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  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">abc</journal-id>
      <journal-title-group>
        <journal-title>Arquivos Brasileiros de Cardiologia</journal-title>
        <abbrev-journal-title abbrev-type="publisher">Arq. Bras. Cardiol.</abbrev-journal-title>
      </journal-title-group>
      <issn pub-type="ppub">0066-782X</issn>
      <issn pub-type="epub">1678-4170</issn>
      <publisher>
        <publisher-name>Sociedade Brasileira de Cardiologia - SBC</publisher-name>
        <publisher-loc>S&#227;o Paulo, SP, Brazil</publisher-loc>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id" specific-use="scielo-v3">Kx97yLHtHC89BWHBQxWRQYs</article-id>
      <article-id pub-id-type="other">00005</article-id>
      <article-id pub-id-type="publisher-id" specific-use="scielo-v2">S0066-782X1997000900005</article-id>
      <article-id pub-id-type="publisher-id" specific-use="scielo-v1">S0066-782X(97)06900305</article-id>
      <article-id pub-id-type="doi">10.1590/S0066-782X1997000900005</article-id>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Artigos Originais</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Efeito do treinamento f&#237;sico de membros superiores aer&#243;bio de curta dura&#231;&#227;o no deficiente f&#237;sico com hipertens&#227;o leve</article-title>
        <trans-title-group xml:lang="en">
          <trans-title>The effect of short term Aerobic physical training using upper limbs in paraplegic persons with mild to moderate hypertension</trans-title>
        </trans-title-group>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <name>
            <surname>Haddad</surname>
            <given-names>Sandra</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Silva</surname>
            <given-names>Paulo Roberto Santos</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Pereira Barretto</surname>
            <given-names>Antonio Carlos</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Ferraretto</surname>
            <given-names>Ivan</given-names>
          </name>
        </contrib>
      </contrib-group>
      <pub-date date-type="collection" publication-format="electronic">
        <month>09</month>
        <year>1997</year>
      </pub-date>
      <volume>69</volume>
      <issue>3</issue>
      <fpage>169</fpage>
      <lpage>173</lpage>
      <history>
        <date date-type="accepted">
          <day>02</day>
          <month>07</month>
          <year>1997</year>
        </date>
        <date date-type="received">
          <day>07</day>
          <month>01</month>
          <year>1997</year>
        </date>
      </history>
      <permissions>
        <license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc/4.0/" xml:lang="en">
          <license-p>This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.</license-p>
        </license>
      </permissions>
      <abstract>
        <p>OBJETIVO: Verificar as altera&#231;&#245;es provocadas pelo treinamento f&#237;sico (TF), com membros superiores (MMSS), em condi&#231;&#227;o aer&#243;bia de curta dura&#231;&#227;o, sobre vari&#225;veis dos sistemas cardiovascular e metab&#243;lico. M&#201;TODOS: Foram estudados 11 deficientes f&#237;sicos (DF) parapl&#233;gicos, com m&#233;dia de idade de 59 anos, sendo 7 homens e 4 mulheres, com les&#227;o de T9 a T11 e grau leve de hipertens&#227;o arterial sist&#234;mica (HAS). Os DF foram avaliados antes e ap&#243;s 12 semanas de um programa de TF supervisionado de MMSS, por meio de teste ergom&#233;trico (TE) em cicloerg&#244;metro mec&#226;nico adaptado para MMSS, utilizando-se protocolo intermitente com incremento de carga de 125kgm/min (20w) para mulheres e 140kgm/min (25w) para homens a cada 3min., em velocidade que variou de 83 a 95rpm. O consumo de oxig&#234;nio (VO2) foi calculado de acordo com a equa&#231;&#227;o para MMSS do American College of Sports Medicine. A intensidade do exerc&#237;cio durante o programa de TF foi estabelecida pela reserva de freq&#252;&#234;ncia card&#237;aca (RFC) de Karvonen, com varia&#231;&#227;o de 65% a 85% e escala de percep&#231;&#227;o subjetiva ao esfor&#231;o de Borg obtida pelo TE. RESULTADOS: A capacidade aer&#243;bia m&#225;xima estimada aumentou 22% (930&#177;349 vs 1138&#177;290mL/min; p=0,003); a press&#227;o arterial sist&#243;lica (PAS) e diast&#243;lica (PAD) em repouso e no exerc&#237;cio subm&#225;ximo diminu&#237;ram em 4%, 15% e 5%, 5%, respectivamente. CONCLUS&#195;O: O TF aer&#243;bio de intensidade leve a moderada com MMSS, al&#233;m de melhorar a aptid&#227;o funcional exerce tamb&#233;m papel importante como modelo terap&#234;utico n&#227;o medicamentoso na resposta hipertensiva observada em DF parapl&#233;gicos.</p>
      </abstract>
      <trans-abstract xml:lang="en">
        <p>PURPOSE: To study the modifications induced by physical training (PT) using upper limbs in aerobic condition of short duration on cardiovascular and metabolic variables. METHODS: Eleven paraplegic persons, with a mean age of 59 years, 7 men and 4 women with lesions at T9 through T11 and mild hypertension (HAS) were studied. The patients were studied before and after 12 weeks of a supervised program of PT, through exercise tests in a mechanic ergometer (ST) adapted for the arms. We emploied an intermittent protocol with stress increments of 125 (20w) and 140kgm/min (25w) for women and men, respectively every 3min. The ergometric speed ranged from 83 to 95rpm. The oxygen consumption (VO2) was estimated according to American College of Sports Medicine equation for arms. The exercise intensity during the TF program was estimated through the Karvonen cardiac frequency reserve, with a variation of 65% to 85% and the Borg stress scale of subjetive perception during the stress test. RESULTS: The mean maximal aerobic capacity increased in 22% (930+349 vs 1138+290mL/min; p=0.003); there was a reduction of systolic and diastolic pressures at rest and after submaximal exercise of 4%,15% and 5% and 5%, respectively. CONCLUSION: Physical training of mild to moderate intensity using the upper limbs in paraplegic persons, besides inducing functional capacity increment , is an important model of non drug control of the hypertensive response.</p>
      </trans-abstract>
      <kwd-group xml:lang="pt" kwd-group-type="author-generated">
        <kwd>hipertens&#227;o arterial sist&#234;mica</kwd>
        <kwd>exerc&#237;cio f&#237;sico</kwd>
        <kwd>deficiente f&#237;sico</kwd>
        <kwd>paraplegia</kwd>
      </kwd-group>
      <kwd-group xml:lang="en" kwd-group-type="author-generated">
        <kwd>hypertension</kwd>
        <kwd>physic exercise</kwd>
        <kwd>physical deficient</kwd>
        <kwd>paraplegia</kwd>
      </kwd-group>
      <pub-date publication-format="electronic" date-type="pub">
        <day>09</day>
        <month>02</month>
        <year>2001</year>
      </pub-date>
    </article-meta>
  </front>
  <body>
    <p>Artigo Original </p>
    <p>
      <bold>Efeito do Treinamento F&#237;sico de Membros Superiores Aer&#243;bio de Curta Dura&#231;&#227;o no Deficiente F&#237;sico com Hipertens&#227;o Leve</bold>
    </p>
    <p>Sandra Haddad, Paulo Roberto Santos Silva, Antonio Carlos Pereira Barretto, Ivan Ferraretto </p>
    <p>
      <bold>S&#227;o Paulo, SP </bold>
    </p>
    <p><bold><italic>OBJETIVO: </italic></bold>Verificar as altera&#231;&#245;es provocadas pelo treinamento f&#237;sico (TF), com membros superiores (MMSS), em condi&#231;&#227;o aer&#243;bia de curta dura&#231;&#227;o, sobre vari&#225;veis dos sistemas cardiovascular e metab&#243;lico. </p>
    <p><bold><italic>M&#201;TODOS: </italic></bold>Foram estudados 11 deficientes f&#237;sicos (DF) parapl&#233;gicos, com m&#233;dia de idade de 59 anos, sendo 7 homens e 4 mulheres, com les&#227;o de T9 a T11 e grau leve de hipertens&#227;o arterial sist&#234;mica (HAS). Os DF foram avaliados antes e ap&#243;s 12 semanas de um programa de TF supervisionado de MMSS, por meio de teste ergom&#233;trico (TE) em cicloerg&#244;metro mec&#226;nico adaptado para MMSS, utilizando-se protocolo intermitente com incremento de carga de 125kgm/min (20w) para mulheres e 140kgm/min (25w) para homens a cada 3min., em velocidade que variou de 83 a 95rpm. O consumo de oxig&#234;nio (VO<sub><italic>2</italic></sub>) foi calculado de acordo com a equa&#231;&#227;o para MMSS do American College of Sports Medicine. A intensidade do exerc&#237;cio durante o programa de TF foi estabelecida pela reserva de freq&#252;&#234;ncia card&#237;aca (RFC) de Karvonen, com varia&#231;&#227;o de 65% a 85% e escala de percep&#231;&#227;o subjetiva ao esfor&#231;o de Borg obtida pelo TE. </p>
    <p><bold><italic>RESULTADOS: </italic></bold>A capacidade aer&#243;bia m&#225;xima estimada aumentou 22% (930&#177;349 vs 1138&#177;290mL/min; p=0,003); a press&#227;o arterial sist&#243;lica (PAS) e diast&#243;lica (PAD) em repouso e no exerc&#237;cio subm&#225;ximo diminu&#237;ram em 4%, 15% e 5%, 5%, respectivamente. </p>
    <p><bold><italic>CONCLUS&#195;O: </italic></bold>O TF aer&#243;bio de intensidade leve a moderada com MMSS, al&#233;m de melhorar a aptid&#227;o funcional exerce tamb&#233;m papel importante como modelo terap&#234;utico n&#227;o medicamentoso na resposta hipertensiva observada em DF parapl&#233;gicos. </p>
    <p><bold>Palavras-chave:</bold> hipertens&#227;o arterial sist&#234;mica, exerc&#237;cio f&#237;sico, deficiente f&#237;sico, paraplegia </p>
    <p>
      <bold>The Effect of Short Term Aerobic Physical Training Using Upper Limbs in Paraplegic Persons with Mild to Moderate Hypertension </bold>
    </p>
    <p><bold><italic>PURPOSE: </italic></bold>To study the modifications induced by physical training (PT) using upper limbs in aerobic condition of short duration on cardiovascular and metabolic variables. </p>
    <p><bold><italic>METHODS: </italic></bold>Eleven paraplegic persons, with a mean age of 59 years, 7 men and 4 women with lesions at T9 through T11 and mild hypertension (HAS) were studied. The patients were studied before and after 12 weeks of a supervised program of PT, through exercise tests in a mechanic ergometer (ST) adapted for the arms. We emploied an intermittent protocol with stress increments of 125 (20w) and 140kgm/min (25w) for women and men, respectively every 3min. The ergometric speed ranged from 83 to 95rpm. The oxygen consumption (VO<sub><italic>2</italic></sub>) was estimated according to American College of Sports Medicine equation for arms. The exercise intensity during the TF program was estimated through the Karvonen cardiac frequency reserve, with a variation of 65% to 85% and the Borg stress scale of subjetive perception during the stress test. </p>
    <p><bold><italic>RESULTS: </italic></bold>The mean maximal aerobic capacity increased in 22% (930<underline><italic>+</italic></underline>349 vs 1138<underline><italic>+</italic></underline>290mL/min; p=0.003); there was a reduction of systolic and diastolic pressures at rest and after submaximal exercise of 4%,15% and 5% and 5%, respectively. </p>
    <p><bold><italic>CONCLUSION: </italic></bold>Physical training of mild to moderate intensity using the upper limbs in paraplegic persons, besides inducing functional capacity increment , is an important model of non drug control of the hypertensive response. </p>
    <p><bold>Key-words: </bold>hypertension, physic exercise, physical deficient, paraplegia </p>
    <p>A hipertens&#227;o arterial sist&#234;mica (HAS) e o sedentarismo s&#227;o considerados fatores de risco para o desenvolvimento de doen&#231;as cardiovasculares. A HAS &#233; uma doen&#231;a em geral silenciosa, constituindo-se em importante determinante de morbidade e mortalidade cardiovascular. </p>
    <p>Em seguimento de 4 anos, no ambulat&#243;rio da Associa&#231;&#227;o de Assist&#234;ncia &#224; Crian&#231;a Defeituosa (AACD), pudemos verificar a incid&#234;ncia de HAS em 25% dos indiv&#237;duos parapl&#233;gicos. </p>
    <p>Estudos anteriores <sup>1,2</sup> demonstraram que o risco relativo de morte aumenta em at&#233; 70% em portadores de HAS estabelecida e, quando associado a estilo de vida sedent&#225;ria, este risco aumenta em cerca de 25% <sup>3,4</sup>. </p>
    <p>Os deficientes f&#237;sicos (DF) parapl&#233;gicos, em geral, apresentam maior n&#250;mero de fatores de risco, pois, pela necessidade de modificarem seus h&#225;bitos de vida, aumentam usualmente de peso e tornam-se sedent&#225;rios, o que favorece ainda mais o desenvolvimento de doen&#231;as do aparelho cardiovascular. </p>
    <p>Programas de atividades f&#237;sicas t&#234;m sido empregados em estudos epidemiol&#243;gicos sobre o desenvolvimento de HAS, na tentativa de atenuar a resposta hipertensiva <sup>5,6</sup></p>
    <p>Assim, em v&#225;rios estudos em homens <sup>7,8</sup> e animais <sup>9,10</sup> t&#234;m se empregado o exerc&#237;cio din&#226;mico de curta dura&#231;&#227;o, por se constituir em modelo interessante de estudo das adapta&#231;&#245;es cardiovasculares, induzidas de modo agudo e cr&#244;nico. </p>
    <p>Neste trabalho procuramos verificar os efeitos do treinamento f&#237;sico (TF) aer&#243;bio de curta dura&#231;&#227;o, com membros superiores (MMSS), sobre vari&#225;veis dos sistemas cardiovascular e metab&#243;lico, em DF parapl&#233;gicos com HAS leve. </p>
    <p>M&#233;todos </p>
    <p>Foram estudados 11 DF parapl&#233;gicos com n&#237;vel de les&#227;o de T9 a T11 e grau leve de HAS, com m&#233;dia de idade de 59 anos, sendo sete do sexo masculino e quatro do feminino. Todos foram avaliados antes e ap&#243;s 12 semanas de um programa de TF supervisionado com MMSS. </p>
    <p>Previamente ao TF, foram submetidos a eletrocardiograma (ECG) de 12 deriva&#231;&#245;es em repouso com eletrocardi&#243;grafo de inscri&#231;&#227;o a tinta (Dixtal, modelo Cardiop&#225;gina DX 2500) e a estudo ecocardiogr&#225;fico, com ecocardi&#243;grafo Aloka, modelo SSD 870 (com Doppler pulsado cont&#237;nuo e mapeamento de fluxo a cores), para diagnosticar e excluir do programa pacientes com poss&#237;veis altera&#231;&#245;es que pudessem interferir no estudo. </p>
    <p>Antecedendo ao programa de TF, os DF realizaram teste ergom&#233;trico (TE) em cicloerg&#244;metro mec&#226;nico (Monark), adaptado para MMSS. A engrenagem e circunfer&#234;ncia do volante desse erg&#244;metro foram dimensionadas de modo que, uma volta completa dos pedais desenvolvesse uma dist&#226;ncia te&#243;rica compar&#225;vel a 6m. O volante era freado mecanicamente por uma correia que se situava em volta do aro. Ambas as extremidades dessa correia eram presas a um tambor girat&#243;rio ao qual estava fixado um p&#234;ndulo. Agindo assim, como uma balan&#231;a de p&#234;ndulo, media-se a diferen&#231;a de for&#231;a em cada ponta da correia. A escala de gradua&#231;&#227;o &#233; em kilopounds (kp) (1kp &#233; a for&#231;a que age sobre uma massa de 1kg) &#224; acelera&#231;&#227;o normal da gravidade. O poder de frenagem (kp) estipulado pelo ajuste da tens&#227;o da correia, multiplicado pela dist&#226;ncia pedalada ou ciclada (m), fornece o montante de trabalho em kilopounds/metros (kpm) ou kilograma/metros (kgm). Se a dist&#226;ncia for expressa pelo tempo gasto na realiza&#231;&#227;o do exerc&#237;cio, ent&#227;o, obt&#233;m-se a m&#233;dia do trabalho em kpm/min<sup>-1</sup> ou kgm/min<sup>-1</sup>. Os testes foram realizados de acordo com protocolo elaborado pelo Departamento de Cardiologia. O TE intermitente foi iniciado com carga livre ou carga equivalente a aproximadamente 55kgm/min<sup>-1</sup> (9w). Posteriormente, foi utilizado incremento de carga de 125kgm/min<sup>-1</sup> (20w) e 140kgm/min<sup>-1 </sup>(25w), para mulheres e homens, respectivamente. Cada est&#225;gio teve dura&#231;&#227;o de 3min, intervalo ativo de 1min e velocidade individualizada, variando de 83 a 95rpm.. </p>
    <p>A freq&#252;&#234;ncia card&#237;aca (FC) foi monitorizada continuamente em repouso, durante o esfor&#231;o e na fase de recupera&#231;&#227;o por monitor acoplado ao ECG com tr&#234;s deriva&#231;&#245;es simult&#226;neas (MC<sub>5</sub>, AV<sub>F</sub> e V<sub>2</sub>) registradas a cada minuto. </p>
    <p>As press&#245;es arteriais sist&#243;lica (PAS) e dist&#243;lica (PAD) foram medidas por m&#233;todo auscultat&#243;rio, utilizando-se esfigmoman&#244;metro aner&#243;ide (Tycos) em repouso, no final de cada est&#225;gio do TE e durante o intervalo ativo. A medida de PA durante o intervalo ativo, foi verificada em um dos bra&#231;os, enquanto o outro, continuava ciclando. Os crit&#233;rios de determina&#231;&#227;o da PAS e PAD foram, o 1&#186; e o 5&#186; som de Korotkoff, respectivamente. </p>
    <p>Utilizou-se para se calcular o consumo m&#225;ximo de oxig&#234;nio (VO2m&#225;x) para MMSS a equa&#231;&#227;o do <italic>American College of Sports Medicine</italic>, ou seja, VO2m&#225;x= (kgm/min<sup>-1</sup> x 3,0mLO<sub>2</sub>/kg<sup><bold>-</bold>1</sup> min<sup><bold>-</bold>1</sup>) + (peso [kg ] x 3,5mLO<sub>2</sub><bold> /</bold>kg<sup>-1</sup> min<bold><sup>-1</sup></bold>) <sup>11</sup>. </p>
    <p>O regime de TF foi iniciado logo ap&#243;s o TE de MMSS, sendo a intensidade inicial de exerc&#237;cio no cicloerg&#244;metro com MMSS de 65% da reserva de FC preconizada por Karvonen e ajustada ao longo do TF ao m&#225;ximo de 85% obtida pelo TE <sup>12</sup>. Foi utilizada para ajustar a progress&#227;o do TF, a escala de percep&#231;&#227;o subjetiva ao esfor&#231;o de Borg at&#233; o per&#237;odo final do programa <sup>13,14</sup>. </p>
    <p>Cada sess&#227;o consistiu de aquecimento (5min), exerc&#237;cio no cicloerg&#244;metro (30min) e volta &#224; calma (15min). Foram realizadas tr&#234;s sess&#245;es semanais at&#233; o fim do programa que durou 12 semanas. </p>
    <p>O estudo estat&#237;stico constituiu-se no c&#225;lculo da m&#233;dia e desvio padr&#227;o das vari&#225;veis num&#233;ricas. Para verificar se as vari&#225;veis analisadas diferiram nos per&#237;odos pr&#233; e p&#243;s TF, utilizou-se o teste de Student para dados pareados. Para fins de an&#225;lise, foi considerado o n&#237;vel de signific&#226;ncia p&lt;0,05 <sup>15</sup>. </p>
    <p>Resultados </p>
    <p>Os DF terminaram o per&#237;odo de 12 semanas de TF com ader&#234;ncia de 90%. Em repouso, verificaram-se diminui&#231;&#227;o da FC em 14% (88 vs 76bpm), (<xref ref-type="fig" rid="figura1">fig. 1</xref>), do duplo produto em 10% (120 vs 108 PAS x FC/100), (<xref ref-type="fig" rid="figura2">fig. 2</xref>) enquanto as PAS e PAD diminu&#237;ram 6mmHg (4%) e 15mmHg (15%), respectivamente, ap&#243;s TF (<xref ref-type="table" rid="tabela1">tab. I</xref>). Resultados semelhantes foram observados no exerc&#237;cio subm&#225;ximo (55kgm<bold>.</bold>min<sup>-1</sup>). A FC ap&#243;s o TF nessa intensidade foi reduzida em 9% (112 vs 102bpm), sendo de 8mmHg (5%) a diminui&#231;&#227;o das PAS e PAD e de 13% no DP (<xref ref-type="table" rid="tabela2">tab. II</xref>). No exerc&#237;cio m&#225;ximo, o tempo de toler&#226;ncia aumentou 21% (532 vs 644s), a carga m&#225;xima de trabalho 33% (224 vs 298kgm/min); a capacidade aer&#243;bia m&#225;xima aumentou 22% (930 vs 1138mLO<sub>2</sub>/min) e o pulso de oxig&#234;nio 19% (6,09 vs 9,36mLO<sub>2</sub>/FC). A FC m&#225;xima atingida n&#227;o foi modificada (<xref ref-type="table" rid="tabela3">tab. III</xref>). </p>
    <fig id="figura1">
      <graphic xlink:href="1678-4170-abc-69-03-0169-00005-gf01.jpg"/></fig>
    <fig id="figura2">
      <graphic xlink:href="1678-4170-abc-69-03-0169-00005-gf02.jpg"/></fig>
    <table-wrap id="tabela1">
      <graphic xlink:href="1678-4170-abc-69-03-0169-00005-gt01.jpg"/></table-wrap>
    <table-wrap id="tabela2">
      <graphic xlink:href="1678-4170-abc-69-03-0169-00005-gt02.jpg"/></table-wrap>
    <table-wrap id="tabela3">
      <graphic xlink:href="1678-4170-abc-69-03-0169-00005-gt03.jpg"/></table-wrap>
    <p>Discuss&#227;o </p>
    <p>Nosso objetivo foi estudar o efeito do TF com MMSS, como modelo importante de atenua&#231;&#227;o e/ou controle da HAS de grau leve, em indiv&#237;duos DF com paraplegia. </p>
    <p>Tem sido comum na rotina cl&#237;nica, a utiliza&#231;&#227;o de terap&#234;utica farmacol&#243;gica no manuseio de indiv&#237;duos com HAS, entretanto, os resultados de v&#225;rios ensaios randomizados, que demonstraram efeitos indesej&#225;veis no tratamento farmacol&#243;gico em portadores de HAS, induziram a uma mudan&#231;a de atitude da comunidade m&#233;dica no combate a HAS. </p>
    <p>V&#225;rios s&#227;o os estudos que demonstraram evid&#234;ncias favor&#225;veis do efeito anti-hipertensivo do TF com caracter&#237;sticas aer&#243;bias, entretanto, ainda existem controv&#233;rsias sobre os meios e controles utilizados nos programas de atividade f&#237;sica para hipertens&#227;o, a metodologia mais adequada para a avalia&#231;&#227;o das intensidades de exerc&#237;cio e os poss&#237;veis mecanismos respons&#225;veis pela atenua&#231;&#227;o desta s&#237;ndrome cardiovascular <sup>16-24</sup>. Embora o efeito cr&#244;nico do TF na PA de indiv&#237;duos normotensos seja controversa, a maioria dos estudos tem demonstrado que o exerc&#237;cio aer&#243;bio diminui significativamente a press&#227;o arterial (PA) de repouso <sup>21,22,24,25</sup> . </p>
    <p>Apesar dos mecanismos que determinam a diminui&#231;&#227;o da PA ap&#243;s uma &#250;nica sess&#227;o de exerc&#237;cio ainda n&#227;o estarem totalmente esclarecidos, parece que a atenua&#231;&#227;o da atividade nervosa simp&#225;tica perif&#233;rica pode explicar parcialmente essa resposta no exerc&#237;cio agudo <sup>26</sup>. </p>
    <p>Floras e col <sup>26</sup> verificaram por t&#233;cnica de microneurografia, que a diminui&#231;&#227;o da atividade simp&#225;tica do nervo peronero em hipertensos lim&#237;trofes, observada 60min ap&#243;s uma sess&#227;o de exerc&#237;cio f&#237;sico, coincidia com a diminui&#231;&#227;o da PA. A ativa&#231;&#227;o do sistema de opi&#243;ides pept&#237;dicos tem sido sugerida como um dos prov&#225;veis mecanismos respons&#225;veis por essa atenua&#231;&#227;o da atividade nervosa simp&#225;tica perif&#233;rica <sup>27</sup>. </p>
    <p>Os mecanismos pelos quais o exerc&#237;cio cr&#244;nico, a longo prazo, atenuam a hipertens&#227;o, tamb&#233;m n&#227;o est&#227;o esclarecidos, mas parece que, em parte, eles podem ser explicados por alguns comportamentos: 1) ap&#243;s um programa de TF, a redu&#231;&#227;o da atividade nervosa simp&#225;tica perif&#233;rica contribui para a atenua&#231;&#227;o da PA, visto que, observa-se que os n&#237;veis de norepinefrina circulante <sup>22,25,28-30</sup> est&#227;o diminu&#237;dos; 2) o aumento da excre&#231;&#227;o urin&#225;ria de s&#243;dio e, conseq&#252;entemente, a diminui&#231;&#227;o da atividade da renina plasm&#225;tica <sup>21,25</sup> s&#227;o respostas que tamb&#233;m t&#234;m sido utilizadas para explicar a diminui&#231;&#227;o da PA ap&#243;s TF. </p>
    <p>O nosso estudo n&#227;o apresenta grupo controle, todavia, o grupo comparado antes e ap&#243;s 12 semanas de TF com MMSS, apresentou resultados significativos de melhoria de vari&#225;veis cardiovasculares, com conseq&#252;ente aumento da capacidade funcional dos parapl&#233;gicos. </p>
    <p>A bradicardia observada no homem ap&#243;s TF, em condi&#231;&#245;es de repouso, &#233; um achado freq&#252;ente, ocorrendo tamb&#233;m na presente investiga&#231;&#227;o. Isto evidencia que o TF utilizado constituiu-se de exerc&#237;cio de intensidade predominantemente moderada e de longa dura&#231;&#227;o, pois s&#227;o exerc&#237;cios desta intensidade que induzem a diminui&#231;&#227;o da FC no repouso <sup>3,18</sup>. </p>
    <p>No exerc&#237;cio subm&#225;ximo, com carga de 55kgm/min<sup>-1</sup>, a resposta de FC, tamb&#233;m foi significativamente menor ap&#243;s TF (p&lt;0,05) o que demonstra, provavelmente, aumento da estimula&#231;&#227;o do sistema nervoso aut&#244;nomo parassimp&#225;tico pelo TF aer&#243;bio, com conseq&#252;ente efeito sobre o cronotropismo card&#237;aco <sup>4,18</sup>. </p>
    <p>Ainda hoje, n&#227;o existe consenso, sobre os efeitos redutores do TF na PA. Entretanto, alguns estudos t&#234;m demonstrado efeito hipotensor provocado pelo exerc&#237;cio regular, independente da perda de peso, como demonstraram Arrol e Beaglehole <sup>17</sup>, que encontraram para PAS e PAD decr&#233;scimos de 30 a 20mmHg em repouso e 25 a 12mmHg durante o esfor&#231;o. </p>
    <p>Essa queda tamb&#233;m foi observada por Seals e Hagberg <sup>19</sup>, que verificaram em 12 estudos publicados entre 1976 e 1983, redu&#231;&#227;o m&#233;dia da PAS e PAD em repouso de 9 e 7mmHg, respectivamente. </p>
    <p>Em nosso estudo, obtivemos resultados semelhantes, com diminui&#231;&#227;o de 6mmHg para a PAS e 15mmHg para PAD, em medidas realizadas antes e ap&#243;s exerc&#237;cio. </p>
    <p>Sannersted e col<sup> 5</sup>, ao estudarem indiv&#237;duos com HAS, n&#227;o encontraram diferen&#231;as no d&#233;bito card&#237;aco e na resist&#234;ncia vascular sist&#234;mica, entretanto, mesmo assim, observaram queda da PA em repouso e durante exerc&#237;cio, no valor de 5mmHg. </p>
    <p>Clausen <sup>6 </sup>postula que a diminui&#231;&#227;o da PA com o TF no repouso e durante exerc&#237;cio poderia ser explicada por queda de d&#233;bito card&#237;aco ou redu&#231;&#227;o na resist&#234;ncia perif&#233;rica total ou ainda de ambos, acreditando que com a atividade f&#237;sica ocorra redu&#231;&#227;o da estimula&#231;&#227;o simp&#225;tica ap&#243;s TF, induzindo benef&#237;cios aos indiv&#237;duos com HAS. </p>
    <p>Recentemente, Shenberg e col <sup>20</sup><sub>,</sub> estudando em parapl&#233;gicos submetidos a TF, o efeito do exerc&#237;cio cr&#244;nico na din&#226;mica dos vasos de condu&#231;&#227;o, conclu&#237;ram que a atividade f&#237;sica cr&#244;nica de MMSS provocou melhora na capacidade vasodilatadora e aumento da condut&#226;ncia dos vasos em repouso e durante exerc&#237;cio, quando comparado a um grupo controle. Esses resultados foram obtidos atrav&#233;s do teste de hiperemia reativa, permitindo aos autores <sup>20</sup> confirmar uma das hip&#243;teses de Clausen <sup>6</sup>,que acredita na diminui&#231;&#227;o da resist&#234;ncia perif&#233;rica total, como poss&#237;vel determinante do efeito da TF, na redu&#231;&#227;o da PA. </p>
    <p>Al&#233;m dos efeitos verificados sobre a PA dos DF, nosso estudo mostrou que o TF aer&#243;bio com MMSS foi um est&#237;mulo eficiente para aumentar o tempo de toler&#226;ncia ao exerc&#237;cio e carga m&#225;xima de trabalho (CT), al&#233;m do incremento no pulso de oxig&#234;nio (PO<sub>2</sub>) e melhorar o consumo m&#225;ximo de oxig&#234;nio (VO2m&#225;x) (<xref ref-type="table" rid="tabela3">tab. III</xref>). </p>
    <p>Neste estudo, n&#227;o tivemos a inten&#231;&#227;o de estudar todos os poss&#237;veis mecanismos envolvidos na redu&#231;&#227;o da PA, especialmente considerando-se as controv&#233;rsias discutidas na literatura. Entretanto, o TF nesses indiv&#237;duos &#233; de grande import&#226;ncia, pois pode possibilitar a diminui&#231;&#227;o da dose de drogas anti-hipertensivas a que a maioria dos DF hipertensos est&#225; sujeita ou, at&#233; mesmo, a supress&#227;o do uso delas durante o tratamento de HAS. </p>
    <p>Portanto, &#233; fato que os resultados obtidos neste trabalho demonstraram efeitos favor&#225;veis, que nos permitem acreditar e indicar que o exerc&#237;cio aer&#243;bio controlado, al&#233;m de melhorar a aptid&#227;o funcional, exerce tamb&#233;m, importante papel como modelo terap&#234;utico n&#227;o medicamentoso na poss&#237;vel atenua&#231;&#227;o da resposta hipertensiva de grau leve, em DF parapl&#233;gicos submetidos a TF com MMSS. </p>
    <p>Associa&#231;&#227;o de Assist&#234;ncia &#224; Crian&#231;a Defeituosa e Instituto do Cora&#231;&#227;o do Hospi-tal das Cl&#237;nicas - FMUSP </p>
    <p> Correspond&#234;ncia: Sandra Haddad - Incor - Cardiologia Social - Av. Dr. En&#233;as C. Aguiar, 44 - S&#227;o Paulo, SP - 05403-000 - S&#227;o Paulo, SP </p>
    <p> Recebido para publica&#231;&#227;o em 7/197 </p>
    <p> Aceito em 2/7/97 </p>
  </body>
  <back>
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