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  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">abc</journal-id>
      <journal-title-group>
        <journal-title>Arquivos Brasileiros de Cardiologia</journal-title>
        <abbrev-journal-title abbrev-type="publisher">Arq. Bras. Cardiol.</abbrev-journal-title>
      </journal-title-group>
      <issn pub-type="ppub">0066-782X</issn>
      <issn pub-type="epub">1678-4170</issn>
      <publisher>
        <publisher-name>Sociedade Brasileira de Cardiologia - SBC</publisher-name>
        <publisher-loc>S&#227;o Paulo, SP, Brazil</publisher-loc>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id" specific-use="scielo-v3">ZYHQ83YkjTt3vMgfyCL6Wgr</article-id>
      <article-id pub-id-type="other">00003</article-id>
      <article-id pub-id-type="publisher-id" specific-use="scielo-v2">S0066-782X2009001200003</article-id>
      <article-id pub-id-type="publisher-id" specific-use="scielo-v1">S0066-782X(09)09300603</article-id>
      <article-id pub-id-type="doi">10.1590/S0066-782X2009001200003</article-id>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Editoriais</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Impacto das publica&#231;&#245;es cient&#237;ficas brasileiras nos recentes avan&#231;os cient&#237;ficos na cardiologia</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <name>
            <surname>Bacal</surname>
            <given-names>Fernando</given-names>
          </name>
        </contrib>
      </contrib-group>
      <pub-date date-type="collection" publication-format="electronic">
        <month>12</month>
        <year>2009</year>
      </pub-date>
      <volume>93</volume>
      <issue>6</issue>
      <fpage>581</fpage>
      <lpage>583</lpage>
      <permissions>
        <license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc/4.0/" xml:lang="en">
          <license-p>This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.</license-p>
        </license>
      </permissions>
      <pub-date publication-format="electronic" date-type="pub">
        <day>05</day>
        <month>05</month>
        <year>2010</year>
      </pub-date>
    </article-meta>
  </front>
  <body>
    <p>
      <bold>EDITORIAL</bold>
    </p>
    <p>
      <bold>Impacto das publica&#231;&#245;es cient&#237;ficas brasileiras nos recentes avan&#231;os cient&#237;ficos na cardiologia</bold>
    </p>
    <p>
      <bold>Fernando Bacal</bold>
    </p>
    <p>
      <xref ref-type="corresp" rid="back">Correspond&#234;ncia</xref>
    </p>
    <p><bold>Palavras-chave:</bold> Cardiologia / tend&#234;ncias, Publica&#231;&#245;es Cient&#237;ficas e T&#233;cnicas.</p>
    <p>A pesquisa brasileira, tanto nas &#225;reas cl&#237;nica e cir&#250;rgica como na &#225;rea b&#225;sica tem crescido muito nos &#250;ltimos anos. A cardiologia, por sua vez, tem contribu&#237;do de forma efetiva para esse crescimento. Hoje, os Arquivos Brasileiros de Cardiologia, peri&#243;dico indexado no ISI, se junta a outros importantes peri&#243;dicos nacionais e tamb&#233;m indexados, oferecendo ao pesquisador nacional e internacional boas op&#231;&#245;es para publica&#231;&#227;o de suas pesquisas.</p>
    <p>Discutiremos neste Editorial o impacto das recentes publica&#231;&#245;es cient&#237;ficas brasileiras, nas &#225;reas clinica e cir&#250;rgica em cardiologia.</p>
    <p>A doen&#231;a ateroscler&#243;tica vem sendo alvo de constantes pesquisas nos &#250;ltimos anos. Mais recentemente, a an&#225;lise da doen&#231;a arterial perif&#233;rica, tanto no seu diagn&#243;stico, como pelo seu impacto progn&#243;stico vem sendo estudada, inclusive em ensaios epidemiol&#243;gicos<sup>1,2</sup>.A ocorr&#234;ncia de doen&#231;a ateroscler&#243;tica mais precoce, inclusive afetando crian&#231;as e adolescentes, bem como a influ&#234;ncia do tabagismo e hipertens&#227;o arterial nesta popula&#231;&#227;o, influenciando no perfil lipoproteico, serve de alerta para as autoridades em busca de preven&#231;&#227;o mais efetiva e precoce<sup>3,4</sup>. Outro importante estudo populacional, realizado no Rio de Janeiro, confirmou a import&#226;ncia do tabagismo como problema de sa&#250;de p&#250;blica, aumentando os casos de invalidez, doen&#231;a pulmonar obstrutiva cr&#244;nica, doen&#231;a c&#233;rebro vascular e doen&#231;a cardiovascular<sup>5</sup>. Outro aspecto bastante discutido, foi o risco cardiovascular em cirurgias n&#227;o card&#237;acas, bem como m&#233;todos de monitoriza&#231;&#227;o intraoperat&#243;rios e a import&#226;ncia da avalia&#231;&#227;o cardiol&#243;gica no contexto desta avalia&#231;&#227;o interdisciplinar<sup>6-8</sup>.</p>
    <p>A discuss&#227;o da colabora&#231;&#227;o multiprofissional tamb&#233;m tem sido representada em estudos cl&#237;nicos. A correla&#231;&#227;o entre doen&#231;a periodontal e risco cardiovascular, bem como a possibilidade de tratamento odontol&#243;gico seguro, usando anest&#233;sico com vasoconstrictor, mesmo em pacientes portadores de doen&#231;a arterial coron&#225;ria e presen&#231;a de arritmia ventricular foram alvo de recentes publica&#231;&#245;es<sup>9,10</sup>. O impacto da atividade f&#237;sica no contexto de preven&#231;&#227;o de eventos cardiovasculares, a melhora de disfun&#231;&#227;o endotelial, e o controle da press&#227;o arterial foram amplamente discutidos, inclusive em subpopula&#231;&#245;es espec&#237;ficas, tais como adolescentes, idosos e no sexo feminino<sup>11-13</sup>.</p>
    <p>No campo da insufici&#234;ncia card&#237;aca e da disfun&#231;&#227;o ventricular observamos importantes contribui&#231;&#245;es originais. A discuss&#227;o sobre a import&#226;ncia de atividade f&#237;sica, em pacientes em CF III, com impacto em qualidade de vida, classes funcionais e peculiaridades das vari&#225;veis respirat&#243;rias e de frequ&#234;ncia card&#237;aca, mesmo em pacientes sob efeito betabloqueador, foram avan&#231;os nessa &#225;rea<sup>14-17</sup> . Os crit&#233;rios para confirma&#231;&#227;o diagn&#243;stica da n&#227;o compacta&#231;&#227;o mioc&#225;rdica, bem como orienta&#231;&#245;es terap&#234;uticas nesta rec&#233;m descoberta nova classifica&#231;&#227;o das cardiomiopatias tamb&#233;m despertaram interesse nos pesquisadores<sup>18-20</sup>. Outras formas de apresenta&#231;&#227;o cl&#237;nica e de etiologia das cardiomiopatias, tamb&#233;m t&#234;m sido estudadas. Como ainda &#233; bastante prevalente, inclusive pela elevada taxa de mortalidade em suas fases mais avan&#231;adas, a cardiomiopatia chag&#225;sica oferece grandes oportunidades para pesquisas originais, uma vez que seu mecanismo fisiopatol&#243;gico n&#227;o &#233; completamente elucidado ainda<sup>21</sup>. Da mesma forma, a cardiomiopatia hipertr&#243;fica e comprometimento mioc&#225;rdico por dep&#243;sito amiloide, como diagn&#243;stico diferencial das hipertrofias e de insufici&#234;ncia card&#237;aca com padr&#227;o restritivo tamb&#233;m foram amplamente estudados nos &#250;ltimos anos<sup>22-25</sup>. Estudo avaliando gestantes com disfun&#231;&#227;o ventricular em per&#237;odo perinatal tamb&#233;m trouxe interessantes conceitos e an&#225;lises sobre o risco materno neste per&#237;odo, quest&#227;o que foi pouco estudada na literatura internacional<sup>26</sup>.</p>
    <p>No campo da cirurgia cardiovascular, v&#225;rios avan&#231;os t&#234;m sido apresentados em rela&#231;&#227;o ao tratamento das valvopatias, da insufici&#234;ncia coron&#225;ria, das afec&#231;&#245;es da aorta tor&#225;cica e no emprego de dispositivos de assist&#234;ncia circulat&#243;ria mec&#226;nica em nosso Pa&#237;s. Esses avan&#231;os incluem a padroniza&#231;&#227;o do uso da cirurgia v&#237;deo-assistida na abordagem das valvas card&#237;aca<sup>27,28</sup>, bem como a consolida&#231;&#227;o das t&#233;cnicas de reconstru&#231;&#227;o no tratamento das afec&#231;&#245;es da valva mitral<sup>29,30</sup> e da realiza&#231;&#227;o da cirurgia de Ross com enxertos pulmonares decelularizados para substitui&#231;&#227;o da valva a&#243;rtica<sup>31</sup>. No tratamento da cardiomiopatia isqu&#234;mica, a avalia&#231;&#227;o da seguran&#231;a do emprego da inje&#231;&#227;o intramioc&#225;rdica de c&#233;lulas tronco hematopoi&#233;ticas como terap&#234;utica associada &#224; revasculariza&#231;&#227;o cir&#250;rgica do mioc&#225;rdio foi objeto de dois protocolos cl&#237;nicos<sup>32,33</sup>, que definiram a seguran&#231;a de seu uso. Destacam-se tamb&#233;m os estudos a respeito da melhor preserva&#231;&#227;o dos enxertos venosos<sup>34,35</sup>, do emprego de enxertos arteriais<sup>36,37</sup> e da compara&#231;&#227;o entre a cirurgia de revasculariza&#231;&#227;o do mioc&#225;rdio realizada com ou sem o emprego de circula&#231;&#227;o extracorp&#243;rea<sup>38</sup>. A proposta do emprego de procedimentos h&#237;bridos no tratamento das dissec&#231;&#245;es a&#243;rticas agudas<sup>39</sup> e o estudo do uso de potenciais evocados na monitoriza&#231;&#227;o do sofrimento medular na abordagem cir&#250;rgica da aorta descendente<sup>40</sup> abrem novas perspectivas no tratamento das afec&#231;&#245;es da aorta tor&#225;cica. Por outro lado, a experi&#234;ncia brasileira a respeito do emprego de dispositivos mec&#226;nicos de assist&#234;ncia circulat&#243;ria inclui apenas casu&#237;sticas iniciais com o uso da circula&#231;&#227;o extracorp&#243;rea com oxigenador de membrana<sup>41,42</sup> e de ventr&#237;culos artificiais paracorp&#243;reos no tratamento do choque cardiog&#234;nico ou como ponte para o transplante card&#237;aco<sup>43</sup>.</p>
    <p>O maior controle sobre a qualidade e os resultados da cirurgia card&#237;aca tamb&#233;m s&#227;o temas abordados na literatura nacional<sup>44</sup>, destacando-se os estudos sobre os fatores pr&#233;-operat&#243;rios de risco para o desenvolvimento da insufici&#234;ncia renal no p&#243;s-operat&#243;rio<sup>45</sup> e na abordagem cir&#250;rgica dos pacientes idosos<sup>46</sup>.</p>
    <p>
      <fn id="back" fn-type="corresp">
        <p>Correspond&#234;ncia:</p>
        <p> Fernando Bacal </p>
        <p> Av. Divino Salvador, 395 apt. 201, 2&#186; andar - Planalto Paulista </p>
        <p> 04078-011 - S&#227;o Paulo - SP </p>
        <p> Email: </p>
        <p>
          <email xlink:href="fbacal@cardiol.br">fbacal@cardiol.br</email>
        </p>
      </fn>
    </p>
    <p>Artigo recebido em 08/12/09; revisado recebido em 08/12/09; aceito em 08/12/09.</p>
  </body>
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          <lpage>13</lpage>
          <issue>3</issue>
          <volume>54</volume>
          <person-group person-group-type="author">
            <name>
              <surname>Kochi</surname>
              <given-names>AC</given-names>
            </name>
            <name>
              <surname>Martins</surname>
              <given-names>AS</given-names>
            </name>
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              <surname>Lima</surname>
              <given-names>MC</given-names>
            </name>
            <name>
              <surname>Martin</surname>
              <given-names>LC</given-names>
            </name>
            <name>
              <surname>Balbi</surname>
              <given-names>Al</given-names>
            </name>
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        <mixed-citation>46. Alves Jr L,    Rodrigues AJ, Evora PR, Basseto S, Scorzoni Filho A, Luciano PM, et al. Fatores    de risco em septuagen&#225;rios ou mais idosos submetidos &#224; revasculariza&#231;&#227;o    do mioc&#225;rdio e ou opera&#231;&#245;es valvares. Rev Bras Cir Cardiovasc.    2008; 23 (4): 550-5.</mixed-citation>
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          <article-title>Fatores de risco em septuagen&#225;rios ou mais idosos submetidos &#224; revasculariza&#231;&#227;o do mioc&#225;rdio e ou opera&#231;&#245;es valvares</article-title>
          <source>Rev Bras Cir Cardiovasc</source>
          <date>
            <year>2008</year>
          </date>
          <fpage>550</fpage>
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          <volume>23</volume>
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              <surname>Alves Jr</surname>
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            </name>
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              <surname>Rodrigues</surname>
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            </name>
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              <surname>Evora</surname>
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            </name>
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              <surname>Basseto</surname>
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              <surname>Scorzoni Filho</surname>
              <given-names>A</given-names>
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              <given-names>PM</given-names>
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  </back>
  <sub-article article-type="translation" id="TRen" xml:lang="en">
    <front-stub>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Editorials</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title xml:lang="en">Impact of the Brazilian scientific publications on the recent scientific developments in cardiology</article-title>
      </title-group>
    </front-stub>
    <body>
      <p>
        <bold>EDITORIAL</bold>
      </p>
      <p>
        <fn id="top-body2">
          <label>
            <bold>Impact of the Brazilian Scientific Publications on the recent scientific developments in cardiology</bold>
          </label>
          <p>
            <bold>Fernando Bacal</bold>
          </p>
        </fn>
      </p>
      <p>Mailing address</p>
      <p><bold>Key words:</bold> Cardiology / trends; scientific and technical publications.</p>
      <p>The Brazilian research, in the clinical and surgical areas as well as in the basic areas, has developed greatly in recent years. Cardiology, in turn, has effectively contributed for this development. Currently, the Brazilian Archives of Cardiology (Arquivos Brasileiros de Cardiologia), an ISI-indexed journal, joins other important national and also indexed journals, offering the national and international researchers good options for the publication of their studies.</p>
      <p>This Editorial will discuss the impact of the recent Brazilian scientific publications from the clinical and surgical areas in Cardiology.</p>
      <p>The atherosclerotic disease has been the target of constant research in the last years. More recently, the analysis of peripheral artery disease, both concerning its diagnosis as well as its prognostic impact, has been carried out, including epidemiological studies<sup>1,2</sup>. The occurrence of an earlier onset of atherosclerotic disease, affecting even children and adolescents, as well as the influence of smoking and arterial hypertension in this population, which influences the lipoprotein profile, is a warning to the authorities seeking a more effective and earlier prevention<sup>3,4</sup>. Another important population study, carried out in Rio de Janeiro, confirmed the importance of smoking as a public health problem, increasing the number of cases of disability, chronic obstructive pulmonary disease, cerebrovascular disease and cardiovascular disease<sup>5</sup>. Another aspect that has been broadly discussed was the cardiovascular risk in non-cardiac surgeries, as well as methods of intraoperative monitoring and the importance of the cardiologic assessment in the context of this interdisciplinary evaluation<sup>6-8</sup>.</p>
      <p>The discussion of multiprofessional collaboration has also been represented in clinical studies. The correlation between periodontal disease and cardiovascular risk, as well as the possibility of safe dental treatment, using anesthetic agents with vasoconstrictors, even in patients with coronary artery disease and the presence of ventricular arrhythmia, were the subject of recent publications<sup>9,10</sup>. The impact of physical activity in the context of cardiovascular event prevention, improvement of the endothelial function and control of arterial pressure have been broadly discussed, including in specific subpopulations, such as adolescents, the elderly and the female sex<sup>11-13</sup>.</p>
      <p>In the field of heart failure and ventricular dysfunction, we have observed important original contributions. The discussion on the importance of physical activity in patients with FCII, with impact on the quality of life, functional classes and characteristic features of respiratory variables and heart rate, even in patients undergoing treatment with beta-blockers, have represented advances in this area<sup>14-17</sup> . The criteria for diagnostic confirmation of myocardial noncompaction, as well as therapeutic strategies in this newly discovered novel classification of cardiomyopathies have also aroused the interest of researchers <sup>18-20</sup>. Other forms of clinical presentation and the etiology of cardiomyopathies have also been studied. As it remains quite prevalent, considering its high mortality rate at the more advanced phases, the Chagasic cardiomyopathy offers great opportunities for original researches, as its physiopathological mechanism is yet to be fully elucidated<sup>21</sup>. Similarly, the hypertrophic cardiomyopathy and myocardial damage due to amyloid deposits, as differential diagnoses of cardiac hypertrophies and heart failure with restrictive patterns have also been broadly studied in the last years<sup>22-25</sup>. A study that evaluated pregnant women with ventricular dysfunction during the perinatal period also brought important concepts and analyses of the maternal risk during this period, a question that has been scarcely studied in the international literature<sup>26</sup>.</p>
      <p>In the field of cardiovascular surgery, several advances have been presented regarding the treatment of valvulopathies, coronary failure, thoracic aorta disorders and the use of mechanical circulatory assistance devices in our country. These advances include the standardization of the use of video-assisted surgery in the treatment of heart valve disorders<sup>27,28</sup>, as well as the consolidation of reconstruction techniques in the treatment of mitral valve disorders<sup>29,30</sup> and the performance of Ross surgery with decellularized pulmonary grafts in aortic valve substitutions<sup>31</sup>.</p>
      <p>In the treatment of ischemic cardiomyopathy, the evaluation of the safety of employing intramyocardial injections of hematopoietic stem cells as a therapy associated to coronary artery bypass graft (CABG) surgery was the object of two clinical protocols<sup>32,33</sup> that defined the safety of its use. Other important studies were those on the best preservation of venous grafts<sup>34,35</sup>, the use of arterial grafts<sup>36,37</sup> and the comparison between the on- or off-pump CABG surgery<sup>38</sup>.</p>
      <p>The proposal of employing hybrid procedures in the treatment of acute aortic dissections<sup>39</sup> and the study of the use of evoked potentials in the monitoring of medullary distress during the surgical approach of the descending aorta<sup>40</sup> have opened up new perspectives in the treatment of thoracic aorta disorders. On the other hand, the Brazilian experience regarding the use of mechanical circulatory assistance devices includes only initial series with extracorporeal membrane oxygenation (ECMO)<sup>41,42</sup> and paracorporeal artificial ventricles in the treatment of cardiogenic shock or as bridge to heart transplant<sup>43</sup>.</p>
      <p>The better control of the quality and outcomes of cardiac surgery has also been the subject of studies in the national literature<sup>44</sup>, especially analyses of preoperative risk factors for the development of kidney failure in the postoperative period<sup>45</sup> and in the surgical approach of elderly patients<sup>46</sup>.</p>
      <p>
        <bold>References</bold>
      </p>
    </body>
  </sub-article>
  <sub-article article-type="translation" id="TRes" xml:lang="es">
    <front-stub>
      <article-categories/>
      <title-group>
        <article-title xml:lang="es">Impacto de las publicaciones cient&#237;ficas brasile&#241;as en los recientes avances cient&#237;ficos en la cardiolog&#237;a</article-title>
      </title-group>
    </front-stub>
    <body>
      <p>
        <bold>EDITORIAL</bold>
      </p>
      <p>
        <fn id="top-body3">
          <label>
            <bold>Impacto de las publicaciones cient&#237;ficas brasile&#241;as en los recientes avances cient&#237;ficos en la cardiolog&#237;a</bold>
          </label>
          <p>
            <bold>Fernando Bacal</bold>
          </p>
        </fn>
      </p>
      <p>Correspondencia</p>
      <p><bold>Palabras clave: </bold> Cardiolog&#237;a / tendencias, publicaciones cient&#237;ficas y t&#233;cnicas. </p>
      <p>La investigaci&#243;n brasile&#241;a, tanto en las &#225;reas cl&#237;nica y quir&#250;rgica como en el &#225;rea b&#225;sica ha crecido mucho en los &#250;ltimos a&#241;os. La cardiolog&#237;a, a su vez, ha estado contribuyendo de forma efectiva para este crecimiento. Hoy, <italic>Arquivos Brasileiros de Cardiologia,</italic> peri&#243;dico indexado en el ISI, se junta a otros importantes peri&#243;dicos nacionales y tambi&#233;n indexados, y ofrece al investigador nacional e internacional buenas opciones para publicaci&#243;n de sus investigaciones.</p>
      <p>Discutiremos en este Editorial el impacto de las recientes publicaciones cient&#237;ficas brasile&#241;as, en las &#225;reas cl&#237;nica y quir&#250;rgica en cardiolog&#237;a.</p>
      <p>La enfermedad ateroscler&#243;tica viene siendo blanco de constantes investigaciones en los &#250;ltimos a&#241;os. M&#225;s recientemente, se viene estudiando el an&#225;lisis de la enfermedad arterial perif&#233;rica, tanto en su diagn&#243;stico, como por su impacto pron&#243;stico, inclusive en ensayos epidemiol&#243;gicos<sup>1,2</sup>. La ocurrencia de enfermedad ateroscler&#243;tica m&#225;s precoz, incluso cuando se afecta a ni&#241;os y adolescentes, as&#237; como la influencia del tabaquismo e hipertensi&#243;n arterial en esta poblaci&#243;n, lo que influencia en el perfil lipoproteico, sirve de alerta para las autoridades en b&#250;squeda de prevenci&#243;n m&#225;s efectiva y precoz<sup>3,4</sup>. Otro importante estudio poblacional, que se llev&#243; a cabo en R&#237;o de Janeiro, confirm&#243; la importancia del tabaquismo como problema de salud p&#250;blica, aumentando los casos de invalidez, enfermedad pulmonar obstructiva cr&#243;nica, enfermedad cerebrovascular y enfermedad cardiovascular<sup>5</sup>. Otro aspecto bastante discutido, fue el riesgo cardiovascular en cirug&#237;as no cardiacas, as&#237; como m&#233;todos de monitorizaci&#243;n intraoperatorios y la importancia de la evaluaci&#243;n cardiol&#243;gica en el marco de esta evaluaci&#243;n interdisciplinaria<sup>6-8</sup> .</p>
      <p>La discusi&#243;n de la colaboraci&#243;n multiprofesional tambi&#233;n se viene representando en estudios cl&#237;nicos. La correlaci&#243;n entre enfermedad periodontal y riesgo cardiovascular, as&#237; como la posibilidad de tratamiento odontol&#243;gico seguro, usando anest&#233;sico con vasoconstrictor, aun en pacientes portadores de enfermedad arterial coronaria y presencia de arritmia ventricular fueron blanco de recientes publicaciones<sup>9,10</sup>.</p>
      <p>El impacto de la actividad f&#237;sica en el contexto de prevenci&#243;n de eventos cardiovasculares, la mejora de disfunci&#243;n endotelial, y el control de la presi&#243;n arterial fueron ampliamente discutidos, inclusive en subpoblaciones espec&#237;ficas, tales como adolescentes, ancianos y en el sexo femenino<sup>11-13</sup>.</p>
      <p>En el campo de la insuficiencia cardiaca y de la disfunci&#243;n ventricular observamos importantes contribuciones originales. La discusi&#243;n sobre la importancia de actividad f&#237;sica, en pacientes en CF III, con impacto en calidad de vida, clases funcionales y peculiaridades de las variables respiratorias y de frecuencia cardiaca, aun en pacientes bajo efecto betabloqueante, fueron avances en esta &#225;rea<sup>14-17</sup>. Los criterios para confirmaci&#243;n diagn&#243;stica de no compactaci&#243;n mioc&#225;rdica, as&#237; como orientaciones terap&#233;uticas en esta reci&#233;n descubierta nueva clasificaci&#243;n de la cardiomiopat&#237;a tambi&#233;n despertaron inter&#233;s en los investigadores<sup>18-20</sup>. Otras formas de presentaci&#243;n cl&#237;nica y de etiolog&#237;a de las cardiomiopat&#237;as, tambi&#233;n se viene estudiando. Como a&#250;n es muy prevalente, inclusive por la elevada tasa de mortalidad en sus fases m&#225;s avanzadas, la cardiomiopat&#237;a chag&#225;sica ofrece grandes oportunidades para investigaciones originales, una vez que su mecanismo fisiopatol&#243;gico no es completamente elucidado todav&#237;a<sup>21</sup>. De igual manera, la cardiomiopat&#237;a hipertr&#243;fica y el compromiso mioc&#225;rdico por dep&#243;sito amiloide, como diagn&#243;stico diferencial de las hipertrofias y de insuficiencia cardiaca con est&#225;ndar restrictivo tambi&#233;n fueron ampliamente estudiados en los &#250;ltimos a&#241;os<sup>22-25</sup>. Estudio que evalu&#243; a gestante con disfunci&#243;n ventricular en per&#237;odo perinatal tambi&#233;n trajo interesantes conceptos y an&#225;lisis sobre el riesgo materno en este per&#237;odo, cuesti&#243;n que se estudi&#243; poco en la literatura internacional<sup>26</sup>.</p>
      <p>En el campo de la cirug&#237;a cardiovascular, se vienen presentando diversos avances respecto al tratamiento de las valvulopat&#237;as, de la insuficiencia coronaria, de las afecciones de la aorta tor&#225;cica y en el empleo de dispositivos de asistencia circulatoria mec&#225;nica en nuestro Pa&#237;s. Estos avances incluyen la estandarizaci&#243;n del empleo de la cirug&#237;a video-asistida en el abordaje de las v&#225;lvulas cardiacas<sup>27,28</sup>, as&#237; como al consolidaci&#243;n de las t&#233;cnicas de reconstrucci&#243;n en el tratamiento de las afecciones de la v&#225;lvula mitral<sup>29,</sup><sup>30</sup> y de la realizaci&#243;n de la cirug&#237;a de Ross con injerto pulmonares descelularizados para sustituci&#243;n de la v&#225;lvula a&#243;rtica. En el tratamiento de la cardiomiopat&#237;a isqu&#233;mica, la evaluaci&#243;n de la seguridad del empleo de la inyecci&#243;n intramioc&#225;rdica de c&#233;lulas tronco hematopoy&#233;ticas como terap&#233;utica asociada a la revascularizaci&#243;n quir&#250;rgica del miocardio fue objeto de dos protocolos cl&#237;nicos<sup>32,33</sup>, que definieron la seguridad de su uso. Se destacan tambi&#233;n los estudios respecto de la mejor preservaci&#243;n de los injertos venosos<sup>34,35</sup>, del empleo de injertos arteriales<sup>36,37</sup> y de la comparaci&#243;n entre la cirug&#237;a de</p>
      <p>revascularizaci&#243;n del miocardio realizada con o sin el empleo de circulaci&#243;n extracorp&#243;rea. La propuesta del empleo de procedimientos h&#237;bridos en el tratamiento de las disecciones a&#243;rticas agudas<sup>39</sup> y el estudio del uso de potenciales evocados en la monitorizaci&#243;n del sufrimiento medular en el abordaje quir&#250;rgico de la aorta descendente<sup>40</sup> abren nuevas perspectivas en el tratamiento de las afecciones de la aorta tor&#225;cica. Por otro lado, la experiencia brasile&#241;a a respeto del empleo de dispositivos mec&#225;nicos de asistencia circulatoria incluye solamente casu&#237;sticas iniciales con el uso de la circulaci&#243;n</p>
      <p>extracorp&#243;rea con oxigenador de membrana<sup>41,42</sup> y de ventr&#237;culos artificiales paracorp&#243;reos en el tratamiento do shock cardiog&#233;nico o como puente para el trasplante cardiaco<sup>43</sup>.</p>
      <p>El mayor control sobre la calidad y los resultados de la cirug&#237;a card&#237;aca tambi&#233;n son temas abordados en la literatura nacional<sup>44</sup>, destac&#225;ndose los estudios sobre los factores preoperatorio de riesgo para el desarrollo de la insuficiencia renal en el postoperatorio y en el abordaje quir&#250;rgico de los pacientes ancianos<sup>46</sup>.</p>
      <p>
        <bold>Referencias</bold>
      </p>
    </body>
  </sub-article>
</article>
