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  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">abc</journal-id>
      <journal-title-group>
        <journal-title>Arquivos Brasileiros de Cardiologia</journal-title>
        <abbrev-journal-title abbrev-type="publisher">Arq. Bras. Cardiol.</abbrev-journal-title>
      </journal-title-group>
      <issn pub-type="ppub">0066-782X</issn>
      <issn pub-type="epub">1678-4170</issn>
      <publisher>
        <publisher-name>Sociedade Brasileira de Cardiologia - SBC</publisher-name>
        <publisher-loc>S&#227;o Paulo, SP, Brazil</publisher-loc>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id" specific-use="scielo-v3">mKw3SwW8D585Z54kGVbXJWC</article-id>
      <article-id pub-id-type="other">00004</article-id>
      <article-id pub-id-type="publisher-id" specific-use="scielo-v2">S0066-782X2008001600004</article-id>
      <article-id pub-id-type="publisher-id" specific-use="scielo-v1">S0066-782X(08)09100404</article-id>
      <article-id pub-id-type="doi">10.1590/S0066-782X2008001600004</article-id>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Artigos Originais</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Fatores de risco cardiovascular em adolescentes com diferentes n&#237;veis de gasto energ&#233;tico</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <name>
            <surname>Vasconcelos</surname>
            <given-names>Italo Quenni Araujo de</given-names>
          </name>
          <xref ref-type="aff" rid="aff01"/>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Stabelini Neto</surname>
            <given-names>Antonio</given-names>
          </name>
          <xref ref-type="aff" rid="aff01"/>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Mascarenhas</surname>
            <given-names>Lu&#237;s Paulo Gomes</given-names>
          </name>
          <xref ref-type="aff" rid="aff01"/>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Bozza</surname>
            <given-names>Rodrigo</given-names>
          </name>
          <xref ref-type="aff" rid="aff01"/>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Ulbrich</surname>
            <given-names>Anderson Zampier</given-names>
          </name>
          <xref ref-type="aff" rid="aff01"/>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Campos</surname>
            <given-names>Wagner de</given-names>
          </name>
          <xref ref-type="aff" rid="aff01"/>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Bertin</surname>
            <given-names>Renata Labronici</given-names>
          </name>
          <xref ref-type="aff" rid="aff01"/>
        </contrib>
      </contrib-group>
      <aff id="aff01">
        <addr-line>
          <named-content content-type="city">Curitiba</named-content>
          <named-content content-type="state">Paran&#225;</named-content>
        </addr-line>
        <institution content-type="orgname">Universidade Federal do Paran&#225;</institution>
        <country country="BR">Brazil</country>
      </aff>
      <pub-date date-type="collection" publication-format="electronic">
        <month>10</month>
        <year>2008</year>
      </pub-date>
      <volume>91</volume>
      <issue>4</issue>
      <fpage>227</fpage>
      <lpage>233</lpage>
      <history>
        <date date-type="received">
          <day>30</day>
          <month>05</month>
          <year>2007</year>
        </date>
        <date date-type="rev-recd">
          <day>17</day>
          <month>07</month>
          <year>2007</year>
        </date>
        <date date-type="accepted">
          <day>25</day>
          <month>02</month>
          <year>2008</year>
        </date>
      </history>
      <permissions>
        <license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc/4.0/" xml:lang="en">
          <license-p>This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.</license-p>
        </license>
      </permissions>
      <abstract>
        <p>FUNDAMENTO: A inatividade f&#237;sica na adolesc&#234;ncia est&#225; relacionada com o ac&#250;mulo de gordura corporal, o que aparentemente pode aumentar a probabilidade do surgimento e desenvolvimento das altera&#231;&#245;es metab&#243;licas. OBJETIVO: Verificar a predisposi&#231;&#227;o dos fatores de risco para doen&#231;as cardiovasculares em adolescentes com diferentes n&#237;veis de gasto energ&#233;tico. M&#201;TODOS: Foram selecionados 108 rapazes e 132 mo&#231;as, com idades entre 12 e 17 anos. O gasto energ&#233;tico di&#225;rio foi obtido pelo question&#225;rio proposto por Bouchard e cols. Previamente dividiu-se amostra atrav&#233;s dos quartis de gasto energ&#233;tico (kcal/kg/dia) para composi&#231;&#227;o dos grupos: sedent&#225;rio (GS), moderadamente ativo (GM) e ativo (GA). Para avaliar as concentra&#231;&#245;es de colesterol total (CT), HDL-C e triglic&#233;rides (TG), utilizou-se o m&#233;todo enzim&#225;tico-colorim&#233;trico. O LDL-C foi calculado pela f&#243;rmula de Friedewald e cols. Para an&#225;lise estat&#237;stica utilizou-se a an&#225;lise de vari&#226;ncia de um fator, adotando p&lt;0,05. RESULTADOS: Para o sexo masculino, foram encontradas diferen&#231;as significativas entre os grupos na vari&#225;vel CT (mg/dl), sendo o GA (121,56&#177;19,15) diferente do GM (142,70&#177;27,65) e do GS (145,63&#177;36,54), assim como o GM diferiu do GS (F=3,70 e p=0,03). Para a vari&#225;vel TG (mg/dl), o GA (65,69&#177;18,95) diferiu-se do GM (82,25&#177;33,73) e do GS (97,44&#177;45,95), assim como o GM diferiu do GS (F=3,40 e p=0,04). Para o sexo feminino n&#227;o foram encontradas diferen&#231;as significativas em raz&#227;o do gasto energ&#233;tico di&#225;rio. CONCLUS&#195;O: Os rapazes mais ativos apresentam menores concentra&#231;&#245;es de CT e TG quando comparados aos seus pares moderadamente ativos e sedent&#225;rios.</p>
      </abstract>
      <kwd-group xml:lang="pt" kwd-group-type="author-generated">
        <kwd>Fatores de risco</kwd>
        <kwd>gasto energ&#233;tico</kwd>
        <kwd>adolescente</kwd>
      </kwd-group>
      <pub-date publication-format="electronic" date-type="pub">
        <day>11</day>
        <month>11</month>
        <year>2008</year>
      </pub-date>
    </article-meta>
  </front>
  <body>
    <p>ARTIGO ORIGINAL </p>
    <p> CARDIOLOGIA PEDI&#193;TRICA</p>
    <p>
      <bold>Fatores de risco cardiovascular em adolescentes com diferentes n&#237;veis de gasto energ&#233;tico</bold>
    </p>
    <p>
      <bold>Italo Quenni Araujo de Vasconcelos; Antonio Stabelini Neto; Lu&#237;s Paulo Gomes Mascarenhas; Rodrigo Bozza; Anderson Zampier Ulbrich; Wagner de Campos; Renata Labronici Bertin</bold>
    </p>
    <p>Universidade Federal do Paran&#225;, Curitiba, PR - Brasil</p>
    <p>
      <xref ref-type="corresp" rid="back">Correspond&#234;ncia</xref>
    </p>
    <p>
      <bold>RESUMO</bold>
    </p>
    <p><bold>FUNDAMENTO:</bold> A inatividade f&#237;sica na adolesc&#234;ncia est&#225; relacionada com o ac&#250;mulo de gordura corporal, o que aparentemente pode aumentar a probabilidade do surgimento e desenvolvimento das altera&#231;&#245;es metab&#243;licas. </p>
    <p><bold>OBJETIVO:</bold> Verificar a predisposi&#231;&#227;o dos fatores de risco para doen&#231;as cardiovasculares em adolescentes com diferentes n&#237;veis de gasto energ&#233;tico. </p>
    <p><bold>M&#201;TODOS:</bold> Foram selecionados 108 rapazes e 132 mo&#231;as, com idades entre 12 e 17 anos. O gasto energ&#233;tico di&#225;rio foi obtido pelo question&#225;rio proposto por Bouchard e cols. Previamente dividiu-se amostra atrav&#233;s dos quartis de gasto energ&#233;tico (kcal/kg/dia) para composi&#231;&#227;o dos grupos: sedent&#225;rio (GS), moderadamente ativo (GM) e ativo (GA). Para avaliar as concentra&#231;&#245;es de colesterol total (CT), HDL-C e triglic&#233;rides (TG), utilizou-se o m&#233;todo enzim&#225;tico-colorim&#233;trico. O LDL-C foi calculado pela f&#243;rmula de Friedewald e cols. Para an&#225;lise estat&#237;stica utilizou-se a an&#225;lise de vari&#226;ncia de um fator, adotando p&lt;0,05. </p>
    <p><bold>RESULTADOS:</bold> Para o sexo masculino, foram encontradas diferen&#231;as significativas entre os grupos na vari&#225;vel CT (mg/dl), sendo o GA (121,56&#177;19,15) diferente do GM (142,70&#177;27,65) e do GS (145,63&#177;36,54), assim como o GM diferiu do GS (F=3,70 e p=0,03). Para a vari&#225;vel TG (mg/dl), o GA (65,69&#177;18,95) diferiu-se do GM (82,25&#177;33,73) e do GS (97,44&#177;45,95), assim como o GM diferiu do GS (F=3,40 e p=0,04). Para o sexo feminino n&#227;o foram encontradas diferen&#231;as significativas em raz&#227;o do gasto energ&#233;tico di&#225;rio. </p>
    <p><bold>CONCLUS&#195;O:</bold> Os rapazes mais ativos apresentam menores concentra&#231;&#245;es de CT e TG quando comparados aos seus pares moderadamente ativos e sedent&#225;rios.</p>
    <p><bold>Palavras-chave: </bold> Fatores de risco, gasto energ&#233;tico, adolescente.</p>
    <p>
      <bold>Introdu&#231;&#227;o</bold>
    </p>
    <p>Atualmente, pesquisadores da &#225;rea da sa&#250;de, como m&#233;dicos, nutricionistas e educadores f&#237;sicos, t&#234;m investigado sobre os diversos fatores que comp&#245;e um estilo de vida desej&#225;vel para a popula&#231;&#227;o pedi&#225;trica. Estabelecendo-se a sa&#250;de como um dos componentes mais importantes, essa &#233; definida como um estado de completo bem-estar f&#237;sico, mental e social, e n&#227;o apenas a aus&#234;ncia de doen&#231;as<sup>1</sup>.</p>
    <p>Nesse sentido, partindo da premissa de que os h&#225;bitos adotados pelos adolescentes nessa fase podem ser mantidos futuramente em sua vida adulta, h&#225; de preocupar com os elementos principais do estilo de vida, principalmente quando s&#227;o analisados os fatores comportamentais como a atividade f&#237;sica.</p>
    <p>Dessa forma, a inatividade f&#237;sica na adolesc&#234;ncia est&#225; relacionada com o ac&#250;mulo de gordura corporal, que aparentemente pode aumentar a probabilidade do surgimento e desenvolvimento das altera&#231;&#245;es metab&#243;licas como a hipercolesterolemia, hipertrigliceridemia e hipertens&#227;o arterial<sup>2-4</sup>, constituindo um importante fator de preocupa&#231;&#227;o de sa&#250;de p&#250;blica<sup>5</sup>.</p>
    <p>Em adultos, existe um substancial corpo de evid&#234;ncia de que a inatividade f&#237;sica est&#225; diretamente associada com o desenvolvimento de doen&#231;as cardiovasculares e diabete tipo 2<sup>6,7</sup>, demonstrando associa&#231;&#227;o inversa entre atividade f&#237;sica e altera&#231;&#245;es metab&#243;licas<sup>8</sup>, mas em indiv&#237;duos jovens essa rela&#231;&#227;o permanece contradit&#243;ria<sup>9</sup>.</p>
    <p>Considerando que a adolesc&#234;ncia &#233; uma fase de extrema facilidade para a incorpora&#231;&#227;o de novos h&#225;bitos no estilo de vida, a detec&#231;&#227;o precoce dos fatores de risco para sa&#250;de torna-se importante, no sentido de aplicar uma eficiente estrat&#233;gia de interven&#231;&#227;o<sup>10,11</sup>. Em vista desses aspectos, estabeleceu-se como objetivo deste estudo analisar a predisposi&#231;&#227;o dos fatores de risco para doen&#231;as cardiovasculares em adolescentes de 12 a 17 anos, com diferentes n&#237;veis de gasto energ&#233;tico.</p>
    <p>
      <bold>M&#233;todos</bold>
    </p>
    <p>
      <bold>Amostra</bold>
    </p>
    <p>A amostra aleat&#243;ria foi composta por 240 adolescentes (108 rapazes e 132 mo&#231;as), com faixa et&#225;ria entre 12 e 16 anos, da cidade de S&#227;o Mateus do Sul, Paran&#225;, extra&#237;dos do banco de dados do projeto de pesquisa "An&#225;lise dos fatores de risco para doen&#231;as cardiovasculares e defici&#234;ncia do sistema imunol&#243;gico em adolescentes das escolas p&#250;blicas de S&#227;o Mateus do Sul, PR", que est&#225; sendo desenvolvido pelo Centro de Pesquisa em Exerc&#237;cio e Esporte da UFPR.</p>
    <p>O tamanho amostral foi calculado de acordo com os seguintes crit&#233;rios: a) n&#250;mero total de rapazes e mo&#231;as matriculados na rede p&#250;blica de ensino; b) intervalo de confian&#231;a de 95%; c) erro amostral de 5% e preval&#234;ncia de 20%<sup>12</sup>. A estimativa de preval&#234;ncia de 20% foi adotada considerando que a distribui&#231;&#227;o dos fatores de risco encontrada em outros estudos com indiv&#237;duos jovens apresenta valores inferiores a 20%<sup>2,13,14</sup>.</p>
    <p>Inicialmente, foi enviada uma "carta convite" para cada escola com informa&#231;&#245;es pertinentes ao estudo, contendo breve explica&#231;&#227;o sobre os objetivos da pesquisa e as avalia&#231;&#245;es a serem realizadas. Assim, os adolescentes sorteados que aceitaram participar das avalia&#231;&#245;es receberam um "termo de consentimento" livre e esclarecido que foi preenchido pelos pais ou respectivos respons&#225;veis, autorizando a participa&#231;&#227;o nas avalia&#231;&#245;es.</p>
    <p>O Comit&#234; de &#201;tica em Pesquisa da Universidade Federal do Paran&#225; aprovou a realiza&#231;&#227;o deste estudo, conforme resolu&#231;&#227;o 196/96 do Conselho Nacional de Sa&#250;de envolvendo pesquisas em seres humanos, processo n&#186; 018-06.</p>
    <p>
      <bold>Instrumentos e procedimentos</bold>
    </p>
    <p>
      <bold>Est&#225;gio maturacional</bold>
    </p>
    <p>Para determina&#231;&#227;o do est&#225;gio de matura&#231;&#227;o sexual foi utilizado o m&#233;todo proposto por Tanner<sup>15</sup>, em que os est&#225;gios maturacionais se dividem de um a cinco, sendo o est&#225;gio um quando a crian&#231;a se encontra no n&#237;vel considerado pr&#233;-p&#250;bere, e o outro extremo, o est&#225;gio cinco, quando o processo maturacional est&#225; finalizado.</p>
    <p>O teste foi aplicado em forma de auto-avalia&#231;&#227;o do desenvolvimento da pilosidade pubiana, conforme sugerido por Martin e cols.<sup>16</sup> e Bojikian e cols.<sup>17</sup>, que identificaram satisfat&#243;ria concord&#226;ncia desse m&#233;todo com a avalia&#231;&#227;o m&#233;dica de k = 0,61 e k = 0,53 para o sexo masculino e feminino respectivamente.</p>
    <p>
      <bold>Gasto energ&#233;tico di&#225;rio</bold>
    </p>
    <p>Utilizou-se o question&#225;rio auto-recordat&#243;rio desenvolvido por Bouchard e cols.<sup>18</sup>. Esse consiste em uma ficha para registro das atividades realizadas em dois dias da semana e um dia do final de semana, sendo esses divididos em partes de 15 minutos. As atividades s&#227;o classificadas em um continuum envolvendo nove categorias, que representam o gasto energ&#233;tico m&#233;dio das atividades realizadas. Essas categorias s&#227;o classificadas de um a nove, e a categoria um se caracteriza pelas atividades de menor gasto cal&#243;rico (sono e repouso na cama), e a categoria nove, com atividades de elevado gasto cal&#243;rico (trabalho manual intenso e esporte competitivo).</p>
    <p>De posse dessas informa&#231;&#245;es, foi poss&#237;vel estimar o gasto energ&#233;tico di&#225;rio (GED) dividido por quilograma de peso corporal por dia (kcal/kg/dia), bem como o GED pela m&#233;dia dos tr&#234;s dias do recordativo. O question&#225;rio apresenta reprodutibilidade de r=0,91 em indiv&#237;duos a partir de 10 anos de idade<sup>18</sup>.</p>
    <p>A fim de classificar os indiv&#237;duos quanto ao GED, a amostragem foi dividida em quartis (Q) de acordo com o sexo<sup>8</sup>. A discrimina&#231;&#227;o da forma&#231;&#227;o dos grupos de acordo com o GED (kcal/kg/dia) e os pontos de corte estabelecidos &#233; apresentada na <xref ref-type="table" rid="tab1">tabela 1</xref>.</p>
    <table-wrap id="tab1">
      <graphic xlink:href="1678-4170-abc-91-04-0227-00004-gt01.jpg"/></table-wrap>
    <p>
      <bold>Antropometria</bold>
    </p>
    <p>Para avaliar a estatura total foi utilizado um estadi&#244;metro port&#225;til da marca WCS com resolu&#231;&#227;o de 0,1 cm. A massa corporal foi mensurada utilizando-se uma balan&#231;a digital port&#225;til, marca PLENNA, com resolu&#231;&#227;o de 100 g. Os sujeitos no momento da avalia&#231;&#227;o permaneceram descal&#231;os e vestindo somente trajes leves<sup>19</sup>.</p>
    <p>Para obten&#231;&#227;o dos valores do &#237;ndice de massa corporal (IMC), utilizou-se &#224; rela&#231;&#227;o peso (kg), dividido pela estatura (m) elevada ao quadrado<sup>20</sup>. O estado nutricional dos adolescentes foi classificado utilizando as tabelas de refer&#234;ncia proposta por Anjos e cols.<sup>21</sup>: adequado <underline>&gt;</underline> percentil 5&#186; e &lt; percentil 85&#186;; sobrepeso <underline>&gt;</underline> percentil 85&#186; e &lt; percentil 95&#186;; obesidade <underline>&gt;</underline> percentil 95&#186;.</p>
    <p>O per&#237;metro da cintura (PC) foi mensurado no ponto m&#233;dio entre o &#250;ltimo arco costal e a crista il&#237;aca, no momento de respira&#231;&#227;o m&#237;nima, utilizando-se uma fita antropom&#233;trica met&#225;lica flex&#237;vel da marca SANNY, com escala de 0,1 cm<sup>22</sup>. O per&#237;metro da cintura foi classificado de acordo com as tabelas propostas por Fernandez e cols.<sup>23</sup>, adotando valores de percentil &lt; 75&#186; como estado adequado e valores de percentil <underline>&gt;</underline> 75&#186; como valor aumentado.</p>
    <p>
      <bold>Press&#227;o arterial</bold>
    </p>
    <p>A press&#227;o arterial sist&#243;lica (PAS) e diast&#243;lica (PAD) foram aferidas no bra&#231;o esquerdo do avaliado com um esfigmoman&#244;metro de coluna de merc&#250;rio com capacidade de 300 mmHg e varia&#231;&#227;o de 2 mmHg, postado ao n&#237;vel do cora&#231;&#227;o acompanhado de estetosc&#243;pio. A mensura&#231;&#227;o foi realizada ap&#243;s o indiv&#237;duo permanecer sentado em repouso por um per&#237;odo de no m&#237;nimo cinco minutos.</p>
    <p>Os adolescentes foram inicialmente classificados pela estatura de acordo com a proposta do Centers for Disease Control<sup>24</sup>, e os valores obtidos juntamente com a idade cronol&#243;gica foram considerados para a classifica&#231;&#227;o das press&#245;es arteriais em estado desej&#225;vel (&lt;90&#186;) e estado indesej&#225;vel (<underline>&gt;</underline>90&#186;) de acordo com o consenso do The Fourth Report on the Diagnosis, Evaluation, and Treatment of High Blood Pressure in Children and Adolescents <sup>25</sup>.</p>
    <p>
      <bold>Vari&#225;veis bioqu&#237;micas</bold>
    </p>
    <p>Conforme as Diretrizes da Sociedade Brasileira de Cardiologia (SBC)<sup>5</sup>, os adolescentes foram orientados a estar em jejum pr&#233;vio de no m&#237;nimo 12h, evitar o consumo excessivo de gordura e n&#227;o ingerir bebidas alco&#243;licas tr&#234;s dias antes do teste.</p>
    <p>As concentra&#231;&#245;es de colesterol total (CT), HDL e triglic&#233;rides (TG) foram analisadas pelo m&#233;todo enzim&#225;tico colorim&#233;trico automatizado. O LDL-C em mg/dl foi calculado pela f&#243;rmula de Friedewald e cols.<sup>26</sup>: LDL-C= CT-HDL-TG/5. O VLDL foi calculado pela f&#243;rmula: VLDL= TG/5. Os valores de refer&#234;ncias adotados para definir o perfil lip&#237;dico-lipoprot&#233;ico de risco aterog&#234;nico, est&#227;o de acordo com a I Diretriz de Preven&#231;&#227;o da Aterosclerose na Inf&#226;ncia e Adolesc&#234;ncia<sup>13</sup> (<xref ref-type="table" rid="tab2">tab. 2</xref>).</p>
    <table-wrap id="tab2">
      <graphic xlink:href="1678-4170-abc-91-04-0227-00004-gt02.jpg"/></table-wrap>
    <p>
      <bold>Tratamento dos dados e an&#225;lise estat&#237;stica</bold>
    </p>
    <p>Para a caracteriza&#231;&#227;o da amostra foi utilizada a estat&#237;stica descritiva expressa em valores m&#233;dios e desvio padr&#227;o. A distribui&#231;&#227;o de freq&#252;&#234;ncia foi empregada para a classifica&#231;&#227;o dos indiv&#237;duos de acordo com os pontos de corte adotados para cada vari&#225;vel. An&#225;lises de vari&#226;ncia (ANOVA) de um fator foram adotadas para compara&#231;&#227;o das vari&#225;veis entre os diferentes &#237;ndices de GED. Subseq&#252;entemente, para localizar as diferen&#231;as encontradas na ANOVA, foi utilizado o teste de compara&#231;&#227;o m&#250;ltipla de Tukey, com um n&#237;vel de signific&#226;ncia estipulado em p&lt;0,05. Todos esses procedimentos foram realizados no software estat&#237;stico SPSS 13.0 (Chicago, IL).</p>
    <p>
      <bold>Resultados</bold>
    </p>
    <p>Inicialmente, apresenta-se na <xref ref-type="table" rid="tab3">tabela 3</xref> a caracteriza&#231;&#227;o da amostra dos grupos masculino e feminino, com valores m&#233;dios e desvios padr&#227;o das vari&#225;veis: idade decimal, estatura, massa corporal e GED. Da amostra total, 7,7% dos adolescentes encontram-se no est&#225;gio dois, 12,9% no est&#225;gio tr&#234;s, 52,8 % no est&#225;gio quatro e 26,6% no est&#225;gio cinco de matura&#231;&#227;o sexual.</p>
    <table-wrap id="tab3">
      <graphic xlink:href="1678-4170-abc-91-04-0227-00004-gt03.jpg"/></table-wrap>
    <p>Em vista das particularidades da popula&#231;&#227;o avaliada quanto &#224;s caracter&#237;sticas biol&#243;gicas, s&#227;o apresentadas na <xref ref-type="table" rid="t4">tabela 4</xref> as preval&#234;ncias de sujeitos com valores desej&#225;veis e indesej&#225;veis das vari&#225;veis antropom&#233;tricas (IMC e PC), hemodin&#226;micas (PAS e PAD) e bioqu&#237;micas (CT, LDL-C, HDL-C e TG) correspondentes aos fatores de risco cardiovascular.</p>
    <p content-type="asset">
      <table-wrap id="t4">
        <graphic xlink:href="1678-4170-abc-91-04-0227-00004-gt04.jpg"/></table-wrap>
    </p>
    <p>Na <xref ref-type="table" rid="t5">tabela 5</xref> s&#227;o apresentados os valores m&#233;dios e desvios-padr&#227;o para os rapazes divididos em: GS, GM e GA. A an&#225;lise de vari&#226;ncia indicou diferen&#231;as significativas entre os grupos para o gasto energ&#233;tico nas atividades di&#225;rias (F=123,24 e p=0,0001), demonstrando que os grupos s&#227;o heterog&#234;neos quanto ao n&#237;vel habitual de atividades f&#237;sicas. Foram observadas diferen&#231;as estat&#237;sticas entre os grupos para o CT e TG (F=3,70 e p=0,03; F=3,40 e p=0,04, respectivamente). Para as demais vari&#225;veis, n&#227;o foram observadas diferen&#231;as significativas.</p>
    <p content-type="asset">
      <table-wrap id="t5">
        <graphic xlink:href="1678-4170-abc-91-04-0227-00004-gt05.jpg"/></table-wrap>
    </p>
    <p>Na <xref ref-type="table" rid="t6">tabela 6</xref> s&#227;o apresentados os valores m&#233;dios e desvios padr&#227;o dos valores apresentados pelas mo&#231;as. A an&#225;lise de vari&#226;ncia indicou diferen&#231;as significativas entre os grupos somente para o GED (F=123,24 e p=0,0001). Para as demais vari&#225;veis, n&#227;o foram observadas diferen&#231;as significativas.</p>
    <p content-type="asset">
      <table-wrap id="t6">
        <graphic xlink:href="1678-4170-abc-91-04-0227-00004-gt06.jpg"/></table-wrap>
    </p>
    <p>
      <bold>Discuss&#227;o</bold>
    </p>
    <p>Diante das preval&#234;ncias apresentadas na <xref ref-type="table" rid="t4">tabela 4</xref>, observa-se para o IMC que a maior propor&#231;&#227;o de rapazes e mo&#231;as se encontra com valores adequados quanto ao estado nutricional, seguido de uma menor propor&#231;&#227;o com sobrepeso e obesidade. Contudo, a propor&#231;&#227;o de sujeitos com valores adequados se apresenta menor quando comparada ao estudo realizado com adolescentes do Estado da Bahia<sup>27</sup>, que encontraram uma propor&#231;&#227;o de 90,4% dos rapazes e 94,1% das mo&#231;as com estado nutricional adequado.</p>
    <p>Quanto &#224;s vari&#225;veis hemodin&#226;micas, a maior propor&#231;&#227;o de adolescentes, tanto os rapazes quanto as mo&#231;as, apresentaram valores desej&#225;veis. No entanto, deve-se preocupar com a incid&#234;ncia de adolescentes com valores indesej&#225;veis de PAD, que geralmente est&#227;o associados ao excesso de peso e obesidade<sup>28,29</sup>. Os valores lim&#237;trofes da press&#227;o arterial do presente estudo s&#227;o maiores do que apresentados por Ribeiro e cols.<sup>28</sup> na cidade de Belo Horizonte, que encontraram 12% dos indiv&#237;duos com valores lim&#237;trofes ou aumentados de PAS ou PAD.</p>
    <p>Guedes e cols.<sup>2</sup> apresentaram uma preval&#234;ncia de valores indesej&#225;veis para a PAS de 9,7% para as mo&#231;as e 8,8% para os rapazes, e para PAD as mo&#231;as apresentaram valores 10,8% e os rapazes apresentaram 8,1%. As diferen&#231;as entre os resultados podem ocorrer pelos diferentes pontos de corte utilizados para a press&#227;o arterial.</p>
    <p>O presente estudo demonstrou uma preval&#234;ncia de hipercolesterolemia em 16,7% nos meninos e 13,8% nas meninas, diferindo das observadas no estudo de Giuliano e cols.<sup>14</sup>, que encontraram 10% de valores aumentados, enquanto Guedes e cols.<sup>2</sup> encontraram 5,6% dos rapazes, e 12,9% das mo&#231;as com valores aumentados de CT. Entretanto, a diferen&#231;a entre os resultados dos estudos se deve ao diferente ponto de corte utilizado para hipercolesterolemia, ressaltando que a presente pesquisa utilizou os pontos de corte de acordo com a I Diretriz de Preven&#231;&#227;o da Aterosclerose na Inf&#226;ncia e Adolesc&#234;ncia<sup>13</sup>.</p>
    <p>Quanto ao LDL-C, o estudo de Giuliano e cols.<sup>14</sup> encontrou menor propor&#231;&#227;o de sujeitos com valores lim&#237;trofes (14%) e aumentados (6%), assim como, menor a incid&#234;ncia de valores indesej&#225;veis de HDL-C (5%), quando comparados ao presente estudo. Desse modo, h&#225; de preocupar com a propor&#231;&#227;o de adolescentes com valores indesej&#225;veis de LDL-C, a qual pode levar ao surgimento de indicadores de risco cardiovascular como hipertens&#227;o arterial, intoler&#226;ncia a glicose e defici&#234;ncia nos receptores de insulina<sup>14,28-30</sup>.</p>
    <p>Tratando-se dos n&#237;veis de TG, a amostra deste estudo apresentou menor preval&#234;ncia de adolescentes com valores aumentados quando comparada &#224; amostra avaliada por Giuliano e cols.<sup>14</sup>, que detectaram 22% dos sujeitos com valores indesej&#225;veis, indicando quadro de hipertrigliceridemia plasm&#225;tica<sup>31</sup>.</p>
    <p>Dessa forma, como as vari&#225;veis investigadas nas an&#225;lises de preval&#234;ncia demonstraram estado de risco cardiovascular para uma parte dos indiv&#237;duos, e sabendo das contribui&#231;&#245;es da atividade f&#237;sica sobre o estado de sa&#250;de, pretendeu-se verificar a predisposi&#231;&#227;o destes indicadores nos adolescentes com diferentes n&#237;veis de gasto energ&#233;tico (<xref ref-type="table" rid="t5">tab. 5</xref> e <xref ref-type="table" rid="t6">6</xref>).</p>
    <p>Observa-se pela an&#225;lise de vari&#226;ncia que, em ambos os sexos, as vari&#225;veis antropom&#233;tricas n&#227;o diferiram significativamente entre os grupos, possivelmente pelo fato de que a maioria dos sujeitos avaliados se encontra com estado nutricional adequado.</p>
    <p>Quanto &#224;s vari&#225;veis bioqu&#237;micas, os rapazes mais ativos fisicamente apresentaram menores valores de colesterol total e de triglic&#233;rides, quando comparados aos menos ativos (moderado e sedent&#225;rio). Al&#233;m disso, apesar de n&#227;o apresentar signific&#226;ncia em linguagem estat&#237;stica, verifica-se que os valores m&#233;dios do GA para as vari&#225;veis LDL-C e VLDL-C se apresentaram inferiores aos valores m&#233;dios do GM e GS. Assim, percebe-se que o maior GED nas atividades f&#237;sicas habituais, conseq&#252;entemente, contribui na redu&#231;&#227;o dos valores excessivos de lipoprote&#237;nas e lip&#237;dios plasm&#225;ticos nos adolescentes do sexo masculino.</p>
    <p>Condizentes com esses achados, Durstine e Haskell<sup>32</sup> observaram que indiv&#237;duos fisicamente ativos e envolvidos em programas de treinamento aer&#243;bico apresentam menores concentra&#231;&#245;es de colesterol total e triglic&#233;rides, quando comparados aos seus pares sedent&#225;rios.</p>
    <p>Al&#233;m disso, em estudo de interven&#231;&#227;o, foi demonstrado que o exerc&#237;cio f&#237;sico &#233; um dos principais respons&#225;veis em favorecer o estado desej&#225;vel do perfil de lip&#237;dios, lipoprote&#237;nas e patologias por doen&#231;as coronarianas<sup>33</sup>. Isso se deve as caracter&#237;sticas fisiol&#243;gicas do exerc&#237;cio f&#237;sico, que melhoram a capacidade do tecido muscular em realizar a oxida&#231;&#227;o dos &#225;cidos graxos; al&#233;m disso, estimula a atividade da enzima l&#237;pase no m&#250;sculo, contribuindo assim para a diminui&#231;&#227;o das lipoprote&#237;nas e lip&#237;dios plasm&#225;ticos, inclusive em indiv&#237;duos jovens<sup>32-34</sup>.</p>
    <p>A mesma situa&#231;&#227;o, todavia, n&#227;o se confirmou para as mo&#231;as, as quais n&#227;o apresentaram diferen&#231;as significativas entre os grupos classificados pelo GED em nenhum dos indicadores de risco cardiovascular analisados. Isso sugere que, para essa amostra, o maior GED por si s&#243; n&#227;o ocasionou menores valores de IMC, PC, press&#227;o arterial, lip&#237;dios e lipoprote&#237;nas plasm&#225;ticas nas adolescentes ativas.</p>
    <p>Esses resultados corroboram os estudos de Guedes e cols.<sup>2</sup>, em que o gasto energ&#233;tico di&#225;rio das adolescentes n&#227;o foi determinante para diminui&#231;&#227;o dos indicadores correspondentes aos fatores de risco para doen&#231;as cardiovasculares. Da mesma forma, Sung e cols.<sup>34</sup> observaram que seis semanas de treinamento n&#227;o foram suficientes para a diminui&#231;&#227;o dos valores de CT e LDL-C em indiv&#237;duos jovens do sexo feminino.</p>
    <p>Sendo assim, os resultados n&#227;o significativos do presente estudo levam a crer que outros fatores como caracter&#237;sticas da puberdade, hist&#243;rico familiar de doen&#231;as cardiovasculares, tabagismo e o uso de &#225;lcool podem estar influenciando no comprometimento dos indicadores correspondentes aos fatores de risco para doen&#231;as cardiovasculares<sup>2,30</sup>.</p>
    <p>Sabendo, portanto, das limita&#231;&#245;es da presente pesquisa, futuros estudos devem ser conduzidos, com maior n&#250;mero de participantes realizando acompanhamento em m&#233;dio ou longo prazo, ou envolvendo aplica&#231;&#227;o de tratamento experimental com controle dos h&#225;bitos alimentares, a fim de melhor diagnosticar o estado de sa&#250;de e suas inter-rela&#231;&#245;es com aspectos comportamentais da popula&#231;&#227;o pedi&#225;trica.</p>
    <p>Em s&#237;ntese, verificou-se que uma parcela significativa dos adolescentes dessa amostra se encontra com n&#237;veis indesej&#225;veis de IMC, PC, PAD, CT, LDL-C, HDL-C e TG, o que demonstra a necessidade de adotar medidas de interven&#231;&#227;o para esses sujeitos. Levando em considera&#231;&#227;o o gasto energ&#233;tico di&#225;rio, os rapazes do GA apresentaram menores concentra&#231;&#245;es de CT e TG, quando comparados aos seus pares moderadamente ativos e sedent&#225;rios.</p>
    <p>
      <bold>Agradecimentos</bold>
    </p>
    <p>Aos adolescentes e seus respectivos respons&#225;veis, que colaboraram como sujeitos da pesquisa, bem como &#224;s Secretarias Municipal de Educa&#231;&#227;o, Cultura e Lazer e Sa&#250;de da cidade de S&#227;o Mateus do Sul, PR, pelo apoio dado na execu&#231;&#227;o do projeto.</p>
    <p>
      <bold>Potencial Conflito de Interesses</bold>
    </p>
    <p>Declaro n&#227;o haver conflito de interesses pertinentes.</p>
    <p>
      <bold>Fontes de Financiamento</bold>
    </p>
    <p>O presente estudo n&#227;o teve fontes de financiamento externas.</p>
    <p>
      <bold>Vincula&#231;&#227;o Acad&#234;mica</bold>
    </p>
    <p>N&#227;o h&#225; vincula&#231;&#227;o deste estudo a programas de p&#243;s-gradua&#231;&#227;o.</p>
    <p>
      <fn id="back" fn-type="corresp">
        <label>
          <bold>Correspond&#234;ncia:</bold>
        </label>
        <p> Italo Quenni Araujo de Vasconcelos </p>
        <p> Rua Lamartini Babo, 201 - Castelo Branco </p>
        <p> 86812-320 - Apucarana, PR - Brasil </p>
        <p> E-mail: </p>
        <p>
          <email xlink:href="italo@ufpr.br">italo@ufpr.br</email>
        </p>
      </fn>
    </p>
    <p> Artigo enviado em 30/05/07; revisado enviado em 17/07/07; aceito em 25/02/08.</p>
  </body>
  <back>
    <ref-list>
      <ref id="B1">
        <mixed-citation>1. World Health    Organization. Working for health: an introduction to the WHO. Washington: WHO;    2007.</mixed-citation>
        <element-citation publication-type="book">
          <source>Working for health: an introduction to the WHO</source>
          <date>
            <year>2007</year>
          </date>
        </element-citation>
      </ref>
      <ref id="B2">
        <mixed-citation>2. Guedes DP, Guedes    JERP, Barbosa DS, Oliveira JA, Stanganelli LCR. Fatores de risco cardiovasculares    em adolescentes: indicadores biol&#243;gicos e comportamentais. Arq Bras Cardiol.    2006; 86 (6): 439-50.</mixed-citation>
        <element-citation publication-type="journal">
          <article-title>Fatores de risco cardiovasculares em adolescentes: indicadores biol&#243;gicos e comportamentais</article-title>
          <source>Arq Bras Cardiol</source>
          <date>
            <year>2006</year>
          </date>
          <fpage>439</fpage>
          <lpage>50</lpage>
          <issue>6</issue>
          <volume>86</volume>
          <person-group person-group-type="author">
            <name>
              <surname>Guedes</surname>
              <given-names>DP</given-names>
            </name>
            <name>
              <surname>Guedes</surname>
              <given-names>JERP</given-names>
            </name>
            <name>
              <surname>Barbosa</surname>
              <given-names>DS</given-names>
            </name>
            <name>
              <surname>Oliveira</surname>
              <given-names>JA</given-names>
            </name>
            <name>
              <surname>Stanganelli</surname>
              <given-names>LCR</given-names>
            </name>
          </person-group>
        </element-citation>
      </ref>
      <ref id="B3">
        <mixed-citation>3. Kim HM, Park    J, Kim H, Kim DH, Park SH. Obesity and cardiovascular risk factors in Korean    children and adolescents aged 10-18 years from the Korean National Health and    Nutrition Examination Survey, 1998 and 2001. Am J Epidem. 2006 (8): 787-93.</mixed-citation>
        <element-citation publication-type="journal">
          <article-title>Obesity and cardiovascular risk factors in Korean children and adolescents aged 10-18 years from the Korean National Health and Nutrition Examination Survey, 1998 and 2001</article-title>
          <source>Am J Epidem.</source>
          <date>
            <year>2006</year>
          </date>
          <fpage>787</fpage>
          <lpage>93</lpage>
          <volume>8</volume>
          <person-group person-group-type="author">
            <name>
              <surname>Kim</surname>
              <given-names>HM</given-names>
            </name>
            <name>
              <surname>Park</surname>
              <given-names>J</given-names>
            </name>
            <name>
              <surname>Kim</surname>
              <given-names>H</given-names>
            </name>
            <name>
              <surname>Kim</surname>
              <given-names>DH</given-names>
            </name>
            <name>
              <surname>Park</surname>
              <given-names>SH.</given-names>
            </name>
          </person-group>
        </element-citation>
      </ref>
      <ref id="B4">
        <mixed-citation>4. Katzmarzyk PT,    Srinivasan SR, Chen W, Malina RM, Bouchard C, Berenson GS. Body mass index,    waist circumference, and clustering of cardiovascular disease risk factors in    a biracial sample of children and adolescents. Pediatrics. 2004; 114: e198-205.</mixed-citation>
        <element-citation publication-type="journal">
          <article-title>Body mass index, waist circumference, and clustering of cardiovascular disease risk factors in a biracial sample of children and adolescents</article-title>
          <source>Pediatrics</source>
          <date>
            <year>2004</year>
          </date>
          <fpage>e198</fpage>
          <lpage>205</lpage>
          <volume>114</volume>
          <person-group person-group-type="author">
            <name>
              <surname>Katzmarzyk</surname>
              <given-names>PT</given-names>
            </name>
            <name>
              <surname>Srinivasan</surname>
              <given-names>SR</given-names>
            </name>
            <name>
              <surname>Chen</surname>
              <given-names>W</given-names>
            </name>
            <name>
              <surname>Malina</surname>
              <given-names>RM</given-names>
            </name>
            <name>
              <surname>Bouchard</surname>
              <given-names>C</given-names>
            </name>
            <name>
              <surname>Berenson</surname>
              <given-names>GS</given-names>
            </name>
          </person-group>
        </element-citation>
      </ref>
      <ref id="B5">
        <label>5</label>
        <mixed-citation>5. Sociedade Brasileira de Cardiologia. III Diretrizes Brasileiras sobre dislipidemias e diretriz de preven&#231;&#227;o da aterosclerose do departamento de aterosclerose. Arq Bras Cardiol. 2001; 77 (supl. 3): 1-48.</mixed-citation>
        <element-citation publication-type="journal">
          <article-title>III Diretrizes Brasileiras sobre dislipidemias e diretriz de preven&#231;&#227;o da aterosclerose do departamento de aterosclerose</article-title>
          <source>Arq Bras Cardiol.</source>
          <date>
            <year>2001</year>
          </date>
          <fpage>1</fpage>
          <lpage>48</lpage>
          <volume>77</volume>
        </element-citation>
      </ref>
      <ref id="B6">
        <mixed-citation>6. Freedman D,    Srinavasan S, Burke G. Relationship of body fat distribution in children and    adolescents: the Bogalusa Heart Study. Am J Clin Nutr. 1987; 46: 403-10.</mixed-citation>
        <element-citation publication-type="journal">
          <article-title>Relationship of body fat distribution in children and adolescents: the Bogalusa Heart Study</article-title>
          <source>Am J Clin Nutr</source>
          <date>
            <year>1987</year>
          </date>
          <fpage>403</fpage>
          <lpage>10</lpage>
          <volume>46</volume>
          <person-group person-group-type="author">
            <name>
              <surname>Freedman</surname>
              <given-names>D</given-names>
            </name>
            <name>
              <surname>Srinavasan</surname>
              <given-names>S</given-names>
            </name>
            <name>
              <surname>Burke</surname>
              <given-names>G</given-names>
            </name>
          </person-group>
        </element-citation>
      </ref>
      <ref id="B7">
        <mixed-citation>7. Ciolac EG, Guimar&#227;es    GV. Exerc&#237;cio f&#237;sico e s&#237;ndrome metab&#243;lica. Rev    Bras Med Esporte. 2004; 10 (4): 319-24.</mixed-citation>
        <element-citation publication-type="journal">
          <article-title>Exerc&#237;cio f&#237;sico e s&#237;ndrome metab&#243;lica</article-title>
          <source>Rev Bras Med Esporte</source>
          <date>
            <year>2004</year>
          </date>
          <fpage>319</fpage>
          <lpage>24</lpage>
          <issue>4</issue>
          <volume>10</volume>
          <person-group person-group-type="author">
            <name>
              <surname>Ciolac</surname>
              <given-names>EG</given-names>
            </name>
            <name>
              <surname>Guimar&#227;es</surname>
              <given-names>GV</given-names>
            </name>
          </person-group>
        </element-citation>
      </ref>
      <ref id="B8">
        <mixed-citation>8. Franks PW, Ekelund    U, Brage S, Wong M, Wareham NJ. Does the association of habitual physical activity    with the metabolic syndrome differ by level of cardiorespiratory fitness? Diabete    Care. 2004; 27 (3): 1187-93.</mixed-citation>
        <element-citation publication-type="journal">
          <article-title>Does the association of habitual physical activity with the metabolic syndrome differ by level of cardiorespiratory fitness?</article-title>
          <source>Diabete Care</source>
          <date>
            <year>2004</year>
          </date>
          <fpage>1187</fpage>
          <lpage>93</lpage>
          <issue>3</issue>
          <volume>27</volume>
          <person-group person-group-type="author">
            <name>
              <surname>Franks</surname>
              <given-names>PW</given-names>
            </name>
            <name>
              <surname>Ekelund</surname>
              <given-names>U</given-names>
            </name>
            <name>
              <surname>Brage</surname>
              <given-names>S</given-names>
            </name>
            <name>
              <surname>Wong</surname>
              <given-names>M</given-names>
            </name>
            <name>
              <surname>Wareham</surname>
              <given-names>NJ</given-names>
            </name>
          </person-group>
        </element-citation>
      </ref>
      <ref id="B9">
        <mixed-citation>9. Eriksson J,    Taimela S, Koivisto VA. Exercise and the metabolic syndrome. Diabetologia. 1997;    40: 125-35.</mixed-citation>
        <element-citation publication-type="journal">
          <article-title>Exercise and the metabolic syndrome</article-title>
          <source>Diabetologia</source>
          <date>
            <year>1997</year>
          </date>
          <fpage>125</fpage>
          <lpage>35</lpage>
          <volume>40</volume>
          <person-group person-group-type="author">
            <name>
              <surname>Eriksson</surname>
              <given-names>J</given-names>
            </name>
            <name>
              <surname>Taimela</surname>
              <given-names>S</given-names>
            </name>
            <name>
              <surname>Koivisto</surname>
              <given-names>VA</given-names>
            </name>
          </person-group>
        </element-citation>
      </ref>
      <ref id="B10">
        <mixed-citation>10. Sarni RS, Souza    FIS, Schoeps DO, Catherino P, Oliveira MCP, Pessotti CFX, et al. Rela&#231;&#227;o    da cintura abdominal com a condi&#231;&#227;o nutricional, perfil lip&#237;dico    e press&#227;o arterial em pr&#233;-escolares de baixo estrato socioecon&#244;mico.    Arq Bras Cardiol. 2006; 87 (2): 153-8.</mixed-citation>
        <element-citation publication-type="journal">
          <article-title>Rela&#231;&#227;o da cintura abdominal com a condi&#231;&#227;o nutricional, perfil lip&#237;dico e press&#227;o arterial em pr&#233;-escolares de baixo estrato socioecon&#244;mico</article-title>
          <source>Arq Bras Cardiol</source>
          <date>
            <year>2006</year>
          </date>
          <fpage>153</fpage>
          <lpage>8</lpage>
          <issue>2</issue>
          <volume>87</volume>
          <person-group person-group-type="author">
            <name>
              <surname>Sarni</surname>
              <given-names>RS</given-names>
            </name>
            <name>
              <surname>Souza</surname>
              <given-names>FIS</given-names>
            </name>
            <name>
              <surname>Schoeps</surname>
              <given-names>DO</given-names>
            </name>
            <name>
              <surname>Catherino</surname>
              <given-names>P</given-names>
            </name>
            <name>
              <surname>Oliveira</surname>
              <given-names>MCP</given-names>
            </name>
            <name>
              <surname>Pessotti</surname>
              <given-names>CFX</given-names>
            </name>
          </person-group>
        </element-citation>
      </ref>
      <ref id="B11">
        <mixed-citation>11. Mendes GA,    Martinez TL, Izar MC, Am&#226;ncio OM, Novo NF, Matheus SC, et al. Perfil lip&#237;dico    e efeitos da orienta&#231;&#227;o nutricional em adolescentes com hist&#243;ria    familiar de doen&#231;a arterial coronariana prematura. Arq Bras Cardiol.    2006; 86 (5): 361-5.</mixed-citation>
        <element-citation publication-type="journal">
          <article-title>Perfil lip&#237;dico e efeitos da orienta&#231;&#227;o nutricional em adolescentes com hist&#243;ria familiar de doen&#231;a arterial coronariana prematura</article-title>
          <source>Arq Bras Cardiol</source>
          <date>
            <year>2006</year>
          </date>
          <fpage>361</fpage>
          <lpage>5</lpage>
          <issue>5</issue>
          <volume>86</volume>
          <person-group person-group-type="author">
            <name>
              <surname>Mendes</surname>
              <given-names>GA</given-names>
            </name>
            <name>
              <surname>Martinez</surname>
              <given-names>TL</given-names>
            </name>
            <name>
              <surname>Izar</surname>
              <given-names>MC</given-names>
            </name>
            <name>
              <surname>Am&#226;ncio</surname>
              <given-names>OM</given-names>
            </name>
            <name>
              <surname>Novo</surname>
              <given-names>NF</given-names>
            </name>
            <name>
              <surname>Matheus</surname>
              <given-names>SC</given-names>
            </name>
          </person-group>
        </element-citation>
      </ref>
      <ref id="B12">
        <mixed-citation>12. Luiz RR, Magnanini    MMF. A l&#243;gica da determina&#231;&#227;o do tamanho da amostra em    investiga&#231;&#245;es epidemiol&#243;gicas. Cad Sa&#250;de P&#250;blica.    2000; 8 (2): 9-28.</mixed-citation>
        <element-citation publication-type="journal">
          <article-title>A l&#243;gica da determina&#231;&#227;o do tamanho da amostra em investiga&#231;&#245;es epidemiol&#243;gicas</article-title>
          <source>Cad Sa&#250;de P&#250;blica</source>
          <date>
            <year>2000</year>
          </date>
          <fpage>9</fpage>
          <lpage>28</lpage>
          <issue>2</issue>
          <volume>8</volume>
          <person-group person-group-type="author">
            <name>
              <surname>Luiz</surname>
              <given-names>RR</given-names>
            </name>
            <name>
              <surname>Magnanini</surname>
              <given-names>MMF</given-names>
            </name>
          </person-group>
        </element-citation>
      </ref>
      <ref id="B13">
        <mixed-citation>13. Sociedade Brasileira    de Cardiologia. I Diretriz de preven&#231;&#227;o da aterosclerose na inf&#226;ncia    e adolesc&#234;ncia. Arq Bras Cardiol. 2005; 85 (supl 6): 1-36.</mixed-citation>
        <element-citation publication-type="journal">
          <article-title>I Diretriz de preven&#231;&#227;o da aterosclerose na inf&#226;ncia e adolesc&#234;ncia</article-title>
          <source>Arq Bras Cardiol.</source>
          <date>
            <year>2005</year>
          </date>
          <fpage>1</fpage>
          <lpage>36</lpage>
          <volume>85</volume>
        </element-citation>
      </ref>
      <ref id="B14">
        <mixed-citation>14. Giuliano ICB,    Coutinho MSSA, Freitas SFT, Pires MMS, Zunino JN, Ribeiro RQC. L&#237;pides    s&#233;ricos em crian&#231;as e adolescentes de Florian&#243;polis, SC    - Estudo Floripa Saud&#225;vel 2040. Arq Bras Cardiol. 2005; 85 (2): 85-91.</mixed-citation>
        <element-citation publication-type="journal">
          <article-title>L&#237;pides s&#233;ricos em crian&#231;as e adolescentes de Florian&#243;polis, SC: Estudo Floripa Saud&#225;vel 2040</article-title>
          <source>Arq Bras Cardiol</source>
          <date>
            <year>2005</year>
          </date>
          <fpage>85</fpage>
          <lpage>91</lpage>
          <issue>2</issue>
          <volume>85</volume>
          <person-group person-group-type="author">
            <name>
              <surname>Giuliano</surname>
              <given-names>ICB</given-names>
            </name>
            <name>
              <surname>Coutinho</surname>
              <given-names>MSSA</given-names>
            </name>
            <name>
              <surname>Freitas</surname>
              <given-names>SFT</given-names>
            </name>
            <name>
              <surname>Pires</surname>
              <given-names>MMS</given-names>
            </name>
            <name>
              <surname>Zunino</surname>
              <given-names>JN</given-names>
            </name>
            <name>
              <surname>Ribeiro</surname>
              <given-names>RQC</given-names>
            </name>
          </person-group>
        </element-citation>
      </ref>
      <ref id="B15">
        <mixed-citation>15. Tanner JM.    Growth and adolescence. Oxford: Blackwell Scientific Publication; 1962.</mixed-citation>
        <element-citation publication-type="book">
          <source>Growth and adolescence</source>
          <date>
            <year>1962</year>
          </date>
          <person-group person-group-type="author">
            <name>
              <surname>Tanner</surname>
              <given-names>JM</given-names>
            </name>
          </person-group>
        </element-citation>
      </ref>
      <ref id="B16">
        <mixed-citation>16. Martin RHC,    Uezu R, Parra AS, Arena SS, Bojikian LP, Bohme MTS. Auto-avalia&#231;&#227;o    da matura&#231;&#227;o sexual masculina por meio da utiliza&#231;&#227;o    de desenhos e fotos. Rev Paul Ed Fis. 2001; 15 (2): 212-22.</mixed-citation>
        <element-citation publication-type="journal">
          <article-title>Auto-avalia&#231;&#227;o da matura&#231;&#227;o sexual masculina por meio da utiliza&#231;&#227;o de desenhos e fotos</article-title>
          <source>Rev Paul Ed Fis</source>
          <date>
            <year>2001</year>
          </date>
          <fpage>212</fpage>
          <lpage>22</lpage>
          <issue>2</issue>
          <volume>15</volume>
          <person-group person-group-type="author">
            <name>
              <surname>Martin</surname>
              <given-names>RHC</given-names>
            </name>
            <name>
              <surname>Uezu</surname>
              <given-names>R</given-names>
            </name>
            <name>
              <surname>Parra</surname>
              <given-names>AS</given-names>
            </name>
            <name>
              <surname>Arena</surname>
              <given-names>SS</given-names>
            </name>
            <name>
              <surname>Bojikian</surname>
              <given-names>LP</given-names>
            </name>
            <name>
              <surname>Bohme</surname>
              <given-names>MTS</given-names>
            </name>
          </person-group>
        </element-citation>
      </ref>
      <ref id="B17">
        <mixed-citation>17. Bojikian LP,    Massa M, Martin RHC, Texeira CP, Kiss MAPD, Bohme MTS. Auto-avalia&#231;&#227;o    puberal feminina por meio da utiliza&#231;&#227;o de desenhos e fotos. Rev    Bras Ativ Fis Sa&#250;de. 2002; 7 (2): 24-34.</mixed-citation>
        <element-citation publication-type="journal">
          <article-title>Auto-avalia&#231;&#227;o puberal feminina por meio da utiliza&#231;&#227;o de desenhos e fotos</article-title>
          <source>Rev Bras Ativ Fis Sa&#250;de</source>
          <date>
            <year>2002</year>
          </date>
          <fpage>24</fpage>
          <lpage>34</lpage>
          <issue>2</issue>
          <volume>7</volume>
          <person-group person-group-type="author">
            <name>
              <surname>Bojikian</surname>
              <given-names>LP</given-names>
            </name>
            <name>
              <surname>Massa</surname>
              <given-names>M</given-names>
            </name>
            <name>
              <surname>Martin</surname>
              <given-names>RHC</given-names>
            </name>
            <name>
              <surname>Texeira</surname>
              <given-names>CP</given-names>
            </name>
            <name>
              <surname>Kiss</surname>
              <given-names>MAPD</given-names>
            </name>
            <name>
              <surname>Bohme</surname>
              <given-names>MTS</given-names>
            </name>
          </person-group>
        </element-citation>
      </ref>
      <ref id="B18">
        <mixed-citation>18. Bouchard CA,    Tremblay C, Leblanc G, Lortie R, Savard R, Theriault GA. Method to assess energy    expenditure in children and adults. Am J Clin Nutrition. 1983; 37: 461-7.</mixed-citation>
        <element-citation publication-type="journal">
          <article-title>Method to assess energy expenditure in children and adults</article-title>
          <source>Am J Clin Nutrition</source>
          <date>
            <year>1983</year>
          </date>
          <fpage>461</fpage>
          <lpage>7</lpage>
          <volume>37</volume>
          <person-group person-group-type="author">
            <name>
              <surname>Bouchard</surname>
              <given-names>CA</given-names>
            </name>
            <name>
              <surname>Tremblay</surname>
              <given-names>C</given-names>
            </name>
            <name>
              <surname>Leblanc</surname>
              <given-names>G</given-names>
            </name>
            <name>
              <surname>Lortie</surname>
              <given-names>R</given-names>
            </name>
            <name>
              <surname>Savard</surname>
              <given-names>R</given-names>
            </name>
            <name>
              <surname>Theriault</surname>
              <given-names>GA</given-names>
            </name>
          </person-group>
        </element-citation>
      </ref>
      <ref id="B19">
        <mixed-citation>19. Docherty D.    Measurement in pediatric exercise science. Champaign: Human Kinetics; 1996.</mixed-citation>
        <element-citation publication-type="book">
          <source>Measurement in pediatric exercise science</source>
          <date>
            <year>1996</year>
          </date>
          <person-group person-group-type="author">
            <name>
              <surname>Docherty</surname>
              <given-names>D</given-names>
            </name>
          </person-group>
        </element-citation>
      </ref>
      <ref id="B20">
        <label>20</label>
        <mixed-citation>20. American College of Sports Medicine. Diretrizes do ACSM para os testes de esfor&#231;o e sua prescri&#231;&#227;o. 6&#170; ed. Rio de Janeiro: Guanabara Koogan; 2003.</mixed-citation>
        <element-citation publication-type="book">
          <source>Diretrizes do ACSM para os testes de esfor&#231;o e sua prescri&#231;&#227;o</source>
          <date>
            <year>2003</year>
          </date>
        </element-citation>
      </ref>
      <ref id="B21">
        <mixed-citation>21. Anjos LA, Veiga    GV, Castro IRR. Distribui&#231;&#227;o dos valores do &#237;ndice de massa    corporal da popula&#231;&#227;o brasileira at&#233; 25 anos. Rev Panam    Salud Publica. 1998; 3 (3): 167-73.</mixed-citation>
        <element-citation publication-type="journal">
          <article-title>Distribui&#231;&#227;o dos valores do &#237;ndice de massa corporal da popula&#231;&#227;o brasileira at&#233; 25 anos</article-title>
          <source>Rev Panam Salud Publica</source>
          <date>
            <year>1998</year>
          </date>
          <fpage>167</fpage>
          <lpage>73</lpage>
          <issue>3</issue>
          <volume>3</volume>
          <person-group person-group-type="author">
            <name>
              <surname>Anjos</surname>
              <given-names>LA</given-names>
            </name>
            <name>
              <surname>Veiga</surname>
              <given-names>GV</given-names>
            </name>
            <name>
              <surname>Castro</surname>
              <given-names>IRR</given-names>
            </name>
          </person-group>
        </element-citation>
      </ref>
      <ref id="B22">
        <mixed-citation>22. Costa RF. Composi&#231;&#227;o    corporal: teoria e pr&#225;tica da avalia&#231;&#227;o. S&#227;o Paulo:    Manole; 2001.</mixed-citation>
        <element-citation publication-type="book">
          <source>Composi&#231;&#227;o corporal: teoria e pr&#225;tica da avalia&#231;&#227;o</source>
          <date>
            <year>2001</year>
          </date>
          <person-group person-group-type="author">
            <name>
              <surname>Costa</surname>
              <given-names>RF</given-names>
            </name>
          </person-group>
        </element-citation>
      </ref>
      <ref id="B23">
        <mixed-citation>23. Fernandez JR,    Redden T, Pietrobelli A, Allison B. Waist circumference percentiles in nationally    representative samples of African-American, European-American, and Mexican-American    children and adolescents. J Pediatr. 2004; 145: 439-44.</mixed-citation>
        <element-citation publication-type="journal">
          <article-title>Waist circumference percentiles in nationally representative samples of African-American, European-American, and Mexican-American children and adolescents</article-title>
          <source>J Pediatr</source>
          <date>
            <year>2004</year>
          </date>
          <fpage>439</fpage>
          <lpage>44</lpage>
          <volume>145</volume>
          <person-group person-group-type="author">
            <name>
              <surname>Fernandez</surname>
              <given-names>JR</given-names>
            </name>
            <name>
              <surname>Redden</surname>
              <given-names>T</given-names>
            </name>
            <name>
              <surname>Pietrobelli</surname>
              <given-names>A</given-names>
            </name>
            <name>
              <surname>Allison</surname>
              <given-names>B</given-names>
            </name>
          </person-group>
        </element-citation>
      </ref>
      <ref id="B24">
        <mixed-citation>24. Kuczmarski    RJ, Odgen CL, Grummer-Strawn LM, Flegal KM, Guo SS, Wei R, et al. CDC growth    charts: United States. Adv Data. 2000; 314: 1-27.</mixed-citation>
        <element-citation publication-type="journal">
          <article-title>CDC growth charts: United States</article-title>
          <source>Adv Data</source>
          <date>
            <year>2000</year>
          </date>
          <fpage>1</fpage>
          <lpage>27</lpage>
          <volume>314</volume>
          <person-group person-group-type="author">
            <name>
              <surname>Kuczmarski</surname>
              <given-names>RJ</given-names>
            </name>
            <name>
              <surname>Odgen</surname>
              <given-names>CL</given-names>
            </name>
            <name>
              <surname>Grummer-Strawn</surname>
              <given-names>LM</given-names>
            </name>
            <name>
              <surname>Flegal</surname>
              <given-names>KM</given-names>
            </name>
            <name>
              <surname>Guo</surname>
              <given-names>SS</given-names>
            </name>
            <name>
              <surname>Wei</surname>
              <given-names>R</given-names>
            </name>
          </person-group>
        </element-citation>
      </ref>
      <ref id="B25">
        <mixed-citation>25. National High    Blood Pressure Education Program Working Group on High Blood Pressure in Children    and Adolescents. The fourth report on the diagnosis, evaluation, and treatment    of high blood pressure in children and adolescents. Pediatrics. 2004; 114 (2    Suppl 4th Report): 555-76.</mixed-citation>
        <element-citation publication-type="journal">
          <article-title>National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents: The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents</article-title>
          <source>Pediatrics.</source>
          <date>
            <year>2004</year>
          </date>
          <fpage>555</fpage>
          <lpage>76</lpage>
          <volume>114</volume>
        </element-citation>
      </ref>
      <ref id="B26">
        <mixed-citation>26. Friedewald    WT, Levy RL, Fredrickson DS. Estimation of the concentration of low-density    lipoprotein cholesterol in plasma without the use of preparative ultracentrifuge.    Clin Chem. 1972; 18: 499-502.</mixed-citation>
        <element-citation publication-type="journal">
          <article-title>Estimation of the concentration of low-density lipoprotein cholesterol in plasma without the use of preparative ultracentrifuge</article-title>
          <source>Clin Chem</source>
          <date>
            <year>1972</year>
          </date>
          <fpage>499</fpage>
          <lpage>502</lpage>
          <volume>18</volume>
          <person-group person-group-type="author">
            <name>
              <surname>Friedewald</surname>
              <given-names>WT</given-names>
            </name>
            <name>
              <surname>Levy</surname>
              <given-names>RL</given-names>
            </name>
            <name>
              <surname>Fredrickson</surname>
              <given-names>DS</given-names>
            </name>
          </person-group>
        </element-citation>
      </ref>
      <ref id="B27">
        <mixed-citation>27. Santos JS,    Costa MCO, Nascimento Sobrinho CL, Silva MCM, Souza KEP, Melo BO. Perfil antropom&#233;trico    e consumo alimentar de adolescentes de Teixeira de Freitas - Bahia. Rev Nutr    Campinas. 2005; 18 (5): 623-32.</mixed-citation>
        <element-citation publication-type="journal">
          <article-title>Perfil antropom&#233;trico e consumo alimentar de adolescentes de Teixeira de Freitas - Bahia</article-title>
          <source>Rev Nutr Campinas</source>
          <date>
            <year>2005</year>
          </date>
          <fpage>623</fpage>
          <lpage>32</lpage>
          <issue>5</issue>
          <volume>18</volume>
          <person-group person-group-type="author">
            <name>
              <surname>Santos</surname>
              <given-names>JS</given-names>
            </name>
            <name>
              <surname>Costa</surname>
              <given-names>MCO</given-names>
            </name>
            <name>
              <surname>Nascimento Sobrinho</surname>
              <given-names>CL</given-names>
            </name>
            <name>
              <surname>Silva</surname>
              <given-names>MCM</given-names>
            </name>
            <name>
              <surname>Souza</surname>
              <given-names>KEP</given-names>
            </name>
            <name>
              <surname>Melo</surname>
              <given-names>BO</given-names>
            </name>
          </person-group>
        </element-citation>
      </ref>
      <ref id="B28">
        <mixed-citation>28. Ribeiro RQC,    Lotufo PA, Lamounier JA, Oliveira RG, Soares JF, Botter DA. Fatores adicionais    de risco cardiovascular associados ao excesso de peso em crian&#231;as e adolescentes:    o estudo do cora&#231;&#227;o de Belo Horizonte. Arq Bras Cardiol. 2006;    86 (6): 408-18.</mixed-citation>
        <element-citation publication-type="journal">
          <article-title>Fatores adicionais de risco cardiovascular associados ao excesso de peso em crian&#231;as e adolescentes: o estudo do cora&#231;&#227;o de Belo Horizonte</article-title>
          <source>Arq Bras Cardiol</source>
          <date>
            <year>2006</year>
          </date>
          <fpage>408</fpage>
          <lpage>18</lpage>
          <issue>6</issue>
          <volume>86</volume>
          <person-group person-group-type="author">
            <name>
              <surname>Ribeiro</surname>
              <given-names>RQC</given-names>
            </name>
            <name>
              <surname>Lotufo</surname>
              <given-names>PA</given-names>
            </name>
            <name>
              <surname>Lamounier</surname>
              <given-names>JA</given-names>
            </name>
            <name>
              <surname>Oliveira</surname>
              <given-names>RG</given-names>
            </name>
            <name>
              <surname>Soares</surname>
              <given-names>JF</given-names>
            </name>
            <name>
              <surname>Botter</surname>
              <given-names>DA</given-names>
            </name>
          </person-group>
        </element-citation>
      </ref>
      <ref id="B29">
        <mixed-citation>29. Carneiro JRI,    Kushni MC, Clemente ELS, Brand&#227;o MG, Gomes MB. Obesidade na adolesc&#234;ncia:    fator de risco para complica&#231;&#245;es cl&#237;nico-metab&#243;licas.    Arq Bras Endocrinol Metabol. 2000; 44 (5): 390-6.</mixed-citation>
        <element-citation publication-type="journal">
          <article-title>Obesidade na adolesc&#234;ncia: fator de risco para complica&#231;&#245;es cl&#237;nico-metab&#243;licas</article-title>
          <source>Arq Bras Endocrinol Metabol</source>
          <date>
            <year>2000</year>
          </date>
          <fpage>390</fpage>
          <lpage>6</lpage>
          <issue>5</issue>
          <volume>44</volume>
          <person-group person-group-type="author">
            <name>
              <surname>Carneiro</surname>
              <given-names>JRI</given-names>
            </name>
            <name>
              <surname>Kushni</surname>
              <given-names>MC</given-names>
            </name>
            <name>
              <surname>Clemente</surname>
              <given-names>ELS</given-names>
            </name>
            <name>
              <surname>Brand&#227;o</surname>
              <given-names>MG</given-names>
            </name>
            <name>
              <surname>Gomes</surname>
              <given-names>MB</given-names>
            </name>
          </person-group>
        </element-citation>
      </ref>
      <ref id="B30">
        <mixed-citation>30. Gerber ZRSG,    Zielinski P. Fatores de risco de aterosclerose na inf&#226;ncia: um estudo    epidemiol&#243;gico. Arq Bras Cardiol. 1997; 69 (4): 231-6.</mixed-citation>
        <element-citation publication-type="journal">
          <article-title>Fatores de risco de aterosclerose na inf&#226;ncia: um estudo epidemiol&#243;gico</article-title>
          <source>Arq Bras Cardiol</source>
          <date>
            <year>1997</year>
          </date>
          <fpage>231</fpage>
          <lpage>6</lpage>
          <issue>4</issue>
          <volume>69</volume>
          <person-group person-group-type="author">
            <name>
              <surname>Gerber</surname>
              <given-names>ZRSG</given-names>
            </name>
            <name>
              <surname>Zielinski</surname>
              <given-names>P</given-names>
            </name>
          </person-group>
        </element-citation>
      </ref>
      <ref id="B31">
        <mixed-citation>31. Schiavo M,    Lunardelli A, Oliveira JR. Influ&#234;ncia de triglic&#233;rides na concentra&#231;&#227;o    s&#233;rica de triglic&#233;rides. J Bras Patol Med Lab. 2003; 39 (4): 283-8.</mixed-citation>
        <element-citation publication-type="journal">
          <article-title>Influ&#234;ncia de triglic&#233;rides na concentra&#231;&#227;o s&#233;rica de triglic&#233;rides</article-title>
          <source>J Bras Patol Med Lab</source>
          <date>
            <year>2003</year>
          </date>
          <fpage>283</fpage>
          <lpage>8</lpage>
          <issue>4</issue>
          <volume>39</volume>
          <person-group person-group-type="author">
            <name>
              <surname>Schiavo</surname>
              <given-names>M</given-names>
            </name>
            <name>
              <surname>Lunardelli</surname>
              <given-names>A</given-names>
            </name>
            <name>
              <surname>Oliveira</surname>
              <given-names>JR</given-names>
            </name>
          </person-group>
        </element-citation>
      </ref>
      <ref id="B32">
        <mixed-citation>32. Durstine JL,    Haskell WL. Effects of exercise on plasma lipids and lipoproteins. Exerc Sport    Sci Rev. 1994; 22: 477-521.</mixed-citation>
        <element-citation publication-type="journal">
          <article-title>Effects of exercise on plasma lipids and lipoproteins</article-title>
          <source>Exerc Sport Sci Rev</source>
          <date>
            <year>1994</year>
          </date>
          <fpage>477</fpage>
          <lpage>521</lpage>
          <volume>22</volume>
          <person-group person-group-type="author">
            <name>
              <surname>Durstine</surname>
              <given-names>JL</given-names>
            </name>
            <name>
              <surname>Haskell</surname>
              <given-names>WL</given-names>
            </name>
          </person-group>
        </element-citation>
      </ref>
      <ref id="B33">
        <mixed-citation>33. Ekelund LG,    Haskell WL, Johnson JL, Whaley FS, Criqui MH, Sheps DS. Physical fitness as    predictor of cardiovascular mortality in asymptomatic North American men: The    Lipid Research Clinics Mortality Follow-Up Study. N Engl J Med. 1988; 319: 1379-84.</mixed-citation>
        <element-citation publication-type="journal">
          <article-title>Physical fitness as predictor of cardiovascular mortality in asymptomatic North American men: The Lipid Research Clinics Mortality Follow-Up Study</article-title>
          <source>N Engl J Med</source>
          <date>
            <year>1988</year>
          </date>
          <fpage>1379</fpage>
          <lpage>84</lpage>
          <volume>319</volume>
          <person-group person-group-type="author">
            <name>
              <surname>Ekelund</surname>
              <given-names>LG</given-names>
            </name>
            <name>
              <surname>Haskell</surname>
              <given-names>WL</given-names>
            </name>
            <name>
              <surname>Johnson</surname>
              <given-names>JL</given-names>
            </name>
            <name>
              <surname>Whaley</surname>
              <given-names>FS</given-names>
            </name>
            <name>
              <surname>Criqui</surname>
              <given-names>MH</given-names>
            </name>
            <name>
              <surname>Sheps</surname>
              <given-names>DS</given-names>
            </name>
          </person-group>
        </element-citation>
      </ref>
      <ref id="B34">
        <mixed-citation>34. Sung RYT, Yu    CW, Chang SKY, Mo SW, Woo KS, Lam CWK. Effects of dietary intervention and strength    training on blood lipid level in obese children. Arch Dis Child. 2002; 86: 407-10.</mixed-citation>
        <element-citation publication-type="journal">
          <article-title>Effects of dietary intervention and strength training on blood lipid level in obese children</article-title>
          <source>Arch Dis Child</source>
          <date>
            <year>2002</year>
          </date>
          <fpage>407</fpage>
          <lpage>10</lpage>
          <volume>86</volume>
          <person-group person-group-type="author">
            <name>
              <surname>Sung</surname>
              <given-names>RYT</given-names>
            </name>
            <name>
              <surname>Yu</surname>
              <given-names>CW</given-names>
            </name>
            <name>
              <surname>Chang</surname>
              <given-names>SKY</given-names>
            </name>
            <name>
              <surname>Mo</surname>
              <given-names>SW</given-names>
            </name>
            <name>
              <surname>Woo</surname>
              <given-names>KS</given-names>
            </name>
            <name>
              <surname>Lam</surname>
              <given-names>CWK</given-names>
            </name>
          </person-group>
        </element-citation>
      </ref>
    </ref-list>
  </back>
  <sub-article article-type="translation" id="TRen" xml:lang="en">
    <front-stub>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Original Articles</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title xml:lang="en">Cardiovascular risk factors in adolescents with different levels of energy expenditure</article-title>
      </title-group>
      <abstract xml:lang="en">
        <p>BACKGROUND: Physical inactivity in adolescence is related to body fat accumulation, which apparently can increase the probability of onset and development of metabolic changes. OBJECTIVE: To verify the predisposition to cardiovascular risk factors in adolescents with different levels of energy expenditure. METHODS: A total of 108 young men and 132 young women aged between 12 and 16 years were selected. Daily energy expenditure was obtained using the questionnaire proposed by Bouchard et al. The sample was previously divided according to the quartiles of energy expenditure (Kcal/kg/day) into three groups: sedentary (SG), moderately active (MG), and active (AG). The enzyme-colorimetric method was used to determine the total cholesterol (TC), HDL-C, and triglycerides (TG) levels. LDL-C was calculated using the Friedewald et al's formula. The one-factor analysis of variance was used for statistical analysis, considering p&lt;0.05. RESULTS: For the male gender, significant differences were found between the groups for the TC variable (mg/dl); AG (121.56&#177;19.15) was different from MG (142.70&#177;27.65) and from SG (145.63&#177;36.54). Likewise, MG was different from SG (F=3.70 and p=0.03). For the TG variable (mg/dl), AG (65.69&#177;18.95) was different from MG (82.25&#177;33.73) and from SG (97.44&#177;45.95). Also, MG was different from SG (F=3.40 and p=0.04). For the female gender, no significant differences were found in relation to daily energy expenditure. CONCLUSION: More active young men show lower TC and TG levels in comparison with their moderately active and sedentary peers.</p>
      </abstract>
      <kwd-group xml:lang="en">
        <kwd>Risk factors</kwd>
        <kwd>energy metabolism</kwd>
        <kwd>adolescent</kwd>
      </kwd-group>
    </front-stub>
    <body>
      <p>
        <bold>ORIGINAL ARTICLE</bold>
      </p>
      <p>
        <fn id="top-body2">
          <label>
            <bold>Cardiovascular risk factors in adolescents with different levels of energy expenditure</bold>
          </label>
          <p>
            <bold>Italo Quenni Araujo de Vasconcelos; Antonio Stabelini Neto; Lu&#237;s Paulo Gomes Mascarenhas; Rodrigo Bozza; Anderson Zampier Ulbrich; Wagner de Campos; Renata Labronici Bertin</bold>
          </p>
        </fn>
      </p>
      <p>Universidade Federal do Paran&#225;, Curitiba, PR - Brazil</p>
      <p>Mailing Address</p>
      <p>
        <bold>SUMMARY</bold>
      </p>
      <p><bold>BACKGROUND:</bold> Physical inactivity in adolescence is related to body fat accumulation, which apparently can increase the probability of onset and development of metabolic changes.</p>
      <p><bold>OBJECTIVE:</bold> To verify the predisposition to cardiovascular risk factors in adolescents with different levels of energy expenditure.</p>
      <p><bold>METHODS:</bold> A total of 108 young men and 132 young women aged between 12 and 16 years were selected. Daily energy expenditure was obtained using the questionnaire proposed by Bouchard et al. The sample was previously divided according to the quartiles of energy expenditure (Kcal/kg/day) into three groups: sedentary (SG), moderately active (MG), and active (AG). The enzyme-colorimetric method was used to determine the total cholesterol (TC), HDL-C, and triglycerides (TG) levels. LDL-C was calculated using the Friedewald et al's formula. The one-factor analysis of variance was used for statistical analysis, considering p&lt;0.05.</p>
      <p><bold>RESULTS:</bold> For the male gender, significant differences were found between the groups for the TC variable (mg/dL); AG (121.56&#177;19.15) was different from MG (142.70&#177;27.65) and from SG (145.63&#177;36.54). Likewise, MG was different from SG (F=3.70 and p=0.03). For the TG variable (mg/dL), AG (65.69&#177;18.95) was different from MG (82.25&#177;33.73) and from SG (97.44&#177;45.95). Also, MG was different from SG (F=3.40 and p=0.04). For the female gender, no significant differences were found in relation to daily energy expenditure.</p>
      <p><bold>CONCLUSION:</bold> More active young men show lower TC and TG levels in comparison with their moderately active and sedentary peers.</p>
      <p><bold>Key words:</bold> Risk factors; energy metabolism; adolescent.</p>
      <p>
        <bold>Introduction</bold>
      </p>
      <p>Health researchers such as physicians, nutritionists, and physical educators have currently investigated the different factors that make up a desirable lifestyle for the pediatric population. Health is deemed one of the most important components, and is defined as a state of complete physical, mental and social well-being and not merely the absence of diseases<sup>1</sup>.</p>
      <p>In this sense, starting from the assumption that the habits adopted by adolescents may be further maintained during their adulthood, we should be aware of the main elements of lifestyle, especially when behavioral factors such as physical activity are analyzed.</p>
      <p>Thereby, physical inactivity in adolescence is related to body fat accumulation, which apparently can increase the probability of the onset and development of metabolic changes such as hypercholesterolemia, hypertriglyceridemia and hypertension<sup>2-4</sup>, thus representing an important factor of public health concern<sup>5</sup>.</p>
      <p>In adults, there is substantial evidence that physical inactivity is directly associated with the development of cardiovascular diseases and type-2 diabetes<sup>6,7</sup>; an inverse association is demonstrated between physical activity and metabolic changes<sup>8</sup>. However, this relation remains contradictory in young adults<sup>9</sup>.</p>
      <p>Considering that adolescence is a phase in which it is extremely easy to incorporate new habits into the lifestyle, early detection of risk factors for health becomes important in the sense of applying an efficient intervention strategy<sup>10,11</sup>. In view of these aspects, the objective of this study was to analyze the predisposition to cardiovascular risk factors in adolescents aged between 12 and 17 years with different levels of energy expenditure.</p>
      <p>
        <bold>Methods</bold>
      </p>
      <p>
        <bold>Sample</bold>
      </p>
      <p>The randomized sample was comprised of 240 adolescents (108 young men and 132 young women) aged between 12 and 16 years, from the city of S&#227;o Mateus do Sul, State of Paran&#225;, Brazil, retrieved from the database of the research project "Analysis of cardiovascular risk factors and immune system deficiency in adolescents attending public schools of S&#227;o Mateus do Sul, PR" which is being conducted by the UFPR's Research Center on Exercise and Sports.</p>
      <p>The sample size was calculated according to the following criteria: a) total number of young men and young women enrolled in the public school network; b) 95% confidence interval; c) sample error of 5% and prevalence of 20%<sup>12</sup>. The prevalence estimate was set at 20% considering that the distribution of risk factors found in other studies with young individuals shows values lower than 20%<sup>2,13,14</sup>.</p>
      <p>Initially, an "invitation letter" with information relative to the study and containing a short explanation of the objectives of the research and assessments to be carried out was sent to each school. Next, the adolescents were drawn by lot; of these, those who accepted to participate in the assessments received an informed consent form which was filled out by their parents or respective guardians, who gave their permission for participation in the study.</p>
      <p>This study was approved by the Research Ethics Committee of <italic>Universidade Federal do Paran&#225;</italic> according to resolution 196/96 of the National Health Council involving human research, process no. 018-06.</p>
      <p>
        <bold>Instruments and procedures</bold>
      </p>
      <p>
        <bold>Maturation stage</bold>
      </p>
      <p>The method proposed by Tanner<sup>15</sup> was used for determination of the sexual maturation stage, which is divided from one to five. Stage one corresponds to the prepubertal level, and stage five, in the other extreme, to the final maturation process.</p>
      <p>The test was administered as a self-assessment of the development of pubic hair as suggested by Martin et al<sup>16</sup> and Bojikian et al<sup>17</sup>, who identified satisfactory agreement between this method and the physician's assessment, with <italic>k</italic> = 0.61 and <italic>k</italic> = 0.53 for the male and female gender, respectively.</p>
      <p>
        <bold>Daily energy expenditure</bold>
      </p>
      <p>The diary-record questionnaire developed by Bouchard et al<sup>18</sup> was used. It consists of a form where the activities performed in two days of the week and one day of the weekend, divided in 15-minute periods, are recorded. The activities are classified in a continuum involving nine categories that represent the mean energy expenditure of the activities performed. These categories are classified from one to nine. Category one is characterized by activities with lower energy expenditure (sleeping and resting in bed) and category nine, by activities with high calorie expenditure (intense manual work and sports competition).</p>
      <p>Based on this information, the daily energy expenditure (DEE) divided by kilogram of body weight per day (kcal/kg/day) could be estimated, as well as the DEE by the mean of the three-day diary record. The questionnaire has a reproducibility of r=0.91 in individuals from 10 years of age<sup>18</sup>.</p>
      <p>In order to classify the individuals as regards DEE, the sample was divided into quartiles (Q) according to gender<sup>8</sup>. The discrimination of group formation according to the DEE (kcal/kg/day) and the cut-off points established are shown in <xref ref-type="table" rid="tab1-body2">Table 1</xref>.</p>
      <table-wrap id="tab1-body2">
        <graphic xlink:href="1678-4170-abc-91-04-0227-00004-gt01-en.jpg"/></table-wrap>
      <p>
        <bold>Anthropometry</bold>
      </p>
      <p>Total height was measured with a portable WCS stadiometer to the nearest 0.1 cm. Body mass was measured using a portable digital PLENNA scale to the nearest 100g. At the moment of assessment, the individuals were barefoot and wearing only light clothes<sup>19</sup>.</p>
      <p>The ratio weight (Kg) divided by square height (m) was used to obtain the values of body mass index (BMI)<sup>20</sup>. The adolescents' nutritional status was classified using the reference tables proposed by Anjos et al<sup>21</sup>: adequate <underline>&gt;</underline> 5th percentile and &lt; 85th percentile; overweight <underline>&gt;</underline> 85th percentile and &lt; 95th percentile; obesity <underline>&gt;</underline> 95th percentile.</p>
      <p>Waist circumference (WC) was measured at the mean point between the lower rib and the iliac crest, at the moment of minimum respiration, using a SANNY flexible metal anthropometric tape measure with a 0.1-cm scale<sup>22</sup>. Waist circumference was classified according to the tables proposed by Fernandez et al<sup>23</sup>, adopting measurements &lt; 75th percentile as adequate values and measurements <underline>&gt;</underline> 75th percentile as increased values.</p>
      <p>
        <bold>Blood pressure</bold>
      </p>
      <p>Systolic (SBP) and diastolic blood pressure (DBP) were measured in the individual's left arm using a stethoscope and a mercury sphygmomanometer with scale up to 300 mmHg and variation of 2 mmHg placed at the level of the heart. Measurements were performed after the individual had remained sitting at rest for a period of at least five minutes.</p>
      <p>The adolescents were initially classified by height according to the values proposed by the Centers for Disease Control<sup>24</sup>. The values obtained along with the chronological age were considered for the classification of blood pressure levels as desirable level (&lt;90th percentile) and undesirable level (<underline>&gt;</underline> 90th percentile), according to the consensus of The Fourth Report on the Diagnosis, Evaluation, and Treatment of High Blood Pressure in Children and Adolescents<sup>25</sup>.</p>
      <p>
        <bold>Biochemical variables</bold>
      </p>
      <p>According to the Guidelines of the Brazilian Society of Cardiology (BSC)<sup>5</sup>, the adolescents were advised to remain fasting for at least 12 hours, to avoid excessive consumption of fat, and not to drink alcoholic beverages three days prior to the test.</p>
      <p>Total cholesterol (TC), HDL and triglyceride (TG) levels were analyzed by the automated colorimetric-enzyme method. LDL-C in mg/dL was calculated using the Friedewald et al's formula<sup>26</sup>: LDL-C= TC-HDL-TG/5. VLDL levels were calculated by the formula: VLDL= TG/5. Reference values adopted to define the lipid-lipoproteic profile of atherogenic risk are in accordance with the I Guideline on the Prevention of Atherosclerosis in Childhood and Adolescence<sup>13</sup> (<xref ref-type="table" rid="tab2-body2">Table 2</xref>).</p>
      <table-wrap id="tab2-body2">
        <graphic xlink:href="1678-4170-abc-91-04-0227-00004-gt02-en.jpg"/></table-wrap>
      <p>
        <bold>Data treatment and statistical analysis</bold>
      </p>
      <p>Descriptive statistics expressed as mean values and standard deviation was used for sample characterization. Frequency distribution was used for the classification of individuals according to the cut-off points adopted for each variable. One-factor analysis of variance (ANOVA) was used for comparison of the variables among the different DEE levels. Subsequently, the Tukey multiple comparison test was used to locate the differences found in ANOVA, with a significance level set at p&lt;0.05. All procedures were performed in the SPSS 13.0 (Chicago, IL) statistical software.</p>
      <p>
        <bold>Results</bold>
      </p>
      <p>Sample characterization of the male and female groups with mean values and standard deviation of the decimal age, height, body mass, and DEE variables are shown in <xref ref-type="table" rid="tab3-body2">Table 3</xref>. Of the total sample, 7.7% of the adolescents were in stage two, 12.9% in stage three, 52.8% in stage four, and 26.6% in stage five of sexual maturation.</p>
      <table-wrap id="tab3-body2">
        <graphic xlink:href="1678-4170-abc-91-04-0227-00004-gt03-en.jpg"/></table-wrap>
      <p>In view of the peculiarities of the population studied with respect to the biological characteristics, <xref ref-type="table" rid="en_04t4-body2">Table 4</xref> shows the prevalence of subjects with desirable and undesirable values of anthropometric variables (BMI and WC), hemodynamic variables (SBP and DBP) and biochemical variables (TC, LDL-C, HDL-C and TG) corresponding to the cardiovascular risk factors.</p>
      <p content-type="asset">
        <table-wrap id="en_04t4-body2">
          <graphic xlink:href="1678-4170-abc-91-04-0227-00004-gt04-en.jpg"/></table-wrap>
      </p>
      <p>Mean values and standard deviations for the young men in the SG, MG, and AG are shown in <xref ref-type="table" rid="en_04t5-body2">Table 5</xref>. Analysis of variance showed significant differences between the groups as regards energy expenditure in daily activities (F=123.24 and p=0.0001), thus demonstrating that the groups were heterogeneous with respect to the usual level of physical activities. Statistically significant differences were observed between the groups for TC and TG (F=3.70 and p=0.03; F=3.40 and p=0.04, respectively). No significant differences were found for the other variables.</p>
      <p content-type="asset">
        <table-wrap id="en_04t5-body2">
          <graphic xlink:href="1678-4170-abc-91-04-0227-00004-gt05-en.jpg"/></table-wrap>
      </p>
      <p><xref ref-type="table" rid="en_04t6-body2">Table 6</xref> shows the mean values and standard deviations of the values presented by the young girls. Analysis of variance showed significant differences between the groups only for DEE (F=123.24 and p=0.0001). No significant differences were observed for the other variables.</p>
      <p content-type="asset">
        <table-wrap id="en_04t6-body2">
          <graphic xlink:href="1678-4170-abc-91-04-0227-00004-gt06-en.jpg"/></table-wrap>
      </p>
      <p>
        <bold>Discussion</bold>
      </p>
      <p>According to the prevalences shown in <xref ref-type="table" rid="en_04t4-body2">Table 4</xref>, we can observe that in relation to BMI the majority of young men and girls present adequate values of nutritional status, followed by a smaller proportion with overweight and obesity. However, the proportion of subjects with adequate values is lower when compared to the study conducted with adolescents in the State of Bahia<sup>27</sup>, in which 90.4% of the young men and 94.1% of young women were found with adequate nutritional status.</p>
      <p>As regards the hemodynamic variables, the majority of the adolescents, both males and females, presented desirable values. However, we should be concerned about the incidence of adolescents with undesirable DBP values, which are usually associated with excess weight and obesity<sup>28,29</sup>. Borderline blood pressure values in the present study are greater than those found in the study conducted in the city of Belo Horizonte by Ribeiro et al<sup>28</sup>, who reported 12% of individuals with borderline or increased SBP or DBP values.</p>
      <p>Guedes et al<sup>2</sup> presented a prevalence of undesirable SBP values of 9.7% for young women and 8.8% for young men; for DBP, the prevalences were 10.8% and 8.1% for young women and young men, respectively. The differences between the results may be due to the different cut-off points used for blood pressure.</p>
      <p>The present study demonstrated a prevalence of hypercholesterolemia of 16.7% among boys and 13.8% among girls, different from that observed in Giuliano et al's study<sup>14</sup>, which found 10% of increased values, whereas Guedes et al<sup>2</sup> found 5.6% of the young men and 12.9% of the young women with increased TC levels. However, the difference between the findings of the studies is due to the different cut-off points used for hypercholesterolemia, and we emphasize that the present research used the cut-off points suggested by the I Guideline on the Prevention of Atherosclerosis in Childhood and Adolescents<sup>13</sup>.</p>
      <p>As regards LDL-C, Giuliano et al's study<sup>14</sup> found a lower proportion of subjects with borderline (14%) and increased values (6%), as well as a lower incidence of undesirable HDL-C values (5%) in comparison with the present study. Thus, we should be concerned about the proportion of adolescents with undesirable LDL-C levels, which can lead to the development of cardiovascular risk factors such as hypertension, glucose intolerance and insulin-receptor deficiency<sup>14,28-30</sup>.</p>
      <p>In relation to TG levels, this study sample presented a lower prevalence of adolescents with increased values when compared to the sample of Giuliano et al's study<sup>14</sup>, in which 22% of the subjects were found with undesirable values, thus indicating hypertriglyceridemia<sup>31</sup>.</p>
      <p>Accordingly, since the variables investigated in the prevalence analyses demonstrated cardiovascular risk status for part of the individuals, and aware of the benefits of physical activity on health status, we sought to verify the predisposition to these factors in adolescents with different levels of energy expenditure (<xref ref-type="table" rid="en_04t5-body2">Tables 5</xref> and <xref ref-type="table" rid="en_04t6-body2">6</xref>).</p>
      <p>The analysis of variance showed that the anthropometric variables were not significantly different between the groups for both genders, possibly because the majority of the subjects assessed had an adequate nutritional status.</p>
      <p>As regards the biochemical variables, more physically active young men had lower values of total cholesterol and triglycerides when compared with those less active (moderately active and sedentary). Additionally, although not statistically significant, the mean values of the AG for the LDL-C and VLDL-C variables were lower than the mean values of the MG and SG. Thus, we can observe that a higher DEE in usual physical activities consequently contributes to the reduction of excessive values of plasma lipoproteins and lipids in male adolescents.</p>
      <p>Corroborating these findings, Durstine &amp; Haskell<sup>32</sup> observed that individuals physically active and engaged in aerobic training programs had lower total cholesterol and triglyceride levels when compared with their sedentary peers.</p>
      <p>Additionally, in an intervention study, it was demonstrated that physical exercise is one of the major factors contributing to a desirable status of lipid and lipoprotein profiles and coronary diseases<sup>33</sup>. This is due to the physiological characteristics of physical exercises that improve the ability of the muscle tissue to perform fatty acid oxidation, in addition to stimulating the lipase enzyme activity in muscles, thus contributing to the decrease of plasma lipids and lipoproteins even in young individuals<sup>32-34</sup>.</p>
      <p>However, this situation was not observed among the young women, and no significant differences were found among the female groups classified by DEE for any of the cardiovascular risk indicators analyzed. This suggests that, for this sample, a higher DEE in itself did not lead to lower values of BMI, WC, blood pressure, and plasma lipids and lipoproteins in active female adolescents.</p>
      <p>These results corroborate Guedes et al's study<sup>2</sup>, in which the daily energy expenditure of female adolescents was not a determinant of reduction of the indicators corresponding to cardiovascular risk factors. Likewise, Sung et al<sup>34</sup> observed that six weeks of training were not enough to reduce TC and LDL-C levels in young female individuals.</p>
      <p>Thus, the non-significant results of the present study lead us to believe that other factors such as puberty characteristics, family history of cardiovascular diseases, smoking, and alcohol use may influence the alteration of indicators corresponding to cardiovascular risk factors<sup>2,30</sup>.</p>
      <p>Therefore, due to the limitations of the present research, further studies with a greater number of participants being followed up in the mid- or long-term, or involving the administration of experimental treatment controlling the eating habits should be conducted with the purpose of providing a better diagnosis of the health status and its interrelations with behavioral aspects of the pediatric population.</p>
      <p>In summary, a significant percentage of the adolescents in this sample was observed to present undesirable levels of BMI, WC, DBP, TC, LDL-C, HDL-C and TG, which demonstrates the need for adoption of intervention measures for these subjects. Considering the daily energy expenditure, the young men in the AG presented lower TC and TG levels when compared with their moderately active and sedentary peers.</p>
      <p>
        <bold>Acknowledgements</bold>
      </p>
      <p>To the adolescents who collaborated as research subjects and their respective guardians, as well as to the Departments of Education, Culture, Leisure and Health of the city of S&#227;o Mateus do Sul, PR, for supporting this project.</p>
      <p>
        <bold>Potential Conflict of Interest</bold>
      </p>
      <p>No potential conflict of interest relevant to this article was reported.</p>
      <p>
        <bold>Sources of Funding</bold>
      </p>
      <p>There were no external funding sources for this study.</p>
      <p>
        <bold>Study Association</bold>
      </p>
      <p>This study is not associated with any graduation program.</p>
      <p>
        <bold>References</bold>
      </p>
    </body>
  </sub-article>
</article>
