Arq Bras Cardiol abc Arquivos Brasileiros de Cardiologia Arq. Bras. Cardiol. 0066-782X 1678-4170 Sociedade Brasileira de Cardiologia - SBC K5rZpc8nCQmfPzJpmk6D6wz S0066-782X2023000300503 00503 10.36660/abc.20220665 Carta ao Editor Genótipo da Paraoxonase-1 e Angiograma Positivo para Doença Arterial Coronariana 0000-0003-0078-7897 Mungmunpuntipantip Rujittika 1 Wiwanitkit Viroj 2 Consultor Acadêmico Privado Bangkok Tailândia Consultor Acadêmico Privado, Bangkok – Tailândia Universidade Dr. DY Patil Pune Índia Universidade Dr. DY Patil, Pune – Índia Correspondência: Rujittika Mungmunpuntipantip • Private Academic Consultant 111 Bangkok 122 Bangkok 103300 – Tailândia. E-mail: rujittika@gmail.com 07 04 2023 2023 120 3 e20220665 This is an open-access article distributed under the terms of the Creative Commons Attribution License Palavras-chave Doença Arterial Coronariana/genética Mortalidade Polimorfismo Genético Predisposição Genética para Doença Fatores de Risco

Prezado Editor,

Gostaríamos de compartilhar ideias sobre a publicação “Associação do Genótipo e Fenótipo da Paraoxonase-1 com Angiograma Positivo para Doença Arterial Coronariana.”1 Soflaei et al.,1 observaram que a presença do alelo G do polimorfismo de nucleotídeo único rs662 está independentemente associada a um risco aumentado de doença arterial coronariana (DAC).1 O efeito do polimorfismo é investigado neste estudo. A DAC pode ou não ser afetada pelo componente hereditário estudado neste relatório. Ambos concordamos que a DAC pode estar relacionada ao componente genético subjacente sob pesquisa. No entanto, a DAC tem sido associada a inúmeras variações genéticas. Exemplos de polimorfismos de genes incluem o efeito de polimorfismos (M235T e T174M) no gene do angiotensinogênio (AGT), TGFB1 rs1800469 e BCMO1 rs6564851.2-3 Pesquisas futuras devem examinar as implicações de variantes genéticas inesperadas e possivelmente desconcertantes.

Referências Soflaei SS Baktashian M Moghaddam KH Saberi-Karimian M Kosari N Hashemi SM Association of Paraoxonase-1 Genotype and Phenotype with Angiogram Positive Coronary Artery Disease Arq Bras Cardiol 2022 119 4 593 601 10.36660/abc.20210422 1 Soflaei SS, Baktashian M, Moghaddam KH, Saberi-Karimian M, Kosari N, Hashemi SM, et al. Association of Paraoxonase-1 Genotype and Phenotype with Angiogram Positive Coronary Artery Disease. Arq Bras Cardiol. 2022;119(4):593-601. doi: 10.36660/abc.20210422. Zhang Q Huang Q Wang X Wang Y Hua X The effect of polymorphisms (M235T and T174M) on the angiotensinogen gene (AGT) in coronary artery disease in the Eastern Asian population: A systematic review and meta-analysis Medicine. (Baltimore) 2022 08 26 101 34 e29911 10.1097/MD.0000000000029911 2 Zhang Q, Huang Q, Wang X, Wang Y, Hua X. The effect of polymorphisms (M235T and T174M) on the angiotensinogen gene (AGT) in coronary artery disease in the Eastern Asian population: A systematic review and meta-analysis. Medicine. (Baltimore). 2022 Aug 26;101(34):e29911. DOI: 10.1097/MD.0000000000029911 Mooney RE Linden GJ Winning L Linden K Kee F McKeown PP Association of TGFB1 rs1800469 and BCMO1 rs6564851 with coronary heart disease and IL1B rs16944 with all-cause mortality in men from the Northern Ireland PRIME study PLoS One 2022 08 22 17 8 e0273333 10.1371/journal.pone.0273333 3 Mooney RE, Linden GJ, Winning L, Linden K, Kee F, McKeown PP, et al. Association of TGFB1 rs1800469 and BCMO1 rs6564851 with coronary heart disease and IL1B rs16944 with all-cause mortality in men from the Northern Ireland PRIME study. PLoS One. 2022 Aug 22;17(8):e0273333. DOI: 10.1371/journal.pone.0273333 Letter to the Editor Paraoxonase-1 Genotype and Angiogram Positive Coronary Artery Disease 0000-0003-0078-7897 Mungmunpuntipantip Rujittika 1 Wiwanitkit Viroj 2 Bangkok Thailand Private academic consultant, Bangkok – Thailand Pune India Universidade Dr. DY Patil, Pune – India Mailing Address: Rujittika Mungmunpuntipantip • Private Academic Consultant 111 Bangkok 122 Bangkok 103300 – Thailand. E-mail: rujittika@gmail.com Keywords Coronary Artery Disease/genetics Mortality Polymorphism, Genetic Genetic Predisposition to Disease Risk Factors

Dear Editor,

We would like to share ideas on the publication “Association of Paraoxonase-1 Genotype and Phenotype with Angiogram Positive Coronary Artery Disease”. 1 Soflaei et al.1 noted that The presence of the G allele of the rs662 single nucleotide polymorphism is independently associated with an increased risk of coronary artery disease (CAD).1 The effect of polymorphism is investigated in this study. CAD might or might not be impacted by the hereditary component studied in this report. We both concur that CAD may be related to the underlying genetic component under research. However, CAD has been linked to numerous genetic variations. Examples of gene polymorphisms include the effect of polymorphisms (M235T and T174M) on the angiotensinogen gene (AGT), TGFB1 rs1800469, and BCMO1 rs6564851.2-3 Future research should examine the implications of unexpected, possibly perplexing genetic variants.