5; c) tr&#234;s s&#233;ries de 12 RM com intervalo de 1:3; e d) tr&#234;s s&#233;ries de 12 RM com intervalo de 1:5.</p>
    <p>Os sujeitos foram instru&#237;dos a respeitar as seguintes recomenda&#231;&#245;es antes das sess&#245;es de exerc&#237;cios: a) n&#227;o praticar qualquer tipo de atividade f&#237;sica nas 48 h precedentes; b) abstin&#234;ncia de bebidas alco&#243;licas, com cafe&#237;na ou estimulantes por 24 h; e c) realizar o m&#237;nimo de esfor&#231;o no deslocamento at&#233; o laborat&#243;rio.</p>
    <p>Antes da execu&#231;&#227;o dos protocolos, os sujeitos permaneciam 10 min sentados, em ambiente calmo e silencioso. A FC e a PA em repouso eram ent&#227;o aferidas, registrando-se a m&#233;dia dos &#250;ltimos dois minutos para a FC, e a m&#233;dia de duas medidas realizadas no mesmo per&#237;odo para a PA. Em seguida, era feito um aquecimento de 12 repeti&#231;&#245;es com 30% da carga prevista para a sess&#227;o. Ap&#243;s o aquecimento, os sujeitos descansavam por 5 minutos e iniciavam o exerc&#237;cio.</p>
    <p>A aferi&#231;&#227;o das vari&#225;veis cardiovasculares foi feita nas condi&#231;&#245;es de repouso e em exerc&#237;cio, com aux&#237;lio dos mesmos equipamentos, conforme descrito a seguir:</p>
    <p>a) <italic>Repouso</italic> - os indiv&#237;duos permaneceram sentados por 10 minutos. A FC foi medida continuamente, sendo registrada a m&#233;dia dos &#250;ltimos dois minutos, com uso de um cardiofrequenc&#237;metro <italic>Polar<sup>&#174;</sup></italic> S810 (Kempele, Finl&#226;ndia). A PAS e a press&#227;o arterial diast&#243;lica (PAD) foram aferidas duas vezes, entre o 8&#186; e 10&#186; minuto, pelo m&#233;todo indireto auscultat&#243;rio, com aux&#237;lio de um man&#244;metro tipo coluna de merc&#250;rio Heidji<sup>&#174;</sup> (S&#227;o Paulo, Brasil). O padr&#227;o de medida seguiu as recomenda&#231;&#245;es das V Diretrizes Brasileiras de Hipertens&#227;o Arterial<sup>12</sup>, sendo realizada sempre pelo mesmo avaliador, tanto em repouso quanto em exerc&#237;cio. A PA foi aferida em ambos os bra&#231;os, sendo considerada a maior medida em caso de diferen&#231;a.</p>
    <p>b) <italic>Exerc&#237;cio</italic> - A FC foi medida continuamente, sendo registrado o maior valor apresentado ao final das s&#233;ries. Para medida da PA, respeitaram-se recomenda&#231;&#245;es previamente validadas para aferi&#231;&#227;o durante exerc&#237;cios resistidos<sup>13,14</sup>, conforme detalhado no <xref ref-type="fig" rid="fig12q01">Quadro 1</xref>.</p>
    <p content-type="asset">
      <fig id="fig12q01">
        <graphic xlink:href="1678-4170-abc-95-04-0493-00119-gf01.jpg"/></fig>
    </p>
    <p>Em linhas gerais, a abertura da v&#225;lvula ocorria antes do t&#233;rmino da s&#233;rie, de forma a registrar-se o valor sist&#243;lico entre a pen&#250;ltima e a &#250;ltima repeti&#231;&#227;o. Uma aferi&#231;&#227;o piloto era feita para determinar o valor de pico da PAS, a fim de que se elevasse a press&#227;o do manguito a um valor aproximado de 30 mmHg maior antes da abertura da v&#225;lvula. O esvaziamento do manguito deu-se a uma taxa aproximada de 6 mmHg/s. Os sujeitos foram orientados a n&#227;o contrair os bra&#231;os, mantendo o bra&#231;o esquerdo utilizado para a medida na posi&#231;&#227;o de supina&#231;&#227;o, com cotovelo levemente flexionado e apoiado em suporte pr&#243;prio. As medidas foram feitas sempre pelo mesmo avaliador treinado, que n&#227;o tinha conhecimento dos objetivos do presente estudo.</p>
    <p>Para a determina&#231;&#227;o da confiabilidade da medida da PA em repouso, foram feitas duas aferi&#231;&#245;es da PA, com intervalo de 10 minutos, em 20 sujeitos (ICC = 0,93 para PAS intra-avaliador; ICC = 0,86 para PAS inter-avaliador). A confiabilidade da medida durante o exerc&#237;cio foi testada em duas sess&#245;es separadas por 48 h, nos mesmos 20 sujeitos (ICC = 0,84 e p = 0,03 para PAS intra-avaliador; ICC = 0,82 e p = 0,022 para PAS inter-avaliador).</p>
    <p>Em estudo pr&#233;vio de valida&#231;&#227;o<sup>14</sup>, constatou-se uma elevada correla&#231;&#227;o entre as medidas tomadas por ausculta&#231;&#227;o e fotopletismografia, tanto no repouso quanto em diferentes repeti&#231;&#245;es m&#225;ximas para exerc&#237;cio de membros inferiores (p &lt; 0,05) (repouso: r = 0,89; 6 RM: r = 0,85; 15 RM: r = 0,88). Al&#233;m disso, o percentual de concord&#226;ncia na classifica&#231;&#227;o em tercis das medidas em todas as situa&#231;&#245;es ficou sempre acima de 60%, chegando a 75% para a PAS durante o exerc&#237;cio. A associa&#231;&#227;o n&#227;o param&#233;trica entre os m&#233;todos, considerando os n&#237;veis de classifica&#231;&#227;o por tercis no repouso, 6 RM e 12 RM, tamb&#233;m produziu elevados coeficientes de correla&#231;&#227;o de Gamma e Kruskall (&#947; = 0,77 - 0,97, p &lt; 0,05).</p>
    <p>
      <bold>Determina&#231;&#227;o dos intervalos de recupera&#231;&#227;o entre s&#233;ries</bold>
    </p>
    <p>A dura&#231;&#227;o dos intervalos de recupera&#231;&#227;o entre s&#233;ries levou em considera&#231;&#227;o a dura&#231;&#227;o destas &#250;ltimas. A execu&#231;&#227;o do exerc&#237;cio era cronometrada e o resultado multiplicado por tr&#234;s ou 5, para a determina&#231;&#227;o de um intervalo que respeitasse, respectivamente, propor&#231;&#245;es de 1:3 ou 1:5, entre tempo de execu&#231;&#227;o e tempo de recupera&#231;&#227;o. Para a obten&#231;&#227;o do tempo de execu&#231;&#227;o das s&#233;ries, foi utilizado cron&#244;metro digital com fun&#231;&#227;o progressiva. O cron&#244;metro foi acionado no momento em que havia deslocamento da plataforma de apoio dos p&#233;s e era interrompido quando esta tocava em sua base ao final da s&#233;rie.</p>
    <p>O cron&#244;metro permitia reiniciar a medida de forma simples, com o mesmo bot&#227;o de sua interrup&#231;&#227;o, o que permitiu que se estipulassem intervalos precisos. Para facilitar a visualiza&#231;&#227;o do per&#237;odo de recupera&#231;&#227;o (1:3 ou 1:5) e minimizar a chance de erro no c&#225;lculo do intervalo, foi utilizada tabela de convers&#227;o previamente elaborada.</p>
    <p>
      <bold>Tratamento dos resultados</bold>
    </p>
    <p>O teste de Shapiro-Wilk foi utilizado para verificar a normalidade dos dados e o teste de Levene para confirma&#231;&#227;o da homogeneidade de vari&#226;ncias. A estabilidade dos valores de FC e PAS aferidos durante o repouso, em cada uma das sess&#245;es, foi testada com aux&#237;lio de ANOVA de uma entrada. A influ&#234;ncia isolada e combinada dos fatores observados (RM, s&#233;ries e intervalos) sobre DP, FC e PAS foi testada com ANOVA de tr&#234;s entradas, seguida de testes <italic>post hoc</italic> de Fisher, adotando-se como limiar de signific&#226;ncia um valor de p <underline>&lt;</underline> 0,05. O <italic>software</italic> Statistica 6.0 (Statsoft<sup>&#174;</sup>, Tulsa, EUA) foi utilizado em todos os c&#225;lculos.</p>
    <p>
      <bold>Resultados</bold>
    </p>
    <p>N&#227;o houve diferen&#231;a significativa entre os valores de FC e PAS de repouso aferidos em cada uma das sess&#245;es de exerc&#237;cios (F = 2,02; p = 0,78). Para fins de an&#225;lise, portanto, foram adotados os menores valores obtidos para essas vari&#225;veis nos per&#237;odos de repouso pr&#233;-exerc&#237;cio. Os valores de FC e PAS durante as s&#233;ries revelaram-se sempre significativamente superiores &#224;s medidas tomadas durante o repouso (F = 1,41 a 2,56; p = 0,027 a p = 0,039).</p>
    <p>Vale ressaltar ainda que o dobro do n&#250;mero de repeti&#231;&#245;es m&#225;ximas (6 RM e 12 RM) n&#227;o esteve relacionado com a mesma propor&#231;&#227;o de varia&#231;&#227;o na carga absoluta de trabalho (peso em kg). A raz&#227;o entre as cargas de 6 e 12 RM foi de apenas 12%, ou, em termos absolutos, 7,5 &#177; 0,8 kg.</p>
    <p>O impacto das vari&#225;veis manipuladas foi diverso sobre FC e a PAS. Assim, a FC sofreu influ&#234;ncia significativa do efeito isolado do n&#250;mero de repeti&#231;&#245;es m&#225;ximas (F = 7,33; p = 0,008) e do n&#250;mero de s&#233;ries (F = 77,65; p &lt; 0,001), mas n&#227;o do intervalo de recupera&#231;&#227;o (F = 3,00; p = 0,087). O efeito combinado das s&#233;ries com os intervalos, contudo, revelou-se significativo (F = 4,87; p = 0,02). Quanto &#224; PAS, o efeito isolado estatisticamente mais forte residiu no n&#250;mero de s&#233;ries (F = 63,33; p &lt; 0,001), seguido do intervalo de recupera&#231;&#227;o (F = 5,97; p = 0,017). A vari&#225;vel intensidade n&#227;o teve efeito independente significativo (F = 0,042; p = 0,95).</p>
    <p>As <xref ref-type="fig" rid="f01">Figuras 1</xref> e <xref ref-type="fig" rid="f02">2</xref> apresentam os resultados das verifica&#231;&#245;es <italic>post hoc</italic> para FC e PAS. Constata-se que, sistematicamente, a influ&#234;ncia do n&#250;mero de s&#233;ries deu-se no sentido de elevar as respostas cardiovasculares. Por outro lado, o intervalo de recupera&#231;&#227;o teve influ&#234;ncia oposta, chegando a compensar o efeito cumulativo das s&#233;ries em alguns casos, principalmente no tocante &#224; PAS.</p>
    <p content-type="asset">
      <fig id="f01">
        <graphic xlink:href="1678-4170-abc-95-04-0493-00119-gf02.jpg"/></fig>
    </p>
    <p content-type="asset">
      <fig id="f02">
        <graphic xlink:href="1678-4170-abc-95-04-0493-00119-gf03.jpg"/></fig>
    </p>
    <p>Tamb&#233;m foram comparadas as varia&#231;&#245;es absolutas em cada situa&#231;&#227;o, considerando os valores de pico registrados entre a primeira e a terceira s&#233;ries. No tocante &#224; FC, para os protocolos de 6 RM, a varia&#231;&#227;o nas s&#233;ries com intervalo de 1:3 foi significativamente maior do que a observada em 1:5 (&#916; = 11,2 &#177; 1,1 bpm <italic>versus</italic> &#916; = 4,5 &#177; 0,2 bpm, respectivamente) (F = 9,98; p = 0,002). J&#225; na carga de 12 RM, a varia&#231;&#227;o da FC nas s&#233;ries com intervalo de 1:3 n&#227;o apresentou diferen&#231;a significativa em rela&#231;&#227;o ao observado no intervalo 1:5 (&#916; = 21,1 &#177; 2,2 bpm <italic>versus</italic> &#916; = 18,9 &#177; 2,0 bpm, respectivamente) (F = 0,58; p = 0,83). As varia&#231;&#245;es de PAS entre a 1&#170; e 3&#170; s&#233;ries foram influenciadas pelo intervalo de recupera&#231;&#227;o, independentemente da carga. Nos protocolos com 6 RM, as varia&#231;&#245;es para os intervalos de 1:3 e 1:5 foram, respectivamente, de 10,6 &#177; 0,9 mmHg e 6,6 &#177; 0,7 mmHg (F = 6,67; p = 0,02). Para os protocolos de 12 RM, a varia&#231;&#227;o com intervalo 1:3 foi de 15,2 &#177; 1,1 mmHg e com intervalo 1:5 foi de 8,4 &#177; 0,7 mmHg (F = 5,12; p = 0,04).</p>
    <p>Os resultados para a PAS mostraram-se mais sens&#237;veis &#224; manipula&#231;&#227;o das tr&#234;s vari&#225;veis do treinamento, tomadas isolada ou combinadamente. Isso repercutiu sobre o comportamento do DP, numa rela&#231;&#227;o diretamente proporcional ao n&#250;mero de repeti&#231;&#245;es m&#225;ximas (F = 4,57; p = 0,036) e ao n&#250;mero de s&#233;ries (F = 141,38; p &lt; 0,001), enquanto inversamente proporcional ao intervalo entre as s&#233;ries (F = 5,38; p = 0,006).</p>
    <p>A <xref ref-type="fig" rid="f03">Figura 3</xref> apresenta os resultados para as verifica&#231;&#245;es <italic>post hoc</italic> referentes ao DP.</p>
    <p content-type="asset">
      <fig id="f03">
        <graphic xlink:href="1678-4170-abc-95-04-0493-00119-gf04.jpg"/></fig>
    </p>
    <p>A varia&#231;&#227;o entre a primeira e a terceira s&#233;ries realizadas com intervalo de 1:3 foi de 2.892 &#177; 189 mmHg.bpm para 6 RM e de 4.587 &#177; 300 mmHg.bpm para 12 RM (F = 4,17; p = 0,018). Quando se aplicou o intervalo de maior dura&#231;&#227;o (1:5), a varia&#231;&#227;o do DP para a carga de 6 RM foi de 1.224 &#177; 141 mmHg.bpm, ao passo que para 12 RM obteve-se um delta de 2.332 &#177; 194 mmHg.bpm (F = 0,56; p = 0,58).</p>
    <p>
      <bold>Discuss&#227;o</bold>
    </p>
    <p>O presente estudo comparou as respostas de FC, PAS e DP, durante s&#233;ries consecutivas de exerc&#237;cio resistido, realizado com diferentes n&#250;meros de repeti&#231;&#245;es m&#225;ximas e intervalos de recupera&#231;&#227;o, estes &#250;ltimos estabelecidos com base no tempo total de execu&#231;&#227;o de cada s&#233;rie.</p>
    <p>Tanto a FC quanto a PAS elevaram-se significativamente no decorrer das s&#233;ries, independentemente da intensidade e intervalo de recupera&#231;&#227;o. Entretanto, as respostas cardiovasculares associadas ao <italic>leg press</italic> horizontal foram minimizadas pela manipula&#231;&#227;o do tempo de recupera&#231;&#227;o: quando a propor&#231;&#227;o foi maior em rela&#231;&#227;o ao tempo de tens&#227;o, os valores de FC e, principalmente, de PAS, foram inferiores. O maior intervalo de recupera&#231;&#227;o tamb&#233;m se associou a uma menor eleva&#231;&#227;o da FC e PAS no decorrer das s&#233;ries, em ambas as intensidades programadas. Assim, o exerc&#237;cio realizado com maior intervalo de recupera&#231;&#227;o ocasionou menor estresse cardiovascular nas duas intensidades testadas.</p>
    <p>&#201; interessante notar que o valor m&#233;dio para a PAS de pico na &#250;ltima s&#233;rie do estudo de Gotshall e cols.<sup>5</sup>, mensurada por fotoplestimografia, foi de 293 &#177; 21 mmHg, bem superior ao valor registrado na &#250;ltima s&#233;rie do presente estudo (181 &#177; 16 mmHg para o protocolo de 12 RM com intervalo progressivo na propor&#231;&#227;o 1:3). Essa diferen&#231;a pode ser atribu&#237;da ao tempo de tens&#227;o em cada s&#233;rie (um minuto no estudo de Gotshall e cols.<sup>5</sup><italic>versus</italic> 24 segundos no presente estudo), mas tamb&#233;m, e talvez principalmente, &#224; medida da PA. Como se sabe, apesar de satisfat&#243;rio para compara&#231;&#227;o entre diferentes protocolos de exerc&#237;cios de for&#231;a, o m&#233;todo auscultat&#243;rio realizado em membro inativo pode subestimar os valores press&#243;ricos absolutos<sup>14,15</sup>. Em outras palavras, o m&#233;todo auscultat&#243;rio &#233; extremamente &#250;til em situa&#231;&#245;es pr&#225;ticas, tendo se revelado v&#225;lido e reprodut&#237;vel para indicar diferen&#231;as das respostas de PA a exerc&#237;cios resistidos. Com isso, consiste em estrat&#233;gia &#250;til para a elabora&#231;&#227;o de sess&#245;es de treinamento com menor sobrecarga cardiovascular. Por outro lado, o m&#233;todo auscultat&#243;rio n&#227;o deveria ser utilizado para o estabelecimento preciso dos valores press&#243;ricos durante o exerc&#237;cio de for&#231;a.</p>
    <p>Os estudos que se aprofundaram na observa&#231;&#227;o da influ&#234;ncia do intervalo de recupera&#231;&#227;o entre s&#233;ries e exerc&#237;cios sobre o comportamento da PA e FC s&#227;o relativamente escassos. N&#227;o foi poss&#237;vel localizar pesquisas que tivessem investigado a quest&#227;o em uma abordagem similar &#224; presentemente aplicada.</p>
    <p>Polito e cols.<sup>9</sup> submeteram jovens normotensos a 4 s&#233;ries de 8 RM, separadas por intervalos fixos de um e dois minutos, tamb&#233;m observando valores mais elevados de press&#227;o arterial para a sequ&#234;ncia com menor intervalo. As respostas cardiovasculares mais pronunciadas a curtos intervalos de recupera&#231;&#227;o podem associar-se a uma menor recupera&#231;&#227;o sist&#234;mica do estresse gerado pelo exerc&#237;cio. O ac&#250;mulo de metab&#243;litos, com consequente estimula&#231;&#227;o nervosa via receptores qu&#237;micos e mec&#226;nicos, pode potencializar essas respostas<sup>16</sup>.</p>
    <p>Nesse sentido, Ratamess e cols.<sup>10</sup> observaram os efeitos de diferentes intervalos fixos de recupera&#231;&#227;o (30s, um, dois, tr&#234;s e 5 minutos) sobre as respostas cardiovasculares e metab&#243;licas durante a realiza&#231;&#227;o de 5 s&#233;ries em duas intensidades de treinamento (5 RM e 10 RM) no exerc&#237;cio supino reto. N&#227;o se constataram diferen&#231;as entre os intervalos de recupera&#231;&#227;o, considerando os valores de FC de pico em ambas as intensidades de treinamento. Entretanto, houve aumento da FC &#224; medida que as s&#233;ries eram executadas (p &lt; 0,05), principalmente para intervalos de recupera&#231;&#227;o mais curtos. A produ&#231;&#227;o de lactato foi igualmente maior para intervalos de recupera&#231;&#227;o mais curtos, o que &#233; sugestivo da rela&#231;&#227;o entre fadiga acumulada devido &#224; recupera&#231;&#227;o insuficiente e &#224;s respostas cardiovasculares.</p>
    <p>Os presentes resultados indicaram que a carga de trabalho tamb&#233;m pode influenciar de forma independente as respostas de FC e PAS. Em compara&#231;&#227;o com o protocolo com carga de 12 RM, as s&#233;ries feitas com 6 RM apresentaram menor impacto sobre as respostas cardiovasculares para intervalos de recupera&#231;&#227;o similares. &#201; poss&#237;vel que o tempo de tens&#227;o (6 RM = 17 &#177; 3 s <italic>versus</italic> 12 RM = 29 &#177; 5 s) esteja relacionado com esses resultados. Essa possibilidade ratifica os resultados relatados por Lamotte e cols.<sup>17</sup>, os quais analisaram o efeito da execu&#231;&#227;o da extens&#227;o de joelhos na cadeira, com cargas equivalentes a 40% e 70% de um RM (4 s&#233;ries com um minuto de intervalo entre s&#233;ries), sobre as respostas de FC e PA em cardiopatas. A dura&#231;&#227;o m&#233;dia das s&#233;ries envolvendo intensidade de 40% foi de 34 s (para 17 repeti&#231;&#245;es), contra 20 s da s&#233;rie conduzida com 70% da carga m&#225;xima (para 10 repeti&#231;&#245;es). Houve diferen&#231;a significativa para os valores de pico de PAS, com maior sobrecarga card&#237;aca para o protocolo de menor intensidade (p &lt; 0,01). Verificou-se efeito cumulativo das s&#233;ries sobre a press&#227;o arterial (p &lt; 0,01), o que foi atribu&#237;do pelos autores ao curto intervalo de recupera&#231;&#227;o aplicado.</p>
    <p>No presente estudo, tamb&#233;m ocorreu um efeito cumulativo das s&#233;ries sobre as respostas de FC e PAS, com maior eleva&#231;&#227;o a partir da segunda s&#233;rie, principalmente para um menor intervalo esfor&#231;o-recupera&#231;&#227;o. De forma similar, Gotshall e cols.<sup>5</sup> aplicaram tr&#234;s s&#233;ries de 10 RM no <italic>leg press</italic> bilateral em jovens saud&#225;veis (intervalo de recupera&#231;&#227;o fixo de tr&#234;s minutos; velocidade de tr&#234;s segundos nas fases conc&#234;ntrica e exc&#234;ntrica). Ao t&#233;rmino de cada uma das s&#233;ries, os valores de PAS e PAD revelaram-se sempre significativamente superiores ao observado na s&#233;rie precedente. Outros estudos t&#234;m demonstrado que h&#225; influ&#234;ncia do n&#250;mero de s&#233;ries sobre as respostas cardiovasculares<sup>2,17</sup>.</p>
    <p>Dois fatores podem estar na origem dos resultados referentes ao efeito cumulativo das s&#233;ries consecutivas sobre as respostas cardiovasculares. O primeiro decorreria da fadiga acumulada em virtude do menor tempo de recupera&#231;&#227;o<sup>18</sup>. O segundo leva em considera&#231;&#227;o o tempo de tens&#227;o: o exerc&#237;cio din&#226;mico resistido ocasiona oclus&#227;o dos vasos e pode, dependendo de sua intensidade e dura&#231;&#227;o, levar a uma resposta barorreflexa compensat&#243;ria, o que &#233; mais frequente em exerc&#237;cios executados at&#233; a fadiga<sup>19,20</sup>.</p>
    <p>As respostas hemodin&#226;micas ao trabalho muscular em exerc&#237;cios resistidos tamb&#233;m podem estar atreladas a um aumento da atividade simp&#225;tica e &#224; diminui&#231;&#227;o da atividade parassimp&#225;tica, pela maior ativa&#231;&#227;o de comando central e mecanorreceptores musculares e articulares<sup>16</sup>. O mecanismo central envolve o envio de impulsos do c&#243;rtex motor para o centro de controle cardiovascular. J&#225; o mecanismo perif&#233;rico consiste em uma via de reflexo com diversas bases de controle<sup>21</sup>. O aumento da resist&#234;ncia vascular perif&#233;rica, causado pela oclus&#227;o parcial do fluxo sangu&#237;neo, contribui com um desequil&#237;brio entre oferta e demanda de O<sub>2</sub> no tecido. De fato, a partir de 15% da contra&#231;&#227;o volunt&#225;ria m&#225;xima, verifica-se impedimento progressivo do fluxo sangu&#237;neo muscular<sup>22</sup>. Com isso, dificulta-se a remo&#231;&#227;o de metab&#243;litos (lactato, hidrog&#234;nio, fosfato, adenosina, pot&#225;ssio etc), estimulando-se os quimiorreceptores no sentido de aumentar a atividade nervosa simp&#225;tica<sup>16</sup>.</p>
    <p>Enfim, o aumento da press&#227;o arterial tamb&#233;m poderia sofrer influ&#234;ncia do n&#250;mero de unidades motoras solicitadas. Nesse caso, mecanorreceptores musculares e articulares, sens&#237;veis ao aumento da for&#231;a volunt&#225;ria (recrutamento de unidades motoras) e &#224; carga sobre as articula&#231;&#245;es, informam o centro de controle cardiovascular sobre a necessidade de modificar as respostas cardiovasculares para a regula&#231;&#227;o do fluxo<sup>23</sup>.</p>
    <p>O aumento da resist&#234;ncia vascular perif&#233;rica associado &#224; oclus&#227;o arterial durante o exerc&#237;cio &#233; outro fator a ser considerado. O <italic>leg press</italic>, al&#233;m de envolver diversos e grandes grupamentos musculares, tamb&#233;m &#233; feito em uma postura que pode dificultar a perfus&#227;o de sangue para os m&#250;sculos ativos, uma vez que as principais art&#233;rias que os irrigam t&#234;m seu curso modificado pela flex&#227;o do quadril<sup>24</sup>. Esse problema &#233; ainda maior durante o per&#237;odo de transi&#231;&#227;o entre as fases conc&#234;ntrica e exc&#234;ntrica. Nesse contexto, a ativa&#231;&#227;o de barorreceptores e quimiorreceptores pode provocar resposta press&#243;rica compensat&#243;ria, para que se alcance um d&#233;bito card&#237;aco satisfat&#243;rio durante os exerc&#237;cios.</p>
    <p>As respostas cardiovasculares ao exerc&#237;cio resistido, portanto, podem associar-se a uma adapta&#231;&#227;o central frente &#224; maior resist&#234;ncia perif&#233;rica. A maior necessidade de perfus&#227;o estaria diretamente relacionada &#224; capacidade inotr&#243;pica do cora&#231;&#227;o, j&#225; que modifica&#231;&#245;es na FC tendem a ocorrer de forma mais lenta do que na PAS<sup>25</sup>. Ali&#225;s, essa sobrecarga press&#243;rica associada ao exerc&#237;cio resistido pode ser ben&#233;fica sob o ponto de vista profil&#225;tico, principalmente para portadores de doen&#231;as cardiovasculares cr&#244;nicas e usu&#225;rios de medica&#231;&#227;o anti-hipertensiva<sup>26</sup>. Alguns estudos t&#234;m relatado que coronariopatas, sob tratamento farmacol&#243;gico, podem realizar exerc&#237;cios resistidos de intensidade moderada e os resultados dessa pr&#225;tica incluem a melhora da fun&#231;&#227;o global do ventr&#237;culo esquerdo, especialmente da fra&#231;&#227;o de eje&#231;&#227;o<sup>26,27</sup>.</p>
    <p>Quanto &#224; eleva&#231;&#227;o da FC, o tempo de tens&#227;o muscular parece exercer importante influ&#234;ncia. Hunter e cols.<sup>28</sup> compararam as respostas metab&#243;licas e da frequ&#234;ncia card&#237;aca a 10 exerc&#237;cios feitos com duas velocidades de contra&#231;&#227;o, uma 'tradicional' (2 s&#233;ries de 8 repeti&#231;&#245;es com 65% de um RM, velocidade de execu&#231;&#227;o de um segundo para a fase conc&#234;ntrica e exc&#234;ntrica, um minuto de recupera&#231;&#227;o) e 'super <italic>slow'</italic> (2 s&#233;ries de 8 repeti&#231;&#245;es com 25% de um RM, velocidade de execu&#231;&#227;o de 10 s para a fase conc&#234;ntrica e 5 s para a fase exc&#234;ntrica, com mesmo intervalo e n&#250;mero de exerc&#237;cios). Verificou-se que o protocolo 'tradicional' induziu eleva&#231;&#227;o significativamente superior da FC em compara&#231;&#227;o com o 'super <italic>slow'</italic> (143 &#177; 8 bpm contra 113 &#177; 12 bpm).</p>
    <p>Kleiner e cols.<sup>4</sup> estudaram a resposta cardiovascular aguda no exerc&#237;cio isocin&#233;tico em 6 sujeitos que realizaram extens&#227;o de joelhos com tr&#234;s velocidades de execu&#231;&#227;o (50, 100 e 200&#186;/s) at&#233; a fadiga (70% do pico de torque). N&#227;o foram encontradas diferen&#231;as significativas entre os valores de FC, PAS, PAD e DP. Contudo, nas velocidades programadas, os valores de FC variaram entre 163,3 &#177; 28,4 bpm (50&#186;/s) e 183,5 &#177; 16,8 bpm (200&#176;/s). Contrariamente, os valores de PAS foram superiores para uma menor velocidade angular (PAS = 348,2 &#177; 18,1 mmHg para 50&#186;/s <italic>versus</italic> PAS = 335,5 &#177; 27,4 mmHg para 200&#186;/s), com influ&#234;ncia sobre o DP (50&#186;/s = 56.861 &#177; 514 mmHg.bpm; 100&#186;/s = 58.875 &#177; 479 mmHg.bpm; 200&#186;/s = 61.564 &#177; 460 mmHg.bpm). Os autores justificam seus resultados pela caracter&#237;stica das sess&#245;es, tendo o n&#250;mero de repeti&#231;&#245;es variado entre 30 (50&#186;/s), 80 (100&#186;/s) e 140 (200&#186;/s).</p>
    <p>Como os protocolos com maior velocidade oferecem menor resist&#234;ncia, e, uma vez tendo produzido quantidade expressivamente maior de repeti&#231;&#245;es, a execu&#231;&#227;o do exerc&#237;cio teria se aproximado do que se encontra em exerc&#237;cios din&#226;micos cont&#237;nuos de longa dura&#231;&#227;o, com maior repercuss&#227;o sobre a FC. Por outro lado, a eleva&#231;&#227;o da PAS para menores velocidades estaria relacionada a uma maior produ&#231;&#227;o de for&#231;a, em compara&#231;&#227;o com as maiores velocidades angulares.</p>
    <p>Extrapolar resultados obtidos em exerc&#237;cios isocin&#233;ticos para din&#226;micos do tipo 'isot&#244;nico' n&#227;o &#233;, em geral, prudente. No entanto, n&#227;o se pode deixar de notar que o efeito do tempo de tens&#227;o sobre a FC &#233; ratificado pelos resultados de Kleiner e cols.<sup>4</sup>, bem como fica n&#237;tido que os valores da PAS s&#227;o sens&#237;veis &#224; tens&#227;o produzida, com forte influ&#234;ncia sobre o DP.</p>
    <p>Outro exemplo &#233; encontrado em Kawano e cols.<sup>29</sup>, que submeteram normotensos jovens e de meia-idade a uma s&#233;rie no exerc&#237;cio de <italic>leg press</italic> com tr&#234;s intensidades (40%, 60% e 80% de um RM). N&#227;o houve diferen&#231;a para os valores de FC nas intensidades testadas, em quaisquer dos grupos. No entanto, os jovens apresentaram maiores valores press&#243;ricos de pico do que os sujeitos de meia-idade em todas as intensidades, sendo que de forma significativa apenas para a intensidade de 80% de um RM (jovens = 190 mmHg <italic>versus</italic> meia-idade = 150 mmHg, p &lt; 0,05). A amplitude de varia&#231;&#227;o da PAS em rela&#231;&#227;o ao repouso (&#916;) ocorreu de forma significativa para todas as intensidades, sendo maior nos jovens, talvez por exibirem menores valores de repouso de forma geral (40% RM: jovens = 34 mmHg <italic>versus</italic> meia-idade = 18 mmHg; 60% RM: jovens = 54 mmHg <italic>versus</italic> meia-idade = 31 mmHg; 80% RM: jovens = 73 mmHg <italic>versus</italic> meia-idade = 42 mmHg, p &lt; 0,05).</p>
    <p>Depreende-se desses resultados que a aferi&#231;&#227;o &#250;nica da FC pode n&#227;o ser suficiente para avaliar adequadamente a sobrecarga cardiovascular imposta pelo exerc&#237;cio resistido. Estimula-se, portanto, a mensura&#231;&#227;o da PA quando do delineamento de programas de treinamento da for&#231;a, sobretudo para sujeitos nos quais manter essas respostas sob controle &#233; desej&#225;vel (pacientes em reabilita&#231;&#227;o card&#237;aca, por exemplo). Para isso, o protocolo de aferi&#231;&#227;o da press&#227;o arterial, durante exerc&#237;cios resistidos atrav&#233;s do m&#233;todo auscultat&#243;rio, proposto por Polito e Farinatti<sup>13</sup> e posteriormente validado<sup>14</sup>, parece ser uma op&#231;&#227;o vi&#225;vel e acess&#237;vel &#224; maior parte dos centros de treinamento.</p>
    <p>
      <bold>Conclus&#227;o</bold>
    </p>
    <p>Em conclus&#227;o, s&#233;ries m&#250;ltiplas de exerc&#237;cio resistido para membros inferiores acarretaram eleva&#231;&#227;o significativa e cumulativa das respostas cardiovasculares, especialmente de PA, com impacto sobre o DP. O n&#237;vel de estresse cardiovascular associado ao exerc&#237;cio n&#227;o dependeu apenas da carga de trabalho definida em termos de repeti&#231;&#245;es m&#225;ximas, mas tamb&#233;m das demais vari&#225;veis do treinamento, principalmente o n&#250;mero de s&#233;ries. Por outro lado, intervalos de recupera&#231;&#227;o mais longos entre as s&#233;ries contribu&#237;ram significativamente para a redu&#231;&#227;o das respostas de FC, PA e DP, mantendo-se a carga e volume de treinamento. A propor&#231;&#227;o entre tempo de est&#237;mulo e tempo de recupera&#231;&#227;o, por si s&#243;, acarretou modifica&#231;&#245;es significativas nas respostas cardiovasculares, independentemente do n&#250;mero de repeti&#231;&#245;es m&#225;ximas executado. Desse modo, o planejamento dos intervalos de recupera&#231;&#227;o no contexto da elabora&#231;&#227;o de sess&#245;es de treinamento resistido parece ser um aspecto clinicamente importante para o aumento da seguran&#231;a em sua pr&#225;tica, especialmente em popula&#231;&#245;es com maior risco cardiovascular.</p>
    <p>Estudos adicionais devem ser conduzidos, comparando as respostas hemodin&#226;micas associadas a diferentes estrat&#233;gias para a rela&#231;&#227;o esfor&#231;o-recupera&#231;&#227;o (intervalos fixos, intervalos progressivos, fracionamento de s&#233;ries, altern&#226;ncia de segmentos etc). Investiga&#231;&#245;es em tal sentido s&#227;o importantes para estabelecer o m&#233;todo mais efetivo para minimizar a sobrecarga cardiovascular associada a s&#233;ries m&#250;ltiplas de exerc&#237;cios resistidos, ao mesmo tempo em que se mant&#233;m elevado o volume de trabalho nas sess&#245;es de treinamento.</p>
    <p>
      <bold>Agradecimentos</bold>
    </p>
    <p>Esse estudo foi parcialmente financiado pelo CNPq (processo 305729/2006-3) e pela FAPERJ (processo E26/102.916/2008).</p>
    <p>
      <bold>Potencial Conflito de Interesses</bold>
    </p>
    <p>Declaro n&#227;o haver conflito de interesses pertinentes.</p>
    <p>
      <bold>Fontes de Financiamento</bold>
    </p>
    <p>O presente estudo foi parcialmente financiado pelo CNPq e pela FAPERJ.</p>
    <p>
      <bold>Vincula&#231;&#227;o Acad&#234;mica</bold>
    </p>
    <p>N&#227;o h&#225; vincula&#231;&#227;o deste estudo a programas de p&#243;s-gradua&#231;&#227;o.</p>
    <p>
      <fn id="back" fn-type="corresp">
        <label>
          <bold>Correspond&#234;ncia:</bold>
        </label>
        <p> Paulo T. V. Farinatti </p>
        <p> Universidade Salgado de Oliveira </p>
        <p> Rua Marechal Deodoro 211, Bloco C, 1&#186; andar </p>
        <p> 24030-060 - Centro - Niter&#243;i, RJ - Brasil </p>
        <p> E-mail: </p>
        <p>
          <email xlink:href="pfarinatti@gmail.com">pfarinatti@gmail.com</email>
        </p>
      </fn>
    </p>
    <p>Artigo recebido em 01/08/09; revisado recebido em 17/03/10; aceito em 11/05/10.</p>
  </body>
  <back>
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  <sub-article article-type="translation" id="TRen" xml:lang="en">
    <front-stub>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Original Articles</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title xml:lang="en">Cardiovascular responses to resistance exercise are affected by workload and intervals between sets</article-title>
      </title-group>
      <abstract xml:lang="en">
        <p>BACKGROUND: The control of cardiovascular responses during resistance exercise (RE) is important for patient safety. OBJECTIVE: To investigate the influence of repetition maximum (RM) and rest interval between sets (RI) on heart rate (HR), systolic blood pressure (SBP) and rate-pressure product (RPP) during RE. METHODS: Twenty healthy subjects (26 &#177; 5 years of age) underwent RE protocols involving three sets of leg press (6 and 12 RM) and RI proportional to the contraction time (1:3 and 1:5). The HR was checked on a continuous basis by using a cardiotachometer and the SBP was checked at the end of the sets, via a protocol validated by the auscultatory method. RESULTS: The HR was influenced by the workload (p = 0.008) and sets (p &lt; 0.001), but not by the RI (p = 0.087). The SBP suffered from the isolated effect of the number of sets (p &lt; 0.001) and RI (p = 0.017), but not from the workload (p = 0.95). The RPP rose in direct proportion to the workload (p = 0.036) and sets (p &lt; 0.001), but in inverse proportion to the RI (p = 0.006). In 6 RM protocols, the variation in the HR was higher for RI = 1:3 (&#916; = 11.2 &#177; 1.1 bpm) than for RI = 1:5 (&#916; = 4.5 &#177; 0.2 bpm; p = 0.002), but there was no difference for 12 RM (&#916; 1:3 = 21.1 &#177; 2.2 bpm; &#916; 1:5 = 18.9 &#177; 2.0 bpm, p = 0.83). The RI influenced the variation in SBP in all loads (6 RM - &#916; 1:3 = 10.6 &#177; 0.9 mmHg, &#916; 1:5 = 6.6 &#177; 0.7 mmHg; p = 0.02 and 12 RM - &#916; 1:3 = 15.2 &#177; 1.1 mmHg, &#916; 1:5 = 8.4 &#177; 0.7 mmHg; p = 0.04). The RPP rose in proportion to the workload (p = 0.036) and to the sets (p &lt; 0.001), but in inverse proportion to the RI (p = 0.006). With RI = 1:3, there was difference in RPP for 6 RM (&#916; = 2,892 &#177; 189 mmHg.bpm) and 12 RM (&#916; = 4,587 &#177; 300 mmHg.bpm; p = 0.018), but not with RI = 1:5 (6 RM: &#916; = 1,224 &#177; 141 mmHg.bpm, 12 RM: &#916; = 2,332 &#177; 194 mmHg.bpm; p = 0.58). CONCLUSION: Regardless of the workload, an increased RI was associated with lower cardiovascular responses during RE, especially of SBP.</p>
      </abstract>
      <kwd-group xml:lang="en">
        <kwd>Exercise</kwd>
        <kwd>resistance training</kwd>
        <kwd>heart rate</kwd>
        <kwd>blood pressure</kwd>
      </kwd-group>
    </front-stub>
    <body>
      <p>
        <bold>ORIGINAL ARTICLE</bold>
      </p>
      <p>
        <fn id="top-body2">
          <label>
            <bold>Cardiovascular responses to resistance exercise are affected by workload and intervals between sets</bold>
          </label>
          <p>
            <bold>Antonio Gil Castinheiras-Neto<sup>I</sup>; Irineu Rodrigues da Costa-Filho<sup>I</sup>; Paulo Tarso Veras Farinatti<sup>I, II</sup></bold>
          </p>
        </fn>
      </p>
      <p><sup>I</sup>Programa de P&#243;s-Gradua&#231;&#227;o em Ci&#234;ncias da Atividade F&#237;sica - Universidade Salgado de Oliveira, Niter&#243;i, RJ - Brazil</p>
      <p><sup>II</sup>Instituto de Educa&#231;&#227;o F&#237;sica e Desportos - Laborat&#243;rio de Atividade F&#237;sica e Promo&#231;&#227;o da Sa&#250;de - Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ - Brazil</p>
      <p>Mailing address</p>
      <p>
        <bold>ABSTRACT</bold>
      </p>
      <p><bold>BACKGROUND:</bold> The control of cardiovascular responses during resistance exercise (RE) is important for patient safety.</p>
      <p><bold>OBJECTIVE:</bold> To investigate the influence of repetition maximum (RM) and rest interval between sets (RI) on heart rate (HR), systolic blood pressure (SBP) and rate-pressure product (RPP) during RE.</p>
      <p><bold>METHODS:</bold> Twenty healthy subjects (26 &#177; 5 years of age) underwent RE protocols involving three sets of leg press (6 and 12 RM) and RI proportional to the contraction time (1:3 and 1:5). The HR was checked on a continuous basis by using a cardiotachometer and the SBP was checked at the end of the sets, via a protocol validated by the auscultatory method.</p>
      <p><bold>RESULTS:</bold> The HR was influenced by the workload (p = 0.008) and sets (p &lt; 0.001), but not by the RI (p = 0.087). The SBP suffered from the isolated effect of the number of sets (p &lt; 0.001) and RI (p = 0.017), but not from the workload (p = 0.95). The RPP rose in direct proportion to the workload (p = 0.036) and sets (p &lt; 0.001), but in inverse proportion to the RI (p = 0.006). In 6 RM protocols, the variation in the HR was higher for RI = 1:3 (&#916; = 11.2 &#177; 1.1 bpm) than for RI = 1:5 (&#916; = 4.5 &#177; 0.2 bpm; p = 0.002), but there was no difference for 12 RM (&#916; 1:3 = 21.1 &#177; 2.2 bpm; &#916; 1:5 = 18.9 &#177; 2.0 bpm, p = 0.83). The RI influenced the variation in SBP in all loads (6 RM - &#916; 1:3 = 10.6 &#177; 0.9 mmHg, &#916; 1:5 = 6.6 &#177; 0.7 mmHg; p = 0.02 and 12 RM - &#916; 1:3 = 15.2 &#177; 1.1 mmHg, &#916; 1:5 = 8.4 &#177; 0.7 mmHg; p = 0.04). The RPP rose in proportion to the workload (p = 0.036) and to the sets (p &lt; 0.001), but in inverse proportion to the RI (p = 0.006). With RI = 1:3, there was difference in RPP for 6 RM (&#916; = 2,892 &#177; 189 mmHg.bpm) and 12 RM (&#916; = 4,587 &#177; 300 mmHg.bpm; p = 0.018), but not with RI = 1:5 (6 RM: &#916; = 1,224 &#177; 141 mmHg.bpm, 12 RM: &#916; = 2,332 &#177; 194 mmHg.bpm; p = 0.58).</p>
      <p><bold>CONCLUSION:</bold> Regardless of the workload, an increased RI was associated with lower cardiovascular responses during RE, especially of SBP.</p>
      <p><bold>Key words:</bold> Exercise; resistance training; heart rate: blood pressure.</p>
      <p>
        <bold>Introduction</bold>
      </p>
      <p>Resistance training causes significant increase in heart rate (HR) and blood pressure (BP)<sup>1,2</sup>. The adjustment of training variables can control these responses and change the cardiovascular overload during exercise<sup>2,3</sup>. Previous studies investigated the influence of several variables, such as speed of movement<sup>4</sup>, number of sets<sup>5</sup>, the intensity and number of repetitions<sup>2,6</sup>, the muscle mass involved<sup>2,7</sup>, the types of exercise<sup>1</sup> or training status<sup>8</sup>.</p>
      <p>However, there is scarce information about the influence of the rest interval between sets and exercises. Only one study specifically investigated the influence of this variable on HR and BP values<sup>9</sup>, identifying greater pressure response in sessions with shorter intervals. Ratamess et al<sup>10</sup> did not specifically measure the BP, but they did not find significant differences in HR responses to exercise done with different rest intervals. However, the gradual increase in pulse rate throughout the sets was more evident for shorter intervals.</p>
      <p>It is worth highlighting that these studies<sup>9,10</sup> applied fixed rest intervals. So, they did not consider the cumulative effect of muscle fatigue in the course of the sets. In practice, it is possible to notice that different exercises require different execution times, either due to their complexity or due to the required range of motion. We could argue, for example, that if the rest interval were proportional to the exercise execution time, there would be a smaller ratio of decrease in workload due to lower accumulated fatigue.</p>
      <p>Rest strategies with fixed time may not allow full recovery in consecutive sets, and this may intensify the increase in BP and HR<sup>5,9,11</sup>. It may be more appropriate to establish the rest interval according to the exercise execution time (or time under tension), depending on the overload with one is working. Unfortunately, it was not possible to find studies that have confirmed this hypothesis, which would be especially important in the context of training programs for patients at risk of cardiovascular complications.</p>
      <p>Thus, this study investigated the influence of two rest intervals established according to the time under tension, in multiple sets of resistance exercise, performed with different repetition maximums, by normotensive individuals, on acute responses of HR and systolic BP (SBP) and, consequently, of the rate-pressure product (RPP).</p>
      <p>
        <bold>Methods</bold>
      </p>
      <p>
        <bold>Sampling</bold>
      </p>
      <p>Twenty volunteers (26 &#177; 5 years; 70.9 &#177; 8.1 kg, 173.9 &#177; 7.0 cm), with 6 to 12 months of experience in resistance training, participated in this study.</p>
      <p>The following exclusion criteria were observed: a) use of drugs that could influence cardiovascular responses at rest or during exercise, b) musculoskeletal limitations that would cause the exercises to be contraindicated c) diagnosis of hypertension, heart disease or other cardiovascular problem that would cause the exercises to be contraindicated or which would influence the results.</p>
      <p>The study was approved by the Institutional Ethics Committee and all participants signed an informed consent form, as recommended by the National Health Council (Resolution 196/96).</p>
      <p>
        <bold>Determination of workloads - 6 and 12 repetition maximum (RM)</bold>
      </p>
      <p>Four visits were required for conducting the tests that established the workloads associated with the execution of 6 RM and 12 RM on the leg press, as well as for checking the reliability of the results obtained. The horizontal leg press was chosen because it involves large groups of muscles and, therefore, it supposedly has greater impact on blood pressure values. Moreover, it is an exercise that is easy to do, which is often included in exercise routines prescribed for patients with cardiovascular disease.</p>
      <p>Before the RM tests were conducted, the subjects performed a specific warm-up, which consisted in the execution of 12 repetitions with workload equivalent to 30% of the maximum workload predicted. Every day, the subjects could make up to 5 attempts to successfully complete the tests, with an interval of 5 min between each attempt.</p>
      <p>The tests of 6 RM and 12 RM were conducted on different days, with an interval of at least 48 h in between. The subjects were verbally stimulated so as to keep the high level of stimulation during the exercises. The weights used were previously weighed on a precision scale. If it was not possible to determine the workload associated with 6 RM or 12 RM by the 5<sup>th</sup> attempt, a new date was scheduled, also after an interval of at least 48 h. The reproducibility of the RM tests was tested by the intraclass correlation coefficient (ICC), and it proved to be satisfactory (6 RM ICC = 0.89; p &lt; 0.01 and 12 RM ICC = 0.85; p &lt; 0.01).</p>
      <p>
        <bold>Experimental protocol</bold>
      </p>
      <p>Once the 6 RM and 12 RM workloads had been determined, the subjects underwent 4 random protocols of exercises, in an order defined in a counterbalanced way. Each session took place on a specific day, with a total of other 4 visits to the laboratory, with intervals of 48 hours in between. All subjects performed the following procedures: a) three "6 RM" sets with interval of 1:3; b) three "6 RM" sets with interval of 1:5; c) three "12 RM" sets with interval of 1:3; and d) three "12 RM" sets with interval of 1:5.</p>
      <p>The subjects were instructed to observe the following recommendations before the exercise sessions: a) not to do any type of physical activity within 48 hours before the test; b) abstain from alcohol, caffeinated drinks or stimulants for 24 hours; c) make as little effort as possible during the trip to the laboratory.</p>
      <p>Before performing the protocols, the subjects remained seated for 10 minutes, in a calm and quiet environment. Then, the HR and BP at rest were measured and the average HR of the last two 2 minutes was recorded, and the average of two measurements of BP made in the same period was also recorded. Then, the subjects performed a warm-up of 12 repetitions with 30% of the expected workload for the session. After the warm-up, the subjects rested for 5 minutes and started the exercise.</p>
      <p>The cardiovascular variables were measured at rest and during the exercise, by using the same equipment, as described below:</p>
      <p>a) <italic>Rest</italic> - the individuals remained seated for 10 minutes. The HR was measured continuously and the average of the last two minutes was recorded, by using heart rate monitor Polar&#153; S810 (Kempele, Finland). The SBP and diastolic blood pressure (DBP) were measured twice, between the 8<sup>th</sup> and 10<sup>th</sup> minutes, by the indirect auscultatory method, with the use of a mercury column manometer Heidji&#153; (S&#227;o Paulo, Brazil). The standard of measurement followed the recommendations of the 5<sup>th</sup> Brazilian Guidelines on Hypertension<sup>12</sup>, with the measurements always made by the same observer, both at rest and during the exercise. The BP was measured in both arms and the largest measure was considered, in case of difference.</p>
      <p>b) <italic>Exercise</italic> - The HR was measured on a continuous basis, and the highest value presented at the end of the sets was recorded. For measuring the BP, the recommendations previously validated for measurement during resistance exercises<sup>13,14</sup> were observed, as detailed in <xref ref-type="fig" rid="en_12b01-body2">Box 1</xref>.</p>
      <p content-type="asset">
        <fig id="en_12b01-body2">
          <graphic xlink:href="1678-4170-abc-95-04-0493-00119-gf01-en.jpg"/></fig>
      </p>
      <p>In general, the valve opened before the end of the set, in order to record the systolic value between the last but one repetition and last repetition. A pilot measurement was made to determine the SBP peak value, so as to increase the pressure of the cuff to an approximate value of 30 mmHg higher, before the opening of the valve. The cuff was deflated at a rate of approximately 6 mmHg/s. The subjects were instructed not to curl their arms and to keep the left arm, used for the measurement, in supination, with elbows slightly flexed and supported on proper support. The measurements were made by the same trained observer, who was unaware of the purposes of this study.</p>
      <p>To determine the reliability of the BP measurement at rest, two measurements of BP were made, 10 minutes apart from each other, in 20 subjects (ICC = 0.93 for intra-observer SBP; ICC = 0.86 for inter-observer SBP). The reliability of the measurement during exercise was tested in two sessions, 48 hours apart from each other, in the same 20 subjects (ICC = 0.84 and p = 0.03 for intra-observer SBP; ICC = 0.82 and p = 0.022 for inter-observer SBP).</p>
      <p>In a previous study of validation<sup>14</sup>, there was evidence of a high correlation between the measurements made by auscultation and PPG, both at rest and in different repetition maximums for exercise of the lower limbs (p &lt;0.05) (rest: r = 0.89; 6 RM: r = 0.85; 15 RM: r = 0.88). Moreover, the percentage of match in the classification into tertiles of the measurements in all situations was always above 60%, reaching 75% for SBP during the exercise. The non-parametric association between the methods, considering the levels of classification by tertiles at rest, 6 RM and 12 RM, also produced high correlation coefficients of Gamma and Kruskall (&#947; = 0.77 - 0.97, p &lt; 0.05).</p>
      <p>
        <bold>Determination of the rest intervals between sets</bold>
      </p>
      <p>The duration of rest intervals between sets took into account the duration of the sets. The execution of the exercise was timed and the result was multiplied by three or 5, for determining an interval that would be in accordance, respectively, with the ratios of 1:3 or 1:5, between the execution time and rest time. To determine the execution time of the set, a progressive digital timer was used. The timer was started when the feet support platform moved and the timer was stopped when the platform touched its base at the end of the set.</p>
      <p>The timer allowed restarting the measurement in a simple way, by using the same button used to interrupt such timer, thereby allowing the definition of precise intervals. To make it easier to view the rest period (1:3 or 1:5) and to minimize the chance of error in the interval calculation, a previously prepared conversion table was used.</p>
      <p>
        <bold>Statistical analyses</bold>
      </p>
      <p>The Shapiro-Wilk test was used to verify the normality of the data and the Levene's test was used to confirm the equality of variances. The stability of SBP and HR values measured at rest, in each one of the sessions, was tested by means of a one-way ANOVA. The isolated and combined influence of factors observed (RM, sets and intervals) on RPP, HR and SBP was tested by means of a three-way ANOVA, followed by Fisher's post-hoc test, with the adoption of p <underline>&lt;</underline> 0.05 as a significance threshold. Software Statistica 6.0 (Statsoft&#153;, Tulsa, USA) was used on all calculations.</p>
      <p>
        <bold>Results</bold>
      </p>
      <p>There was no significant difference between the values of HR and SBP at rest measured in each one of the exercise sessions (F = 2.02; p = 0.78). Therefore, for analysis purposes, we adopted the lowest values obtained for these variables during the rest periods prior to exercise. The HR and SBP values during the sets proved to be always significantly higher than measurements taken at rest (F = 1.41 to 2.56; p = 0.027 to p = 0.039).</p>
      <p>It is also important to highlight that the double of repetitions maximum (6 RM and 12 RM) was not related to the same proportion of variation in the absolute work load (weight in kg). The ratio between the loads of 6 and 12 RM was only 12% or, in absolute terms, 7.5 &#177; 0.8 kg.</p>
      <p>The impact of the manipulated variables was different on HR and SBP. Thus, HR was significantly influenced by the isolated effect of the number of repetitions maximum (F = 7.33; p = 0.008) and the number of sets (F = 77.65; p &lt; 0.001), but not by the rest interval (F = 3.00; p = 0.087). However, the combined effect of the sets with the intervals proved to be significant (F = 4.87; p = 0.02). As for the SBP, the isolated and statistically stronger effect resided in the number of sets (F = 63.33; p &lt; 0.001), followed by the rest interval (F = 5.97; p = 0.017). The variable intensity had no significant independent effect (F = 0.042; p = 0.95).</p>
      <p><xref ref-type="fig" rid="en_12f01-body2">Figures 1</xref> and <xref ref-type="fig" rid="en_12f02-body2">2</xref> present the results of the post-hoc tests for HR and SBP. It was found that the influence of the number of sets systematically consisted in an increase in cardiovascular responses. On the other hand, the rest interval had the opposite influence and it even offset the cumulative effect of the sets in some cases, particularly with respect to SBP.</p>
      <p content-type="asset">
        <fig id="en_12f01-body2">
          <graphic xlink:href="1678-4170-abc-95-04-0493-00119-gf02-en.jpg"/></fig>
      </p>
      <p content-type="asset">
        <fig id="en_12f02-body2">
          <graphic xlink:href="1678-4170-abc-95-04-0493-00119-gf03-en.jpg"/></fig>
      </p>
      <p>We also compared the absolute variations in each situation, considering the peak values recorded between the first and third sets. With regard to HR, for 6 RM protocols, the variation in the sets with an interval of 1:3 was significantly higher than that the one observed in 1:5 (&#916; = 11.2 &#177; 1.1 bpm <italic>versus</italic> &#916; = 4.5 &#177; 0.2 bpm, respectively) (F = 9.98; p = 0.002). As to the 12 RM workload, there was no significant difference in the variation in HR in sets with an interval of 1:3 compared to the variation observed in the 1:5 interval (&#916; = 21.1 &#177; 2.2 bpm <italic>versus</italic> &#916; = 18.9 &#177; 2.0 bpm, respectively) (F = 0.58; p = 0.83). The variations in SBP between the 1<sup>st</sup> and 3<sup>rd</sup> sets were influenced by the rest interval, regardless of the load. In protocols with 6 RM, the variations for the intervals of 1:3 and 1:5 were, respectively, 10.6 &#177; 0.9 mmHg and 6.6 &#177; 0.7 mmHg (F = 6.67; p = 0.02). For protocols of 12 RM, the variation with the interval of 1:3 was of 15.2 &#177; 1.1 mmHg, and the variation with the interval of 1:5 was of 8.4 &#177; 0.7 mmHg (F = 5.12; p = 0.04).</p>
      <p>The results for SBP proved to be more sensitive to manipulation of the three training variables, considered separately or in combination. This reflected on the behavior of the RPP, in direct proportion to the number of repetitions maximum (F = 4.57, p = 0.036) and number of sets (F = 141.38, p &lt;0.001), and in inverse proportion to the interval between sets (F = 5.38, p = 0.006).</p>
      <p><xref ref-type="fig" rid="en_12f03-body2">Figure 3</xref> shows the results for the post hoc tests referring to the standard deviation.</p>
      <p content-type="asset">
        <fig id="en_12f03-body2">
          <graphic xlink:href="1678-4170-abc-95-04-0493-00119-gf04-en.jpg"/></fig>
      </p>
      <p>The variation between the first and third sets performed with an interval of 1:3 was of 2,892 &#177; 189 mmHg.bpm for 6 RM and 4,587 &#177; 300 mmHg.bpm for 12 RM (F = 4.17; p = 0.018). When we applied a longer interval (1:5), the variation in RPP for the 6 RM load was 1,224 &#177; 141 mmHg.bpm, while for 12 RM we obtained a delta of 2,332 &#177; 194 mmHg.bpm (F = 0.56; p = 0.58).</p>
      <p>
        <bold>Discussion</bold>
      </p>
      <p>This study compared the responses of HR, SBP and RPP during consecutive sets of resistance exercise, performed with different numbers of repetitions maximum and rest intervals, considering that these rest intervals were based on the total execution time of each set.</p>
      <p>Both HR and SBP increased significantly in the course of the sets, regardless of the intensity and rest interval. However, the cardiovascular responses associated with the horizontal leg press were minimized by manipulating the rest time: when the proportion was higher compared to the time under tension, the HR value and especially the SBP value were lower. The longer rest interval was also associated with lower rise in HR and SBP during the sets, in the two pre-determined intensities. Thus, the exercise done with longer rest interval caused less cardiovascular stress for both intensities tested.</p>
      <p>Interestingly, the average peak SBP value in the last sets of the study conducted by Gotshall et al<sup>5</sup>, measured by photoplethysmography, was 293 &#177; 21 mmHg, which is well above the value recorded in the last set of this study (181 &#177; 16 mmHg for the 12 RM protocol with progressive interval in the 1:3 ratio). This difference can be attributed to the time under tension in each set (one minute in the study conducted by Gotshall et al<sup>5</sup><italic>versus</italic> 24 seconds in this study), but also, and perhaps mainly, to the BP measurement. As we known, even though the auscultatory method is suitable for comparing different resistance-exercise protocols, when such method is used on an inactive limb, it may underestimate absolute pressure values<sup>14,15</sup>. In other words, the auscultatory method is extremely useful in practical situations and it has proved valid and reproducible to indicate differences in BP responses to resistance exercise. Thus, this method is a useful strategy to develop training sessions with lower cardiovascular overload. Moreover, the auscultatory method should not be used to accurately establish blood pressure values during resistance exercise.</p>
      <p>Studies that examine in detail the influence of rest intervals between sets and exercises on the behavior of BP and HR are relatively scarce. It was not possible to find studies that investigated the matter by adopting an approach similar to the one taken in this study.</p>
      <p>Polito et al<sup>9</sup> had young normotensive individuals do 4 sets of 8 RM, separated by fixed intervals of one and two minutes, and they also found higher values of blood pressure for the sequence with the shortest interval. The most pronounced cardiovascular responses at short rest intervals can be associated with lower systemic recovery from the stress generated by the exercise. The accumulation of metabolites, with consequent nerve stimulation via mechanical and chemical receptors, may potentiate these responses<sup>16</sup>.</p>
      <p>In this sense, Ratamess et al<sup>10</sup> observed the effects of different fixed rest intervals (30s, one, two, three and five minutes) on cardiovascular and metabolic responses throughout the course of 5 sets in two training intensities (5 RM and 10 RM), in the bench press exercise. No difference was found between the rest intervals, considering the peak values of HR in both training intensities. However, there was significant increase in HR as the sets were performed (p &lt; 0.05), mainly for shorter rest intervals. The production of lactate was also higher for shorter rest intervals, which is suggestive of the relationship between accumulated fatigue due to insufficient rest and cardiovascular responses.</p>
      <p>Our results indicated that the workload can also independently influence the responses of HR and SBP. By comparison with the protocol with a workload of 12 RM, the sets done with 6 RM had less impact on the cardiovascular responses for similar rest intervals. There may be a relationship between the time under tension (6 RM = 17 &#177; 3 s <italic>versus</italic> 12 RM = 29 &#177; 5 s) and such results. This possibility confirms the results reported by Lamotte et al<sup>17</sup>, who analyzed the effect of the execution of leg extension exercise in a leg extension machine, with workloads equivalent to 40% and 70% of an RM (4 sets with one-minute interval between sets), on the responses of HR and BP in patients with heart disease. The sets involving the intensity of 40% lasted 34s on average (for 17 repetitions) against 20s of the set done with 70% of the maximum workload (for 10 repetitions). There was a significant difference for the peak values of SBP, with higher cardiac overload for the protocol of lower intensity (p &lt; 0.01). There was a cumulative effect of the sets on blood pressure (p &lt; 0.01), which was attributed by the authors to the short rest interval applied.</p>
      <p>In the present study, there was also a cumulative effect of the sets on HR and SBP responses, with greater increase from the second set onwards, especially for a shorter effort-rest interval. Similarly, Gotshall et al<sup>5</sup> had three young and healthy individuals do three sets of 10 RM in the bilateral leg press (fixed rest interval of three minutes; speed of three seconds in the concentric and eccentric phases). At the end of each set, the values of SBP and DBP always proved to be significantly higher than the ones observed in the previous sets. Other studies have demonstrated that there is influence of the number of sets on cardiovascular responses<sup>2,17</sup>.</p>
      <p>Two factors may be in the origin of the results referring to the cumulative effect of consecutive sets on cardiovascular responses. The first one would result from the fatigue accumulated due to the shorter rest time<sup>18</sup>. The second one takes into account the time under tension: the dynamic resistance exercise causes occlusion of blood vessels and it may, depending on its intensity and duration, lead to a compensatory baroreflex response, which is more common in exercises done until fatigue<sup>19,20</sup>.</p>
      <p>The hemodynamic responses to muscular work in resistance exercises can also be linked to increased sympathetic activity and decreased parasympathetic activity, due to the greater activation of central command and muscle and joint mechanoreceptors<sup>16</sup>. The central mechanism involves the transmission of impulses from the motor cortex to the cardiovascular control center. On the other hand, the peripheral mechanism consists of a reflex pathway with multiple control bases<sup>21</sup>. The increased peripheral vascular resistance, caused by partial occlusion of blood flow, contributes to an imbalance between supply and demand of O<sub>2</sub> in tissue. In fact, starting from 15% of the maximum voluntary contraction, it is possible to notice progressive obstruction of muscle blood flow<sup>22</sup>. As a result, the removal of metabolites (lactate, hydrogen, phosphate, adenosine, potassium etc) is hindered, by the stimulation of chemoreceptors to increase sympathetic nervous activity<sup>16</sup>.</p>
      <p>Finally, the increase in blood pressure could also be influenced by the number of motor units requested. In this case, muscle and joint mechanoreceptors, sensitive to the increase in voluntary strength (recruitment of motor units) and the load on the joints, inform the cardiovascular control center about the need to modify the cardiovascular responses to regulate the flow<sup>23</sup>.</p>
      <p>The increased peripheral vascular resistance associated with arterial occlusion during exercise is another factor to be considered. The leg press exercise, besides involving several major muscle groups, is also done in a posture that can hinder the perfusion of blood into active muscles, since the course of the main arteries that irrigate such muscles is changed by the hip flexion<sup>24</sup>. This problem is even greater during the transition from the concentric phase to the eccentric phase. In this context, the activation of baroreceptors and chemoreceptors may lead to a compensatory blood pressure response, so as to reach a satisfactory cardiac output during exercise.</p>
      <p>Therefore, the cardiovascular responses to resistance exercise may be associated with the central adaptation resulting from the greater peripheral resistance. The increased need for perfusion is likely to be directly related to the inotropic capacity of the heart, since changes in HR tend to be slower than changes in SBP<sup>25</sup>. By the way, this pressure overload associated with resistance exercise can be beneficial from the standpoint of prophylaxis, especially for patients with chronic cardiovascular disease and users of anti-hypertensive medication<sup>26</sup>. Some studies have reported that coronary patients, under pharmacological treatment, can do resistance exercise of moderate intensity and the results of this practice include the improvement in global left ventricular function, especially of the ejection fraction<sup>26,27</sup>.</p>
      <p>As for the rise in HR, the time under tension seems to exert important influence. Hunter et al<sup>28</sup> compared the metabolic responses and heart rate responses to 10 exercises done at two speeds of contraction, a 'traditional' speed (2 sets of 8 repetitions with 65% of one RM, speed of execution of one second for the concentric phase and eccentric phase, one minute of rest) and a 'super slow' speed (2 sets of 8 repetitions with 25% of one RM, execution speed of 10s for the concentric phase and 5s for the eccentric phase, with the same interval and number of exercises). It was found that the 'traditional' protocol led to a significantly higher increase in HR compared to the 'super slow' protocol (143 &#177; 8 bpm against 113 &#177; 12 bpm).</p>
      <p>Kleiner et al<sup>4</sup> studied the acute cardiovascular response in isokinetic exercises in 6 subjects that did knee extension exercises at three execution speeds (50, 100 and 200&#176;/s) until fatigue (70% of peak torque). There were no significant differences in HR, SBP, DBP and RPP values. However, at programmed speeds, the HR values varied between 163.3 &#177; 28.4 bpm (50&#186;/s) and 183.5 &#177; 16.8 bpm (200&#186;/s). In contrast, the SBP values were higher for a lower angular speed (SBP = 348.2 &#177; 18.1 mmHg for 50&#186;/s <italic>versus</italic> SBP = 335.5 &#177; 27.4 mmHg for 200&#186;/s), with influence on RPP (50&#186;/s = 56,861 &#177; 514 mmHg.bpm; 100&#186;/s = 58,875 &#177; 479 mmHg.bpm; 200&#186;/s = 61,564 &#177; 460 mmHg.bpm). The authors explain that their results are justified by the characteristic of the sessions, with the number of repeats varying among 30 (50&#186;/s), 80 (100&#186;/s) and 140 (200&#186;/s).</p>
      <p>As the protocols at higher speed offer less resistance, and, as a significantly greater amount of repetitions was produced, the execution of the exercise would have gotten close to what is found in continuous dynamic exercises of long duration, with greater impact on the HR. On the other hand, the increase in SBP for lower speeds would be related to the greater production of force, compared to the higher angular speeds.</p>
      <p>In general, it is not prudent to extrapolate results of isokinetic exercises to dynamic isotonic exercises. However, it is important to note that the effect of 'time under tension' on HR is confirmed by the results of Kleiner et al<sup>4</sup>, and it is also clear that SBP values are sensitive to the tension produced, with strong influence on the RPP.</p>
      <p>Another example is found in the study conducted by Kawano et al<sup>29</sup>, who had young and middle-aged normotensive patients do a set of leg press exercises at three levels of intensity (40%, 60% and 80% of one RM). There was no difference in the HR values at the levels of intensity tested, in any of the groups. However, the peak pressure values of young subjects was higher than the values of middle-aged subjects, for all intensities, and significantly higher only for the intensity of 80% of one RM (young subjects = 190 mmHg <italic>versus</italic> middle-aged subjects = 150 mmHg, p &lt; 0.05). The variation in SBP compared to rest (&#916;) was significant for all intensities, and it was greater among young subjects, perhaps because their values at rest were generally lower (40% RM: young subjects = 34 mmHg <italic>versus</italic> middle-aged subjects = 18 mmHg; 60% RM: young subjects = 54 mmHg <italic>versus</italic> middle-aged subjects = 31 mmHg; 80% RM: young subjects = 73 mmHg <italic>versus</italic> middle-aged subjects = 42 mmHg; p &lt; 0.05).</p>
      <p>One may infer from these results that the single measurement of HR may not be sufficient to properly assess the cardiovascular overload produced by the resistance exercise. Therefore, we encourage the measurement of BP during the development of resistance training programs, especially for subjects in whom it is desirable to keep these responses under control (patients in cardiac rehabilitation, for example). That is why the protocol for measuring blood pressure during resistance exercise by the auscultation method, proposed by Polito and Farinatti<sup>13</sup> and subsequently validated<sup>14</sup>, appears to be a viable and accessible option to most training centers.</p>
      <p>In conclusion, multiple sets of resistance exercises for lower limbs cause significant and cumulative increase in cardiovascular responses, especially of BP, with an impact on the RPP. The level of cardiovascular stress associated with exercise did not depend only on the workload defined in terms of maximum repetitions, but also on the other training variables, especially the number of sets. On the other hand, longer rest intervals between sets contributed significantly to the reduction in RPP, BP and HR responses, while the workload and volume of training remained unchanged. The ratio between stimulation time and rest time, by itself, caused significant changes in cardiovascular responses, regardless of the maximum number of repetitions performed. Thus, the planning of rest intervals during the preparation of resistance training sessions appears to be a clinically important aspect for improving safety in such practice, especially in populations that are at a higher cardiovascular risk.</p>
      <p>Further studies should be conducted to compare the hemodynamic responses associated with different strategies for the effort-rest ratio (fixed intervals, progressive intervals, division of sets, alternation of segments, etc). Such investigations are important to establish the most effective method to minimize the cardiovascular overload associated with multiple sets of resistance exercises, while the workload at training sessions is kept high.</p>
      <p>
        <bold>Acknowledgments</bold>
      </p>
      <p>This study was partially funded by CNPq (proceedings number 305729/2006-3) and by FAPERJ (proceedings E26/102.916/2008).</p>
      <p>
        <bold>Potential Conflict of Interest</bold>
      </p>
      <p>No potential conflict of interest relevant to this article was reported.</p>
      <p>
        <bold>Sources of Funding</bold>
      </p>
      <p>This study was partially funded by CNPq and by FAPERJ.</p>
      <p>
        <bold>Study Association</bold>
      </p>
      <p>This study is not associated with any post-graduation program.</p>
      <p>
        <bold>References</bold>
      </p>
    </body>
  </sub-article>
  <sub-article article-type="translation" id="TRes" xml:lang="es">
    <front-stub>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Art&#237;culos Originales</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title xml:lang="es">Respuestas cardiovasculares al ejercicio de resistencia son afectadas por la carga e intervalos entre series</article-title>
      </title-group>
      <abstract xml:lang="es">
        <p>FUNDAMENTO: El control de las respuestas cardiovasculares durante ejercicio de resistencia (ER) es importante para la seguridad del paciente. OBJETIVO: Investigar la influencia del n&#250;mero de repeticiones m&#225;ximas (RM) y de los intervalos de recuperaci&#243;n entre series (IR) sobre la frecuencia card&#237;aca (FC), presi&#243;n arterial sist&#243;lica (PAS) y doble producto (DP) durante ER. M&#201;TODOS: Veinte sujetos sanos (26 &#177; 5 a&#241;os) realizaron protocolos de ER comprendiendo tres series del leg press (6 y 12 RM) y IR proporcional al tiempo de contracci&#243;n (1:3 y 1:5). Se midi&#243; la FC continuamente con cardiofrecuenc&#237;metro y la PAS fue verificada al final de las series, por medio de protocolo validado con m&#233;todo auscultatorio. RESULTADOS: La FC sufri&#243; influencia de la carga (p = 0,008) y de las series (p &lt; 0,001), pero no del IR (p = 0,087). La PAS sufri&#243; efecto aislado del n&#250;mero de series (p &lt; 0,001) y del IR (p = 0,017), pero no de la carga (p = 0,95). El DP se elev&#243; en relaci&#243;n directa con la carga (p = 0,036) y con las series (p &lt; 0,001), pero inversamente al IR (p = 0,006). En los protocolos de 6 RM, la variaci&#243;n de la FC fue mayor para IR = 1:3 (&#916; = 11,2 &#177; 1,1 lpm) que para IR = 1:5 (&#916; = 4,5 &#177; 0,2 lpm; p = 0,002), pero no hubo diferencia para 12 RM (&#916; 1:3 = 21,1 &#177; 2,2 lpm; &#916; 1:5 = 18,9 &#177; 2,0 lpm, p = 0,83). El IR influenci&#243; la variaci&#243;n de la PAS en todas las cargas (6 RM - &#916; 1:3 = 10,6 &#177; 0,9 mmHg, &#916; 1:5 = 6,6 &#177; 0,7 mmHg; p = 0,02 y 12 RM - &#916; 1:3 = 15,2 &#177; 1,1 mmHg, &#916; 1:5 = 8,4 &#177; 0,7 mmHg; p = 0,04). El DP se elev&#243; proporcionalmente a la carga (p = 0,036) y para series (p &lt; 0,001), pero inversamente al IR (p = 0,006). Con IR = 1:3, hubo diferencia de DP para 6 RM (&#916; = 2.892 &#177; 189 mmHg.lpm) y 12 RM (&#916; = 4.587 &#177; 300 mmHg.lpm; p = 0,018), pero no con IR = 1:5 (6 RM: &#916; = 1.224 &#177; 141 mmHg.lpm, 12 RM: &#916; = 2.332 &#177; 194 mmHg.lpm; p = 0,58). CONCLUSI&#211;N: Independientemente de la carga, un mayor IR se asoci&#243; a menores respuestas cardiovasculares durante ER, especialmente de PAS.</p>
      </abstract>
      <kwd-group xml:lang="es">
        <kwd>Ejercicio</kwd>
        <kwd>entrenamiento de resistencia</kwd>
        <kwd>frecuencia card&#237;aca</kwd>
        <kwd>presi&#243;n arterial</kwd>
      </kwd-group>
    </front-stub>
    <body>
      <p>
        <bold>ART&#205;CULO ORIGINAL</bold>
      </p>
      <p>
        <fn id="top-body3">
          <label>
            <bold>Respuestas cardiovasculares al ejercicio de resistencia son afectadas por la carga e intervalos entre series</bold>
          </label>
          <p>
            <bold>Antonio Gil Castinheiras-Neto<sup>I</sup>; Irineu Rodrigues da Costa-Filho<sup>I</sup>; Paulo Tarso Veras Farinatti<sup>I, II</sup></bold>
          </p>
        </fn>
      </p>
      <p><sup>I</sup>Programa de P&#243;s-Gradua&#231;&#227;o em Ci&#234;ncias da Atividade F&#237;sica - Universidade Salgado de Oliveira, Niter&#243;i, RJ - Brasil</p>
      <p><sup>II</sup>Instituo de Educa&#231;&#227;o F&#237;sica e Desportos - Laborat&#243;rio de Atividade F&#237;sica e Promo&#231;&#227;o da Sa&#250;de - Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ - Brasil</p>
      <p>Correspondencia</p>
      <p>
        <bold>RESUMEN</bold>
      </p>
      <p><bold>FUNDAMENTO:</bold> El control de las respuestas cardiovasculares durante ejercicio de resistencia (ER) es importante para la seguridad del paciente.</p>
      <p><bold>OBJETIVO:</bold> Investigar la influencia del n&#250;mero de repeticiones m&#225;ximas (RM) y de los intervalos de recuperaci&#243;n entre series (IR) sobre la frecuencia card&#237;aca (FC), presi&#243;n arterial sist&#243;lica (PAS) y doble producto (DP) durante ER.</p>
      <p> M&#201;TODOS: Veinte sujetos sanos (26 &#177; 5 a&#241;os) realizaron protocolos de ER comprendiendo tres series del leg press (6 y 12 RM) y IR proporcional al tiempo de contracci&#243;n (1:3 y 1:5). Se midi&#243; la FC continuamente con cardiofrecuenc&#237;metro y la PAS fue verificada al final de las series, por medio de protocolo validado con m&#233;todo auscultatorio.</p>
      <p><bold>RESULTADOS:</bold> La FC sufri&#243; influencia de la carga (p = 0,008) y de las series (p &lt; 0,001), pero no del IR (p = 0,087). La PAS sufri&#243; efecto aislado del n&#250;mero de series (p &lt; 0,001) y del IR (p = 0,017), pero no de la carga (p = 0,95). El DP se elev&#243; en relaci&#243;n directa con la carga (p = 0,036) y con las series (p &lt; 0,001), pero inversamente al IR (p = 0,006). En los protocolos de 6 RM, la variaci&#243;n de la FC fue mayor para IR = 1:3 (&#916; = 11,2 &#177; 1,1 lpm) que para IR = 1:5 (&#916; = 4,5 &#177; 0,2 lpm; p = 0,002), pero no hubo diferencia para 12 RM (&#916; 1:3 = 21,1 &#177; 2,2 lpm; &#916; 1:5 = 18,9 &#177; 2,0 lpm, p = 0,83). El IR influenci&#243; la variaci&#243;n de la PAS en todas las cargas (6 RM - &#916; 1:3 = 10,6 &#177; 0,9 mmHg, &#916; 1:5 = 6,6 &#177; 0,7 mmHg; p = 0,02 y 12 RM - &#916; 1:3 = 15,2 &#177; 1,1 mmHg, &#916; 1:5 = 8,4 &#177; 0,7 mmHg; p = 0,04). El DP se elev&#243; proporcionalmente a la carga (p = 0,036) y para series (p &lt; 0,001), pero inversamente al IR (p = 0,006). Con IR = 1:3, hubo diferencia de DP para 6 RM (&#916; = 2.892 &#177; 189 mmHg.lpm) y 12 RM (&#916; = 4.587 &#177; 300 mmHg.lpm; p = 0,018), pero no con IR = 1:5 (6 RM: &#916; = 1.224 &#177; 141 mmHg.lpm, 12 RM: &#916; = 2.332 &#177; 194 mmHg.lpm; p = 0,58).</p>
      <p><bold>CONCLUSI&#211;N:</bold> Independientemente de la carga, un mayor IR se asoci&#243; a menores respuestas cardiovasculares durante ER, especialmente de PAS.</p>
      <p><bold>Palabras clave:</bold> Ejercicio, entrenamiento de resistencia; frecuencia card&#237;aca, presi&#243;n arterial.</p>
      <p>
        <bold>Introducci&#243;n</bold>
      </p>
      <p>El entrenamiento de resistencia acarrea elevaci&#243;n importante de la frecuencia card&#237;aca (FC) y presi&#243;n arterial (PA)<sup>1,2</sup>. La manipulaci&#243;n de variables del entrenamiento puede controlar esas respuestas, modificando la sobrecarga cardiovascular durante los ejercicios<sup>2,3</sup>. Estudios previos investigaron la influencia de diversas variables, como la velocidad de movimiento<sup>4</sup>, el n&#250;mero de series<sup>5</sup>, la intensidad y el n&#250;mero de repeticiones<sup>2,6</sup>, la masa muscular comprendida<sup>2,7</sup>, los tipos de ejercicio<sup>1</sup> o el estado de entrenamiento<sup>8</sup>.</p>
      <p>Mientras tanto, son escasas las informaciones sobre la influencia del intervalo de recuperaci&#243;n entre series y ejercicios. Apenas un estudio investig&#243; espec&#237;ficamente la influencia de tal variable sobre los valores de FC y PA<sup>9</sup>, identificando mayor respuesta pres&#243;rica en sesiones con intervalos m&#225;s cortos. Ratamess et al<sup>10</sup> no midieron espec&#237;ficamente la PA, pero no identificaron diferencias significativas en las respuestas de FC a ejercicio hecho con diferentes intervalos de recuperaci&#243;n. Sin embargo, el aumento progresivo de la pulsaci&#243;n a lo largo de las series fue m&#225;s evidente para intervalos m&#225;s cortos.</p>
      <p>Vale resaltar que esos estudios<sup>9,10</sup> aplicaron intervalos de recuperaci&#243;n fijos. As&#237;, no consideraron el efecto acumulativo de la fatiga muscular en el transcurso de las series. En la pr&#225;ctica, se percibe que diferentes ejercicios necesitan de tiempo de ejecuci&#243;n variable, ya sea por la complejidad o por la amplitud requerida del movimiento. Se puede pensar, por ejemplo, que, si el intervalo de recuperaci&#243;n fuese proporcional al tiempo de ejecuci&#243;n del ejercicio, ocurrir&#237;a una menor raz&#243;n de la disminuci&#243;n de la carga en virtud de menor fatiga acumulada.</p>
      <p>Estrategias de recuperaci&#243;n con tiempo fijo pueden no permitir plena recuperaci&#243;n en series consecutivas, lo que puede potencializar el aumento de PA y FC<sup>5,9,11</sup>. Fijar el intervalo de recuperaci&#243;n con base en el tiempo de ejecuci&#243;n del ejercicio (o tiempo de tensi&#243;n) puede ser m&#225;s adecuado, dependiendo de la sobrecarga con que se trabaja. Infelizmente, no fue posible encontrar estudios que hayan confirmado esa hip&#243;tesis, lo que ser&#237;a especialmente importante en el &#225;mbito de programas de entrenamiento para pacientes con riesgo de intercurrencia cardiovascular.</p>
      <p>De ese modo, el presente estudio investig&#243; la influencia de dos intervalos de recuperaci&#243;n, establecidos con base en el tiempo de tensi&#243;n, en series m&#250;ltiples de ejercicio de resistencia, realizado con diferentes repeticiones m&#225;ximas, por individuos normotensos, sobre las respuestas agudas de FC y PA sist&#243;lica (PAS) y, consecuentemente, del doble producto (DP).</p>
      <p>
        <bold>M&#233;todos</bold>
      </p>
      <p>
        <bold>Muestra</bold>
      </p>
      <p>Veinte volunt&#225;rios (26 &#177; 5 a&#241;os; 70,9 &#177; 8,1 kg; 173,9 &#177; 7,0 cm), con experiencia previa de 6-12 meses en entrenamiento de resistencia, participaron del estudio.</p>
      <p>Los siguientes criterios de exclusi&#243;n fueron observados: a) utilizaci&#243;n de drogas que pudiesen influenciar las respuestas cardiovasculares en reposo o ejercicio; b) limitaciones osteomioarticulares que contraindicasen la realizaci&#243;n de los ejercicios; c) diagn&#243;stico de hipertensi&#243;n, enfermedad card&#237;aca u otro compromiso cardiovascular que contraindicase la realizaci&#243;n de los ejercicios o influenciase en los resultados.</p>
      <p>El estudio fue aprobado por comit&#233; de &#233;tica institucional y todos los participantes firmaron t&#233;rmino de consentimiento libre y aclarado, seg&#250;n recomendado por el Consejo Nacional de Salud (Resoluci&#243;n 196/96).</p>
      <p>
        <bold>Determinaci&#243;n de las cargas - 6 y 12 repeticiones m&#225;ximas (RM)</bold>
      </p>
      <p>Fueron necesarias 4 visitas para la realizaci&#243;n de los tests que establecieron las cargas asociadas a la ejecuci&#243;n de 6 RM y 12 RM en el leg press, as&#237; como verificar la confiabilidad de los resultados medidos. La elecci&#243;n del leg press horizontal fue motivada por el hecho de envolver grandes grupos musculares y, por lo tanto, sugerir mayor impacto sobre los valores de presi&#243;n arterial. Adem&#225;s de eso, se trata de un ejercicio de f&#225;cil ejecuci&#243;n, frecuentemente incluido en las rutinas de prescripci&#243;n de ejercicios para pacientes con enfermedad cardiovascular.</p>
      <p>Antes de la realizaci&#243;n de los tests de RM, fue realizado calentamiento espec&#237;fico, que consisti&#243; en la ejecuci&#243;n de 12 repeticiones con carga equivalente a 30% de la carga m&#225;xima predicha. En cada d&#237;a, los sujetos tuvieron hasta 5 tentativas para concluir con &#233;xito los tests, con intervalo de 5 min. entre cada tentativa.</p>
      <p>Los tests de 6 RM y 12 RM fueron realizados en d&#237;as diferentes, espaciados por por lo menos 48 h. Est&#237;mulos verbales fueron usados para mantener elevado el nivel de estimulaci&#243;n durante los ejercicios. Los pesos utilizados fueron previamente medidos en balanza de precisi&#243;n. En el caso de que no fuese posible establecer la carga asociada a las 6 RM o 12 RM hasta la 5&#170; tentativa, una nueva fecha era marcada, respet&#225;ndose igualmente un intervalo de por lo menos 48 h. La reproductibilidad de los tests de RM fue testeada por el coeficiente de correlaci&#243;n intraclase, revel&#225;ndose satisfactoria (ICC 6 RM = 0,89; p &lt; 0,01 y ICC 12 RM = 0,85; p &lt; 0,01).</p>
      <p>
        <bold>Protocolo experimental</bold>
      </p>
      <p>Una vez determinadas las cargas de 6 RM y 12 RM, los sujetos realizaron 4 protocolos aleatorios de ejercicios, en orden definido de forma contrabalanceada. Cada sesi&#243;n tuvo lugar en d&#237;a espec&#237;fico, realizando un total de 4 visitas m&#225;s al laboratorio, espaciadas por intervalos de 48 horas. Todos los sujetos ejecutaron los siguientes procedimientos: a) tres series de 6 RM con intervalo de 1:3; b) tres series de 6 RM con intervalo de 1:5; c) tres series de 12 RM con intervalo de 1:3; y d) tres series de 12 RM con intervalo de 1:5.</p>
      <p>Los sujetos fueron instruidos a respetar las siguientes recomendaciones antes de las sesiones de ejercicios: a) no practicar ning&#250;n tipo de actividad f&#237;sica en las 48 h precedentes; b) abstinencia de bebidas alcoh&#243;licas, con cafe&#237;na o estimulantes por 24 h; y c) realizar el m&#237;nimo de esfuerzo en el desplazamiento hasta el laboratorio.</p>
      <p>Antes de la ejecuci&#243;n de los protocolos, los sujetos permanec&#237;an 10 min. sentados, en ambiente calmo y silencioso. La FC y la PA en reposo eran entonces medidas, registr&#225;ndose la media de los &#250;ltimos dos minutos para la FC, y la media de dos medidas realizadas en el mismo per&#237;odo para la PA. Enseguida, era hecho un calentamiento de 12 repeticiones con 30% de la carga prevista para la sesi&#243;n. Despu&#233;s del calentamiento, los sujetos descansaban 5 minutos e iniciaban el ejercicio.</p>
      <p>La medici&#243;n de las variables cardiovasculares fue hecha en las condiciones de reposo y en ejercicio, con auxilio de los mismos equipamientos, seg&#250;n descripto a seguir:</p>
      <p><italic>a) Reposo -</italic> los individuos permanecieron sentados por 10 minutos. La FC fue medida continuamente, siendo registrada la media de los &#250;ltimos dos minutos, con uso de un cardiofrecuenc&#237;metro Polar<sup>&#174;</sup> S810 (Kempele, Finlandia). La PAS y la presi&#243;n arterial diast&#243;lica (PAD) fueron medidas dos veces, entre el 8&#186; y 10&#186; minuto, por el m&#233;todo indirecto auscultatorio, con auxilio de un man&#243;metro tipo columna de mercurio Heidji<sup>&#174;</sup> (S&#227;o Paulo, Brasil). El est&#225;ndar de medida sigui&#243; las recomendaciones de las V Directrices Brasile&#241;as de Hipertensi&#243;n Arterial<sup>12</sup>, siendo realizado siempre por el mismo evaluador, tanto en reposo como en ejercicio. La PA fue medida en ambos brazos, siendo considerada la mayor medida en caso de diferencia.</p>
      <p><italic>b) Ejercicio -</italic> La FC fue medida continuamente, siendo registrado el mayor valor presentado al final de las series. Para medida de la PA, se respetaron recomendaciones previamente validadas para medici&#243;n durante ejercicios de resistencia<sup>13,14</sup>, seg&#250;n detallado en el <xref ref-type="fig" rid="es_12c01-body3">Cuadro 1</xref>.</p>
      <p content-type="asset">
        <fig id="es_12c01-body3">
          <graphic xlink:href="1678-4170-abc-95-04-0493-00119-gf01-es.jpg"/></fig>
      </p>
      <p>En l&#237;neas generales, la apertura de la v&#225;lvula ocurr&#237;a antes del t&#233;rmino de la serie, de forma de registrar el valor sist&#243;lico entre la pen&#250;ltima y la &#250;ltima repetici&#243;n. Una medici&#243;n piloto era hecha para determinar el valor de pico de la PAS, a fin de que se elevase la presi&#243;n del manguito a un valor aproximado de 30 mmHg mayor, antes de la apertura de la v&#225;lvula. El vaciado del manguito se dio a una tasa aproximada de 6 mmHg/s. Los sujetos fueron orientados a no contraer los brazos, manteniendo el brazo izquierdo utilizado para la medida en la posici&#243;n de supinaci&#243;n, con codo levemente flexionado y apoyado en soporte propio. Las medidas fueron hechas siempre por el mismo evaluador entrenado, que no ten&#237;a conocimiento de los objetivos del presente estudio.</p>
      <p>Para la determinaci&#243;n de la confiabilidad de la medida de la PA en reposo, fueron hechas dos medidas de la PA, con intervalo de 10 minutos, en 20 sujetos (ICC = 0,93 para PAS intra-evaluador; ICC = 0,86 para PAS inter-evaluador). La confiabilidad de la medida durante el ejercicio fue testeada en dos sesiones separadas por 48 h, en los mismos 20 sujetos (ICC = 0,84 y p = 0,03 para PAS intra-evaluador; ICC = 0,82 y p = 0,022 para PAS inter-evaluador).</p>
      <p>En estudio previo de validaci&#243;n<sup>14</sup>, se constat&#243; una elevada correlaci&#243;n entre las medidas tomadas por auscultaci&#243;n y fotopletismograf&#237;a, tanto en reposo como en diferentes repeticiones m&#225;ximas para ejercicio de miembros inferiores (p &lt; 0,05) (reposo: r = 0,89; 6 RM: r = 0,85; 15 RM: r = 0,88). Adem&#225;s de eso, el porcentaje de concordancia en la clasificaci&#243;n en terciles de las medidas en todas las situaciones estuvo siempre encima de 60%, llegando a 75% para la PAS durante el ejercicio. La asociaci&#243;n no param&#233;trica entre los m&#233;todos, considerando los niveles de clasificaci&#243;n por terciles en reposo, 6 RM y 12 RM, tambi&#233;n produjo elevados coeficientes de correlaci&#243;n de Gamma y Kruskall (&#947; = 0,77 - 0,97, p &lt; 0,05).</p>
      <p>
        <bold>Determinaci&#243;n de los intervalos de recuperaci&#243;n entre series</bold>
      </p>
      <p>La duraci&#243;n de los intervalos de recuperaci&#243;n entre series tuvo en consideraci&#243;n la duraci&#243;n de estas &#250;ltimas. La ejecuci&#243;n del ejercicio era cronometrada y el resultado multiplicado por tres o 5, para la determinaci&#243;n de un intervalo que respetase, respectivamente, proporciones de 1:3 o 1:5, entre tiempo de ejecuci&#243;n y tiempo de recuperaci&#243;n. Para la obtenci&#243;n del tiempo de ejecuci&#243;n de las series, fue utilizado cron&#243;metro digital con funci&#243;n progresiva. El cron&#243;metro fue accionado en el momento en que hab&#237;a desplazamiento de la plataforma de apoyo de los pies y era interrumpido cuando esta tocaba en su base al final de la serie.</p>
      <p>El cron&#243;metro permit&#237;a reiniciar la medida de forma simple, con el mismo bot&#243;n de su interrupci&#243;n, lo que permiti&#243; que se estipulasen intervalos precisos. Para facilitar la visualizaci&#243;n del per&#237;odo de recuperaci&#243;n (1:3 o 1:5) y minimizar la posibilidad de error en el c&#225;lculo del intervalo, fue utilizada tabla de conversi&#243;n previamente elaborada.</p>
      <p>
        <bold>Tratamiento de los resultados</bold>
      </p>
      <p>El test de Shapiro-Wilk fue utilizado para verificar la normalidad de los datos y el test de Levene para confirmaci&#243;n de la homogeneidad de variancias. La estabilidad de los valores de FC y PAS medidos durante el reposo, en cada una de las sesiones, fue testeada con auxilio de ANOVA de una entrada. La influencia aislada y combinada de los factores observados (RM, series y intervalos) sobre DP, FC y PAS fue testeada con ANOVA de tres entradas, seguida de test post hoc de Fisher, adopt&#225;ndose como umbral de significancia un valor de p <underline>&lt;</underline> 0,05. El <italic>software</italic> Statistica 6.0 (Statsoft<sup>&#174;</sup>, Tulsa, EUA) fue utilizado en todos los c&#225;lculos.</p>
      <p>
        <bold>Resultados</bold>
      </p>
      <p>No hubo diferencia significativa entre los valores de FC y PAS de reposo medidos en cada una de las sesiones de ejercicios (F = 2,02; p = 0,78). Para fines de an&#225;lisis, por lo tanto, fueron adoptados los menores valores obtenidos para esas variables en los per&#237;odos de reposo pre ejercicio. Los valores de FC y PAS durante las series se revelaron siempre significativamente superiores a las medidas tomadas durante el reposo (F = 1,41 la 2,56; p = 0,027 la p = 0,039).</p>
      <p>Vale resaltar aun que el doble del n&#250;mero de repeticiones m&#225;ximas (6 RM y 12 RM) no estuvo relacionado con la misma proporci&#243;n de variaci&#243;n en la carga absoluta de trabajo (peso en kg). La raz&#243;n entre las cargas de 6 y 12 RM fue de apenas 12%, o, en t&#233;rminos absolutos, 7,5 &#177; 0,8 kg.</p>
      <p>El impacto de las variables manipuladas fue diverso sobre FC y la PAS. As&#237;, la FC sufri&#243; influencia significativa del efecto aislado del n&#250;mero de repeticiones m&#225;ximas (F = 7,33; p = 0,008) y del n&#250;mero de series (F = 77,65; p &lt; 0,001), pero no del intervalo de recuperaci&#243;n (F = 3,00; p = 0,087). El efecto combinado de las series con los intervalos, con todo, se revel&#243; significativo (F = 4,87; p = 0,02). En cuanto a la PAS, el efecto aislado estad&#237;sticamente m&#225;s fuerte residi&#243; en el n&#250;mero de series (F = 63,33; p &lt; 0,001), seguido del intervalo de recuperaci&#243;n (F = 5,97; p = 0,017). La variable intensidad no tuvo efecto independiente significativo (F = 0,042; p = 0,95).</p>
      <p>Las <xref ref-type="fig" rid="es_12f01-body3">Figuras 1</xref> y <xref ref-type="fig" rid="es_12f02-body3">2</xref> presentan los resultados de las verificaciones post hoc para FC y PAS. Se constata que, sistem&#225;ticamente, la influencia del n&#250;mero de series se dio en el sentido de elevar las respuestas cardiovasculares. Por otro lado, el intervalo de recuperaci&#243;n tuvo influencia opuesta, llegando a compensar el efecto acumulativo de las series en algunos casos, principalmente en lo tocante a la PAS.</p>
      <p content-type="asset">
        <fig id="es_12f01-body3">
          <graphic xlink:href="1678-4170-abc-95-04-0493-00119-gf02-es.jpg"/></fig>
      </p>
      <p content-type="asset">
        <fig id="es_12f02-body3">
          <graphic xlink:href="1678-4170-abc-95-04-0493-00119-gf03-es.jpg"/></fig>
      </p>
      <p>Tambi&#233;n fueron comparadas las variaciones absolutas en cada situaci&#243;n, considerando los valores de pico registrados entre la primera y la tercera series. En lo tocante a la FC, para los protocolos de 6 RM, la variaci&#243;n en las series con intervalo de 1:3 fue significativamente mayor que la observada en 1:5 (&#916; = 11,2 &#177; 1,1 lpm <italic>versus</italic> &#916; = 4,5 &#177; 0,2 lpm, respectivamente) (F = 9,98; p = 0,002). En la carga de 12 RM, la variaci&#243;n de la FC en las series con intervalo de 1:3 no present&#243; diferencia significativa en relaci&#243;n a lo observado en el intervalo 1:5 (&#916; = 21,1 &#177; 2,2 lpm <italic>versus</italic> &#916; = 18,9 &#177; 2,0 lpm, respectivamente) (F = 0,58; p = 0,83). Las variaciones de PAS entre la 1&#170; y 3&#170; series fueron influenciadas por el intervalo de recuperaci&#243;n, independientemente de la carga. En los protocolos con 6 RM, las variaciones para los intervalos de 1:3 y 1:5 fueron, respectivamente, de 10,6 &#177; 0,9 mmHg y 6,6 &#177; 0,7 mmHg (F = 6,67; p = 0,02). Para los protocolos de 12 RM, la variaci&#243;n con intervalo 1:3 fue de 15,2 &#177; 1,1 mmHg y con intervalo 1:5 fue de 8,4 &#177; 0,7 mmHg (F = 5,12; p = 0,04).</p>
      <p>Los resultados para la PAS se mostraron m&#225;s sensibles a la manipulaci&#243;n de las tres variables del entrenamiento, tomadas aislada o combinadamente. Eso repercuti&#243; sobre el comportamiento del DP, en una relaci&#243;n directamente proporcional al n&#250;mero de repeticiones m&#225;ximas (F = 4,57; p = 0,036) y al n&#250;mero de series (F = 141,38; p &lt; 0,001), mientras que inversamente proporcional al intervalo entre las series (F = 5,38; p = 0,006).</p>
      <p>La <xref ref-type="fig" rid="es_12f03-body3">Figura 3</xref> presenta los resultados para las verificaciones post hoc referentes al DP.</p>
      <p content-type="asset">
        <fig id="es_12f03-body3">
          <graphic xlink:href="1678-4170-abc-95-04-0493-00119-gf04-es.jpg"/></fig>
      </p>
      <p>La variaci&#243;n entre la primera y la tercera series realizadas con intervalo de 1:3 fue de 2.892 &#177; 189 mmHg.lpm para 6 RM y de 4.587 &#177; 300 mmHg.lpm para 12 RM (F = 4,17; p = 0,018). Cuando se aplic&#243; el intervalo de mayor duraci&#243;n (1:5), la variaci&#243;n del DP para la carga de 6 RM fue de 1.224 &#177; 141 mmHg.lpm, al tiempo que para 12 RM se obtuvo un delta de 2.332 &#177; 194 mmHg.lpm (F = 0,56; p = 0,58).</p>
      <p>
        <bold>Discusi&#243;n</bold>
      </p>
      <p>El presente estudio compar&#243; las respuestas de FC, PAS y DP, durante series consecutivas de ejercicio de resistencia, realizado con diferentes n&#250;meros de repeticiones m&#225;ximas e intervalos de recuperaci&#243;n, estos &#250;ltimos establecidos con base en el tiempo total de ejecuci&#243;n de cada serie.</p>
      <p>Tanto la FC como la PAS se elevaron significativamente en el transcurso de las series, independientemente de la intensidad e intervalo de recuperaci&#243;n. Mientras tanto, las respuestas cardiovasculares asociadas al leg press horizontal fueron minimizadas por la manipulaci&#243;n del tiempo de recuperaci&#243;n: cuando la proporci&#243;n fue mayor en relaci&#243;n al tiempo de tensi&#243;n, los valores de FC y, principalmente, de PAS, fueron inferiores. El mayor intervalo de recuperaci&#243;n tambi&#233;n se asoci&#243; a una menor elevaci&#243;n de la FC y PAS en el transcurso de las series, en ambas intensidades programadas. As&#237;, el ejercicio realizado con mayor intervalo de recuperaci&#243;n ocasion&#243; menor estr&#233;s cardiovascular en las dos intensidades testeadas.</p>
      <p>Es interesante notar que el valor medio para la PAS de pico en la &#250;ltima serie del estudio de Gotshall et al<sup>5</sup>, medida por fotoplestimograf&#237;a, fue de 293 &#177; 21 mmHg, bien superior al valor registrado en la &#250;ltima serie del presente estudio (181 &#177; 16mmHg para el protocolo de 12 RM con intervalo progresivo en la proporci&#243;n 1:3). Esa diferencia puede ser atribuida al tiempo de tensi&#243;n en cada serie (un minuto en el estudio de Gotshall et al<sup>5</sup><italic>versus</italic> 24 segundos en el presente estudio), pero tambi&#233;n, y tal vez principalmente, a la medida de la PA. Como se sabe, a pesar de ser satisfactorio para comparaci&#243;n entre diferentes protocolos de ejercicios de fuerza, el m&#233;todo auscultatorio realizado en miembro inactivo puede subestimar los valores pres&#243;ricos absolutos<sup>14,15</sup>. En otras palabras, el m&#233;todo auscultatorio es extremamente &#250;til en situaciones pr&#225;cticas, habi&#233;ndose revelado v&#225;lido y reproducible para indicar diferencias de las respuestas de PA a ejercicios de resistencia. Con eso, consiste en estrategia &#250;til para la elaboraci&#243;n de sesiones de entrenamiento con menor sobrecarga cardiovascular. Por otro lado, el m&#233;todo auscultatorio no deber&#237;a ser utilizado para el establecimiento preciso de los valores pres&#243;ricos durante el ejercicio de fuerza.</p>
      <p>Los estudios que profundizaron en la observaci&#243;n de la influencia del intervalo de recuperaci&#243;n entre series y ejercicios sobre el comportamiento de la PA y FC son relativamente escasos. No fue posible encontrar pesquisas que hubiesen investigado la cuesti&#243;n en un abordaje similar al presentemente aplicado.</p>
      <p>Polito et al<sup>9</sup> sometieron j&#243;venes normotensos a 4 series de 8 RM, separadas por intervalos fijos de uno y dos minutos, tambi&#233;n observando valores m&#225;s elevados de presi&#243;n arterial para la secuencia con menor intervalo. Las respuestas cardiovasculares m&#225;s pronunciadas a cortos intervalos de recuperaci&#243;n pueden asociarse a una menor recuperaci&#243;n sist&#233;mica del estr&#233;s generado por el ejercicio. La acumulaci&#243;n de metabolitos, con consecuente estimulaci&#243;n nerviosa v&#237;a receptores qu&#237;micos y mec&#225;nicos, puede potencializar esas respuestas<sup>16</sup>.</p>
      <p>En ese sentido, Ratamess et al<sup>10</sup> observaron los efectos de diferentes intervalos fijos de recuperaci&#243;n (30s, uno, dos, tres y 5 minutos) sobre las respuestas cardiovasculares y metab&#243;licas durante la realizaci&#243;n de 5 series en dos intensidades de entrenamiento (5 RM y 10 RM) en el ejercicio supino recto. No se constataron diferencias entre los intervalos de recuperaci&#243;n, considerando los valores de FC de pico en ambas intensidades de entrenamiento. Mientras tanto, hubo aumento de la FC a medida que las series eran ejecutadas (p &lt; 0,05), principalmente para intervalos de recuperaci&#243;n m&#225;s cortos. La producci&#243;n de lactato fue igualmente mayor para intervalos de recuperaci&#243;n m&#225;s cortos, lo que es sugestivo de la relaci&#243;n entre fatiga acumulada debido a la recuperaci&#243;n insuficiente y a las respuestas cardiovasculares.</p>
      <p>Los presentes resultados indicaron que la carga de trabajo tambi&#233;n puede influenciar de forma independiente las respuestas de FC y PAS. En comparaci&#243;n con el protocolo con carga de 12 RM, las series hechas con 6 RM presentaron menor impacto sobre las respuestas cardiovasculares para intervalos de recuperaci&#243;n similares. Es posible que el tiempo de tensi&#243;n (6 RM = 17 &#177; 3s <italic>versus</italic> 12 RM = 29 &#177; 5s) est&#233; relacionado con esos resultados. Esa posibilidad ratifica los resultados relatados por Lamotte et al<sup>17</sup>, los cuales analizaron el efecto de la ejecuci&#243;n de la extensi&#243;n de rodillas en la silla, con cargas equivalentes a 40% y 70% de un RM (4 series con un minuto de intervalo entre series), sobre las respuestas de FC y PA en cardi&#243;patas. La duraci&#243;n media de las series envolviendo intensidad de 40% fue de 34s (para 17 repeticiones), contra 20s de la serie conducida con 70% de la carga m&#225;xima (para 10 repeticiones). Hubo diferencia significativa para los valores de pico de PAS, con mayor sobrecarga card&#237;aca para el protocolo de menor intensidad (p &lt; 0,01). Se verific&#243; efecto acumulativo de las series sobre la presi&#243;n arterial (p &lt; 0,01), lo que fue atribuido por los autores al corto intervalo de recuperaci&#243;n aplicado.</p>
      <p>En el presente estudio, tambi&#233;n ocurri&#243; un efecto acumulativo de las series sobre las respuestas de FC y PAS, con mayor elevaci&#243;n a partir de la segunda serie, principalmente para un menor intervalo esfuerzo-recuperaci&#243;n. De forma similar, Gotshall et al<sup>5</sup> aplicaron tres series de 10 RM en el leg press bilateral en j&#243;venes sanos (intervalo de recuperaci&#243;n fijo de tres minutos; velocidad de tres segundos en las fases conc&#233;ntrica y exc&#233;ntrica). Al t&#233;rmino de cada una de las series, los valores de PAS y PAD se revelaron siempre significativamente superiores al observado en la serie precedente. Otros estudios han demostrado que hay influencia del n&#250;mero de series sobre las respuestas cardiovasculares<sup>2,17</sup>.</p>
      <p>Dos factores pueden estar en el origen de los resultados referentes al efecto acumulativo de las series consecutivas sobre las respuestas cardiovasculares. El primero resultar&#237;a de la fatiga acumulada en virtud del menor tiempo de recuperaci&#243;n<sup>18</sup>. El segundo tiene en consideraci&#243;n el tiempo de tensi&#243;n: el ejercicio din&#225;mico de resistencia ocasiona oclusi&#243;n de los vasos y puede, dependiendo de su intensidad y duraci&#243;n, llevar a una respuesta barorrefleja compensatoria, lo que es m&#225;s frecuente en ejercicios ejecutados hasta la fatiga<sup>19,20</sup>.</p>
      <p>Las respuestas hemodin&#225;micas al trabajo muscular en ejercicios de resistencia tambi&#233;n pueden estar conectadas a un aumento de la actividad simp&#225;tica y a la disminuci&#243;n de la actividad parasimp&#225;tica, por la mayor activaci&#243;n de comando central y mecanorreceptores musculares y articulares<sup>16</sup>. El mecanismo central envuelve el env&#237;o de impulsos del c&#243;rtex motor para el centro de control cardiovascular. El mecanismo perif&#233;rico consiste en una v&#237;a de reflejo con diversas bases de control<sup>21</sup>. El aumento de la resistencia vascular perif&#233;rica, causado por la oclusi&#243;n parcial del flujo sangu&#237;neo, contribuye a un desequilibrio entre oferta y demanda de O<sub>2</sub> en el tejido. De hecho, a partir de 15% de la contracci&#243;n voluntaria m&#225;xima, se verifica impedimento progresivo del flujo sangu&#237;neo muscular<sup>22</sup>. Con eso, se dificulta la remoci&#243;n de metabolitos (lactato, hidr&#243;geno, fosfato, adenosina, potasio etc.), estimul&#225;ndose los quimiorreceptores en el sentido de aumentar la actividad nerviosa simp&#225;tica<sup>16</sup>.</p>
      <p>En fin, el aumento de la presi&#243;n arterial tambi&#233;n podr&#237;a sufrir influencia del n&#250;mero de unidades motoras solicitadas. En ese caso, mecanorreceptores musculares y articulares, sensibles al aumento de la fuerza voluntaria (reclutamiento de unidades motoras) y a la carga sobre las articulaciones, informan al centro de control cardiovascular sobre la necesidad de modificar las respuestas cardiovasculares para la regulaci&#243;n del flujo<sup>23</sup>.</p>
      <p>El aumento de la resistencia vascular perif&#233;rica asociada a la oclusi&#243;n arterial durante el ejercicio es otro factor a ser considerado. El leg press, adem&#225;s de envolver diversos y grandes grupos musculares, tambi&#233;n es hecho en una postura que puede dificultar la perfusi&#243;n de sangre hacia los m&#250;sculos activos, una vez que las principales arterias que los irrigan tienen su curso modificado por la flexi&#243;n de la cadera<sup>24</sup>. Ese problema es aun mayor durante el per&#237;odo de transici&#243;n entre las fases conc&#233;ntrica y exc&#233;ntrica. En ese contexto, la activaci&#243;n de barorreceptores y quimiorreceptores puede provocar respuesta pres&#243;rica compensatoria, para que se alcance un d&#233;bito card&#237;aco satisfactorio durante los ejercicios.</p>
      <p>Las respuestas cardiovasculares al ejercicio de resistencia, por lo tanto, pueden asociarse a una adaptaci&#243;n central frente a la mayor resistencia perif&#233;rica. La mayor necesidad de perfusi&#243;n estar&#237;a directamente relacionada a la capacidad inotr&#243;pica del coraz&#243;n, ya que modificaciones en la FC tienden a ocurrir de forma m&#225;s lenta que en la PAS<sup>25</sup>. Esa sobrecarga pres&#243;rica asociada al ejercicio de resistencia puede ser ben&#233;fica desde el punto de vista profil&#225;ctico, principalmente para portadores de enfermedades cardiovasculares cr&#243;nicas y usuarios de medicaci&#243;n antihipertensiva<sup>26</sup>. Algunos estudios han relatado que coronarios, bajo tratamiento farmacol&#243;gico, pueden realizar ejercicios de resistencia de intensidad moderada y los resultados de esa pr&#225;ctica incluyen la mejora de la funci&#243;n global del ventr&#237;culo izquierdo, especialmente de la fracci&#243;n de eyecci&#243;n<sup>26,27</sup>.</p>
      <p>En cuanto a la elevaci&#243;n de la FC, el tiempo de tensi&#243;n muscular parece ejercer importante influencia. Hunter et al<sup>28</sup> compararon las respuestas metab&#243;licas y de la frecuencia card&#237;aca a 10 ejercicios hechos con dos velocidades de contracci&#243;n, una 'tradicional' (2 series de 8 repeticiones con 65% de un RM, velocidad de ejecuci&#243;n de un segundo para la fase conc&#233;ntrica y exc&#233;ntrica, un minuto de recuperaci&#243;n) y 'super slow' (2 series de 8 repeticiones con 25% de un RM, velocidad de ejecuci&#243;n de 10s para la fase conc&#233;ntrica y 5s para la fase exc&#233;ntrica, con mismo intervalo y n&#250;mero de ejercicios). Se verific&#243; que el protocolo 'tradicional' indujo elevaci&#243;n significativamente superior de la FC en comparaci&#243;n con el 'super slow' (143 &#177; 8 lpm contra 113 &#177; 12 lpm).</p>
      <p>Kleiner et al<sup>4</sup> estudiaron la respuesta cardiovascular aguda en el ejercicio isocin&#233;tico en 6 sujetos que realizaron extensi&#243;n de rodillas con tres velocidades de ejecuci&#243;n (50, 100 y 200&#176;/s) hasta la fatiga (70% del pico de torque). No fueron encontradas diferencias significativas entre los valores de FC, PAS, PAD y DP. Con todo, en las velocidades programadas, los valores de FC variaron entre 163,3 &#177; 28,4 lpm (50&#186;/s) y 183,5 &#177; 16,8 lpm (200&#186;/s). Contrariamente, los valores de PAS fueron superiores para una menor velocidad angular (PAS = 348,2 &#177; 18,1 mmHg para 50&#186;/s <italic>versus</italic> PAS = 335,5 &#177; 27,4 mmHg para 200&#186;/s), con influencia sobre el DP (50&#186;/s = 56.861 &#177; 514 mmHg.lpm; 100&#186;/s = 58.875 &#177; 479 mmHg.lpm; 200&#186;/s = 61.564 &#177; 460 mmHg.lpm). Los autores justifican sus resultados por la caracter&#237;stica de las sesiones, habiendo variado el n&#250;mero de repeticiones entre 30 (50&#186;/s), 80 (100&#186;/s) y 140 (200&#186;/s).</p>
      <p>Como los protocolos con mayor velocidad ofrecen menor resistencia, y, una vez habiendo producido cantidad significativamente mayor de repeticiones, la ejecuci&#243;n del ejercicio se habr&#237;a aproximado a lo que se encuentra en ejercicios din&#225;micos continuos de larga duraci&#243;n, con mayor repercusi&#243;n sobre la FC. Por otro lado, la elevaci&#243;n de la PAS para menores velocidades estar&#237;a relacionada a una mayor producci&#243;n de fuerza, en comparaci&#243;n con las mayores velocidades angulares.</p>
      <p>Extrapolar resultados obtenidos en ejercicios isocin&#233;ticos para din&#225;micos del tipo 'isot&#243;nico' no es, en general, prudente. Mientras tanto, no se puede dejar de notar que el efecto del tiempo de tensi&#243;n sobre la FC es ratificado por los resultados de Kleiner et al<sup>4</sup>, as&#237; como aparece n&#237;tido que los valores de la PAS son sensibles a la tensi&#243;n producida, con fuerte influencia sobre el DP.</p>
      <p>Otro ejemplo es encontrado en Kawano et al<sup>29</sup>, que sometieron normotensos j&#243;venes y de media edad a una serie en el ejercicio de leg press con tres intensidades (40%, 60% y 80% de un RM). No hubo diferencia para los valores de FC en las intensidades testeadas, en cualquiera de los grupos. Mientras tanto, los j&#243;venes presentaron mayores valores pres&#243;ricos de pico que los sujetos de media edad en todas las intensidades, aunque de forma significativa apenas para la intensidad de 80% de un RM (j&#243;venes = 190 mmHg <italic>versus</italic> media edad = 150 mmHg, p &lt; 0,05). La amplitud de variaci&#243;n de la PAS en relaci&#243;n al reposo (&#916;) ocurri&#243; de forma significativa para todas las intensidades, siendo mayor en los j&#243;venes, tal vez por exhibir menores valores de reposo de forma general (40% RM: j&#243;venes = 34 mmHg <italic>versus</italic> media edad = 18 mmHg; 60% RM: j&#243;venes = 54 mmHg <italic>versus</italic> media edad = 31 mmHg; 80% RM: j&#243;venes = 73 mmHg <italic>versus</italic> media edad = 42 mmHg, p &lt; 0,05).</p>
      <p>Se desprende de esos resultados que la medici&#243;n &#250;nica de la FC puede no ser suficiente para evaluar adecuadamente la sobrecarga cardiovascular impuesta por el ejercicio de resistencia. Se estimula, por lo tanto, la medida de la PA en el delineamiento de programas de entrenamiento de la fuerza, sobre todo para sujetos en los cuales mantener esas respuestas bajo control es deseable (pacientes en rehabilitaci&#243;n card&#237;aca, por ejemplo). Para eso, el protocolo de medici&#243;n de la presi&#243;n arterial, durante ejercicios de resistencia a trav&#233;s del m&#233;todo auscultatorio, propuesto por Polito y Farinatti<sup>13</sup> y posteriormente validado<sup>14</sup>, parece ser una opci&#243;n viable y accesible a la mayor parte de los centros de entrenamiento.</p>
      <p>En conclusi&#243;n, series m&#250;ltiples de ejercicio de resistencia para miembros inferiores acarrearon elevaci&#243;n significativa y acumulativa de las respuestas cardiovasculares, especialmente de PA, con impacto sobre el DP. El nivel de estr&#233;s cardiovascular asociado al ejercicio no dependi&#243; apenas de la carga de trabajo definida en t&#233;rminos de repeticiones m&#225;ximas, sino tambi&#233;n de las dem&#225;s variables del entrenamiento, principalmente el n&#250;mero de series. Por otro lado, intervalos de recuperaci&#243;n m&#225;s largos entre las series contribuyeron significativamente a la reducci&#243;n de las respuestas de FC, PA y DP, manteni&#233;ndose la carga y volumen de entrenamiento. La proporci&#243;n entre tiempo de est&#237;mulo y tiempo de recuperaci&#243;n, por s&#237; s&#243;lo, acarre&#243; modificaciones significativas en las respuestas cardiovasculares, independientemente del n&#250;mero de repeticiones m&#225;ximas ejecutado. De ese modo, el planeamiento de los intervalos de recuperaci&#243;n en el contexto de la elaboraci&#243;n de sesiones de entrenamiento de resistencia parece ser un aspecto cl&#237;nicamente importante para el aumento de la seguridad en su pr&#225;ctica, especialmente en poblaciones con mayor riesgo cardiovascular.</p>
      <p>Estudios adicionales deben ser conducidos, comparando las respuestas hemodin&#225;micas asociadas a diferentes estrategias para la relaci&#243;n esfuerzo-recuperaci&#243;n (intervalos fijos, intervalos progresivos, fraccionamiento de series, alternancia de segmentos, etc). Investigaciones en tal sentido son importantes para establecer el m&#233;todo m&#225;s efectivo para minimizar la sobrecarga cardiovascular asociada a series m&#250;ltiples de ejercicios de resistencia, al mismo tiempo en que se mantiene elevado el volumen de trabajo en las sesiones de entrenamiento.</p>
      <p>
        <bold>Agradecimientos</bold>
      </p>
      <p>Ese estudio fue parcialmente financiado por el CNPq (proceso 305729/2006-3) y por la FAPERJ (proceso E26/102.916/2008).</p>
      <p>
        <bold>Potencial Conflicto de Intereses</bold>
      </p>
      <p>Declaro no haber conflicto de intereses pertinentes.</p>
      <p>
        <bold>Fuentes de Financiamiento</bold>
      </p>
      <p>El presente estudio fue financiado por el CNPq y parcialmente financiado por la FAPERJ.</p>
      <p>
        <bold>Vinculaci&#243;n Acad&#233;mica</bold>
      </p>
      <p>No hay vinculaci&#243;n de este estudio a programas de post-grado.</p>
      <p>
        <bold>Referencias</bold>
      </p>
    </body>
  </sub-article>
</article>
