abc Arquivos Brasileiros de Cardiologia Arq. Bras. Cardiol. 0066-782X 1678-4170 Sociedade Brasileira de Cardiologia - SBC São Paulo, SP, Brazil k8G3Bsz9TrMdgF9bn87V9hc 00002 S0066-782X2005001500002 S0066-782X(05)08500202 10.1590/S0066-782X2005001500002 Editorial Angioplastia coronariana e revascularização cirúrgica do miocárdio devem ser consideradas métodos eficientes para o controle da isquemia miocárdica na angina estável? Silva Paulo Roberto Dutra da Rocha Antonio Sérgio Cordeiro da Hospital Pró-Cardíaco Rio de Janeiro RJ Instituto Nacional de Cardiologia Laranjeiras 08 2005 85 2 82 84 This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. 29 09 2005

EDITORIAL

Angioplastia coronariana e revascularização cirúrgica do miocárdio devem ser consideradas métodos eficientes para o controle da isquemia miocárdica na angina estável?

Should percutaneous coronary intervention and coronary artery bypass graft surgery be considered effective methods to control myocardial ischemia in stable angina?

Paulo Roberto Dutra da Silva; Antonio Sérgio Cordeiro da Rocha

Hospital Pró-Cardíaco e Instituto Nacional de Cardiologia Laranjeiras - Rio de Janeiro, RJ

Endereço para correspondência

Nos últimos quinze anos, vários estudos randomizados foram publicados comparando a angioplastia coronariana (ATC) e a cirurgia de revascularização do miocárdio (CRM) em grupos de pacientes multiarteriais e portadores de angina estável1,2,3. Poucos artigos, no entanto, enfocaram nos seus desenhos a presença de angina (BARI3, MASS II4) e a avaliação quantitativa de isquemia miocárdica mediante variáveis no teste de esforço ou na cintilografia de perfusão miocárdica1,4.

Os estudos que compararam a CRM e a ATC mostraram que tanto em um ano quanto em longo prazo (cinco anos), a mortalidade e o infarto agudo do miocárdio com Q apresentam resultados semelhantes nos dois grupos, mas a vantagem na ausência de angina ao final do primeiro ano de seguimento no grupo CRM é perdida no quinto ano, pós-randomização5,6,7 .

Alazráki e cols.8 também demonstraram os mesmos resultados na avaliação do spect, empregando Tálio 201 em três anos de seguimento, não havendo evidência de isquemia miocárdica predominante em nenhum dos dois grupos.

Esses estudos correspondem a uma época em que os grupos selecionados para a randomização eram formados por pacientes portadores de doença arterial coronariana multiarterial, com predomínio de lesões biarteriais; os stents somente eram permitidos em condições extraordinárias (bailout); a revascularização era mais completa nos grupos alocados para a cirurgia; ainda assim, em seguimentos de longo prazo, a cirurgia não conseguiu se mostrar superior à angioplastia na análise de morte ou infarto com Q.

Além disso, o grupo de pacientes randomizados para ATC apresentava resultados semelhantes aos do grupo CRM na análise de isquemia miocárdica esforço-induzido por TE, pela cintilografia ou mesmo em relação à angina. Isso ocorreu em razão dos elevados níveis porcentuais de uma nova revascularização do miocárdio no grupo ATC1-4,9.

Moreira e cols.10 desenharam um estudo de coorte, randomizado, prospectivo, unicêntrico, que compara uma população estratificada em dois grupos para tratamento de revascularização do miocárdio isquêmico. O primeiro deles por meio da cirurgia (CRM), em que era estimulado o emprego de enxertos arteriais; e o segundo, por meio da angioplastia coronariana (ATC), que não limitava o emprego de ferramentas para a desobstrução das artérias, variando do cateter-balão, dispositivos ateroablasivos, laser e stents não-farmacológicos. Seus objetivos são claramente definidos mediante a avaliação de angina, das variáveis ergométricas (TE) e cintilográficas com emprego de sestamibi (Spect) para qualificar e quantificar a isquemia miocárdica em dois momentos distintos: na pré-intervenção (M1) e aos seis meses (M2).

A exclusão de complicações agudas e da necessidade de nova revascularização no tratamento cirúrgico e na ATC tentava igualar os dois grupos com base na análise daqueles pacientes que obtiveram sucesso em ambas as estratégias de tratamento. A análise das variáveis angiográficas distingue os dois grupos: há o predomínio de triarteriais e de revascularização anatômica completa no grupo da cirurgia em relação ao da angioplastia, mas as variáveis quantitativas isquêmicas com dados demonstrados por meio do teste ergométrico, cintilografia e sintoma angina eram equivalentes entre os grupos.

Moreira e cols.10 realizaram um elegante e raro estudo randomizado, prospectivo, predominantemente em portadores de coronariopatia multiarterial com função ventricular esquerda normal e situações isquêmicas equivalentes.

Esses dados permitiram concluir que nos dois tipos de tratamento de revascularização do miocárdio, tanto na avaliação sintomática (angina) quanto na avaliação quantitativa de isquemia por meio do TE e da cintilografia de perfusão (carga isquêmica), comparando M1 e M2, ocorreu diminuição significativa da isquemia miocárdica sem diferença entre os dois tipos de tratamento no sexto mês pós-procedimento (M2).

As limitações e críticas ao trabalho de Moreira e cols.10 referem-se aos grupos de pacientes com predomínio de triarteriais no grupo cirúrgico, e de biarteriais no grupo de angioplastia. As exclusões das complicações agudas em ambos os grupos e o elevado porcentual de novas revascularizações no grupo ATC até o sexto mês pós-procedimento tornaram possível os grupos com o mesmo grau de equivalência isquêmica em M1 e M2. Dessa forma, os autores poderiam demonstrar resultados diferentes dos obtidos em relação à isquemia miocárdica no TE e na cintilografia (carga isquêmica), bem como à angina em M2, se aquelas variáveis não fossem suprimidas.

Um outro ponto a ser discutido e relembrado quando se avalia a presença de isquemia miocárdica pós-procedimento de revascularização do miocárdio é que freqüentemente há um viés que se refere à falta de análise do fluxo coronariano, através do enxerto, que chega ao miocárdio viável. Exemplos freqüentes são encontrados, como a oclusão de um enxerto ou de uma artéria tratada por ATC; testes com resposta normal, bem como vasos de pouca importância anatômica, não revascularizados, resultam em resposta isquêmica. Outro dado bastante interessante que deve ser lembrado é que existem artérias abertas pós-ATC, com lesões residuais angiograficamente leves, e que demonstram isquemia miocárdica na aplicação de testes funcionais. Essas ponderações devem ser consideradas quando da análise desses resultados pelo cardiologista não-intervencionista.

Os estudos que comparam o emprego de stents metálicos e, a seguir, farmacológicos em grupos comparativos da CRM e ATC desconhecem a relevância da evolução do tratamento clínico, afastando-o de qualquer tipo de comparação. Há vinte anos, os estudos iniciais que compararam o tratamento clínico e a cirurgia (CASS e VA11,12) não demonstraram superioridade de um tratamento sobre o outro, em pacientes portadores de doença arterial coronariana (DAC) multiarterial com função ventricular normal, quando os objetivos primários eram morte ou infarto agudo do miocárdio (IAM) não-fatal.

Recentemente, estudos empregaram stents recobertos em pacientes com DAC triarterial, comparando a cirurgia com angioplastia em relação a eventos cardíacos maiores, no período de doze meses, incluindo morte, IAM não-fatal, acidente vascular encefálico (AVE), e necessidade de nova revascularização. Dentre esses estudos, destaca-se o ARTS II13 recém-apresentado no ACC Meeting 2005, que comparou os dados de eventos maiores compilados no grupo CRM do estudo ARTS14, com os resultados obtidos para os mesmos eventos no grupo ATC-stent recoberto do ARTS II. Seus resultados anunciam uma redução significativa de nova revascularização do grupo ATC-stent recoberto – 7,4% vs 3,7% do grupo CRM, mas sem alcançar significativa diferença também nos eventos morte ou IAM não-fatal.

Van Domburg e cols.15, em análise de oito anos de seguimento, comparando grupos de ATC-stent com CRM no período de 1997 a 1999 em um único centro, após ajuste, demonstrou maior sobrevida no grupo CRM – 78% vs 64% ATC-stent, p<0,0001.

Hannan et al.16 relataram os resultados comparativos em portadores de cardiopatia isquêmica multiarterial, sendo 37.212 deles submetidos a CRM e 22.102 pacientes à ATC com emprego de stents. O período de compilação desses dados no registro de Nova Iorque foi entre 01/01/1997 e 31/12/2000. O seguimento mediano de ambos os grupos foi de 706 dias. Após ajuste, a mortalidade do grupo submetido à cirurgia era inferior ao da ATC nos subgrupos triarterial com envolvimento proximal da artéria descendente anterior (DA) 10,7% vs 15,6% HR: 0,64 (IC; 0,56 a 0,74) e biarterial sem envolvimento da DA proximal 6,7% vs 8,6% HR:0,76 (IC; 0,60 a 0,96), respectivamente. Em relação à necessidade de nova revascularização, o grupo de stent necessitou de 35,1%, enquanto o grupo da CRM necessitou de 4,9% no mesmo período.

Moreira e cols.10 chamam a atenção para a carga isquêmica freqüentemente não analisada no seguimento dos pacientes a curto e longo prazos. Recentemente, mostramos nossos resultados nesta revista, quando analisamos carga isquêmica e angina em cinco anos de seguimento, comparando ATC e CRM em portadores de angina estável com predomínio de lesões triarteriais em ambos os grupos. Setenta por cento dos pacientes do grupo ATC tiveram implante de stents não-farmacológicos. Ao final de cinco anos de seguimento, tanto a angina quanto o teste de esforço positivo diminuíram significativamente em ambos os grupos, e para se obter esse resultado o grupo de ATC teve que ser submetido a um número elevado de novas reintervenções: 24,75% vs 2,85% CRM.17

Finalmente, há uma expectativa grande com os resultados de dois estudos: o primeiro, Clinical Outcomes Utilizing Revascularization and Agressive druG Evaluation (COURAGE)18 compara, na cardiopatia isquêmica multiarterial sintomática, o tratamento clínico com angioplastia e o tratamento clínico com a cirurgia. Nesse estudo é incentivado o uso pleno e agressivo de agentes para controle de aterosclerose e diabetes mellitus em todos os grupos. O objetivo é analisar, a longo prazo (quatro a sete anos), eventos clínicos: morte, infarto agudo do miocárdio e síndrome isquêmica aguda troponina–positiva.

O segundo é o estudo de Hueb e cols., MASS II4, que compara o tratamento clínico, a angioplastia e a cirurgia em portadores de angina estável cujos resultados finais de cinco anos de seguimento estão para ser publicados e servirão de orientação para o tipo de conduta a ser tomada nos pacientes triarteriais, comparando os três métodos. Ainda nesse estudo, a análise dos objetivos primários (morte, infarto com Q, necessidade de nova revascularização) e secundários (carga isquêmica, freqüentemente esquecida, e angina) será também definida4.

Referências

1. King III SB, Lembo NJ, Weintraub WS et al. for the Emory Angioplasty Versus Surgery Trial (EAST). A randomized trial comparing angioplasty with coronary bypass surgery. Emory Angioplasty versus Surgery Trial. N Engl J Med 1994;331:1044-50.

2. Hamm CW, Reimers J, Ischinger T et al. for the German Angioplasty Bypass Surgery Investigation (GABI). A randomized study of coronary angioplasty compared with bypass surgery in patients with symptomatic multivessel coronary disease. N Eng J Med 1994;331:1037-43.

3. BARI Investigators. Comparison of coronary bypass surgery with angioplasty in patients with multivessel disease. N Engl J Med 1996;335:217-25.

4. Hueb WA, Soares PR, Gersh B et al. The Medicine, Angioplasty, or Surgery Study (MASS-II): a randomized, controlled clinical trial of three therapeutics strategies for multivessel coronary artery disease: one-year results. J Am Coll Cardiol 2004;43:1743-751.

5. King III SB, Kosinski AS, Guyton RA et al. Eight-year mortality in the Emory Angioplasty versus Surgery Trial (EAST) Investigators. J Am Coll Cardiol 2000;35:1116-121.

6. Feit F, Brooks MM, Sopko G et al. for the BARI Investigators. Long Term Clinical Outcome in the Bypass Angioplasty Revascularization Investigation Trial. Circulation 2000;101:2795-802.

7. Bucher HC, Hengsder P, Schindler C et al. Percutaneous transluminal coronary angioplasty versus medical treatment for non-acute coronary heart disease: meta-analysis of randomized controlled trials. BMJ 2000;321:73-77.

8. Alazráki NP, Krawczynska EG, Kosinski AS et al. Prognostic Value of Thallium-201 Single-Photon Emission Computed Tomography for Patients With Multivessel Coronary Artery Disease after Revascularization (The Emory Angioplasty Versus Surgery Trial [EAST]). Am J Cardiol 1999;84:1369-374.

9. Rodriguez A, Boullon F, Perez-Balliño N et al. On behalf of the ERACI Group. Argentine randomized trial of percutaneous transluminal coronary angioplasty versus coronary artery bypass surgery in multivessel disease (ERACI): in-hospital results and 1-year follow up. J Am Coll Cardiol 1993;22:1060-67.

10. Moreira AE, Hueb WA, Soares PR et al. Comparative study between the therapeutics effects of surgical myocardial revascularization and coronary angioplasty in equivalent ischemic situations. Analysis through myocardial scintigraphy with 99m tc- sestamibi. Arq Bras Cardiol 2005;85:92-9.

11. CASS principal Investigators and Their Associates. Coronary Artery Study (CASS): a randomized trial of coronary artery bypass surgery. Survival data. Circulation 1983;68:939-50.

12. Veterans Administration Coronary Bypass Surgery Cooperative Study Group. Eleven Year survival in the Veterans Administration randomized trial of coronary bypass surgery for stable angina. N Engl J Med 1984;311:1333-339.

13. Arterial Revascularization Therapies Study Part II: Sirolimus – Eluting Stents for the Treatment of Patients With Multivessel De Novo Coronary Artery Lesions (ARTS II): Presented at American College of Cardiology 05. Annual Scientific Session. Orlando (USA). March; 6-9.

14. Serruys PW, Unger F, Souza JE. For the Arterial Revascularization Therapies Study Group (ARTS). Comparison of coronary artery bypass surgery and stenting for the treatment of multivessel disease. N Engl J Med 2001;344:1117-124.

15. Van Domburg RT, Takkenberg JM, Noordzij LJ et al. Late outcome after stenting or coronary artery bypass surgery for the treatment of multivessel disease: A Single – Center Matched Propensity Controlled Cohort Study. Ann Thorac Surg 2005;79:1563-569.

16. Hannan EL, Racz MJ, Wallford G et al. Long term outcomes of coronary-artery bypass grafting versus stenting implantation. N Engl J Med 2005;352:2174-183.

17. Silva PRD, Hueb WA, César LA et al. Comparative study of the results of coronary artery bypass grafting and angioplasty for myocardial revascularization in patients with equivalent multivessel disease. Arq Bras Cardiol 2005;84:214-21.

18. O'Rourke RA, Boden WE, Weintraub WS, Hartigan P. Medical therapy versus percutaneous coronary intervention: implications of the AVERT study and the COURAGE trial. Curr Pract Med 1999;2:225-27.

Paulo Roberto Dutra da Silva

Rua General Artigas, 395/101

22441-140 - Rio de Janeiro, RJ

E-mail:

paulo_r_dutra@uol.com.br

Editorial Should percutaneous coronary intervention and coronary artery bypass graft surgery be considered effective methods to control myocardial ischemia in stable angina?

EDITORIAL

Should percutaneous coronary intervention and coronary artery bypass graft surgery be considered effective methods to control myocardial ischemia in stable angina?

Paulo Roberto Dutra da Silva; Antonio Sérgio Cordeiro da Rocha

Hospital Pró-Cardíaco e Instituto Nacional de Cardiologia Laranjeiras - Rio de Janeiro, RJ - Brazil

Correspondence

In the last fifteen years several randomized studies were published comparing percutaneous coronary intervention (PCI) and coronary artery bypass graft surgery (CABG) in patients with stable angina and multivessel coronary artery disease1-3.

Few studies, however, have focused their designs on the presence of angina (BARI3, MASS II)4 or on the quantitative evaluation of myocardial ischemia as obtained at ergometric stress test or at myocardial perfusion scintillography1,4.

Studies that compared CABG and PCI showed that mortality and q-wave myocardial infarction rates were similar either at short term (one year) or at long term (five years) follow-up for both groups. The freedom of angina advantage at one year within the CABG group was lost in the fifth year after randomization5-7.

Alazráki et al8 also showed the same results using Single Photon Emission Computed Tomography (SPECT) evaluation with Thalium 201 at three years of follow-up. There was no evidence of predominant myocardial ischemia in either of the two groups.

These studies correspond to a time when groups selected for randomization consisted of patients with multivessel coronary artery disease, mostly with two-vessel disease; the stents were allowed only under extraordinary conditions (bailout) and complete revascularization was achieved mainly on surgical patients. Still, at long term follow-ups, surgery did not show to be superior to PCI on death or q-wave myocardial infarction analysis.

In addition, patients randomized to PCI presented similar results to those observed in the CABG group in terms of induced myocardial ischemia either on ergometric stress test evaluation or on scintillography, or even in relation to severity of angina. This was due to an elevated necessity of a new revascularization procedure in the PCI group1-4,9.

Moreira et al10 designed a randomized, prospective, unicenter cohort study that compares two different revascularization strategies of the ischemic myocardium. The first group had CABG surgery in which the use of arterial grafts were encouraged. In the second group, PCI was achieved with no limits to the use of different tools to accomplish an unobstructed coronary artery, ranging from balloon-catheter and atheroablasive devices to laser and non-pharmacological stents. Their goal is to quantify and qualify myocardial ischemia at two distinct moments: M1, pre-intervention and M2, at six month follow-up. Angina evaluation, ergometric stress test and SPECT-sestamibi variables were used for that.

The analysis was based on those patients successfully treated in each group by excluding acute complications and the necessity of a new revascularization procedure at the CABG and PCI groups.

The angiographic variables differ between the two groups: there is a predominance in patients with triple-vessel disease and complete anatomic revascularization in the CABG group compared to the PCI group. However, the presence of angina and quantitative ischemic variables at ergometric stress test and scintillography are equivalent.

Moreira et al10 conducted a well-designed and rare randomized and prospective study, predominantly in patients with multivessel coronary artery disease wth normal left ventricular function and equivalent ischemic situations.

These data allowed the conclusion that the two types of myocardial revascularization treatments, at the symptomatic evaluation (angina) as well as at the quantitative ischemia evaluation through ergometric stress test and perfusion scintillography (ischemic load) comparing M1 and M2, resulted in a significant decrease of the myocardial ischemia with no difference between the two types of treatment sixth months after the procedure (M2).

The limitations and critics to the work of Moreira et al10 refer to the groups of patients with a predominance of triple-vessel coronary artery diseae in the surgical group, and two-vessel disease in the PCI group.

The exclusion of acute complications in both groups and the elevated percent levels of new revascularizations in the PCI group up to six months after the procedure possibly made the two groups exhibit the same degree of ischemic equivalency at M1 and M2.

Thus, the authors could have demonstrated different results from those obtained regarding myocardial ischemia at ergometric stress test and at the scintillography (ischemic load) as well as concerning angina at M2, if those variables were not eliminated. Another point to be discussed and remembered refers to the lack of analysis of the coronary blood low through the graft (or coronary artery) that reaches the viable myocardium. Frequent examples are found such as graft occlusion or an artery treated by PCI, that tests with normal responses, as well as non-revascularized vessels of little anatomic importance, resulting in a ischemic response. Another noteworthy point is that there are open arteries after PCI, with angiographically slight residual lesions, which show myocardial ischemia when the functional test is applied. These considerations must be made by the non-interventionist cardiologist during the analysis of such results.

The studies that compare the use of bare metal stents and following, the pharmacological ones, in comparative groups of CABG and PCI, are unaware of the relevance of the evolution of the clinical treatment, setting it apart from any kind of comparison. Twenty years ago, the initial studies that compared the clinical and surgical treatments (CASS and VA11,12) did not show the superiority of one treatment over the other, in patients with multivessel coronary artery disease (CAD) with normal ventricular function, when the primary objectives were death or nonfatal acute myocardial infarction (AMI).

Recent studies have used coated stents in patients with three-vessel CAD, comparing the surgical procedure with angioplasty regarding major cardiac events, in a period of 12 months, including death, nonfatal AMI, stroke, and the need for a new revascularization. Among these studies, the ARTS II13, which was recently presented at the ACC Meeting 2005, is noteworthy. They have shown data on major events obtained at the CABG group of the ARTS14 study and compared with those obtained for the same events in the PCI-coated stent group of ARTS II. Its results showed a significant decrease of a new revascularization procedure in the PCI-coated stent group – 7.4% vs 3.7% in the CABG group. This trend did not reach significant difference. There was no significant difference as well for death or nonfatal AMI events.

Van Domburg et al15 on an eight-year follow-up analysis, comparing groups of PCI-stent with CABG in the period of 1997 to 1999 in a single center, after adjustments, showed a longer survival in the CABG group – 78% vs 64% in PCI-stent group, p<0.0001.

Hannan et al16 reported the comparative results in patients with multivessel ischemic disease, with 37,212 of them having been submitted to CABG and 22,102 to PCI with stents. The data gathering period in the New York registry was from 01/01/1997 to 12/31/2000. The median follow-up of both groups was 706 days. After adjustments, the mortality rate in the group submitted to surgery was lower than that of the PCI in the subgroups with triple-vessel disease with proximal involvement of the left anterior descending artery (LAD) 10,7 vs 15,6% HR: 0,64 (CI: 0.56 to 0.74) and with two-vessel disease with no proximal LAD involvement 6,7% vs 8,6% HR: 0,76 (CI: 0.60 to 0.96). Regarding the need for a new revascularization, the stent group needed it in 35.1%, whereas the CABG group needed it in 4.9% of the cases within the same period.

Moreira et al10 call the attention to the ischemic load that is often not analyzed at the short and long-term follow-up of patients. We recently showed our results in this Journal when we analyzed ischemic load and angina at 5 years of follow-up, comparing PCI and CABG in patients with stable angina with a predominance of triple-vessel disease in both groups. Seventy percent of the patients from the PCI group had non-pharmacological stent implanted. At the end of 5 years of follow-up, angina as well as positive stress test decreased significantly in both groups. However, in order to obtain such results, the PCI group had to be submitted to an elevated number of new procedures, 24.75% vs 2.85% in the CABG group17.

Finally, there is a great expectation regarding the results of two studies: the first, Clinical Outcomes Utilizing Revascularization and Aggressive druG Evaluation (COURAGE)18 compares, in symptomatic multivessel ischemic disease, the clinical treatment with angioplasty and the clinical treatment with surgery. In this study, aggressive use of drugs to control atherosclerosis and diabetes mellitus is advocated for all groups. The objective is to analyze, at long-term, (4 to 7 years) clinical events such as death, acute myocardial infarction, and troponin-positive acute ischemic syndrome.

The second is the study by Hueb et al., MASS II4, which compares clinical treatment, PCI, and the surgery in patients with stable angina. Final results of a 5-year follow-up are about to be published and will serve as a guide for the strategy that should be used in patients with triple-vessel coronary artery disease. This study will also define the analysis of the primary objectives (death, q-wave myocardial infarction, need for a new revascularization) and the secondary ones (often forgotten ischemic load, and angina).

References

1. King III SB, Lembo NJ, Weintraub WS et al. for the Emory Angioplasty Versus Surgery Trial (EAST). A randomized trial comparing angioplasty with coronary bypass surgery. Emory Angioplasty versus Surgery Trial. N Engl J Med 1994;331:1044-50.

2. Hamm CW, Reimers J, Ischinger T et al. for the German Angioplasty Bypass Surgery Investigation (GABI). A randomized study of coronary angioplasty compared with bypass surgery in patients with symptomatic multivessel coronary disease. N Eng J Med 1994;331:1037-43.

3. BARI Investigators. Comparison of coronary bypass surgery with angioplasty in patients with multivessel disease. N Engl J Med 1996;335:217-25.

4. Hueb WA, Soares PR, Gersh B et al. The Medicine, Angioplasty, or Surgery Study (MASS-II): a randomized, controlled clinical trial of three therapeutics strategies for multivessel coronary artery disease: one-year results. J Am Coll Cardiol 2004;43:1743-751.

5. King III SB, Kosinski AS, Guyton RA et al. Eight-year mortality in the Emory Angioplasty versus Surgery Trial (EAST) Investigators. J Am Coll Cardiol 2000;35:1116-121.

6. Feit F, Brooks MM, Sopko G et al. for the BARI Investigators. Long Term Clinical Outcome in the Bypass Angioplasty Revascularization Investigation Trial. Circulation 2000;101:2795-802.

7. Bucher HC, Hengsder P, Schindler C et al. Percutaneous transluminal coronary angioplasty versus medical treatment for non-acute coronary heart disease: meta-analysis of randomized controlled trials. BMJ 2000;321:73-77.

8. Alazráki NP, Krawczynska EG, Kosinski AS et al. Prognostic Value of Thallium-201 Single-Photon Emission Computed Tomography for Patients With Multivessel Coronary Artery Disease after Revascularization (The Emory Angioplasty Versus Surgery Trial [EAST]). Am J Cardiol 1999;84:1369-374.

9. Rodriguez A, Boullon F, Perez-Balliño N et al. On behalf of the ERACI Group. Argentine randomized trial of percutaneous transluminal coronary angioplasty versus coronary artery bypass surgery in multivessel disease (ERACI): in-hospital results and 1-year follow up. J Am Coll Cardiol 1993;22:1060-67.

10. Moreira AE, Hueb WA, Soares PR et al. Comparative study between the therapeutics effects of surgical myocardial revascularization and coronary angioplasty in equivalent ischemic situations. Analysis through myocardial scintigraphy with 99m tc- sestamibi. Arq Bras Cardiol 2005;85:92-9

11. CASS principal Investigators and Their Associates. Coronary Artery Study (CASS): a randomized trial of coronary artery bypass surgery. Survival data. Circulation 1983;68:939-50.

12. Veterans Administration Coronary Bypass Surgery Cooperative Study Group. Eleven Year survival in the Veterans Administration randomized trial of coronary bypass surgery for stable angina. N Engl J Med 1984;311:1333-339.

13. Arterial Revascularization Therapies Study Part II: Sirolimus – Eluting Stents for the Treatment of Patients With Multivessel De Novo Coronary Artery Lesions (ARTS II): Presented at American College of Cardiology 05. Annual Scientific Session. Orlando (USA). March; 6-9.

14. Serruys PW, Unger F, Souza JE. For the Arterial Revascularization Therapies Study Group (ARTS). Comparison of coronary artery bypass surgery and stenting for the treatment of multivessel disease. N Engl J Med 2001;344:1117-124.

15. Van Domburg RT, Takkenberg JM, Noordzij LJ et al. Late outcome after stenting or coronary artery bypass surgery for the treatment of multivessel disease: A Single – Center Matched Propensity Controlled Cohort Study. Ann Thorac Surg 2005;79:1563-569.

16. Hannan EL, Racz MJ, Wallford G et al. Long term outcomes of coronary-artery bypass grafting versus stenting implantation. N Engl J Med 2005;352:2174-183.

17. Silva PRD, Hueb WA, César LA et al. Comparative study of the results of coronary artery bypass grafting and angioplasty for myocardial revascularization in patients with equivalent multivessel disease. Arq Bras Cardiol 2005;84:214-21.

18. O'Rourke RA, Boden WE, Weintraub WS, Hartigan P. Medical therapy versus percutaneous coronary intervention: implications of the AVERT study and the COURAGE trial. Curr Pract Med 1999;2:225-27.

Paulo Roberto Dutra da Silva

Rua General Artigas, 395/101

22441-140 - Rio de Janeiro, RJ - Brazil

E-mail:

paulo_r_dutra@uol.com.br