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  <front>
    <journal-meta>
      <journal-id journal-id-type="nlm-ta">Arq Bras Cardiol</journal-id>
      <journal-id journal-id-type="publisher-id">abc</journal-id>
      <journal-title-group>
        <journal-title>Arquivos Brasileiros de Cardiologia</journal-title>
        <abbrev-journal-title abbrev-type="publisher">Arq. Bras. Cardiol.</abbrev-journal-title>
      </journal-title-group>
      <issn pub-type="ppub">0066-782X</issn>
      <issn pub-type="epub">1678-4170</issn>
      <publisher>
        <publisher-name>Sociedade Brasileira de Cardiologia - SBC</publisher-name>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id specific-use="scielo-v3" pub-id-type="publisher-id">mJmKp8SPc4fcQWNQ7HhyMKf</article-id>
      <article-id specific-use="scielo-v2" pub-id-type="publisher-id">S0066-782X2021001100463</article-id>
      <article-id pub-id-type="publisher-id">abc.20210732</article-id>
      <article-id pub-id-type="doi">10.36660/abc.20210732</article-id>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Minieditorial</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Idade Cronol&#243;gica ou Idade Biol&#243;gica, Principalmente uma Quest&#227;o de Estilo de Vida</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="editor">
          <contrib-id contrib-id-type="orcid">0000-0002-5333-013X</contrib-id>
          <name>
            <surname>Jardim</surname>
            <given-names>Paulo C&#233;sar B. Veiga</given-names>
          </name>
          <xref ref-type="aff" rid="aff1">
            <sup>1</sup>
          </xref>
          <xref ref-type="aff" rid="aff2">
            <sup>2</sup>
          </xref>
          <xref ref-type="corresp" rid="c1"/>
        </contrib>
        <contrib contrib-type="editor">
          <contrib-id contrib-id-type="orcid">0000-0002-7750-2792</contrib-id>
          <name>
            <surname>Jardim</surname>
            <given-names>Thiago de Souza Veiga</given-names>
          </name>
          <xref ref-type="aff" rid="aff1">
            <sup>1</sup>
          </xref>
          <xref ref-type="aff" rid="aff2">
            <sup>2</sup>
          </xref>
          <xref ref-type="aff" rid="aff3">
            <sup>3</sup>
          </xref>
        </contrib>
        <aff id="aff1">
          <label>1</label>
          <institution content-type="orgname">Universidade Federal de Goi&#225;s</institution>
          <addr-line>
            <named-content content-type="city">Goi&#226;nia</named-content>
            <named-content content-type="state">GO</named-content>
          </addr-line>
          <country country="BR">Brasil</country>
          <institution content-type="original">Universidade Federal de Goi&#225;s, Goi&#226;nia, GO - Brasil</institution>
        </aff>
        <aff id="aff2">
          <label>2</label>
          <institution content-type="orgname">Universidade Federal de Goi&#225;s</institution>
          <addr-line>
            <named-content content-type="city">Goi&#226;nia</named-content>
            <named-content content-type="state">GO</named-content>
          </addr-line>
          <country country="BR">Brasil</country>
          <institution content-type="original">Hospital do Cora&#231;&#227;o de Goi&#225;s, Goi&#226;nia, GO - Brasil</institution>
        </aff>
        <aff id="aff3">
          <label>3</label>
          <institution content-type="orgname">Brigham and Womens Hospital</institution>
          <institution content-type="orgdiv1">Harvard Medical School</institution>
          <addr-line>
            <named-content content-type="city">Boston</named-content>
            <named-content content-type="state">Massachusetts</named-content>
          </addr-line>
          <country country="US">Estado Unidos da Am&#233;rica</country>
          <institution content-type="original">Harvard Medical School/Brigham and Womens Hospital, Boston, Massachusetts &#8211; Estado Unidos da Am&#233;rica</institution>
        </aff>
      </contrib-group>
      <author-notes>
        <corresp id="c1"><bold>Correspond&#234;ncia: Paulo C&#233;sar B. Veiga Jardim</bold> &#8226; Universidade Federal de Goi&#225;s &#8211; RUA, 115-F,135. CEP <postal-code>74085-300</postal-code>, Setor Sul, Goi&#226;nia, GO &#8211; Brasil. E-mail: <email>fvjardim.ufg@gmail.com</email></corresp>
      </author-notes>
      <pub-date publication-format="electronic" date-type="pub">
        <day>20</day>
        <month>09</month>
        <year>2021</year>
      </pub-date>
      <pub-date publication-format="electronic" date-type="collection">
        <month>09</month>
        <year>2021</year>
      </pub-date>
      <volume>117</volume>
      <issue>3</issue>
      <fpage>463</fpage>
      <lpage>464</lpage>
      <permissions>
        <license license-type="open-access" xml:lang="en" xlink:href="https://creativecommons.org/licenses/by/4.0/">
          <license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution License</license-p>
        </license>
      </permissions>
      <kwd-group xml:lang="pt">
        <title>Palavras-chave</title>
        <kwd>Idoso</kwd>
        <kwd>Envelhecimento Saud&#225;vel</kwd>
        <kwd>Estilo de Vida</kwd>
        <kwd>Rigidez Arterial</kwd>
        <kwd>&#205;ndice de Massa Corporal</kwd>
        <kwd>Obesidade</kwd>
        <kwd>Estresse</kwd>
        <kwd>Sedentarismo</kwd>
        <kwd>Gen&#233;tica</kwd>
        <kwd>Espiritualidade</kwd>
      </kwd-group>
      <counts>
        <fig-count count="0"/>
        <table-count count="0"/>
        <equation-count count="0"/>
        <ref-count count="15"/>
        <page-count count="2"/>
      </counts>
    </article-meta>
  </front>
  <body>
    <p>Apesar das grandes disparidades socioecon&#244;micas globais, a popula&#231;&#227;o mundial tem crescido de maneira exponencial e a vida m&#233;dia segue aumentando de maneira significativa.<xref ref-type="bibr" rid="B1"><sup>1</sup></xref><sup>&#8211;</sup><xref ref-type="bibr" rid="B4"><sup>4</sup></xref></p>
    <p>Se, no in&#237;cio do s&#233;culo 19, a expectativa de vida na Europa estava em torno dos 35 anos, na atualidade, apenas o continente africano tem popula&#231;&#245;es com expectativa de vida m&#233;dia menor que 60 anos.<xref ref-type="bibr" rid="B1"><sup>1</sup></xref><sup>&#8211;</sup><xref ref-type="bibr" rid="B3"><sup>3</sup></xref></p>
    <p>Temos, em um extremo, o Jap&#227;o, onde a vida m&#233;dia alcan&#231;a 84 anos e no outro, Serra Leoa, na &#193;frica, onde a expectativa &#233; de 46 anos. No Brasil, em 2019, a expectativa de vida passou a 76,6 anos, sendo de 73,1 para homens e 80,1 anos para mulheres.<xref ref-type="bibr" rid="B1"><sup>1</sup></xref><sup>&#8211;</sup><xref ref-type="bibr" rid="B4"><sup>4</sup></xref></p>
    <p>Um conjunto de fatores determinou esta avassaladora modifica&#231;&#227;o e, entre eles, destacam-se claramente as melhores condi&#231;&#245;es de higiene, oferta de maior quantidade de alimentos, avan&#231;os na medicina e tecnologia e, dentro desta vertente, o desenvolvimento fant&#225;stico da imuniza&#231;&#227;o.</p>
    <p>Com estas transforma&#231;&#245;es, o conceito de idade passa a ser revisado, com o progressivo abandono da simples idade cronol&#243;gica, para a agrega&#231;&#227;o da moderna concep&#231;&#227;o de idade biol&#243;gica.<xref ref-type="bibr" rid="B4"><sup>4</sup></xref><sup>&#8211;</sup><xref ref-type="bibr" rid="B6"><sup>6</sup></xref></p>
    <p>A pr&#243;pria conviv&#234;ncia social e os costumes j&#225; se antecipam a esta realidade, reclassificando as faixas et&#225;rias, e no Brasil, a par dos considerados idosos por lei (&gt; = 60 anos), Lei n.10.048, existem os que t&#234;m prioridade perante os demais idosos (&gt; 80 anos), Lei n.13.466.</p>
    <p>Com esta nova perspectiva, o estudo do envelhecimento vascular ganha cada vez mais import&#226;ncia, no sentido de identificar na popula&#231;&#227;o geral indiv&#237;duos que apresentem diferentes est&#225;gios de envelhecimento vascular e, consequentemente, diferentes riscos do aparecimento de doen&#231;as cardiovasculares, que s&#227;o a principal causa de morte, modificando a hist&#243;ria natural do indiv&#237;duo e encurtando sua vida &#250;til.<xref ref-type="bibr" rid="B4"><sup>4</sup></xref><sup>,</sup><xref ref-type="bibr" rid="B7"><sup>7</sup></xref><sup>,</sup><xref ref-type="bibr" rid="B8"><sup>8</sup></xref></p>
    <p>Os cl&#225;ssicos fatores de risco continuam a &#8220;comandar&#8221; o rol de possibilidades de desfechos circulat&#243;rios. Entretanto, o reconhecimento progressivo da associa&#231;&#227;o e correla&#231;&#227;o destes, com o envelhecimento vascular, medido com mais precis&#227;o, come&#231;a a permitir uma atua&#231;&#227;o mais vigorosa para modificar o curso natural destas doen&#231;as.<xref ref-type="bibr" rid="B4"><sup>4</sup></xref><sup>,</sup><xref ref-type="bibr" rid="B9"><sup>9</sup></xref><sup>,</sup><xref ref-type="bibr" rid="B10"><sup>10</sup></xref><sup>,</sup><xref ref-type="bibr" rid="B11"><sup>11</sup></xref></p>
    <p>A composi&#231;&#227;o corporal inadequada est&#225; inclu&#237;da no rol dos fatores que interferem no risco cardiovascular e, neste particular, o artigo de Melo e Silva et al.,<xref ref-type="bibr" rid="B12"><sup>12</sup></xref> traz interessantes &#8220;insights&#8221;, &#233; instigante e indica um caminho novo que vem sendo explorado mundialmente.</p>
    <p>Trata-se de estudo transversal de uma coorte prospectiva de idosos com 80 anos ou mais, vivendo em comunidade, com independ&#234;ncia funcional e cognitiva.</p>
    <p>Foram estudados 124 longevos com idade m&#233;dia de 87,1 anos (74,5% mulheres e 57,3% brancos). A metodologia de investiga&#231;&#227;o, tanto da composi&#231;&#227;o corporal quanto da rigidez arterial, utilizou instrumentos precisos e validados, dando confiabilidade &#224;s medidas.</p>
    <p>Foram correlacionados dados de rigidez arterial representados pela velocidade de onda de pulso (VOP), <italic>augmentation index</italic> (Aix), &#237;ndice de amplifica&#231;&#227;o da press&#227;o de pulso (iAPP), press&#227;o de pulso central (PPc), com os dados de composi&#231;&#227;o corporal representados pela massa magra total (MM), a massa apendicular (MA), o percentual de gordura corporal e ainda o &#237;ndice de Baumgartner (IB), calculado pelo equipamento que substitui a massa corporal total.</p>
    <p>Os interessantes e provocativos achados mostraram correla&#231;&#227;o inversa significativa do AIx com a MM (r = &#8722;0,391, p&lt;0,001), MA (r= &#8722;0,378, p&lt; 0,001) e IB (r = &#8722;0,258, p 0,004). Al&#233;m disso, a PPc apresentou associa&#231;&#227;o inversa com MM (r= &#8722;0,268, p =0,003), MA (r = &#8722;0,288, p= 0,001) e IB (r= &#8722;0,265, p = 0,003). Houve rela&#231;&#227;o direta apenas entre AIx e percentual de gordura corporal (r= 0,197, p= 0,029). Para a VOP n&#227;o foram encontradas signific&#226;ncias estat&#237;sticas.</p>
    <p>O trabalho tem o m&#233;rito de ser o primeiro a avaliar a associa&#231;&#227;o entre a rigidez arterial e composi&#231;&#227;o corporal em idosos longevos na comunidade. Os resultados mostram que, quanto maior a quantidade de massa muscular, menor a rigidez arterial central e, ao contr&#225;rio, quanto maior o percentual de gordura corporal, maior a rigidez arterial. Com rela&#231;&#227;o &#224; VOP, os achados foram semelhantes aos encontrados no estudo Partage (Predictive Values of Blood Pressure and Arterial Stiffness in Institutionalized Very Aged Population) que avaliou indiv&#237;duos com idades semelhantes, mais numeroso, com a diferen&#231;a de serem institucionalizados.<xref ref-type="bibr" rid="B13"><sup>13</sup></xref></p>
    <p>O encontro da fraca associa&#231;&#227;o entre rigidez arterial e gordura corporal vai ao encontro da teoria do paradoxo da obesidade,<xref ref-type="bibr" rid="B14"><sup>14</sup></xref> o chamado vi&#233;s da sobreviv&#234;ncia, ou seja, quem chegou &#224; idade muito avan&#231;ada, estaria livre dos malef&#237;cios metab&#243;licos do excesso de gordura. Este fato, no entanto, n&#227;o ameniza a diminui&#231;&#227;o da qualidade de vida, causada pela gordura corporal, pela perda da funcionalidade e o aumento da fragilidade.<xref ref-type="bibr" rid="B15"><sup>15</sup></xref></p>
    <p>As limita&#231;&#245;es pr&#243;prias de um estudo transversal, unic&#234;ntrico, com um n&#250;mero pequeno de indiv&#237;duos, n&#227;o invalidam sua import&#226;ncia e mostram interessantes possibilidades futuras para estudos longitudinais, com amostras representativas que nos indicar&#227;o caminhos para a preven&#231;&#227;o e tratamento precoce de agravos.</p>
    <p>Este conceito moderno de envelhecimento, como prop&#245;em Sanderson e Scherbov, descreve que &#8220;a idade cronol&#243;gica &#233; a idade retrospectiva e mede quantos anos a pessoa j&#225; viveu. Todos da mesma idade viveram o mesmo n&#250;mero de anos. Em contraste, a idade prospectiva diz respeito ao futuro. Fala sobre os anos de vida a serem vividos. Os que tiverem a mesma idade prospectiva, estes sim, ter&#227;o os mesmos anos de vida futura.&#8221;<xref ref-type="bibr" rid="B5"><sup>5</sup></xref><sup>,</sup><xref ref-type="bibr" rid="B6"><sup>6</sup></xref></p>
    <p>Este futuro est&#225; diretamente ligado &#224; gen&#233;tica, mas, de maneira n&#227;o menos importante, aos h&#225;bitos de vida, rela&#231;&#245;es sociais, capacidade de lidar com estresse e o conceito mais amplo de espiritualidade. Um caminho novo que se descortina.</p>
  </body>
  <back>
    <fn-group>
      <fn fn-type="other" id="fn1">
        <p>Minieditorial referente ao artigo: Associa&#231;&#227;o da Composi&#231;&#227;o Corporal com Rigidez Arterial em Longevos</p>
      </fn>
    </fn-group>
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  <sub-article article-type="translation" id="S01" xml:lang="en">
    <front-stub>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Short Editorial</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Chronological Age or Biological Age, Mainly a Matter of Lifestyle</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="editor">
          <contrib-id contrib-id-type="orcid">0000-0002-5333-013X</contrib-id>
          <name>
            <surname>Jardim</surname>
            <given-names>Paulo C&#233;sar B. Veiga</given-names>
          </name>
          <xref ref-type="aff" rid="aff4">
            <sup>1</sup>
          </xref>
          <xref ref-type="aff" rid="aff5">
            <sup>2</sup>
          </xref>
          <xref ref-type="corresp" rid="c2"/>
        </contrib>
        <contrib contrib-type="editor">
          <contrib-id contrib-id-type="orcid">0000-0002-7750-2792</contrib-id>
          <name>
            <surname>Jardim</surname>
            <given-names>Thiago de Souza Veiga</given-names>
          </name>
          <xref ref-type="aff" rid="aff4">
            <sup>1</sup>
          </xref>
          <xref ref-type="aff" rid="aff5">
            <sup>2</sup>
          </xref>
          <xref ref-type="aff" rid="aff6">
            <sup>3</sup>
          </xref>
        </contrib>
        <aff id="aff4">
          <label>1</label>
          <addr-line>
            <named-content content-type="city">Goi&#226;nia</named-content>
            <named-content content-type="state">GO</named-content>
          </addr-line>
          <country country="BR">Brazil</country>
          <institution content-type="original">Universidade Federal de Goi&#225;s, Goi&#226;nia, GO - Brazil</institution>
        </aff>
        <aff id="aff5">
          <label>2</label>
          <addr-line>
            <named-content content-type="city">Goi&#226;nia</named-content>
            <named-content content-type="state">GO</named-content>
          </addr-line>
          <country country="BR">Brazil</country>
          <institution content-type="original">Hospital do Cora&#231;&#227;o de Goi&#225;s, Goi&#226;nia, GO - Brazil</institution>
        </aff>
        <aff id="aff6">
          <label>3</label>
          <addr-line>
            <named-content content-type="city">Boston</named-content>
            <named-content content-type="state">Massachusetts</named-content>
          </addr-line>
          <country country="US">United States of America</country>
          <institution content-type="original">Harvard Medical School/Brigham and Womens Hospital, Boston, Massachusetts - United States of America</institution>
        </aff>
      </contrib-group>
      <author-notes>
        <corresp id="c2"><bold>Mailing Address: Paulo C&#233;sar B. Veiga Jardim</bold> &#8226; Universidade Federal de Goi&#225;s &#8211; RUA, 115-F,135. Postal Code <postal-code>74085-300</postal-code>, Setor Sul, Goi&#226;nia, GO &#8211; Brazil. E-mail: <email>fvjardim.ufg@gmail.com</email></corresp>
      </author-notes>
      <kwd-group xml:lang="en">
        <title>Keywords</title>
        <kwd>Aged</kwd>
        <kwd>Healthy Aging</kwd>
        <kwd>Life Style</kwd>
        <kwd>Vascular Stiffness</kwd>
        <kwd>Body Mass Index</kwd>
        <kwd>Obesity</kwd>
        <kwd>Stress</kwd>
        <kwd>Sedentarism</kwd>
        <kwd>Genetics</kwd>
        <kwd>Spirituality</kwd>
      </kwd-group>
    </front-stub>
    <body>
      <p>Despite the significant global socioeconomic disparities, the world's population has grown exponentially, and the average life continues to increase significantly.<xref ref-type="bibr" rid="B1"><sup>1</sup></xref><sup>&#8211;</sup><xref ref-type="bibr" rid="B4"><sup>4</sup></xref></p>
      <p>If at the beginning of the 19th century, life expectancy in Europe was around 35 years, at present, only the African continent has populations with an average life expectancy of fewer than 60 years.<xref ref-type="bibr" rid="B1"><sup>1</sup></xref><sup>&#8211;</sup><xref ref-type="bibr" rid="B3"><sup>3</sup></xref></p>
      <p>We have, at one extreme, Japan, where the average life reaches 84 years and the other, Sierra Leone, Africa, where the expectation is 46 years. In 2019, life expectancy in Brazil increased to 76.6 years, being 73.1 for men and 80.1 years for women.<xref ref-type="bibr" rid="B1"><sup>1</sup></xref><sup>&#8211;</sup><xref ref-type="bibr" rid="B4"><sup>4</sup></xref></p>
      <p>A set of factors determined this overwhelming change and, among them, the best hygiene conditions, the offer of a greater quantity of food, advances in medicine and technology and, within this aspect, the fantastic development of immunization stand out.</p>
      <p>With these transformations, the concept of age begins to be revised, with the progressive abandonment of simple chronological age, to aggregate the modern conception of biological age.<xref ref-type="bibr" rid="B4"><sup>4</sup></xref><sup>&#8211;</sup><xref ref-type="bibr" rid="B6"><sup>6</sup></xref></p>
      <p>Social coexistence itself and customs are already anticipated in this reality, reclassifying age groups. In Brazil, along with those considered elderly by law (&gt; = 60 years), Law no. 10,048, some have priority over the other elderly (&gt; 80 years), Law no. 13,466.</p>
      <p>With this new perspective, the study of vascular aging is gaining increasing importance to identify individuals in the general population who present different stages of vascular aging and, consequently, different risks of the onset of cardiovascular diseases, which are the main cause of death, modifying the individual's natural history and shortening its useful life.<xref ref-type="bibr" rid="B4"><sup>4</sup></xref><sup>,</sup><xref ref-type="bibr" rid="B7"><sup>7</sup></xref><sup>,</sup><xref ref-type="bibr" rid="B8"><sup>8</sup></xref></p>
      <p>The classic risk factors continue to &#8220;command&#8221; the list of possibilities of circulatory outcomes. However, the progressive recognition of their association and correlation with vascular aging, measured more accurately, begins to allow a more vigorous action to modify the natural course of these diseases.<xref ref-type="bibr" rid="B4"><sup>4</sup></xref><sup>,</sup><xref ref-type="bibr" rid="B9"><sup>9</sup></xref><sup>,</sup><xref ref-type="bibr" rid="B10"><sup>10</sup></xref><sup>,</sup><xref ref-type="bibr" rid="B11"><sup>11</sup></xref></p>
      <p>Inadequate body composition is included in the list of factors that interfere with cardiovascular risk and, in this regard, the article by Melo e Silva et al.,<xref ref-type="bibr" rid="B12"><sup>12</sup></xref> brings interesting insights, is thought-provoking and indicates a new path that is being explored worldwide.</p>
      <p>This is a cross-sectional study of a prospective cohort of older people aged 80 years or older living in a functional and cognitive independence community.</p>
      <p>124 long-lived with a mean age of 87.1 years (74.5% women and 57.3% white) were studied. The investigation methodology used precise and validated instruments, both of body composition and arterial stiffness, giving reliability to the measurements.</p>
      <p>Data on arterial stiffness represented by pulse wave velocity (PWV), augmentation index (Aix), pulse pressure amplification index (PPAi), central pulse pressure (cPP), with body composition data represented by total lean mass (LM), appendicular mass (AM), body fat percentage and Baumgartner index (BI), calculated by the equipment that replaces total body mass, were correlated.</p>
      <p>The interesting and provocative findings showed a significant inverse correlation between AIx and LM (r = &#8722;0.391, p &lt; 0.001), AM (r = &#8722;0.378, p &lt; 0.001) and BI (r = &#8722;0.258, p 0.004). In addition, CPP presented an inverse association with LM (r = &#8722;0.268, p = 0.003), AM (r = &#8722;0.288, p = 0.001) and BI (r = &#8722;0.265, p = 0.003). There was a direct relationship only between AIx and body fat percentage (r = 0.197, p = 0.029). Statistical significance was not found for PWV.</p>
      <p>The work has the merit of being the first to assess the association between arterial stiffness and body composition in long-lived older adults in the community. The results show that the greater the amount of muscle mass, the lower the central arterial stiffness and, on the contrary, the higher the percentage of body fat, the greater the arterial stiffness. Regarding PWV, the findings were similar to those found in the Partage (Predictive Values of Blood Pressure and Arterial Stiffness in Institutionalized Very Population Aged) study, which evaluated individuals of similar ages, more numerous, with the difference of being institutionalized.<xref ref-type="bibr" rid="B13"><sup>13</sup></xref></p>
      <p>The encounter of the weak association between arterial stiffness and body fat is in line with the theory of the obesity paradox,<xref ref-type="bibr" rid="B14"><sup>14</sup></xref> the so-called survival bias, that is, those who reached a very advanced age would be free of the metabolic harms of excess fat. This fact, however, does not mitigate the decrease in quality of life caused by body fat, loss of functionality and increased frailty.<xref ref-type="bibr" rid="B15"><sup>15</sup></xref></p>
      <p>The limitations of a cross-sectional, single-center study with a small number of individuals do not invalidate its importance and show interesting future possibilities for longitudinal studies, with representative samples that will indicate ways to prevent and early treat of injuries.</p>
      <p>As proposed by Sanderson and Scherbov, this modern concept of aging describes that &#8220;chronological age is the retrospective age and measures how many years the person has lived. Every one of the same age lived the same number of years. In contrast, prospective age concerns the future. It talks about the years of life to be lived. Those who have the same prospective age, these yes, will have the same years of future life.&#8221;<xref ref-type="bibr" rid="B5"><sup>5</sup></xref><sup>,</sup><xref ref-type="bibr" rid="B6"><sup>6</sup></xref></p>
      <p>This future is directly linked to genetics, but, in no less significant way, to life habits, social relationships, the ability to deal with stress and the broader concept of spirituality. A new path that unfolds.</p>
    </body>
    <back>
      <fn-group>
        <fn fn-type="other" id="fn2">
          <p>Short Editorial related to the article: Association of Body Composition with Arterial Stiffness in Long-lived People</p>
        </fn>
      </fn-group>
    </back>
  </sub-article>
</article>
