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  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">abc</journal-id>
      <journal-title-group>
        <journal-title>Arquivos Brasileiros de Cardiologia</journal-title>
        <abbrev-journal-title abbrev-type="publisher">Arq. Bras. Cardiol.</abbrev-journal-title>
      </journal-title-group>
      <issn pub-type="ppub">0066-782X</issn>
      <issn pub-type="epub">1678-4170</issn>
      <publisher>
        <publisher-name>Sociedade Brasileira de Cardiologia - SBC</publisher-name>
        <publisher-loc>S&#227;o Paulo, SP, Brazil</publisher-loc>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id" specific-use="scielo-v3">rtdtgVw6fxbgKYgBTfLBm5t</article-id>
      <article-id pub-id-type="other">00011</article-id>
      <article-id pub-id-type="publisher-id" specific-use="scielo-v2">S0066-782X1998000100011</article-id>
      <article-id pub-id-type="publisher-id" specific-use="scielo-v1">S0066-782X(98)07000111</article-id>
      <article-id pub-id-type="doi">10.1590/S0066-782X1998000100011</article-id>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Relato de Casos</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Utiliza&#231;&#227;o de stent para tratamento de dissec&#231;&#227;o coron&#225;ria iatrog&#234;nica</article-title>
        <trans-title-group xml:lang="en">
          <trans-title>Stenting for iatrogenic coronary dissection</trans-title>
        </trans-title-group>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <name>
            <surname>Copini</surname>
            <given-names>Ronaldo Tadeu</given-names>
          </name>
          <xref ref-type="aff" rid="aff01"/>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Alves</surname>
            <given-names>Claudia Maria Rodrigues</given-names>
          </name>
          <xref ref-type="aff" rid="aff01"/>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Costa</surname>
            <given-names>Francisco de Assis</given-names>
          </name>
          <xref ref-type="aff" rid="aff01"/>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Souza</surname>
            <given-names>Jos&#233; Augusto Marcondes de</given-names>
          </name>
          <xref ref-type="aff" rid="aff01"/>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Herrmann</surname>
            <given-names>Jo&#227;o Louren&#231;o Villari</given-names>
          </name>
          <xref ref-type="aff" rid="aff01"/>
        </contrib>
      </contrib-group>
      <aff id="aff01">
        <addr-line>
          <named-content content-type="city">S&#227;o Paulo</named-content>
          <named-content content-type="state">S&#227;o Paulo</named-content>
        </addr-line>
        <institution content-type="orgname">Universidade Federal de S&#227;o Paulo</institution>
        <institution content-type="orgdiv1">Escola Paulista de Medicina </institution>
        <country country="BR">Brazil</country>
      </aff>
      <pub-date date-type="collection" publication-format="electronic">
        <month>01</month>
        <year>1998</year>
      </pub-date>
      <volume>70</volume>
      <issue>1</issue>
      <fpage>55</fpage>
      <lpage>57</lpage>
      <history>
        <date date-type="received">
          <day>16</day>
          <month>09</month>
          <year>1997</year>
        </date>
        <date date-type="accepted">
          <day>17</day>
          <month>10</month>
          <year>1997</year>
        </date>
      </history>
      <permissions>
        <license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc/4.0/" xml:lang="en">
          <license-p>This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.</license-p>
        </license>
      </permissions>
      <abstract>
        <p>A dissec&#231;&#227;o coron&#225;ria iatrog&#234;nica &#233; rara, entretanto, apresenta alta mortalidade e morbidade. Diante de uma oclus&#227;o coron&#225;ria aguda &#233; fundamental a restaura&#231;&#227;o imediata da perviabilidade do vaso e, com isso, limitar a extens&#227;o e a dura&#231;&#227;o da isquemia. Neste contexto o procedimento usual tem sido a revasculariza&#231;&#227;o mioc&#225;rdica de emerg&#234;ncia, precedido pela coloca&#231;&#227;o de um bal&#227;o intra-a&#243;rtico. A principal desvantagem desta abordagem &#233; o tempo necess&#225;rio para reunir uma equipe cir&#250;rgica. Os autores apresentam caso de uma paciente com dissec&#231;&#227;o iatrog&#234;nica da art&#233;ria circunflexa durante o cateterismo diagn&#243;stico, que foi solucionada atrav&#233;s da implanta&#231;&#227;o de um stent coron&#225;rio, com &#243;timo resultado. Esta t&#233;cnica apresenta vantagens em termos de velocidade de reperfus&#227;o e disponibilidade em centros que realizar&#227;o o cateterismo diagn&#243;stico sem cobertura cir&#250;rgica local.</p>
      </abstract>
      <trans-abstract xml:lang="en">
        <p>Catheter-induced coronary dissection is rare but has a significant mortality and morbidity. The ideal management of acute coronary occlusion, whatever the cause, is the prompt restoration of the vessel patency to limit the extent and duration of ischemia. In the setting of dissection during angiography the usual approach to myocardial salvage has been emergency aortocoronary bypass surgery preceded by insertion of an intra-aortic balloon. The main disadvantages of this approach is the delay in performing emergency surgery, mainly in centers without surgical back-up on site. The authors present a case of an elderly woman with left circumflex artery dissection caused by the catheter during coronary angiography. This problem was successfully managed using an intracoronary stent. This technique has potential advantages in terms of the speed of reperfusion and availability in centers performing diagnostic angiography without surgical back-up on site.</p>
      </trans-abstract>
      <pub-date publication-format="electronic" date-type="pub">
        <day>08</day>
        <month>01</month>
        <year>2002</year>
      </pub-date>
    </article-meta>
  </front>
  <body>
    <p>Relato de Caso </p>
    <p>
      <bold>Utiliza&#231;&#227;o de <italic>Stent</italic> para Tratamento de Dissec&#231;&#227;o Coron&#225;ria Iatrog&#234;nica </bold>
    </p>
    <p>Ronaldo Tadeu Copini, Claudia Maria Rodrigues Alves, Francisco de Assis Costa, Jos&#233; Augusto Marcondes de Souza, Jo&#227;o Louren&#231;o Villari Herrmann </p>
    <p>
      <bold>S&#227;o Paulo, SP </bold>
    </p>
    <p>
      <italic>A dissec&#231;&#227;o coron&#225;ria iatrog&#234;nica &#233; rara, entretanto, apresenta alta mortalidade e morbidade. </italic>
    </p>
    <p>Diante de uma oclus&#227;o coron&#225;ria aguda &#233; fundamental a restaura&#231;&#227;o imediata da perviabilidade do vaso e, com isso, limitar a extens&#227;o e a dura&#231;&#227;o da isquemia. Neste contexto o procedimento usual tem sido a revasculariza&#231;&#227;o mioc&#225;rdica de emerg&#234;ncia, precedido pela coloca&#231;&#227;o de um bal&#227;o intra-a&#243;rtico. A principal desvantagem desta abordagem &#233; o tempo necess&#225;rio para reunir uma equipe cir&#250;rgica. </p>
    <p>Os autores apresentam caso de uma paciente com dissec&#231;&#227;o iatrog&#234;nica da art&#233;ria circunflexa durante o cateterismo diagn&#243;stico, que foi solucionada atrav&#233;s da implanta&#231;&#227;o de um stent coron&#225;rio, com &#243;timo resultado. Esta t&#233;cnica apresenta vantagens em termos de velocidade de reperfus&#227;o e disponibilidade em centros que realizar&#227;o o cateterismo diagn&#243;stico sem cobertura cir&#250;rgica local. </p>
    <p>
      <bold>Stenting for Iatrogenic Coronary Dissection </bold>
    </p>
    <p>
      <italic>Catheter-induced coronary dissection is rare but has a significant mortality and morbidity. </italic>
    </p>
    <p>The ideal management of acute coronary occlusion, whatever the cause, is the prompt restoration of the vessel patency to limit the extent and duration of ischemia. In the setting of dissection during angiography the usual approach to myocardial salvage has been emergency aortocoronary bypass surgery preceded by insertion of an intra-aortic balloon. The main disadvantages of this approach is the delay in performing emergency surgery, mainly in centers without surgical back-up on site. </p>
    <p>The authors present a case of an elderly woman with left circumflex artery dissection caused by the catheter during coronary angiography. This problem was successfully managed using an intracoronary stent. This technique has potential advantages in terms of the speed of reperfusion and availability in centers performing diagnostic angiography without surgical back-up on site. </p>
    <p>A dissec&#231;&#227;o coron&#225;ria provocada pelo cateterismo card&#237;aco diagn&#243;stico &#233; uma complica&#231;&#227;o rara e grave com uma incid&#234;ncia de 0,01% a 0,41%<sup>1 </sup>, sendo geralmente resultado de trauma direto &#224; intima arterial. Dependendo de sua gravidade, rapidamente, se estabelece oclus&#227;o proximal. O tratamento imediato para restabelecimento da perviabilidade vascular &#233; mandat&#243;rio, limitando a dura&#231;&#227;o e extens&#227;o da isquemia. </p>
    <p>Na sala de hemodin&#226;mica, a utiliza&#231;&#227;o de cateteres de perfus&#227;o e bal&#227;o intra-a&#243;rtico, quando h&#225; instabilidade hemodin&#226;mica, ajudam na estabiliza&#231;&#227;o do paciente para encaminhamento cir&#250;rgico. Relatamos um caso de dissec&#231;&#227;o severa tratada com angioplastia e <italic>stent</italic> com excelente resultado. </p>
    <p>Relato do Caso </p>
    <p>Paciente do sexo feminino, 78 anos, encaminhada para cinecoronariografia eletiva, ambulatorial, com antecedente de hipertens&#227;o arterial leve e precordialgia aos esfor&#231;os, h&#225; cerca de um ano, sendo que, nos &#250;ltimos dois meses, tornou-se mais severa em freq&#252;&#234;ncia e dura&#231;&#227;o. O ECG evidenciava apenas sinais de hipertrofia ventricular leve. </p>
    <p>O cateterismo card&#237;aco foi realizado atrav&#233;s de acesso femoral direito, pela t&#233;cnica de Seldinger. Com o cateter Judkins 3,5-6F foi cateterizada a art&#233;ria coron&#225;ria esquerda sob monitoriza&#231;&#227;o press&#243;rica. Duas inje&#231;&#245;es em proje&#231;&#245;es ortogonais revelaram art&#233;ria livre de processos obstrutivos, com um tronco muito curto, e inje&#231;&#245;es semi-seletivas na art&#233;ria circunflexa (Cx), que era de grande calibre, fornecendo grande ramo marginal e segundo ramo p&#243;stero-lateral. Durante a terceira inje&#231;&#227;o, observou-se extensa infiltra&#231;&#227;o de contraste na parede da Cx, comprometendo sua por&#231;&#227;o proximal (<xref ref-type="fig" rid="figura1">fig. 1</xref>), com preju&#237;zo severo do fluxo e que evoluiu, rapidamente, para oclus&#227;o arterial aguda. A origem e fluxo da art&#233;ria descendente anterior (ADA) estavam preservados. A paciente passou a apresentar precordialgia severa, palidez, sudorese e a monitoriza&#231;&#227;o eletrocardiogr&#225;fica mostrou sinais de infarto em instala&#231;&#227;o. </p>
    <fig id="figura1">
      <graphic xlink:href="1678-4170-abc-70-01-0055-00011-gf01.jpg"/></fig>
    <p>A angioplastia arterial coron&#225;ria com cateter de perfus&#227;o foi iniciada, imediatamente. Conseguiu-se f&#225;cil progress&#227;o do fio-guia 0,014" J Ex Hannibal 315cm (Schneider Inc) posicionado no grande ramo marginal da Cx. Cateter SpeedFlow 3,5x30mm (Schneider Inc) foi posicionado ap&#243;s cerca de 5min de oclus&#227;o no ponto de reten&#231;&#227;o de contraste, obtendo-se imediata reperfus&#227;o e fluxo normal na ADA cuja emerg&#234;ncia era cont&#237;gua &#224; les&#227;o. Ap&#243;s 15min de insufla&#231;&#227;o, nova coronariografia demonstrou perviabilidade arterial, logo seguida por nova oclus&#227;o total da art&#233;ria. Considerando a grande import&#226;ncia da art&#233;ria e sua proximidade com o tronco da ACE, optou-se por imediata libera&#231;&#227;o de <italic>stent</italic>. Um microstent II 3,5x39mm (Arterial Vascular Engineering, Inc) foi liberado, ainda com o fio-guia posicionado no ramo marginal. Considerando-se a gravidade do caso, decidimos enfrentar a possibilidade de oclus&#227;o do ramo atrioventricular da Cx, que emergia da por&#231;&#227;o a ser coberta pelo <italic>stent</italic>. A p&#243;s-dilata&#231;&#227;o com cateter mongoose 3,5x20mm (Schneider Inc) foi realizada em toda a extens&#227;o do <italic>stent</italic> at&#233; 17atm de press&#227;o. Ap&#243;s a libera&#231;&#227;o do <italic>stent</italic>, houve completa remiss&#227;o dos sintomas e normaliza&#231;&#227;o eletrocardiogr&#225;fica. </p>
    <p>A quantifica&#231;&#227;o coron&#225;ria autom&#225;tica (CMS - MEDIS) realizada na coronariografia de controle, ap&#243;s retirada do fio-guia, revelou di&#226;metro de refer&#234;ncia de 3,62mm e di&#226;metro da obstru&#231;&#227;o de 3,38mm (1% de estenose do di&#226;metro). As emerg&#234;ncias da ADA e por&#231;&#227;o atrioventricular da Cx estavam livres de obstru&#231;&#227;o e com fluxo normal (<xref ref-type="fig" rid="figura2">fig. 2</xref>). </p>
    <fig id="figura2">
      <graphic xlink:href="1678-4170-abc-70-01-0055-00011-gf02.jpg"/></fig>
    <p>A paciente foi mantida sob monitoriza&#231;&#227;o em UTI por 48h, anticoagulada por 48h e recebeu alta ap&#243;s tr&#234;s dias, em uso de &#225;cido acetil-salic&#237;lico e ticlopidina, n&#227;o tendo ocorrido altera&#231;&#227;o eletrocardiogr&#225;fica ou enzim&#225;tica na evolu&#231;&#227;o. </p>
    <p>Discuss&#227;o </p>
    <p>A dissec&#231;&#227;o coron&#225;ria provocada por cateter e relacionada a procedimentos diagn&#243;sticos, ou seja, excetuando-se aquela relacionada &#224; angioplastia, ocorre igualmente em ambos os sexos, n&#227;o tem rela&#231;&#227;o com a t&#233;cnica - braquial ou femoral - e envolve predominantemente a art&#233;ria coron&#225;ria direita (67%) <sup>2</sup>. Quando a via femoral &#233; a utilizada, h&#225; algumas evid&#234;ncias de que a dissec&#231;&#227;o &#233; mais comum com cateteres mais finos (0,67% para cateteres 6F vs 0,04% para cateteres 8F) <sup>3</sup>. Algumas caracter&#237;sticas dos cateteres 6F como facilidade de penetra&#231;&#227;o profunda na coron&#225;ria e menor torque e estabilidade no &#243;stio facilitam a inj&#250;ria intimal<sup> 4</sup>, especialmente, no ambiente de treinamento que caracteriza a institui&#231;&#227;o de ensino. Obviamente, a dissec&#231;&#227;o &#233; ainda facilitada pela presen&#231;a de aterosclerose. </p>
    <p>Nas dissec&#231;&#245;es coron&#225;rias graves, o procedimento usual, principalmente no per&#237;odo anterior &#224; utiliza&#231;&#227;o dos <italic>stents</italic>, &#233; a revasculariza&#231;&#227;o de emerg&#234;ncia devido a complexidade da sua apresenta&#231;&#227;o e pela grande &#225;rea de mioc&#225;rdio em risco. Apesar dos bons resultados cir&#250;rgicos<sup> 5</sup>, o tempo necess&#225;rio para se reunir uma equipe cir&#250;rgica durante uma emerg&#234;ncia e a morbidade do procedimento s&#227;o pontos desfavor&#225;veis na sua compara&#231;&#227;o com a angioplastia. Servi&#231;os de hemodin&#226;mica n&#227;o ligados a centros cir&#250;rgicos representam outro ambiente onde a ATC deve ser o procedimento terap&#234;utico utilizado. </p>
    <p>O <italic>stent</italic> coron&#225;rio j&#225; tem fun&#231;&#227;o estabelecida no tratamento da doen&#231;a arterial coron&#225;ria, tanto como escolha prim&#225;ria quanto no manuseio das complica&#231;&#245;es de angioplastia. No nosso caso, uma dissec&#231;&#227;o de grande propor&#231;&#227;o e extens&#227;o mal definida, comprometendo a origem da Cx e intimamente relacionada &#224; emerg&#234;ncia da ADA, foi tratada com extrema facilidade e rapidez pela utiliza&#231;&#227;o de <italic>stent</italic> longo. N&#227;o foi observada qualquer dissec&#231;&#227;o residual. </p>
    <p>A utiliza&#231;&#227;o de <italic>stents</italic> para os casos mais dram&#225;ticos de dissec&#231;&#227;o iatrog&#234;nica, quer como tratamento definitivo quer como ponte para posterior revasculariza&#231;&#227;o, deve se tornar uma rotina, uma vez que o procedimento mostra-se bastante simples e proporciona vantagens sobre o tratamento cir&#250;rgico, como rapidez da revasculariza&#231;&#227;o, menor morbidade e economia de recursos<sup> 6</sup>. </p>
    <p>Escola Paulista de Medicina - UNIFESP </p>
    <p> Correspond&#234;ncia: Ronaldo Tadeu Copini - Escola Paulista de Medicina - UNIFESP - Rua Botucatu, 740 - 04023-062 - S&#227;o Paulo, SP </p>
    <p> Recebido para publica&#231;&#227;o em 16/9/97 </p>
    <p> Aceito em 17/10/97 </p>
  </body>
  <back>
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