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  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">abc</journal-id>
      <journal-title-group>
        <journal-title>Arquivos Brasileiros de Cardiologia</journal-title>
        <abbrev-journal-title abbrev-type="publisher">Arq. Bras. Cardiol.</abbrev-journal-title>
      </journal-title-group>
      <issn pub-type="ppub">0066-782X</issn>
      <issn pub-type="epub">1678-4170</issn>
      <publisher>
        <publisher-name>Sociedade Brasileira de Cardiologia - SBC</publisher-name>
        <publisher-loc>S&#227;o Paulo, SP, Brazil</publisher-loc>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id" specific-use="scielo-v3">CcjxkcrHTxtJNvV953L4mbR</article-id>
      <article-id pub-id-type="other">00019</article-id>
      <article-id pub-id-type="publisher-id" specific-use="scielo-v2">S0066-782X2009001000019</article-id>
      <article-id pub-id-type="publisher-id" specific-use="scielo-v1">S0066-782X(09)09300419</article-id>
      <article-id pub-id-type="doi">10.1590/S0066-782X2009001000019</article-id>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Artigo de Revis&#227;o</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>O ecocardiograma na terapia de ressincroniza&#231;&#227;o card&#237;aca</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <name>
            <surname>Veiga</surname>
            <given-names>Viviane Cordeiro</given-names>
          </name>
          <xref ref-type="aff" rid="aff01"/>
          <xref ref-type="aff" rid="aff02"/>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Abensur</surname>
            <given-names>Henry</given-names>
          </name>
          <xref ref-type="aff" rid="aff01"/>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Rojas</surname>
            <given-names>Salom&#243;n Soriano Ordinola</given-names>
          </name>
          <xref ref-type="aff" rid="aff01"/>
          <xref ref-type="aff" rid="aff02"/>
        </contrib>
      </contrib-group>
      <aff id="aff01">
        <addr-line>
          <named-content content-type="city">S&#227;o Paulo</named-content>
          <named-content content-type="state">SP</named-content>
        </addr-line>
        <institution content-type="orgname">Real e Benem&#233;rita Associa&#231;&#227;o Portuguesa de Benefic&#234;ncia</institution>
      </aff>
      <aff id="aff02">
        <addr-line>
          <named-content content-type="city">Campinas</named-content>
          <named-content content-type="state">S&#227;o Paulo</named-content>
        </addr-line>
        <institution content-type="orgname">Universidade Estadual de Campinas</institution>
        <country country="BR">Brazil</country>
      </aff>
      <pub-date date-type="collection" publication-format="electronic">
        <month>10</month>
        <year>2009</year>
      </pub-date>
      <volume>93</volume>
      <issue>4</issue>
      <fpage>441</fpage>
      <lpage>445</lpage>
      <history>
        <date date-type="rev-recd">
          <day>27</day>
          <month>11</month>
          <year>2008</year>
        </date>
        <date date-type="received">
          <day>13</day>
          <month>10</month>
          <year>2008</year>
        </date>
        <date date-type="accepted">
          <day>11</day>
          <month>12</month>
          <year>2008</year>
        </date>
      </history>
      <permissions>
        <license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc/4.0/" xml:lang="en">
          <license-p>This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.</license-p>
        </license>
      </permissions>
      <abstract>
        <p>A terapia de ressincroniza&#231;&#227;o card&#237;aca (TRC) tem sido uma op&#231;&#227;o efetiva nos pacientes com insufici&#234;ncia card&#237;aca avan&#231;ada. No entanto 20% a 30% dos pacientes n&#227;o apresentam benef&#237;cios nessa terap&#234;utica. Crit&#233;rios cl&#237;nicos, eletrocardiogr&#225;ficos e ecocardiogr&#225;ficos t&#234;m sido estudados na tentativa de selecionar os pacientes que ser&#227;o beneficiados com a ressincroniza&#231;&#227;o card&#237;aca, mas o ecocardiograma tem papel importante tanto na sele&#231;&#227;o quanto na avalia&#231;&#227;o e otimiza&#231;&#227;o dessa terap&#234;utica. O objetivo desta revis&#227;o &#233; descrever os principais par&#226;metros ecocardiogr&#225;ficos utilizados na avalia&#231;&#227;o da terapia de ressincroniza&#231;&#227;o card&#237;aca.</p>
      </abstract>
      <kwd-group xml:lang="pt" kwd-group-type="author-generated">
        <kwd>Ecocardiografia</kwd>
        <kwd>insufici&#234;ncia card&#237;aca</kwd>
        <kwd>marcapasso artificial</kwd>
      </kwd-group>
      <pub-date publication-format="electronic" date-type="pub">
        <day>24</day>
        <month>11</month>
        <year>2009</year>
      </pub-date>
    </article-meta>
  </front>
  <body>
    <p>
      <bold>ARTIGO DE REVIS&#195;O</bold>
    </p>
    <p>
      <bold>O ecocardiograma na terapia de ressincroniza&#231;&#227;o card&#237;aca </bold>
    </p>
    <p>
      <bold>Viviane Cordeiro Veiga<sup>I, II</sup>; Henry Abensur<sup>I</sup>; Salom&#243;n Soriano Ordinola Rojas<sup>I, II</sup></bold>
    </p>
    <p><sup>I</sup>Real e Benem&#233;rita Associa&#231;&#227;o Portuguesa de Benefic&#234;ncia, S&#227;o Paulo, SP </p>
    <p><sup>II</sup>Universidade Estadual de Campinas (UNICAMP), Campinas, SP - Brasil</p>
    <p>
      <xref ref-type="corresp" rid="back">Correspond&#234;ncia</xref>
    </p>
    <p>
      <bold>RESUMO</bold>
    </p>
    <p>A terapia de ressincroniza&#231;&#227;o card&#237;aca (TRC) tem sido uma op&#231;&#227;o efetiva nos pacientes com insufici&#234;ncia card&#237;aca avan&#231;ada. No entanto 20% a 30% dos pacientes n&#227;o apresentam benef&#237;cios nessa terap&#234;utica. Crit&#233;rios cl&#237;nicos, eletrocardiogr&#225;ficos e ecocardiogr&#225;ficos t&#234;m sido estudados na tentativa de selecionar os pacientes que ser&#227;o beneficiados com a ressincroniza&#231;&#227;o card&#237;aca, mas o ecocardiograma tem papel importante tanto na sele&#231;&#227;o quanto na avalia&#231;&#227;o e otimiza&#231;&#227;o dessa terap&#234;utica. O objetivo desta revis&#227;o &#233; descrever os principais par&#226;metros ecocardiogr&#225;ficos utilizados na avalia&#231;&#227;o da terapia de ressincroniza&#231;&#227;o card&#237;aca.</p>
    <p><bold>Palavras-chave: </bold> Ecocardiografia / t&#233;cnicas, insufici&#234;ncia card&#237;aca, marcapasso artificial.</p>
    <p>
      <bold>Introdu&#231;&#227;o</bold>
    </p>
    <p>A insufici&#234;ncia card&#237;aca &#233; uma condi&#231;&#227;o com elevada morbimortalidade, que atinge, aproximadamente, 23 milh&#245;es de pessoas no mundo<sup>1</sup>, por&#233;m cerca de dois milh&#245;es de novos casos s&#227;o diagnosticados a cada ano<sup>2</sup>, com custo anual estimado em R$198 milh&#245;es, segundo dados do Banco de Dados do Sistema &#218;nico de Sa&#250;de (DATASUS)<sup>3</sup>.</p>
    <p>A terapia de ressincroniza&#231;&#227;o card&#237;aca tem sido uma op&#231;&#227;o efetiva nos pacientes com insufici&#234;ncia card&#237;aca avan&#231;ada, propiciando benef&#237;cios cl&#237;nicos, tais como a melhora da classe funcional, da capacidade de exerc&#237;cio e da qualidade de vida, com redu&#231;&#227;o das interna&#231;&#245;es e da mortalidade<sup>4</sup>.</p>
    <p>O primeiro relato de estimula&#231;&#227;o biventricular foi em 1994, por Cazeau e cols.<sup>5</sup>, mas a terapia teve sua aprova&#231;&#227;o para uso cl&#237;nico pela <italic>Food and Drug Administration</italic> (FDA) em 20016.</p>
    <p>A indica&#231;&#227;o para a TRC, segundo diretrizes da <italic>American Heart Association</italic>, &#233; a classe I para pacientes em classe funcional III ou IV (<italic>New York Heart Association</italic>), com terapia medicamentosa otimizada para insufici&#234;ncia card&#237;aca, fra&#231;&#227;o de eje&#231;&#227;o menor que 35% ao ecocardiograma, presen&#231;a de QRS <underline>&gt;</underline> 120 ms e ritmo sinusal ao eletrocardiograma<sup>7</sup>.</p>
    <p>No entanto 20% a 30% dos pacientes n&#227;o respondem &#224; TRC8,9, todavia diversos par&#226;metros cl&#237;nicos, eletrocardiogr&#225;ficos e ecocardiogr&#225;ficos t&#234;m sido utilizados para a sele&#231;&#227;o dos candidatos a essa terap&#234;utica.</p>
    <p>O objetivo dessa revis&#227;o &#233; descrever os principais par&#226;metros ecocardiogr&#225;ficos utilizados na avalia&#231;&#227;o da terapia de ressincroniza&#231;&#227;o card&#237;aca.</p>
    <p>
      <bold>Par&#226;metros ecocardiogr&#225;ficos na sele&#231;&#227;o de pacientes para TRC</bold>
    </p>
    <p>A avalia&#231;&#227;o ecocardiogr&#225;fica antes do implante do marcapasso biventricular consiste, preferencialmente, em: confirmar a presen&#231;a de deteriora&#231;&#227;o da fun&#231;&#227;o ventricular esquerda, avaliar a presen&#231;a de dissincronia atrioventricular, interventricular e intraventricular e avaliar as anormalidades estruturais associadas que possam dificultar o implante do marcapasso<sup>10</sup>.</p>
    <p>
      <bold>Avalia&#231;&#227;o da fun&#231;&#227;o ventricular esquerda</bold>
    </p>
    <p>A avalia&#231;&#227;o da fun&#231;&#227;o sist&#243;lica deve ser realizada pelo m&#233;todo bidimensional (Simpson), para avaliar a fra&#231;&#227;o de eje&#231;&#227;o do ventr&#237;culo esquerdo, sendo indica&#231;&#227;o para a TRC um valor inferior a 35%<sup>9</sup> (<xref ref-type="fig" rid="f01">fig. 1</xref>).</p>
    <p content-type="asset">
      <fig id="f01">
        <graphic xlink:href="1678-4170-abc-93-04-0441-00019-gf01.jpg"/></fig>
    </p>
    <p>
      <bold>Avalia&#231;&#227;o da dissincronia atrioventricular</bold>
    </p>
    <p>A dissincronia atrioventricular pode comprometer a fun&#231;&#227;o ventricular, em decorr&#234;ncia das contra&#231;&#245;es atrial e ventricular quase simult&#226;neas, acarretando redu&#231;&#227;o da pr&#233;-carga por diminui&#231;&#227;o da contra&#231;&#227;o atrial. Considera-se dissincronia atrioventricular quando o tempo de pr&#233;-eje&#231;&#227;o a&#243;rtico for superior a 140 ms, ou se o tempo de enchimento diast&#243;lico for menor que 40% do ciclo card&#237;aco, medindo-se o per&#237;odo compreendido entre o in&#237;cio da onda E ao fim da onda A do fluxo mitral<sup>11-13</sup>.</p>
    <p>
      <bold>Avalia&#231;&#227;o da dissincronia interventricular</bold>
    </p>
    <p>A dissincronia interventricular pode ser analisada pelo doppler pulsado, por meio da diferen&#231;a do atraso eletromec&#226;nico entre os ventr&#237;culos, medindo-se o intervalo de tempo entre a onda R do eletrocardiograma e o in&#237;cio da curva de velocidade do fluxo a&#243;rtico e do fluxo pulmonar. Se a diferen&#231;a entre os dois intervalos for superior a 40 ms, &#233; indicativo de dissincronia interventricular<sup>12,14-17</sup> (<xref ref-type="fig" rid="f02">fig. 2</xref>). A limita&#231;&#227;o dessa an&#225;lise refere-se ao fato de que as medidas dos ventr&#237;culos n&#227;o podem ser realizadas simultaneamente. Al&#233;m disso, condi&#231;&#245;es patol&#243;gicas, tais como a hipertens&#227;o pulmonar, podem estar associadas a um prolongamento do tempo de pr&#233;-eje&#231;&#227;o pulmonar, limitando a sua especificidade.</p>
    <p content-type="asset">
      <fig id="f02">
        <graphic xlink:href="1678-4170-abc-93-04-0441-00019-gf02.jpg"/></fig>
    </p>
    <p>O doppler tecidual tamb&#233;m pode ser utilizado na avalia&#231;&#227;o da dissincronia interventricular. Essa t&#233;cnica consiste em identificar e medir as velocidades de movimenta&#231;&#227;o dos segmentos mioc&#225;rdicos. A mensura&#231;&#227;o &#233; feita com a diferen&#231;a entre os intervalos de tempo caracterizados pelo in&#237;cio do complexo QRS do eletrocardiograma at&#233; o pico (ou in&#237;cio) da onda S do doppler tecidual, medidos, respectivamente, na parede livre do ventr&#237;culo direito e na parede lateral do ventr&#237;culo esquerdo<sup>18-20</sup>. No entanto n&#227;o existe um consenso para o valor de corte para essa medida.</p>
    <p>
      <bold>Avalia&#231;&#227;o da dissincronia intraventricular</bold>
    </p>
    <p>A dissincronia intraventricular promove atraso eletromec&#226;nico entre as paredes do ventr&#237;culo esquerdo e pode ser analisada de diversas formas no ecocardiograma.</p>
    <p>Pitzalis e cols.<sup>21</sup>, em 2002, utilizaram o modo M para a avalia&#231;&#227;o da dissincronia interventricular, medindo-se o intervalo de tempo entre a contra&#231;&#227;o do septo e a parede posterior do ventr&#237;culo esquerdo. Essa medida &#233; realizada no corte paraesternal eixo curto, medindo a diferen&#231;a de tempo entre a m&#225;xima incurs&#227;o sist&#243;lica das duas paredes. Um valor superior a 130 ms denota dissincronia significativa.</p>
    <p>Esse m&#233;todo apresenta limita&#231;&#245;es nos pacientes com doen&#231;a arterial coron&#225;ria que apresentam &#225;reas acin&#233;ticas ou hipocin&#233;ticas, em que a identifica&#231;&#227;o do pico de incurs&#227;o sist&#243;lica &#233;, muitas vezes, limitada. Al&#233;m disso, s&#227;o avaliadas apenas as regi&#245;es m&#233;dias de duas paredes<sup>10,12,21-23</sup> (<xref ref-type="fig" rid="f3">fig. 3</xref>).</p>
    <fig id="f3">
      <graphic xlink:href="1678-4170-abc-93-04-0441-00019-gf03.jpg"/></fig>
    <p>O doppler tecidual pode ser utilizado pela obten&#231;&#227;o das velocidades do mioc&#225;rdio, no plano apical, dos segmentos basais das paredes septal, lateral, anterior e inferior. Realiza-se a medida de tempo entre o in&#237;cio do QRS at&#233; o pico da onda sist&#243;lica mioc&#225;rdica do doppler tecidual (onda S) nos diferentes segmentos. Quando o valor da diferen&#231;a de intervalos de tempo for superior a 65 ms entre quaisquer segmentos avaliados, &#233; indicativo de dissincronia significativa<sup>19,20,24-29</sup>.</p>
    <p>Yu e cols.<sup>30</sup> avaliaram a diferen&#231;a de tempo entre o in&#237;cio do QRS e o pico sist&#243;lico do doppler tecidual em doze segmentos mioc&#225;rdicos. Conclu&#237;ram haver dois par&#226;metros indicativos de dissincronia intraventricular: a diferen&#231;a m&#225;xima entre a velocidade de pico sist&#243;lica entre dois segmentos maiores que 100 ms e o desvio padr&#227;o das medidas de tempo at&#233; o pico de velocidade sist&#243;lica dos doze segmentos superiores a 33 ms<sup>30</sup>.</p>
    <p>Outra t&#233;cnica para avalia&#231;&#227;o da dissincronia intraventricular derivada do doppler tecidual &#233; o <italic>tissue tracking</italic>, que expressa a integral da velocidade de movimenta&#231;&#227;o do mioc&#225;rdio em cores, no sentido do &#225;pice para a base ventricular. A aus&#234;ncia de deslocamento &#233; caracterizada pela aus&#234;ncia de cor<sup>31,32</sup>.</p>
    <p>A sincroniza&#231;&#227;o tecidual &#233; uma t&#233;cnica em que h&#225; codifica&#231;&#227;o em cores do atraso eletromec&#226;nico em cada ponto do mioc&#225;rdio. O equipamento mede o intervalo de tempo entre o in&#237;cio do QRS at&#233; o pico sist&#243;lico do doppler tecidual (onda S) em um determinado ponto do mioc&#225;rdio. Se o intervalo for menor que 150 ms (normal), o mioc&#225;rdio &#233; representado em verde; se estiver entre 150 e 300 ms, em amarelo; e se for superior a 300 ms, em vermelho. Deve ser usada com cautela em segmentos apicais<sup>18</sup> (<xref ref-type="fig" rid="f4">fig. 4</xref>).</p>
    <fig id="f4">
      <graphic xlink:href="1678-4170-abc-93-04-0441-00019-gf04.jpg"/></fig>
    <p>Mais recentemente, tem-se utilizado a ecocardiografia tridimensional para indica&#231;&#227;o e avalia&#231;&#227;o dos pacientes submetidos &#224; terapia de ressincroniza&#231;&#227;o card&#237;aca com marcapasso biventricular.</p>
    <p>O ecocardiograma tridimensional fornece o percentual de dissincronia card&#237;aca pela mensura&#231;&#227;o do &#237;ndice de dissincronia card&#237;aca (sigma). Nesse m&#233;todo, o ventr&#237;culo esquerdo &#233; estudado em modelos de 16 ou 17 segmentos parietais, analisando-se a contratilidade regional e global (<xref ref-type="fig" rid="f05">fig. 5</xref>). O sigma representa o desvio-padr&#227;o da m&#233;dia do tempo de contra&#231;&#227;o sist&#243;lica final de cada um dos segmentos card&#237;acos, comparado com a contra&#231;&#227;o sist&#243;lica final global (menor &#237;ndice representa menor dissincronia), considerando-se normais os valores inferiores a 8%. A desvantagem do m&#233;todo &#233; o baixo n&#250;mero de quadros<sup>33-35</sup>.</p>
    <p content-type="asset">
      <fig id="f05">
        <graphic xlink:href="1678-4170-abc-93-04-0441-00019-gf05.jpg"/></fig>
    </p>
    <p>Novas t&#233;cnicas t&#234;m sido desenvolvidas com o objetivo de avaliar a dissincronia intraventricular, como o strain bidimensional, em que um <italic>software</italic> analisa a deformidade sofrida pelo m&#250;sculo em duas dimens&#245;es e n&#227;o apenas no sentido do feixe do doppler<sup>36-38</sup>.</p>
    <p>
      <bold>Avalia&#231;&#227;o do local de implante do eletrodo ventricular</bold>
    </p>
    <p>Ansalone e cols.<sup>36</sup> demonstraram que se colocando o eletrodo no ventr&#237;culo esquerdo, no local de maior atraso na velocidade de ativa&#231;&#227;o, obt&#233;m-se melhor resposta &#224; TRC. Todavia, em 35% dos casos, a parede mais acometida foi a lateral. Portanto, a determina&#231;&#227;o pelo ecocardiograma da regi&#227;o com maior atraso eletromec&#226;nico pode direcionar o melhor local de implante<sup>37</sup>.</p>
    <p>
      <bold>Par&#226;metros ecocardiogr&#225;ficos na avalia&#231;&#227;o dos pacientes submetidos &#224; TRC</bold>
    </p>
    <p>S&#227;o crit&#233;rios ecocardiogr&#225;ficos utilizados na avalia&#231;&#227;o dos pacientes submetidos &#224; TRC:</p>
    <p>&#149; aumento da fra&#231;&#227;o de eje&#231;&#227;o;</p>
    <p>&#149; diminui&#231;&#227;o da regurgita&#231;&#227;o mitral;</p>
    <p>&#149; regress&#227;o do remodelamento ventricular, caracterizada pela diminui&#231;&#227;o de, pelo menos, 15% no volume sist&#243;lico final do ventr&#237;culo esquerdo<sup>21</sup>;</p>
    <p>&#149; presen&#231;a de sincronia atrioventricular, interventricular e intraventricular;</p>
    <p>&#149; ajuste do intervalo atrioventricular (sincronia AV), realizado com o doppler pulsado no fluxo mitral, pela medida do tempo entre o in&#237;cio da onda E ao fim da onda A. A otimiza&#231;&#227;o do intervalo atrioventricular &#233; recomendada quando a onda A do fluxo mitral n&#227;o &#233; identificada, quando as ondas E e A est&#227;o fusionadas, ou quando a onda E &#233; truncada pelo fechamento mitral<sup>14</sup>.</p>
    <p>
      <bold>Conclus&#227;o</bold>
    </p>
    <p>A ecocardiografia &#233; um m&#233;todo diagn&#243;stico que tem sido amplamente utilizada tanto na indica&#231;&#227;o quanto na avalia&#231;&#227;o e otimiza&#231;&#227;o p&#243;s-operat&#243;ria dos pacientes submetidos &#224; terapia de ressincroniza&#231;&#227;o card&#237;aca. No entanto essa &#233; ainda uma tecnologia em evolu&#231;&#227;o, e n&#227;o h&#225; par&#226;metros ecocardiogr&#225;ficos definitivos que possam constatar ou excluir solidamente a presen&#231;a de dissincronia significativa.</p>
    <p>
      <bold>Potencial Conflito de Interesses</bold>
    </p>
    <p>Declaro n&#227;o haver conflito de interesses pertinentes.</p>
    <p>
      <bold>Fontes de Financiamento</bold>
    </p>
    <p>O presente estudo n&#227;o teve fontes de financiamento externas.</p>
    <p>
      <bold>Vincula&#231;&#227;o Acad&#234;mica</bold>
    </p>
    <p>Este artigo &#233; parte de tese de Mestrado de Viviane Cordeiro Veiga pela Universidade Estadual de Campinas - UNICAMP.</p>
    <p>
      <fn id="back" fn-type="corresp">
        <label>
          <bold> Correspond&#234;ncia:</bold>
        </label>
        <p>Viviane Cordeiro Veiga </p>
        <p> Rua Martiniano de Carvalho, 864 - cj 310 </p>
        <p> Bela Vista - 01321-001 </p>
        <p> S&#227;o Paulo, SP - Brasil </p>
        <p> E-mail: </p>
        <p>
          <email xlink:href="vcveiga@cardiol.br">vcveiga@cardiol.br</email>
        </p>
      </fn>
    </p>
    <p>Artigo recebido em 13/10/2008; revisado recebido em 27/11/2008; aceito em 11/12/2008</p>
  </body>
  <back>
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              <surname>Kindermann</surname>
              <given-names>M</given-names>
            </name>
            <name>
              <surname>Frolhig</surname>
              <given-names>G</given-names>
            </name>
            <name>
              <surname>Doerr</surname>
              <given-names>T</given-names>
            </name>
            <name>
              <surname>Schieffer</surname>
              <given-names>H</given-names>
            </name>
          </person-group>
        </element-citation>
      </ref>
      <ref id="B38">
        <mixed-citation>38. Suffoletto    MS, Dohi K, Cannesson M, Saba S, Gorcsan J 3rd. Novel speckle-tracking radial    strain from routine black-and-white echocardiographic images to quantify dyssynchrony    and predict response to cardiac resynchronization therapy. Circulation. 2006;    113 (17): 960-8.</mixed-citation>
        <element-citation publication-type="journal">
          <article-title>Novel speckle-tracking radial strain from routine black-and-white echocardiographic images to quantify dyssynchrony and predict response to cardiac resynchronization therapy</article-title>
          <source>Circulation</source>
          <date>
            <year>2006</year>
          </date>
          <fpage>960</fpage>
          <lpage>8</lpage>
          <issue>17</issue>
          <volume>113</volume>
          <person-group person-group-type="author">
            <name>
              <surname>Suffoletto</surname>
              <given-names>MS</given-names>
            </name>
            <name>
              <surname>Dohi</surname>
              <given-names>K</given-names>
            </name>
            <name>
              <surname>Cannesson</surname>
              <given-names>M</given-names>
            </name>
            <name>
              <surname>Saba</surname>
              <given-names>S</given-names>
            </name>
            <name>
              <surname>Gorcsan 3rd</surname>
              <given-names>J</given-names>
            </name>
          </person-group>
        </element-citation>
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  </back>
  <sub-article article-type="translation" id="TRen" xml:lang="en">
    <front-stub>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Review Article</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title xml:lang="en">Echocardiography in cardiac resynchronization therapy</article-title>
      </title-group>
      <abstract xml:lang="en">
        <p>Cardiac resynchronization therapy has been an effective option in patients with advanced heart failure. However, 20 to 30% of the patients do not benefit from this therapy. Clinical, electrocardiographic and echocardiographic criteria have been studied in an attempt to select patients who will benefit from a cardiac resynchronization therapy, and the echocardiogram is important both in the selection and in the evaluation and optimization of the therapy. The objective of this review is to describe the main echocardiographic parameters used in the evaluation of the cardiac resynchronization therapy.</p>
      </abstract>
      <kwd-group xml:lang="en">
        <kwd>Echocardiography</kwd>
        <kwd>heart failure</kwd>
        <kwd>pacemaker artificial</kwd>
      </kwd-group>
    </front-stub>
    <body>
      <p>
        <bold>REVIEW ARTICLE</bold>
      </p>
      <p>
        <fn id="top-body2">
          <label>
            <bold>Echocardiography in cardiac resynchronization therapy</bold>
          </label>
          <p>
            <bold>Viviane Cordeiro Veiga<sup>I, II</sup>; Henry Abensur<sup>I</sup>; Salom&#243;n Soriano Ordinola Rojas<sup>I, II</sup></bold>
          </p>
        </fn>
      </p>
      <p><sup>I</sup>Real e Benem&#233;rita Associa&#231;&#227;o Portuguesa de Benefic&#234;ncia, S&#227;o Paulo, SP - Brazil</p>
      <p><sup>II</sup>Universidade Estadual de Campinas (UNICAMP), Campinas, SP - Brazil</p>
      <p>Mailing address</p>
      <p>
        <bold>SUMMARY</bold>
      </p>
      <p>Cardiac resynchronization therapy has been an effective option in patients with advanced heart failure. However, 20 to 30% of the patients do not benefit from this therapy. Clinical, electrocardiographic and echocardiographic criteria have been studied in an attempt to select patients who will benefit from a cardiac resynchronization therapy, and the echocardiogram is important both in the selection and in the evaluation and optimization of the therapy. The objective of this review is to describe the main echocardiographic parameters used in the evaluation of the cardiac resynchronization therapy.</p>
      <p><bold>Key Words:</bold> Echocardiography / techniques; heart failure; pacemaker artificial.</p>
      <p>
        <bold>Introduction</bold>
      </p>
      <p>Heart failure is a condition with high morbidity and mortality, which affects approximately 23 million people in the world<sup>1</sup> approximately two million new cases are diagnosed each year<sup>2</sup>, with an annual cost estimated at US$ 198 million, according to DATASUS<sup>3</sup>.</p>
      <p>Cardiac resynchronization therapy (CRT) has been an effective option in patients with advanced heart failure, providing clinical benefits, such as improved functional class, ability to exercise, and quality of life, as well as reduced hospitalization and mortality<sup>4</sup>.</p>
      <p>The first clinical report of biventricular pacing is credited to Cazeau et al<sup>5</sup> in 1994, and the therapy had its approval for clinical use by the Food and Drug Administration (FDA) in 2001<sup>6</sup>.</p>
      <p>The indication for CRT, according to the guidelines of the American Heart Association, is class I for patients in functional class III or IV (New York Heart Association), with optimized heart failure therapy, an ejection fraction of less than 35% on the echocardiogram, and QRS <underline>&gt;</underline> 120 ms and sinus rhythm on the electrocardiogram<sup>7</sup>.</p>
      <p>However, approximately 20 to 30% of patients do not respond to CRT<sup>8,9</sup>, and various clinical, electrocardiographic and echocardiographic parameters have been used for the selection of candidates for this therapy.</p>
      <p>The objective of this review is to describe the main echocardiographic parameters used in the evaluation of the cardiac resynchronization therapy.</p>
      <p>
        <bold>Echocardiographic parameters for selecting patients for CRT</bold>
      </p>
      <p>The echocardiographic evaluation before the implantation of a biventricular pacemaker consists mainly of the following: confirming the presence of left ventricular function deterioration, assessing the presence of atrioventricular, interventricular and intraventricular dyssynchrony, and evaluating associated structural abnormalities that may hinder the implantation of the pacemaker<sup>10</sup>.</p>
      <p>
        <bold>Assessment of left ventricular function</bold>
      </p>
      <p>The assessment of systolic function should be performed by the two-dimensional method (Simpson) to assess the left ventricle ejection fraction indication for CRT is a value of less than 35%<sup>9</sup> (<xref ref-type="fig" rid="en_19f01-body2">Figure 1</xref>).</p>
      <p content-type="asset">
        <fig id="en_19f01-body2">
          <graphic xlink:href="1678-4170-abc-93-04-0441-00019-gf01-en.jpg"/></fig>
      </p>
      <p>
        <bold>Assessment of atrioventricular dyssynchrony</bold>
      </p>
      <p>The atrioventricular dyssynchrony may affect ventricular function due to almost simultaneous atrial and ventricular contractions, which cause a reduction in the preload by decreasing the atrial contraction. Atrioventricular dyssynchrony is characterized when the pre-ejection aortic time exceeds 140 ms, or if the diastolic filling time is less than 40% of the cardiac cycle, by the measurement of the time interval between the beginning of the E wave and the end of the A wave in the mitral flow<sup>11-13</sup>.</p>
      <p>
        <bold>Assessment of interventricular dyssynchrony</bold>
      </p>
      <p>The interventricular dyssynchrony may be assessed by pulsed Doppler ultrasonography, using the difference between the left and right ventricular electromechanical delays by measuring the interval between the R wave of the electrocardiogram and the beginning of the aortic and pulmonary flow velocity curves. If the difference between the two intervals is greater than 40 ms, this is indicative of interventricular dyssynchrony<sup>12,14-17</sup> (<xref ref-type="fig" rid="en_19f02-body2">Figure 2</xref>). The limitation of this analysis is that the ventricles can not be assessed simultaneously. Furthermore, pathological conditions such as pulmonary hypertension may be associated with a prolongation of the pulmonary pre-ejection time interval, thus limiting its specificity.</p>
      <p content-type="asset">
        <fig id="en_19f02-body2">
          <graphic xlink:href="1678-4170-abc-93-04-0441-00019-gf02-en.jpg"/></fig>
      </p>
      <p>Tissue Doppler can also be used in the assessment of interventricular dyssynchrony. This technique is used to identify and measure the velocity of motion of myocardial segments. The assessment is done by measuring the difference between the time intervals characterized by the onset of the QRS complex on the electrocardiogram to the peak (or beginning) of the S-wave on the tissue Doppler recording, respectively measured in the right ventricular free wall and the left ventricular lateral wall<sup>18-20</sup>. However, there is no consensus about the cut-off for this measurement.</p>
      <p>
        <bold>Assessment of intraventricular dyssynchrony</bold>
      </p>
      <p>Intraventricular dyssynchrony promotes electromechanical delays between the walls of the left ventricle, and there are several ways to analyze it through an echocardiography.</p>
      <p>Pitzalis et al<sup>21</sup>, in 2002, used the M mode for the assessment of interventricular dyssynchrony by measuring the time interval between the contraction of the septum and the posterior wall of the left ventricle. This is done in the parasternal short axis view, by measuring the time interval between the maximum systolic excursion of the two walls. More than 130ms denotes significant dyssynchrony.</p>
      <p>This method has limitations in patients with coronary artery disease who present hypokinetic or akinetic areas, where the identification of the peak systolic excursion is often limited. Moreover, only the middle regions of the two walls are evaluated<sup>10,12,21-23</sup> (<xref ref-type="fig" rid="f3-body2">Figure 3</xref>).</p>
      <fig id="f3-body2">
        <graphic xlink:href="1678-4170-abc-93-04-0441-00019-gf03-en.jpg"/></fig>
      <p>Tissue Doppler can be used to obtain the myocardial velocities of the basal segments of septal, lateral, anterior and inferior walls in the apical plane. The time interval between the beginning of the QRS complex to the peak systolic myocardial wave (S-wave) is measured in these segments. A delay between any two segments of more than 65 ms is indicative of significant dyssynchrony<sup>19,20,24-29</sup>.</p>
      <p>Yu et al<sup>30</sup> evaluated the delay between the beginning of the QRS complex and the tissue Doppler peak systolic myocardial wave in twelve segments, concluding that there are two parameters which are indicative of intraventricular dyssynchrony: maximum time difference between 2 distinct segments greater than 100 ms, and standard deviation of time to peak systolic velocity in 12 segments exceeding 33ms<sup>30</sup>.</p>
      <p>Another technique for the assessment of intraventricular dyssynchrony derived from tissue Doppler is <italic>tissue tracking</italic>, which expresses the full speed of myocardial motion in color, from the ventricular apex to the base. The absence of displacement is characterized by the absence of color<sup>31,32</sup>.</p>
      <p>Tissue synchronization is a technique that uses color coding for electromechanical delay in each segment of the myocardium. The equipment measures the time interval between the beginning of the QRS complex and the peak systolic wave (S wave) at a specific point of the myocardium. If the time interval is less than 150ms (normal), the myocardium is represented in green; if it ranges between 150-300ms the myocardium is represented in yellow; and if it is greater than 300ms the myocardium is represented in red. It should be used with caution in apical segments<sup>18</sup> (<xref ref-type="fig" rid="f4-body2">Figure 4</xref>).</p>
      <fig id="f4-body2">
        <graphic xlink:href="1678-4170-abc-93-04-0441-00019-gf04-en.jpg"/></fig>
      <p>More recently, the three-dimensional echocardiography has been used for indicating and assessing patients undergoing cardiac resynchronization therapy with a biventricular pacemaker.</p>
      <p>The three-dimensional echocardiography provides the percentage of cardiac dyssynchrony by measuring the rate of cardiac dyssynchrony (sigma). In this method, the left ventricle is studied in models of 16 or 17 parietal segments, and the regional and global contractility is analyzed (<xref ref-type="fig" rid="en_19f05-body2">Figure 5</xref>). The sigma represents the standard deviation of the mean end-systolic contraction time of each segment compared to global end-systolic contraction (a lower index indicates lower dyssynchrony); a value of less than 8% is considered normal. The disadvantage of this method is the low number of frames<sup>33-35</sup>.</p>
      <p content-type="asset">
        <fig id="en_19f05-body2">
          <graphic xlink:href="1678-4170-abc-93-04-0441-00019-gf05-en.jpg"/></fig>
      </p>
      <p>New techniques have been developed to evaluate intraventricular dyssynchrony, such as the two-dimensional strain, in which a computer software analyzes the deformation suffered by the muscle in two dimensions and not only toward the Doppler<sup>36-38</sup> beam. Assessment of the ventricular electrode implant site.</p>
      <p>
        <bold>Evaluation of the site of the ventricular electrode implant</bold>
      </p>
      <p>Ansalone et al<sup>36</sup> demonstrated that when the electrode was implanted in the left ventricle, in the site of greatest activation delay, a better response to CRT was obtained, and in 35% of cases the lateral wall was the most affected. Therefore, the determination by echocardiography of the region with higher electromechanical delay indicates the best place to implant the electrode<sup>37</sup>.</p>
      <p>
        <bold>Echocardiographic parameters in the evaluation of patients undergoing CRT</bold>
      </p>
      <p>The following are the echocardiographic criteria used in the evaluation of patients undergoing CRT:</p>
      <p>&#149; Increase in ejection fraction;</p>
      <p>&#149; Reduction in mitral regurgitation;</p>
      <p>&#149; Regression of ventricular remodeling, characterized by a reduction by at least 15% in the left ventricle end systolic volume<sup>21</sup>;</p>
      <p>&#149; Presence of atrioventricular, interventricular and intraventricular synchrony;</p>
      <p>&#149; Adjustment of the atrioventricular interval (AV synchrony), performed using pulsed Doppler in mitral flow, by measuring the time interval between the onset of the E wave and the end of the A wave. The optimization of the atrioventricular interval is recommended when: the A wave of mitral flow is not identified, when the E and A waves are merged, or when the E wave is truncated by mitral valve closure <sup>14</sup>.</p>
      <p>
        <bold>Conclusion</bold>
      </p>
      <p>Echocardiography is a diagnostic method that has been widely used both in the indication and in the evaluation and optimization of post-operative patients who undergo cardiac resynchronization therapy. However, this technology is still evolving and there are no definitive echocardiographic parameters that can firmly determine or exclude the presence of significant dyssynchrony.</p>
      <p>
        <bold>Potential Conflict of Interest</bold>
      </p>
      <p>No potential conflict of interest relevant to this article was reported.</p>
      <p>
        <bold>Sources of Funding</bold>
      </p>
      <p>There were no external funding sources for this study.</p>
      <p>
        <bold>Study Association</bold>
      </p>
      <p>This article is part of the thesis of master submitted by Viviane Cordeiro Veiga, from Universidade Estadual de Campinas - UNICAMP.</p>
      <p>
        <bold>References</bold>
      </p>
    </body>
  </sub-article>
  <sub-article article-type="translation" id="TRes" xml:lang="es">
    <front-stub>
      <article-categories/>
      <title-group>
        <article-title xml:lang="es">El ecocardiograma en la terapia de resincronizaci&#243;n cardiaca</article-title>
      </title-group>
      <abstract xml:lang="es">
        <p>La terapia de resincronizaci&#243;n cardiaca (TRC) viene siendo una opci&#243;n efectiva en los pacientes con insuficiencia cardiaca avanzada. Sin embargo, del 20% al 30% de los pacientes no presentan beneficios en esa terap&#233;utica. Criterios cl&#237;nicos, electrocardiogr&#225;ficos y ecocardiogr&#225;ficos est&#225;n siendo estudiados en el intento de seleccionar a los pacientes que se beneficiar&#225;n con la resincronizaci&#243;n cardiaca, pero lo ecocardiograma juega un rol importante tanto en la selecci&#243;n como en la evaluaci&#243;n y la optimizaci&#243;n de esa terap&#233;utica. El objetivo de esta revisi&#243;n es describir los principales par&#225;metros ecocardiogr&#225;ficos utilizados en la evaluaci&#243;n de la terapia de resincronizaci&#243;n cardiaca.</p>
      </abstract>
      <kwd-group xml:lang="es">
        <kwd>Ecocardiograf&#237;a</kwd>
        <kwd>insuficiencia cardiaca</kwd>
        <kwd>marcapaso artificial</kwd>
      </kwd-group>
    </front-stub>
    <body>
      <p>
        <bold>ART&#205;CULO DE REVISI&#211;N</bold>
      </p>
      <p>
        <fn id="top-body3">
          <label>
            <bold>El Ecocardiograma en la terapia de resincronizaci&#243;n cardiaca</bold>
          </label>
          <p>
            <bold>Viviane Cordeiro Veiga<sup>I, II</sup>; Henry Abensur<sup>I</sup>; Salom&#243;n Soriano Ordinola Rojas<sup>I, II</sup></bold>
          </p>
        </fn>
      </p>
      <p><sup>I</sup>Real e Benem&#233;rita Associa&#231;&#227;o Portuguesa de Benefic&#234;ncia, S&#227;o Paulo, SP</p>
      <p><sup>II</sup>Universidade Estadual de Campinas (UNICAMP), Campinas, SP - Brasil</p>
      <p>Correspondencia</p>
      <p>
        <bold>RESUMEN</bold>
      </p>
      <p>La terapia de resincronizaci&#243;n cardiaca (TRC) viene siendo una opci&#243;n efectiva en los pacientes con insuficiencia cardiaca avanzada. Sin embargo, del 20% al 30% de los pacientes no presentan beneficios en esa terap&#233;utica. Criterios cl&#237;nicos, electrocardiogr&#225;ficos y ecocardiogr&#225;ficos est&#225;n siendo estudiados en el intento de seleccionar a los pacientes que se beneficiar&#225;n con la resincronizaci&#243;n cardiaca, pero lo ecocardiograma juega un rol importante tanto en la selecci&#243;n como en la evaluaci&#243;n y la optimizaci&#243;n de esa terap&#233;utica. El objetivo de esta revisi&#243;n es describir los principales par&#225;metros ecocardiogr&#225;ficos utilizados en la evaluaci&#243;n de la terapia de resincronizaci&#243;n cardiaca.</p>
      <p><bold>Palabras clave: </bold> Ecocardiograf&#237;a / t&#233;cnicas, insuficiencia cardiaca, marcapaso artificial.</p>
      <p>
        <bold>Introducci&#243;n</bold>
      </p>
      <p>La insuficiencia cardiaca es una condici&#243;n con elevada morbimortalidad, que afecta, aproximadamente, a 23 millones de personas en el mundo<sup>1</sup>, aunque se diagnostican cerca de dos millones de nuevos casos cada a&#241;o<sup>2</sup>, con coste anual estimado en R$ 198 millones, seg&#250;n informaciones del banco de datos del Sistema &#218;nico de Salud (DATASUS)<sup>3</sup>.</p>
      <p>La terapia de resincronizaci&#243;n cardiaca viene siendo una opci&#243;n efectiva en los pacientes con insuficiencia cardiaca avanzada, propiciando beneficios cl&#237;nicos, tales como la mejora de la clase funcional, de la capacidad de ejercicio y de la calidad de vida, con reducci&#243;n de las internaciones y de la mortalidad<sup>4</sup>.</p>
      <p>El primer relato de estimulaci&#243;n biventricular fue en el 1994, por Cazeau et al.<sup>5</sup>, pero la terapia tuvo su aprobaci&#243;n para uso cl&#237;nico por la <italic>Food and Drug Administration</italic> (FDA) en 2001<sup>6</sup>.</p>
      <p>La indicaci&#243;n para la TRC, seg&#250;n directrices de la <italic>American Heart Association</italic>, es la clase I para pacientes en clase funcional III &#243; IV (<italic>New York Heart Association</italic>), con terapia medicamentosa optimizada para insuficiencia cardiaca, fracci&#243;n de eyecci&#243;n menor que el 35% al ecocardiograma, presencia de QRS <underline>&gt;</underline> 120 ms y ritmo sinusal al electrocardiograma<sup>7</sup>.</p>
      <p>No obstante, del 20% al 30% de los pacientes no responden al TRC<sup>8,9</sup>, todav&#237;a diversos par&#225;metros cl&#237;nicos, electrocardiogr&#225;ficos y ecocardiogr&#225;ficos vienen siendo utilizados para la selecci&#243;n de los candidatos a esa terap&#233;utica.</p>
      <p>El objetivo de esta revisi&#243;n es describir los principales par&#225;metros ecocardiogr&#225;ficos utilizados en la evaluaci&#243;n de la terapia de resincronizaci&#243;n cardiaca.</p>
      <p>
        <bold>Par&#225;metros ecocardiogr&#225;ficos en la selecci&#243;n de pacientes para TRC</bold>
      </p>
      <p>La evaluaci&#243;n ecocardiogr&#225;fica antes del implante del marcapaso biventricular consiste, preferencialmente, en: confirmar la presencia de deterioro de la funci&#243;n ventricular izquierda, evaluar la presencia de disincron&#237;a atrioventricular, interventricular e intraventricular y evaluar las anormalidades estructurales asociadas que puedan dificultar el implante del marcapaso<sup>10</sup>.</p>
      <p>
        <bold>Evaluaci&#243;n de la funci&#243;n ventricular izquierda</bold>
      </p>
      <p>La evaluaci&#243;n de la funci&#243;n sist&#243;lica se debe realizar por el m&#233;todo bidimensional (Simpson), para evaluar la fracci&#243;n de eyecci&#243;n del ventr&#237;culo izquierdo, y con indicaci&#243;n para la TRC de un valor inferior al 35%<sup>9</sup> (<xref ref-type="fig" rid="f1-body3">Fig. 1</xref>).</p>
      <p content-type="asset">
        <fig id="f1-body3">
          <graphic xlink:href=""/>
        </fig>
      </p>
      <p>
        <bold>Evaluaci&#243;n de la disincron&#237;a atriventricular</bold>
      </p>
      <p>La disincron&#237;a atrioventricular puede comprometer la funci&#243;n ventricular, como resultado de las contracciones atrial y ventricular casi simult&#225;neas, conllevando reducci&#243;n de la precarga por disminuci&#243;n de la contracci&#243;n atrial. Se considera disincron&#237;a atrioventricular cuando el tiempo de pre eyecci&#243;n a&#243;rtico sea superior a 140 ms, o si el tiempo de llenado diast&#243;lico es menor que el 40% del ciclo cardiaco, midi&#233;ndose el per&#237;odo comprendido entre el inicio de la onda E al fin de la onda A del flujo mitral<sup>11-13</sup>.</p>
      <p>
        <bold>Evaluaci&#243;n de la disincron&#237;a intraventricular</bold>
      </p>
      <p>Se puede analizar la disincron&#237;a interventricular por doppler pulsado, mediante la diferencia del atraso electromec&#225;nico entre los ventr&#237;culos, midi&#233;ndose el intervalo de tiempo entre la onda R del electrocardiograma y el inicio de la curva de velocidad del flujo a&#243;rtico y del flujo pulmonar. Si la diferencia entre los dos intervalos es superior a 40 ms, es indicativo de disincron&#237;a interventricular<sup>12,14-17</sup> (<xref ref-type="fig" rid="f2-body3">Fig. 2</xref>). La limitaci&#243;n de ese an&#225;lisis se refiere al hecho de que las mediciones de los ventr&#237;culos no se pueden llevar a cabo simult&#225;neamente. Adem&#225;s de ello, condiciones patol&#243;gicas, tales como la hipertensi&#243;n pulmonar, pueden estar asociadas a un prolongamiento del tiempo de pre eyecci&#243;n pulmonar, limitando su especificidad.</p>
      <p content-type="asset">
        <fig id="f2-body3">
          <graphic xlink:href=""/>
        </fig>
      </p>
      <p>El doppler tisular tambi&#233;n se puede utilizar en la evaluaci&#243;n de la disincron&#237;a interventricular. Esa t&#233;cnica consiste en identificar y medir las velocidades de movimiento de los segmentos mioc&#225;rdicos. La medici&#243;n se hace con la diferencia entre los intervalos de tiempo caracterizados por el inicio del complejo QRS del electrocardiograma hasta el pico (o inicio) de la onda S del ventr&#237;culo derecho, medidos, respectivamente, en la pared libre del doppler tisular y en la pared lateral del ventr&#237;culo izquierdo<sup>18-20</sup>. Sin embargo no existe un consenso para el valor de corte para esa medici&#243;n.</p>
      <p>
        <bold>Evaluaci&#243;n de la disincron&#237;a intraventricular</bold>
      </p>
      <p>La disincron&#237;a intraventricular promueve atraso electromec&#225;nico entre las paredes del ventr&#237;culo izquierdo y se puede analizar de diversas formas en el ecocardiograma.</p>
      <p>Pitzalis et al.<sup>21</sup>, en 2002, utilizaron el modo M para la evaluaci&#243;n de la disincron&#237;a interventricular, al medirse el intervalo de tiempo entre la contracci&#243;n del septo y la pared posterior del ventr&#237;culo izquierdo. Esa medici&#243;n es efectuada en el corte paraesternal del eje corto, midiendo la diferencia de tiempo entre la m&#225;xima incursi&#243;n sist&#243;lica de las dos paredes. Un valor superior a 130 ms denota disincron&#237;a significativa.</p>
      <p>Ese m&#233;todo presenta limitaciones en los pacientes con enfermedad coronaria arterial que presentan &#225;reas acin&#233;ticas o hipocin&#233;ticas, en las que la identificaci&#243;n del pico de incursi&#243;n sist&#243;lica es, muchas veces, limitada. Adem&#225;s de eso, se eval&#250;an s&#243;lo las regiones promedios de dos paredes<sup>10,12,21-23</sup> (<xref ref-type="fig" rid="f3-body3">Fig. 3</xref>).</p>
      <p content-type="asset">
        <fig id="f3-body3">
          <graphic xlink:href=""/>
        </fig>
      </p>
      <p>El doppler tisular se puede utilizar por la obtenci&#243;n de las velocidades del miocardio, en el plano apical, de los segmentos basales de las paredes septal, lateral, anterior e inferior. Se lleva a cabo la medici&#243;n del tiempo entre el principio del QRS hasta el pico de la onda sist&#243;lica mioc&#225;rdica del doppler tisular (onda S) en los diferentes segmentos. Cuando el valor de la diferencia de intervalos de tiempo sea superior a 65 ms entre cualesquier segmentos evaluados, es indicativo de disincron&#237;a significativa<sup>19,20,24-29</sup>.</p>
      <p>Yu et al.<sup>30</sup> evaluaron la diferencia de tiempo entre el inicio del QRS y el pico sist&#243;lico del doppler tisular en 12 segmentos mioc&#225;rdicos. Concluyeron que hab&#237;a dos par&#225;metros indicativos de disincron&#237;a intraventricular: la diferencia m&#225;xima entre la velocidad de pico sist&#243;lica entre dos segmentos mayores que 100 ms y la desviaci&#243;n est&#225;ndar de las mediciones de tiempo hasta el pico de velocidad sist&#243;lica de los 12 segmentos superiores a 33 ms<sup>30</sup>.</p>
      <p>Otra t&#233;cnica para evaluaci&#243;n de la disincron&#237;a intraventricular derivada del doppler tisular es el <italic>tissue tracking</italic>, que expresa la integral de la velocidad de movimiento del miocardio en color, en el sentido del doppler tisular para la base ventricular. La ausencia de desplazamiento est&#225; caracterizada por la ausencia de color<sup>31,32</sup>.</p>
      <p>La sincronizaci&#243;n tisular es una t&#233;cnica en la que hay codificaci&#243;n en colores del atraso electromec&#225;nico en cada punto del miocardio. El equipo mide el intervalo de tiempo entre el inicio del QRS hasta el pico sist&#243;lico del doppler tisular (onda S) en un determinado punto del miocardio. Si el intervalo es menor que 150 ms (normal), el miocardio es representado en color verde; si est&#225; entre 150 ms y 300 ms, en color amarillo; y si es superior a 300 ms, en color rojo. Se debe utilizarla como cautela en segmentos apicales<sup>18</sup> (<xref ref-type="fig" rid="f4-body3">Fig. 4</xref>).</p>
      <p content-type="asset">
        <fig id="f4-body3">
          <graphic xlink:href=""/>
        </fig>
      </p>
      <p>M&#225;s recientemente, se viene utilizando la ecocardiograf&#237;a tridimensional para se&#241;alar y evaluar a los pacientes sometidos a la terapia de resincronizaci&#243;n cardiaca con marcapaso biventricular.</p>
      <p>El ecocardiograma tridimensional suministra el porcentaje de disincron&#237;a cardiaca por la medici&#243;n del &#237;ndice de disincron&#237;a cardiaca (sigma). En este m&#233;todo, se estudia el ventr&#237;culo izquierdo en modelos de 16 &#243; 17 segmentos parietales, analiz&#225;ndose la contractilidad regional y global (<xref ref-type="fig" rid="f5-body3">Fig. 5</xref>). El sigma representa la desviaci&#243;n est&#225;ndar del promedio del tiempo de contracci&#243;n sist&#243;lica final de cada uno de los segmentos card&#237;acos, comparado con la contracci&#243;n sist&#243;lica final global (menor &#237;ndice representa menor disincron&#237;a), consider&#225;ndose normales los valores inferiores al 8%. La desventaja del m&#233;todo es el bajo n&#250;mero de cuadros<sup>33-35</sup>.</p>
      <p content-type="asset">
        <fig id="f5-body3">
          <graphic xlink:href=""/>
        </fig>
      </p>
      <p>Se est&#225;n desarrollando nuevas t&#233;cnicas con el objetivo de evaluar la disincron&#237;a intraventricular, como el <italic>strain</italic> bidimensional, en las que un <italic>software</italic> analiza la deformidad sufrida por m&#250;sculo en dos dimensiones y no solamente en el sentido del haz del doppler<sup>36-38</sup>.</p>
      <p>
        <bold>Evaluaci&#243;n del sitio de implante del electrodo ventricular</bold>
      </p>
      <p>Ansalone et al.<sup>36</sup> evidenciaron que si se pone el electrodo en el ventr&#237;culo izquierdo, en el sitio de mayor atraso en la velocidad de activaci&#243;n, se puede obtener una mejor respuesta a la TRC. Sin embargo, en el 35% de los casos, la pared m&#225;s afectada fue la lateral. Por lo tanto, la determinaci&#243;n por medio del ecocardiograma de la regi&#243;n con mayor atraso electromec&#225;nico puede dirigir el mejor local de implante<sup>37</sup>.</p>
      <p>
        <bold>Par&#225;metros ecocardiogr&#225;ficos en la evaluaci&#243;n de los pacientes sometidos a la TRC</bold>
      </p>
      <p>Son criterios ecocardiogr&#225;ficos utilizados en la evaluaci&#243;n de los pacientes sometidos a la TRC:</p>
      <p>&#149; aumento de la fracci&#243;n de eyecci&#243;n;</p>
      <p>&#149; disminuci&#243;n de la regurgitaci&#243;n mitral;</p>
      <p>&#149; regresi&#243;n de la remodelaci&#243;n ventricular, caracterizada por la disminuci&#243;n del 15% en el volumen sist&#243;lico final del ventr&#237;culo izquierdo<sup>21</sup> como m&#237;nimo;</p>
      <p>&#149; presencia de sincron&#237;a atrioventricular, interventricular e intraventricular;</p>
      <p>&#149; ajuste del intervalo atrioventricular (sincron&#237;a AV), llevado a cabo con el doppler pulsado en el flujo mitral, por la medici&#243;n del tiempo entre el inicio de la onda E al fin de la onda A. La optimizaci&#243;n del intervalo atrioventricular se la recomienda cuando se identifica la onda A del flujo mitral, cuando las ondas E y A est&#225;n fusionadas, o cuando la onda E y truncada por el cierre mitral<sup>14</sup>.</p>
      <p>
        <bold>Conclusi&#243;n</bold>
      </p>
      <p>La ecocardiograf&#237;a es un m&#233;todo diagn&#243;stico que est&#225; siendo ampliamente utilizado tanto en la indicaci&#243;n como en la evaluaci&#243;n y optimizaci&#243;n postoperatoria de los pacientes sometidos a la terapia de resincronizaci&#243;n cardiaca. Sin embargo esa es a&#250;n una tecnolog&#237;a que est&#225; en evoluci&#243;n, y no hay par&#225;metros ecocardiogr&#225;ficos definitivos que puedan constatar o excluir solidamente la presencia de disincron&#237;a significativa.</p>
      <p>
        <bold>Potencial Conflicto de Intereses</bold>
      </p>
      <p>Declaro no haber conflicto de intereses pertinentes.</p>
      <p>
        <bold>Fuentes de Financiaci&#243;n</bold>
      </p>
      <p>El presente estudio no tuvo fuentes de financiaci&#243;n externas.</p>
      <p>
        <bold>Vinculaci&#243;n Acad&#233;mica</bold>
      </p>
      <p>Este art&#237;culo forma parte de tesis de Maestr&#237;a de Viviane Cordeiro Veiga, por la Universidad Estadual de Campinas - UNICAMP.</p>
      <p>
        <bold>Referencias</bold>
      </p>
    </body>
  </sub-article>
</article>
