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  <front>
    <journal-meta>
      <journal-id journal-id-type="nlm-ta">Arq Bras Cardiol</journal-id>
      <journal-id journal-id-type="publisher-id">abc</journal-id>
      <journal-title-group>
        <journal-title>Arquivos Brasileiros de Cardiologia</journal-title>
        <abbrev-journal-title abbrev-type="publisher">Arq. Bras. Cardiol.</abbrev-journal-title>
      </journal-title-group>
      <issn pub-type="ppub">0066-782X</issn>
      <issn pub-type="epub">1678-4170</issn>
      <publisher>
        <publisher-name>Sociedade Brasileira de Cardiologia - SBC</publisher-name>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id specific-use="scielo-v3" pub-id-type="publisher-id">SWpmghQx87WbWKZ3VTHc37Q</article-id>
      <article-id specific-use="scielo-v2" pub-id-type="publisher-id">S0066-782X2025000100901</article-id>
      <article-id pub-id-type="other">00901</article-id>
      <article-id pub-id-type="doi">10.36660/abc.20240466</article-id>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Carta ao Editor</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Compreendendo a Rela&#231;&#227;o entre Gordura Visceral e Sa&#250;de Card&#237;aca</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <contrib-id contrib-id-type="orcid">0000-0001-8390-0933</contrib-id>
          <name>
            <surname>Godoy</surname>
            <given-names>Moacir Fernandes</given-names>
          </name>
          <xref ref-type="aff" rid="aff1">
            <sup>1</sup>
          </xref>
        </contrib>
      </contrib-group>
      <aff id="aff1">
        <label>1</label>
        <institution content-type="orgname">Faculdade de Medicina de S&#227;o Jos&#233; do Rio Preto</institution>
        <addr-line>
          <named-content content-type="city">S&#227;o Jos&#233; do Rio Preto</named-content>
          <named-content content-type="state">SP</named-content>
        </addr-line>
        <country country="BR">Brasil</country>
        <institution content-type="original">Faculdade de Medicina de S&#227;o Jos&#233; do Rio Preto (FAMERP) - Cardiologia e Cirurgia Cardiovascular, S&#227;o Jos&#233; do Rio Preto, SP &#8211; Brasil</institution>
      </aff>
      <author-notes>
        <corresp id="c01"><label>Correspond&#234;ncia</label>: Moacir Fernandes Godoy &#8226; Faculdade de Medicina de S&#227;o Jos&#233; do Rio Preto (FAMERP) - Cardiologia e Cirurgia Cardiovascular (FAMERP) - Av. Brigadeiro Faria Lima, 5416. CEP 15090 000, S&#227;o Jos&#233; do Rio Preto, SP - Brasil E-mail: <email>mf60204@gmail.com</email> </corresp>
      </author-notes>
      <pub-date date-type="pub" publication-format="electronic">
        <day>03</day>
        <month>02</month>
        <year>2025</year>
      </pub-date>
      <pub-date date-type="collection" publication-format="electronic">
        <month>01</month>
        <year>2025</year>
      </pub-date>
      <volume>122</volume>
      <issue>1</issue>
      <elocation-id>e20240466</elocation-id>
      <history>
        <date date-type="received">
          <day>04</day>
          <month>07</month>
          <year>2024</year>
        </date>
        <date date-type="rev-recd">
          <day>02</day>
          <month>10</month>
          <year>2024</year>
        </date>
        <date date-type="accepted">
          <day>02</day>
          <month>10</month>
          <year>2024</year>
        </date>
      </history>
      <permissions>
        <license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/" xml:lang="en">
          <license-p> This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. </license-p>
        </license>
      </permissions>
      <kwd-group xml:lang="pt">
        <kwd>Gordura Intra-Abdominal</kwd>
        <kwd>Frequ&#234;ncia Card&#237;aca</kwd>
        <kwd>Sistema Nervoso Aut&#244;nomo</kwd>
      </kwd-group>
      <counts>
        <fig-count count="0"/>
        <table-count count="0"/>
        <equation-count count="0"/>
        <ref-count count="8"/>
      </counts>
    </article-meta>
  </front>
  <body>
    <p>Li com interesse o artigo &#8220;A Variabilidade da Frequ&#234;ncia Card&#237;aca em Repouso est&#225; Independentemente Associada aos Escores de Classifica&#231;&#227;o de Gordura Visceral em Homens Adultos Sauditas&#8221; de Syed Shahid Habib et al., publicado na ABC Cardiol<sup><xref ref-type="bibr" rid="B1">1</xref></sup> comparando a variabilidade da frequ&#234;ncia card&#237;aca (VFC) em 99 homens saud&#225;veis estratificados pela classifica&#231;&#227;o da gordura visceral (CGV) e mostrando associa&#231;&#245;es entre a VFC e as m&#233;tricas de composi&#231;&#227;o corporal, mas tenho algumas reservas.</p>
    <p>A VFC tem sido demonstrada como um m&#233;todo conveniente para avaliar o estado homeost&#225;tico individual. Tentativas de estabelecer valores de refer&#234;ncia de acordo com a faixa et&#225;ria e grau de comprometimento t&#234;m sido numerosas na literatura especializada desde o lan&#231;amento da Task Force em 1996.<sup><xref ref-type="bibr" rid="B2">2</xref>-<xref ref-type="bibr" rid="B4">4</xref></sup> Entre as vari&#225;veis de VFC mais estudadas est&#227;o o desvio padr&#227;o dos intervalos RR normais (SDNN) e a raiz quadrada m&#233;dia das diferen&#231;as sucessivas (RMSSD) no dom&#237;nio do tempo e pot&#234;ncia de baixa frequ&#234;ncia (LF ms<sup>2</sup>) e pot&#234;ncia de alta frequ&#234;ncia (HF) al&#233;m da raz&#227;o LF/HF, no dom&#237;nio da frequ&#234;ncia. Essas foram exatamente as vari&#225;veis estudadas por Habib e colaboradores, concluindo que homens na categoria de menor classifica&#231;&#227;o de gordura visceral (G1) apresentaram a maior VFC. A classifica&#231;&#227;o de gordura visceral foi mais fortemente associada &#224; VFC do que a porcentagem de gordura corporal e a raz&#227;o massa muscular/gordura visceral (MMCGV). Os par&#226;metros do dom&#237;nio do tempo foram mais sens&#237;veis ao tecido adiposo visceral (TAV) do que os par&#226;metros do dom&#237;nio da frequ&#234;ncia. Eles concluem dizendo que os par&#226;metros de VFC podem ser os principais par&#226;metros de interesse no monitoramento do estado card&#237;aco-auton&#244;mico em resposta a interven&#231;&#245;es que visam a redu&#231;&#227;o do TAV. Todos esses s&#227;o pontos relevantes, mas houve um problema crucial na apresenta&#231;&#227;o deste estudo. Os valores de VFC citados nos resultados devem ter sofrido um erro de digita&#231;&#227;o, pois s&#227;o completamente incompat&#237;veis com os intervalos de refer&#234;ncia.</p>
    <p>Assim, os autores apresentam na Tabela 2 valores de SDNN de 1.776&#177;0,229 milissegundos para o Grupo 1, 1.543&#177;0,258 milissegundos para o Grupo 2 e 1.548&#177;0,193 milissegundos para o Grupo 3, com valores muito semelhantes a estes para a vari&#225;vel RMSSD. Est&#225; bem estabelecido na literatura que tanto os valores de SDNN quanto de RMSSD raramente ultrapassam 50 milissegundos, mesmo em indiv&#237;duos saud&#225;veis. Ent&#227;o, certamente houve um erro na digita&#231;&#227;o destes valores. O mesmo pode ser dito em rela&#231;&#227;o &#224; Tabela 3, que apresenta os valores das vari&#225;veis pot&#234;ncia LF e pot&#234;ncia HF e sua rela&#231;&#227;o. Os valores de desvio padr&#227;o apresentados n&#227;o s&#227;o coerentes proporcionalmente com os valores m&#233;dios, al&#233;m disso, a rela&#231;&#227;o LF/HF &#233; extremamente baixa em alguns grupos com valores negativos, o que &#233; imposs&#237;vel por se tratar de uma rela&#231;&#227;o entre valores positivos.</p>
    <p>Temo que ap&#243;s corrigir esses dados, a conclus&#227;o possa ser diferente, mudando a interpreta&#231;&#227;o. No entanto, mesmo que n&#227;o mude, devemos conhecer os valores reais das vari&#225;veis estudadas, por isso solicito respeitosamente aos autores e editores que fa&#231;am as corre&#231;&#245;es necess&#225;rias.</p>
  </body>
  <back>
    <ref-list>
      <title>Refer&#234;ncias</title>
      <ref id="B1">
        <label>1</label>
        <mixed-citation>1. Habib SS, Alkahtani S, Aljawini N, Habib SM, Flatt AA. Resting Heart Rate Variability is Independently Associated with Visceral Fat Rating Scores in Saudi Adult Males. Arq Bras Cardiol. 2024;121(5):e20220780. doi: 10.36660/abc.20220780.</mixed-citation>
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>Habib</surname>
              <given-names>SS</given-names>
            </name>
            <name>
              <surname>Alkahtani</surname>
              <given-names>S</given-names>
            </name>
            <name>
              <surname>Aljawini</surname>
              <given-names>N</given-names>
            </name>
            <name>
              <surname>Habib</surname>
              <given-names>SM</given-names>
            </name>
            <name>
              <surname>Flatt</surname>
              <given-names>AA</given-names>
            </name>
          </person-group>
          <article-title>Resting Heart Rate Variability is Independently Associated with Visceral Fat Rating Scores in Saudi Adult Males</article-title>
          <source>Arq Bras Cardiol</source>
          <year>2024</year>
          <volume>121</volume>
          <issue>5</issue>
          <elocation-id>e20220780</elocation-id>
          <pub-id pub-id-type="doi">10.36660/abc.20220780</pub-id>
        </element-citation>
      </ref>
      <ref id="B2">
        <label>2</label>
        <mixed-citation>2. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Heart Rate Variability: Standards of Measurement, Physiological Interpretation and Clinical Use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Circulation. 1996;93(5):1043-65. doi: 10.1161/01.CIR.93.5.1043.</mixed-citation>
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <collab>Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology</collab>
          </person-group>
          <article-title>Heart Rate Variability: Standards of Measurement, Physiological Interpretation and Clinical Use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology</article-title>
          <source>Circulation</source>
          <year>1996</year>
          <volume>93</volume>
          <issue>5</issue>
          <fpage>1043</fpage>
          <lpage>1065</lpage>
          <pub-id pub-id-type="doi">10.1161/01.CIR.93.5.1043</pub-id>
        </element-citation>
      </ref>
      <ref id="B3">
        <label>3</label>
        <mixed-citation>3. Shaffer F, Ginsberg JP. An Overview of Heart Rate Variability Metrics and Norms. Front Public Health. 2017;5(1):1-17. doi: 10.3389/fpubh.2017.00258.</mixed-citation>
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>Shaffer</surname>
              <given-names>F</given-names>
            </name>
            <name>
              <surname>Ginsberg</surname>
              <given-names>JP</given-names>
            </name>
          </person-group>
          <article-title>An Overview of Heart Rate Variability Metrics and Norms</article-title>
          <source>Front Public Health</source>
          <year>2017</year>
          <volume>5</volume>
          <issue>1</issue>
          <fpage>1</fpage>
          <lpage>17</lpage>
          <pub-id pub-id-type="doi">10.3389/fpubh.2017.00258</pub-id>
        </element-citation>
      </ref>
      <ref id="B4">
        <label>4</label>
        <mixed-citation>4. Godoy MF, Greg&#243;rio ML. Heart Rate Variability as a Marker of Homeostatic Level. In: Aslanidis T, Nouris C, Brzozowski T, editos. Autonomic Nervous System - Special Interest Topics. London: IntechOpen; 2022. Chapter 3. doi: 10.5772/intechopen.102500.</mixed-citation>
        <element-citation publication-type="book">
          <person-group person-group-type="author">
            <name>
              <surname>Godoy</surname>
              <given-names>MF</given-names>
            </name>
            <name>
              <surname>Greg&#243;rio</surname>
              <given-names>ML</given-names>
            </name>
          </person-group>
          <chapter-title>Heart Rate Variability as a Marker of Homeostatic Level</chapter-title>
          <person-group person-group-type="editor">
            <name>
              <surname>Aslanidis</surname>
              <given-names>T</given-names>
            </name>
            <name>
              <surname>Nouris</surname>
              <given-names>C</given-names>
            </name>
            <name>
              <surname>Brzozowski</surname>
              <given-names>T</given-names>
            </name>
            <role>editos</role>
          </person-group>
          <source>Autonomic Nervous System - Special Interest Topics</source>
          <publisher-loc>London</publisher-loc>
          <publisher-name>IntechOpen</publisher-name>
          <year>2022</year>
          <comment>Chapter 3</comment>
          <pub-id pub-id-type="doi">10.5772/intechopen.102500</pub-id>
        </element-citation>
      </ref>
    </ref-list>
  </back>
  <sub-article article-type="reply" id="S1" xml:lang="pt">
    <front-stub>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Carta ao Editor</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Carta-resposta</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <contrib-id contrib-id-type="orcid">0000-0001-5944-8406</contrib-id>
          <name>
            <surname>Habib</surname>
            <given-names>Syed</given-names>
          </name>
          <xref ref-type="aff" rid="aff1r">
            <sup>1</sup>
          </xref>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Flatt</surname>
            <given-names>Andrew</given-names>
          </name>
          <xref ref-type="aff" rid="aff2r">
            <sup>2</sup>
          </xref>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Alkahtani</surname>
            <given-names>Shaea</given-names>
          </name>
          <xref ref-type="aff" rid="aff1r">
            <sup>1</sup>
          </xref>
        </contrib>
      </contrib-group>
      <aff id="aff1r">
        <label>1</label>
        <institution content-type="orgname">King Saud University</institution>
        <addr-line>
          <named-content content-type="city">Riyadh</named-content>
        </addr-line>
        <country country="SA">Ar&#225;bia Saudita</country>
        <institution content-type="original">King Saud University Riyadh - Ar&#225;bia Saudita</institution>
      </aff>
      <aff id="aff2r">
        <label>2</label>
        <institution content-type="orgname">Georgia Southern University</institution>
        <institution content-type="orgdiv1">Armstrong Campus</institution>
        <addr-line>
          <named-content content-type="city">Savannah</named-content>
          <named-content content-type="state">Georgia</named-content>
        </addr-line>
        <country country="US">EUA</country>
        <institution content-type="original">Georgia Southern University - Armstrong Campus, Savannah, Georgia &#8211; EUA</institution>
      </aff>
    </front-stub>
    <body>
      <p>Agradecemos o grande interesse do leitor em nosso artigo.<sup><xref ref-type="bibr" rid="B6">1</xref></sup> Os dados de VFC s&#227;o relatados em unidades transformadas em logaritmo (log10), o que n&#227;o &#233; um procedimento incomum para analisar dados de VFC n&#227;o distribu&#237;dos normalmente.<sup><xref ref-type="bibr" rid="B7">2</xref></sup> Embora tenhamos mencionado que os dados foram transformados em logaritmo na se&#231;&#227;o de an&#225;lise estat&#237;stica, lamentamos n&#227;o t&#234;-los mencionado novamente para o leitor nas descri&#231;&#245;es de tabela correspondentes, pois isso parece explicar a confus&#227;o. Al&#233;m disso, os intervalos padr&#227;o variam consideravelmente, e valores acima de 50 ms s&#227;o poss&#237;veis e podem at&#233; estar acima de 100 ms em alguns indiv&#237;duos saud&#225;veis e em forma.<sup><xref ref-type="bibr" rid="B8">3</xref>,<xref ref-type="bibr" rid="B9">4</xref></sup></p>
    </body>
    <back>
      <ref-list>
        <title>Refer&#234;ncias</title>
        <ref id="B6">
          <label>1</label>
          <mixed-citation>1. Habib SS, Alkahtani S, Aljawini N, Habib SM, Flatt AA. Resting Heart Rate Variability is Independently Associated with Visceral Fat Rating Scores in Saudi Adult Males. Arq Bras Cardiol. 2024;121(5):e20220780. doi: 10.36660/abc.20220780.</mixed-citation>
          <element-citation publication-type="journal">
            <person-group person-group-type="author">
              <name>
                <surname>Habib</surname>
                <given-names>SS</given-names>
              </name>
              <name>
                <surname>Alkahtani</surname>
                <given-names>S</given-names>
              </name>
              <name>
                <surname>Aljawini</surname>
                <given-names>N</given-names>
              </name>
              <name>
                <surname>Habib</surname>
                <given-names>SM</given-names>
              </name>
              <name>
                <surname>Flatt</surname>
                <given-names>AA</given-names>
              </name>
            </person-group>
            <article-title>Resting Heart Rate Variability is Independently Associated with Visceral Fat Rating Scores in Saudi Adult Males</article-title>
            <source>Arq Bras Cardiol</source>
            <year>2024</year>
            <volume>121</volume>
            <issue>5</issue>
            <elocation-id>e20220780</elocation-id>
            <pub-id pub-id-type="doi">10.36660/abc.20220780</pub-id>
          </element-citation>
        </ref>
        <ref id="B7">
          <label>2</label>
          <mixed-citation>2. Romieu I, T&#233;llez-Rojo MM, Lazo M, Manzano-Pati&#241;o A, Cortez-Lugo M, Julien P, et al. Omega-3 Fatty Acid Prevents Heart Rate Variability Reductions Associated with Particulate Matter. Am J Respir Crit Care Med. 2005;172(12):1534-40. doi: 10.1164/rccm.200503-372OC.</mixed-citation>
          <element-citation publication-type="journal">
            <person-group person-group-type="author">
              <name>
                <surname>Romieu</surname>
                <given-names>I</given-names>
              </name>
              <name>
                <surname>T&#233;llez-Rojo</surname>
                <given-names>MM</given-names>
              </name>
              <name>
                <surname>Lazo</surname>
                <given-names>M</given-names>
              </name>
              <name>
                <surname>Manzano-Pati&#241;o</surname>
                <given-names>A</given-names>
              </name>
              <name>
                <surname>Cortez-Lugo</surname>
                <given-names>M</given-names>
              </name>
              <name>
                <surname>Julien</surname>
                <given-names>P</given-names>
              </name>
              <etal>et al</etal>
            </person-group>
            <article-title>Omega-3 Fatty Acid Prevents Heart Rate Variability Reductions Associated with Particulate Matter</article-title>
            <source>Am J Respir Crit Care Med</source>
            <year>2005</year>
            <volume>172</volume>
            <issue>12</issue>
            <fpage>1534</fpage>
            <lpage>1540</lpage>
            <pub-id pub-id-type="doi">10.1164/rccm.200503-372OC</pub-id>
          </element-citation>
        </ref>
        <ref id="B8">
          <label>3</label>
          <mixed-citation>3. Tegegne BS, Man T, van Roon AM, Snieder H, Riese H. Reference Values of Heart Rate Variability from 10-Second Resting Electrocardiograms: The Lifelines Cohort Study. Eur J Prev Cardiol. 2020;27(19):2191-4. doi: 10.1177/2047487319872567.</mixed-citation>
          <element-citation publication-type="journal">
            <person-group person-group-type="author">
              <name>
                <surname>Tegegne</surname>
                <given-names>BS</given-names>
              </name>
              <name>
                <surname>Man</surname>
                <given-names>T</given-names>
              </name>
              <name>
                <surname>van Roon</surname>
                <given-names>AM</given-names>
              </name>
              <name>
                <surname>Snieder</surname>
                <given-names>H</given-names>
              </name>
              <name>
                <surname>Riese</surname>
                <given-names>H</given-names>
              </name>
            </person-group>
            <article-title>Reference Values of Heart Rate Variability from 10-Second Resting Electrocardiograms: The Lifelines Cohort Study</article-title>
            <source>Eur J Prev Cardiol</source>
            <year>2020</year>
            <volume>27</volume>
            <issue>19</issue>
            <fpage>2191</fpage>
            <lpage>2194</lpage>
            <pub-id pub-id-type="doi">10.1177/2047487319872567</pub-id>
          </element-citation>
        </ref>
        <ref id="B9">
          <label>4</label>
          <mixed-citation>4. Sammito S, B&#246;ckelmann I. Reference Values for Time- and Frequency-Domain Heart Rate Variability Measures. Heart Rhythm. 2016;13(6):1309-16. doi: 10.1016/j.hrthm.2016.02.006.</mixed-citation>
          <element-citation publication-type="journal">
            <person-group person-group-type="author">
              <name>
                <surname>Sammito</surname>
                <given-names>S</given-names>
              </name>
              <name>
                <surname>B&#246;ckelmann</surname>
                <given-names>I</given-names>
              </name>
            </person-group>
            <article-title>Reference Values for Time- and Frequency-Domain Heart Rate Variability Measures</article-title>
            <source>Heart Rhythm</source>
            <year>2016</year>
            <volume>13</volume>
            <issue>6</issue>
            <fpage>1309</fpage>
            <lpage>1316</lpage>
            <pub-id pub-id-type="doi">10.1016/j.hrthm.2016.02.006</pub-id>
          </element-citation>
        </ref>
      </ref-list>
    </back>
  </sub-article>
  <sub-article article-type="translation" id="TRen" xml:lang="en">
    <front-stub>
      <article-id pub-id-type="doi">10.36660/abc.20240466i</article-id>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Letter to the Editor</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Understanding the Link between Visceral Fat and Heart Health</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <contrib-id contrib-id-type="orcid">0000-0001-8390-0933</contrib-id>
          <name>
            <surname>Godoy</surname>
            <given-names>Moacir Fernandes</given-names>
          </name>
          <xref ref-type="aff" rid="aff1001">
            <sup>1</sup>
          </xref>
        </contrib>
      </contrib-group>
      <aff id="aff1001">
        <label>1</label>
        <country country="BR">Brazil</country>
        <institution content-type="original">Faculdade de Medicina de S&#227;o Jos&#233; do Rio Preto (FAMERP) - Cardiologia e Cirurgia Cardiovascular, S&#227;o Jos&#233; do Rio Preto, SP &#8211; Brazil</institution>
      </aff>
      <author-notes>
        <corresp id="c01001"><label>Mailing Address</label>: Moacir Fernandes Godoy Faculdade de Medicina de S&#227;o Jos&#233; do Rio Preto (FAMERP) - Cardiologia e Cirurgia Cardiovascular (FAMERP) - Av. Brigadeiro Faria Lima, 5416. Postal Code 15090-000, S&#227;o Jos&#233; do Rio Preto, SP - Brazil E-mail: mf60204@gmail.com </corresp>
      </author-notes>
      <kwd-group xml:lang="en">
        <kwd>Intra-Abdominal Fat</kwd>
        <kwd>Heart Rate</kwd>
        <kwd>Autonomic Nervous System</kwd>
      </kwd-group>
    </front-stub>
    <body>
      <p>I read with interest the paper &#8220;Resting Heart Rate Variability is Independently Associated with Visceral Fat Rating Scores in Saudi Adult Males&#8221; by Syed Shahid Habib et al., published in ABC Cardiol<sup><xref ref-type="bibr" rid="B1">1</xref></sup>comparing heart rate variability (HRV) in 99 healthy men stratified by visceral fat rating (VFR) and showing associations between HRV and body composition metrics, but I have some reservations.</p>
      <p>Heart rate variability has been demonstrated as a convenient method for assessing individual homeostatic status. Attempts to establish reference values according to age group and degree of impairment have been numerous in the specialized literature since the launch of the Task Force in 1996.<sup><xref ref-type="bibr" rid="B2">2</xref>-<xref ref-type="bibr" rid="B4">4</xref></sup> Among the most studied HRV variables are the standard deviation of normal RR intervals (SDNN) and the Root-mean square of successive differences (RMSSD) in the time domain and Low-Frequency power (LF ms<sup>2</sup>) and High-Frequency power (HF) in addition to the LF/HF ratio, in the frequency domain. These were exactly the variables studied by Habib and collaborators, concluding that men in the lowest visceral fat rating category (G1) had the highest HRV. Visceral Fat Rating was more strongly associated with HRV than body fat percentage and muscle mass to visceral fat ratio (MMVFR). Time domain parameters were more sensitive to visceral adipose tissue (VAT) than frequency domain parameters. They conclude by saying that HRV parameters could be the primary parameters of interest in monitoring cardiac-autonomic status in response to interventions targeting VAT reduction. These are all relevant points but there was a crucial problem in the presentation of this study. The HRV values cited in the results must have suffered a typing error as they are completely incompatible with the reference ranges.</p>
      <p>Thus, the authors present in Table 2 SDNN values of 1,776&#177;0.229 milliseconds for Group 1, 1,543&#177;0.258 milliseconds for Group 2, and 1,548&#177;0.193 milliseconds for Group 3, with values very similar to these for the variable RMSSD. It is well established in the literature that both SDNN and RMSSD values rarely exceed 50 milliseconds, even in healthy individuals. So, there was certainly a mistake in typing these values. The same can be said in relation to Table 3, which presents the values of the variables LF power and HF power and their relationship. The standard deviation values presented are not coherent proportionally with the average values , and in addition, the LF/HF ratio is extremely low in some groups with negative values, which is impossible as it is a relationship between positive values.</p>
      <p>I fear that after correcting these data, the conclusion may be different, changing the interpretation. Nevertheless, even if it does not change, we must know the real values of the variables studied, so I respectfully request the authors and editors to make the necessary corrections.</p>
    </body>
    <sub-article article-type="reply" id="S3" xml:lang="en">
      <front-stub>
        <article-categories>
          <subj-group subj-group-type="heading">
            <subject>Letter to the Editor</subject>
          </subj-group>
        </article-categories>
        <title-group>
          <article-title>Reply</article-title>
        </title-group>
        <contrib-group>
          <contrib contrib-type="author">
            <contrib-id contrib-id-type="orcid">0000-0001-5944-8406</contrib-id>
            <name>
              <surname>Habib</surname>
              <given-names>Syed</given-names>
            </name>
            <xref ref-type="aff" rid="aff1r001">
              <sup>1</sup>
            </xref>
          </contrib>
          <contrib contrib-type="author">
            <name>
              <surname>Flatt</surname>
              <given-names>Andrew</given-names>
            </name>
            <xref ref-type="aff" rid="aff2r001">
              <sup>2</sup>
            </xref>
          </contrib>
          <contrib contrib-type="author">
            <name>
              <surname>Alkahtani</surname>
              <given-names>Shaea</given-names>
            </name>
            <xref ref-type="aff" rid="aff1r001">
              <sup>1</sup>
            </xref>
          </contrib>
        </contrib-group>
        <aff id="aff1r001">
          <label>1</label>
          <country country="SA">Ar&#225;bia Saudita</country>
          <institution content-type="original">King Saud University, Riyadh - Ar&#225;bia Saudita</institution>
        </aff>
        <aff id="aff2r001">
          <label>2</label>
          <country country="US">USA</country>
          <institution content-type="original">Georgia Southern University - Armstrong Campus, Savannah, Georgia - USA</institution>
        </aff>
      </front-stub>
      <body>
        <p>We are thankful for the reader&#8217;s keen interest in our paper.<sup><xref ref-type="bibr" rid="B6">1</xref></sup> The heart rate variability data are reported in log-transformed units (log10), which is not an uncommon procedure for analyzing non-normally distributed heart rate variability data.<sup><xref ref-type="bibr" rid="B7">2</xref></sup> Although we mentioned that data were log-transformed in the statistical analysis section, we regret not having mentioned it again for the reader in corresponding table descriptions, as this seems to explain the confusion. Moreover, the standard ranges vary considerably, and values above 50 ms are possible and may even be above 100 ms in some healthy, fit individuals.<sup><xref ref-type="bibr" rid="B8">3</xref>,<xref ref-type="bibr" rid="B9">4</xref></sup></p>
      </body>
      <back>
        <ref-list>
          <title>References</title>
          <ref id="B16">
            <label>1</label>
            <mixed-citation>1. Habib SS, Alkahtani S, Aljawini N, Habib SM, Flatt AA. Resting Heart Rate Variability is Independently Associated with Visceral Fat Rating Scores in Saudi Adult Males. Arq Bras Cardiol. 2024;121(5):e20220780. doi: 10.36660/abc.20220780.</mixed-citation>
            <element-citation publication-type="journal">
              <person-group person-group-type="author">
                <name>
                  <surname>Habib</surname>
                  <given-names>SS</given-names>
                </name>
                <name>
                  <surname>Alkahtani</surname>
                  <given-names>S</given-names>
                </name>
                <name>
                  <surname>Aljawini</surname>
                  <given-names>N</given-names>
                </name>
                <name>
                  <surname>Habib</surname>
                  <given-names>SM</given-names>
                </name>
                <name>
                  <surname>Flatt</surname>
                  <given-names>AA</given-names>
                </name>
              </person-group>
              <article-title>Resting Heart Rate Variability is Independently Associated with Visceral Fat Rating Scores in Saudi Adult Males</article-title>
              <source>Arq Bras Cardiol</source>
              <year>2024</year>
              <volume>121</volume>
              <issue>5</issue>
              <elocation-id>e20220780</elocation-id>
              <pub-id pub-id-type="doi">10.36660/abc.20220780</pub-id>
            </element-citation>
          </ref>
          <ref id="B17">
            <label>2</label>
            <mixed-citation>2. Romieu I, T&#233;llez-Rojo MM, Lazo M, Manzano-Pati&#241;o A, Cortez-Lugo M, Julien P, et al. Omega-3 Fatty Acid Prevents Heart Rate Variability Reductions Associated with Particulate Matter. Am J Respir Crit Care Med. 2005;172(12):1534-40. doi: 10.1164/rccm.200503-372OC.</mixed-citation>
            <element-citation publication-type="journal">
              <person-group person-group-type="author">
                <name>
                  <surname>Romieu</surname>
                  <given-names>I</given-names>
                </name>
                <name>
                  <surname>T&#233;llez-Rojo</surname>
                  <given-names>MM</given-names>
                </name>
                <name>
                  <surname>Lazo</surname>
                  <given-names>M</given-names>
                </name>
                <name>
                  <surname>Manzano-Pati&#241;o</surname>
                  <given-names>A</given-names>
                </name>
                <name>
                  <surname>Cortez-Lugo</surname>
                  <given-names>M</given-names>
                </name>
                <name>
                  <surname>Julien</surname>
                  <given-names>P</given-names>
                </name>
                <etal>et al</etal>
              </person-group>
              <article-title>Omega-3 Fatty Acid Prevents Heart Rate Variability Reductions Associated with Particulate Matter</article-title>
              <source>Am J Respir Crit Care Med</source>
              <year>2005</year>
              <volume>172</volume>
              <issue>12</issue>
              <fpage>1534</fpage>
              <lpage>1540</lpage>
              <pub-id pub-id-type="doi">10.1164/rccm.200503-372OC</pub-id>
            </element-citation>
          </ref>
          <ref id="B18">
            <label>3</label>
            <mixed-citation>3. Tegegne BS, Man T, van Roon AM, Snieder H, Riese H. Reference Values of Heart Rate Variability from 10-Second Resting Electrocardiograms: The Lifelines Cohort Study. Eur J Prev Cardiol. 2020;27(19):2191-4. doi: 10.1177/2047487319872567.</mixed-citation>
            <element-citation publication-type="journal">
              <person-group person-group-type="author">
                <name>
                  <surname>Tegegne</surname>
                  <given-names>BS</given-names>
                </name>
                <name>
                  <surname>Man</surname>
                  <given-names>T</given-names>
                </name>
                <name>
                  <surname>van Roon</surname>
                  <given-names>AM</given-names>
                </name>
                <name>
                  <surname>Snieder</surname>
                  <given-names>H</given-names>
                </name>
                <name>
                  <surname>Riese</surname>
                  <given-names>H</given-names>
                </name>
              </person-group>
              <article-title>Reference Values of Heart Rate Variability from 10-Second Resting Electrocardiograms: The Lifelines Cohort Study</article-title>
              <source>Eur J Prev Cardiol</source>
              <year>2020</year>
              <volume>27</volume>
              <issue>19</issue>
              <fpage>2191</fpage>
              <lpage>2194</lpage>
              <pub-id pub-id-type="doi">10.1177/2047487319872567</pub-id>
            </element-citation>
          </ref>
          <ref id="B19">
            <label>4</label>
            <mixed-citation>4. Sammito S, B&#246;ckelmann I. Reference Values for Time- and Frequency-Domain Heart Rate Variability Measures. Heart Rhythm. 2016;13(6):1309-16. doi: 10.1016/j.hrthm.2016.02.006.</mixed-citation>
            <element-citation publication-type="journal">
              <person-group person-group-type="author">
                <name>
                  <surname>Sammito</surname>
                  <given-names>S</given-names>
                </name>
                <name>
                  <surname>B&#246;ckelmann</surname>
                  <given-names>I</given-names>
                </name>
              </person-group>
              <article-title>Reference Values for Time- and Frequency-Domain Heart Rate Variability Measures</article-title>
              <source>Heart Rhythm</source>
              <year>2016</year>
              <volume>13</volume>
              <issue>6</issue>
              <fpage>1309</fpage>
              <lpage>1316</lpage>
              <pub-id pub-id-type="doi">10.1016/j.hrthm.2016.02.006</pub-id>
            </element-citation>
          </ref>
        </ref-list>
      </back>
    </sub-article>
  </sub-article>
</article>
