<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.1 20151215//EN" "https://jats.nlm.nih.gov/publishing/1.1/JATS-journalpublishing1.dtd">
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" article-type="editorial" dtd-version="1.1" specific-use="sps-1.8" xml:lang="en">
  <front>
    <journal-meta>
      <journal-id journal-id-type="nlm-ta">Arq Bras Cardiol</journal-id>
      <journal-id journal-id-type="publisher-id">abc</journal-id>
      <journal-title-group>
        <journal-title>Arquivos Brasileiros de Cardiologia</journal-title>
        <abbrev-journal-title abbrev-type="publisher">Arq. Bras. Cardiol.</abbrev-journal-title>
      </journal-title-group>
      <issn pub-type="ppub">0066-782X</issn>
      <issn pub-type="epub">1678-4170</issn>
      <publisher>
        <publisher-name>Sociedade Brasileira de Cardiologia - SBC</publisher-name>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id" specific-use="scielo-v3">rczR8sGdZqYhWPMW5RRfHWq</article-id>
      <article-id pub-id-type="publisher-id" specific-use="scielo-v2">S0066-782X2019000100038</article-id>
      <article-id pub-id-type="doi">10.5935/abc.20180257</article-id>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Short Editorial</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Is There a Role For Whole Body Vibration in Protecting Cardiovascular Disease?</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <contrib-id contrib-id-type="orcid">0000-0002-9831-8820</contrib-id>
          <name>
            <surname>Zornoff</surname>
            <given-names>Leonardo</given-names>
          </name>
          <xref ref-type="aff" rid="aff1"/>
          <xref ref-type="corresp" rid="c1"/>
        </contrib>
        <contrib contrib-type="author">
          <contrib-id contrib-id-type="orcid">0000-0002-5980-4367</contrib-id>
          <name>
            <surname>Minicucci</surname>
            <given-names>Marcos Ferreira</given-names>
          </name>
          <xref ref-type="aff" rid="aff1"/>
        </contrib>
        <aff id="aff1">
          <institution content-type="orgname">Universidade Estadual Paulista</institution>
          <institution content-type="orgdiv1">Faculdade de Medicina</institution>
          <addr-line>
            <city>Botucatu</city>
            <state>SP</state>
          </addr-line>
          <country country="BR">Brazil</country>
          <institution content-type="original">Universidade Estadual Paulista (Unesp) - Faculdade de Medicina Campus de Botucatu, Botucatu, SP - Brazil</institution>
        </aff>
      </contrib-group>
      <author-notes>
        <corresp id="c1">Mailing Address: Leonardo Zornoff, Rubi&#227;o J&#250;nior, s/n. Postal Code 18618-970, Botucatu, SP - Brazil. E-mail: <email>lzornoff@fmb.unesp.br</email>
				</corresp>
      </author-notes>
      <pub-date pub-type="epub-ppub">
        <month>1</month>
        <year>2019</year>
      </pub-date>
      <volume>112</volume>
      <issue>1</issue>
      <fpage>38</fpage>
      <lpage>39</lpage>
      <permissions>
        <license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/" xml:lang="en">
          <license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited</license-p>
        </license>
      </permissions>
      <kwd-group xml:lang="en">
        <title>Keywords</title>
        <kwd>Cardiovascular Diseases</kwd>
        <kwd>Mortality</kwd>
        <kwd>Exercise/prevention and control</kwd>
        <kwd>Vibration</kwd>
        <kwd>Exercise Movement Techniques</kwd>
        <kwd>Mobility</kwd>
        <kwd>Stroke/rehabilitation</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <body>
    <p>Cardiovascular disease is the leading cause of death worldwide. In this context, it is well accepted that physical activity plays a critical role as a powerful therapeutic strategy for prevention and progression of cardiovascular disease, both in experimental models and in different clinical situations.<xref ref-type="bibr" rid="B1">1</xref><sup>,</sup><xref ref-type="bibr" rid="B2">2</xref>
		</p>
    <p>Whole body vibration training (WBV) is a new intriguing training program. Importantly, if vibration-induced protection is an effective method of exercise, it could be an alternative to exercise training especially for those who are unable to perform the traditional exercise. Therefore, the effects of WVB on different systems, including the cardiovascular system, has been investigated in recent years.</p>
    <p>Considering clinical studies, the results suggesting benefits with this strategy have been conflicting. For example, the effects of WBV on neuromuscular performance, mobility, spasticity, and cardiovascular responses have been studied after stroke. Although some positive results were reported, recent systematic review concluded that there is no solid evidence confirming the beneficial effects of WBV among people with stroke.<xref ref-type="bibr" rid="B3">3</xref> On the other hand, in pediatric cancer patients, WBV improved lower extremity muscle mass and strength, balance control, gait, and walking ability.<xref ref-type="bibr" rid="B4">4</xref> Likewise, in patients with moderate COPD, WBV increased physical performance and quality of life. However, there were no effects on inflammatory and oxidative biomarkers.<xref ref-type="bibr" rid="B5">5</xref>
		</p>
    <p>In experimental models, WBV therapy after ischemia reduced brain damage in senescent rats.<xref ref-type="bibr" rid="B6">6</xref> In another model, WBV attenuates oxidative stress to ameliorate liver steatosis and improves insulin resistance in db/db mice.<xref ref-type="bibr" rid="B7">7</xref> Likewise, whole-body vibration reversed ageing-induced increases in hepatic lipid storage in mice.<xref ref-type="bibr" rid="B8">8</xref>
		</p>
    <p>In this issue of the Arquivos Brasileiros de Cardiologia, Autor et al studied the safety and efficacy of vibration on myocardial ischemia-reperfusion injury.<xref ref-type="bibr" rid="B9">9</xref> Twenty four male Wistar rats were divided into control and vibration groups and all the rats were subjected to myocardial IR injury. Vibration training consisted of vertical sinusoidal whole body vibration for 30 min per day, 6 days per week. The data showed that vibration training increased the cardiac tolerance to IR injury in rats, as evidenced by the reduction of infarct size and cardiac arrhythmias, and by facilitation of spontaneous defibrillation.</p>
    <p>Although promising, these results should be interpreted with caution, because not infrequently, the success of the experimental treatments studied does not replicate when applied to clinical studies. Additionally, cardioprotection strategies in situations of ischemia reperfusion is the main model used to exemplify the difficulties of translational medicine, since positive results from experimental studies are obfuscated by the fact that to date, cardioprotection strategies in clinical studies have shown negative results.<xref ref-type="bibr" rid="B10">10</xref>
		</p>
    <p>For the above, although the data are not consistent, there is evidence of the benefit of WBV in different models. However, the vast majority of the evidence comes from experimental research and clinical studies with small numbers of patients, single-centre, non-randomized, and not having cardiovascular events as the main outcomes. Therefore, more studies are needed to clarify the exact role of this new modality of physical activity in the management of cardiovascular disease.</p>
  </body>
  <back>
    <ref-list>
      <title>References</title>
      <ref id="B1">
        <label>1</label>
        <mixed-citation>1 Lavie CJ, Milani RV. Cardiac rehabilitation and exercise training in secondary coronary heart disease prevention. Prog Cardiovasc Dis. 2011;53(6):397-403.</mixed-citation>
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>Lavie</surname>
              <given-names>CJ</given-names>
            </name>
            <name>
              <surname>Milani</surname>
              <given-names>RV</given-names>
            </name>
          </person-group>
          <article-title>Cardiac rehabilitation and exercise training in secondary coronary heart disease prevention</article-title>
          <source>Prog Cardiovasc Dis</source>
          <year>2011</year>
          <volume>53</volume>
          <issue>6</issue>
          <fpage>397</fpage>
          <lpage>403</lpage>
        </element-citation>
      </ref>
      <ref id="B2">
        <label>2</label>
        <mixed-citation>2 Ghorbanzadeh V, Mohammadi M, Dariushnejad H, Abhari A, Chodari L, Mohaddes G. Cardioprotective effect of crocin combined with voluntary exercise in rat: role of mir-126 and mir-210 in heart angiogenesis. Arq Bras Cardiol .2017;109(1):54-62.</mixed-citation>
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>Ghorbanzadeh</surname>
              <given-names>V</given-names>
            </name>
            <name>
              <surname>Mohammadi</surname>
              <given-names>M</given-names>
            </name>
            <name>
              <surname>Dariushnejad</surname>
              <given-names>H</given-names>
            </name>
            <name>
              <surname>Abhari</surname>
              <given-names>A</given-names>
            </name>
            <name>
              <surname>Chodari</surname>
              <given-names>L</given-names>
            </name>
            <name>
              <surname>Mohaddes</surname>
              <given-names>G</given-names>
            </name>
          </person-group>
          <article-title>Cardioprotective effect of crocin combined with voluntary exercise in rat: role of mir-126 and mir-210 in heart angiogenesis</article-title>
          <source>Arq Bras Cardiol</source>
          <year>2017</year>
          <volume>109</volume>
          <issue>1</issue>
          <fpage>54</fpage>
          <lpage>62</lpage>
        </element-citation>
      </ref>
      <ref id="B3">
        <label>3</label>
        <mixed-citation>3 Leite HR, Camargos ACR, Mendon&#231;a VA, Lacerda ACR, Soares BA, Oliveira VC. Current evidence does not support whole body vibration in clinical practice in children and adolescents with disabilities: a systematic review of randomized controlled trial. Braz J Phys Ther. 2018 Sep 19.pii:S1413-3555(18)30023-6.</mixed-citation>
        <element-citation publication-type="book">
          <person-group person-group-type="author">
            <name>
              <surname>Leite</surname>
              <given-names>HR</given-names>
            </name>
            <name>
              <surname>Camargos</surname>
              <given-names>ACR</given-names>
            </name>
            <name>
              <surname>Mendon&#231;a</surname>
              <given-names>VA</given-names>
            </name>
            <name>
              <surname>Lacerda</surname>
              <given-names>ACR</given-names>
            </name>
            <name>
              <surname>Soares</surname>
              <given-names>BA</given-names>
            </name>
            <name>
              <surname>Oliveira</surname>
              <given-names>VC</given-names>
            </name>
          </person-group>
          <chapter-title>Current evidence does not support whole body vibration in clinical practice in children and adolescents with disabilities: a systematic review of randomized controlled trial</chapter-title>
          <source>Braz J Phys Ther</source>
          <day>19</day>
          <month>09</month>
          <year>2018</year>
          <pub-id pub-id-type="pii">S1413-3555</pub-id>
          <issue>18</issue>
          <fpage>30023</fpage>
          <lpage>30026</lpage>
        </element-citation>
      </ref>
      <ref id="B4">
        <label>4</label>
        <mixed-citation>4 Rustler V, D&#228;ggelmann J, Streckmann F, Bloch W, Baumann FT. Whole-body vibration in children with disabilities demonstrates therapeutic potentials for pediatric cancer populations: a systematic review. Support Care Cancer. Oct 27 [Epub ahead print]</mixed-citation>
        <element-citation publication-type="book">
          <person-group person-group-type="author">
            <name>
              <surname>Rustler</surname>
              <given-names>V</given-names>
            </name>
            <name>
              <surname>D&#228;ggelmann</surname>
              <given-names>J</given-names>
            </name>
            <name>
              <surname>Streckmann</surname>
              <given-names>F</given-names>
            </name>
            <name>
              <surname>Bloch</surname>
              <given-names>W</given-names>
            </name>
            <name>
              <surname>Baumann</surname>
              <given-names>FT</given-names>
            </name>
          </person-group>
          <chapter-title>Whole-body vibration in children with disabilities demonstrates therapeutic potentials for pediatric cancer populations: a systematic review</chapter-title>
          <source>Support Care Cancer</source>
          <comment>Oct 27 [Epub ahead print]</comment>
        </element-citation>
      </ref>
      <ref id="B5">
        <label>5</label>
        <mixed-citation>5 Neves CDC, Lacerda ACR, Lage VKS, Soares AA, Chaves MGA, Lima LP,et al. Whole body vibration training increases physical measures and quality of life without altering inflammatory-oxidative biomarkers in patients with moderate COPD. J Appl Physiol. 2018;125(2):520-8.</mixed-citation>
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>Neves</surname>
              <given-names>CDC</given-names>
            </name>
            <name>
              <surname>Lacerda</surname>
              <given-names>ACR</given-names>
            </name>
            <name>
              <surname>Lage</surname>
              <given-names>VKS</given-names>
            </name>
            <name>
              <surname>Soares</surname>
              <given-names>AA</given-names>
            </name>
            <name>
              <surname>Chaves</surname>
              <given-names>MGA</given-names>
            </name>
            <name>
              <surname>Lima</surname>
              <given-names>LP</given-names>
            </name>
            <etal/>
          </person-group>
          <article-title>Whole body vibration training increases physical measures and quality of life without altering inflammatory-oxidative biomarkers in patients with moderate COPD</article-title>
          <source>J Appl Physiol</source>
          <year>2018</year>
          <volume>125</volume>
          <issue>2</issue>
          <fpage>520</fpage>
          <lpage>528</lpage>
        </element-citation>
      </ref>
      <ref id="B6">
        <label>6</label>
        <mixed-citation>6 Raval AP, Schatz M, Bhattacharya P, d'Adesky N, Rundek T, Dietrich WD, et al. Whole body vibration therapy after ischemia reduces brain damage in reproductively senescent female rats. Int J Mol Sci. 2018;19(9):2749.</mixed-citation>
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>Raval</surname>
              <given-names>AP</given-names>
            </name>
            <name>
              <surname>Schatz</surname>
              <given-names>M</given-names>
            </name>
            <name>
              <surname>Bhattacharya</surname>
              <given-names>P</given-names>
            </name>
            <name>
              <surname>d'Adesky</surname>
              <given-names>N</given-names>
            </name>
            <name>
              <surname>Rundek</surname>
              <given-names>T</given-names>
            </name>
            <name>
              <surname>Dietrich</surname>
              <given-names>WD</given-names>
            </name>
            <etal/>
          </person-group>
          <article-title>Whole body vibration therapy after ischemia reduces brain damage in reproductively senescent female rats</article-title>
          <source>Int J Mol Sci</source>
          <year>2018</year>
          <volume>19</volume>
          <issue>9</issue>
          <fpage>2749</fpage>
          <lpage>2749</lpage>
        </element-citation>
      </ref>
      <ref id="B7">
        <label>7</label>
        <mixed-citation>7 Liu Y, Zhai M, Guo F, Shi T, Liu J, Wang X, et al. whole body vibration improves insulin resistance in db/db mice: amelioration of lipid accumulation and oxidative stress. Appl Biochem Biotechnol. 2016; 179(5):819-29.</mixed-citation>
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>Liu</surname>
              <given-names>Y</given-names>
            </name>
            <name>
              <surname>Zhai</surname>
              <given-names>M</given-names>
            </name>
            <name>
              <surname>Guo</surname>
              <given-names>F</given-names>
            </name>
            <name>
              <surname>Shi</surname>
              <given-names>T</given-names>
            </name>
            <name>
              <surname>Liu</surname>
              <given-names>J</given-names>
            </name>
            <name>
              <surname>Wang</surname>
              <given-names>X</given-names>
            </name>
            <etal/>
          </person-group>
          <article-title>whole body vibration improves insulin resistance in db/db mice: amelioration of lipid accumulation and oxidative stress</article-title>
          <source>Appl Biochem Biotechnol</source>
          <year>2016</year>
          <volume>179</volume>
          <issue>5</issue>
          <fpage>819</fpage>
          <lpage>829</lpage>
        </element-citation>
      </ref>
      <ref id="B8">
        <label>8</label>
        <mixed-citation>8 Reijne AC, Ciapaite J, van Dijk TH, Havinga R, van der Zee EA, Groen AK, et al. Whole-body vibration partially reverses aging-induced increases in visceral adiposity and hepatic lipid storage in mice. PLoS One 2016; 11(2):e0149419.</mixed-citation>
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>Reijne</surname>
              <given-names>AC</given-names>
            </name>
            <name>
              <surname>Ciapaite</surname>
              <given-names>J</given-names>
            </name>
            <name>
              <surname>van Dijk</surname>
              <given-names>TH</given-names>
            </name>
            <name>
              <surname>Havinga</surname>
              <given-names>R</given-names>
            </name>
            <name>
              <surname>van der Zee</surname>
              <given-names>EA</given-names>
            </name>
            <name>
              <surname>Groen</surname>
              <given-names>AK</given-names>
            </name>
            <etal/>
          </person-group>
          <article-title>Whole-body vibration partially reverses aging-induced increases in visceral adiposity and hepatic lipid storage in mice</article-title>
          <source>PLoS One</source>
          <year>2016</year>
          <volume>11</volume>
          <issue>2</issue>
          <elocation-id>e0149419</elocation-id>
        </element-citation>
      </ref>
      <ref id="B9">
        <label>9</label>
        <mixed-citation>9 Shekarforoush S, Naghii MR. Whole-body vibration training increases myocardial salvage against acute ischemia in adult male rats. Arq Bras Cardiol. 2019; 112(1):32-37.</mixed-citation>
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>Shekarforoush</surname>
              <given-names>S</given-names>
            </name>
            <name>
              <surname>Naghii</surname>
              <given-names>MR</given-names>
            </name>
          </person-group>
          <article-title>Whole-body vibration training increases myocardial salvage against acute ischemia in adult male rats</article-title>
          <source>Arq Bras Cardiol</source>
          <year>2019</year>
          <volume>112</volume>
          <issue>1</issue>
          <fpage>32</fpage>
          <lpage>37</lpage>
        </element-citation>
      </ref>
      <ref id="B10">
        <label>10</label>
        <mixed-citation>10 Garcia LR, Polegato BF, Zornoff LAM. Challenges of translational science. Arq Bras Cardiol 2017;108(5):388-9.</mixed-citation>
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>Garcia</surname>
              <given-names>LR</given-names>
            </name>
            <name>
              <surname>Polegato</surname>
              <given-names>BF</given-names>
            </name>
            <name>
              <surname>Zornoff</surname>
              <given-names>LAM</given-names>
            </name>
          </person-group>
          <article-title>Challenges of translational science</article-title>
          <source>Arq Bras Cardiol</source>
          <year>2017</year>
          <volume>108</volume>
          <issue>5</issue>
          <fpage>388</fpage>
          <lpage>389</lpage>
        </element-citation>
      </ref>
    </ref-list>
  </back>
  <sub-article article-type="translation" id="s1" xml:lang="pt">
    <front-stub>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Minieditorial</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Existe um Papel para a Vibra&#231;&#227;o de Corpo Inteiro na Prote&#231;&#227;o de Doen&#231;as Cardiovasculares?</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <contrib-id contrib-id-type="orcid">0000-0002-9831-8820</contrib-id>
          <name>
            <surname>Zornoff</surname>
            <given-names>Leonardo</given-names>
          </name>
          <xref ref-type="aff" rid="aff2"/>
          <xref ref-type="corresp" rid="c2"/>
        </contrib>
        <contrib contrib-type="author">
          <contrib-id contrib-id-type="orcid">0000-0002-5980-4367</contrib-id>
          <name>
            <surname>Minicucci</surname>
            <given-names>Marcos Ferreira</given-names>
          </name>
          <xref ref-type="aff" rid="aff2"/>
        </contrib>
        <aff id="aff2">
          <institution content-type="original">Universidade Estadual Paulista (Unesp) - Faculdade de Medicina Campus de Botucatu, Botucatu, SP - Brasil</institution>
        </aff>
      </contrib-group>
      <author-notes>
        <corresp id="c2">Correspond&#234;ncia: Leonardo Zornoff, Rubi&#227;o J&#250;nior, s/n. CEP 18618-970, Botucatu, SP - Brasil. E-mail: <email>lzornoff@fmb.unesp.br</email>
				</corresp>
      </author-notes>
      <kwd-group xml:lang="pt">
        <title>Palavras-chave</title>
        <kwd>Doen&#231;as Cardiovasculares</kwd>
        <kwd>Mortalidade</kwd>
        <kwd>Exerc&#237;cio/preven&#231;&#227;o e controle</kwd>
        <kwd>Vibra&#231;&#227;o</kwd>
        <kwd>T&#233;cnicas de Exerc&#237;cio e Movimento, Mobilidade, Acidente Vascular Cerebral/reabilita&#231;&#227;o</kwd>
      </kwd-group>
    </front-stub>
    <body>
      <p>A doen&#231;a cardiovascular &#233; a principal causa de morte no mundo. Nesse contexto, &#233; bem aceito que a atividade f&#237;sica desempenha um papel cr&#237;tico como poderosa estrat&#233;gia terap&#234;utica para preven&#231;&#227;o e progress&#227;o de doen&#231;as cardiovasculares, tanto em modelos experimentais quanto em diferentes situa&#231;&#245;es cl&#237;nicas.<xref ref-type="bibr" rid="B1">1</xref><sup>,</sup><xref ref-type="bibr" rid="B2">2</xref>
			</p>
      <p>O treinamento com Vibra&#231;&#227;o de Corpo Inteiro (WBV, do ingl&#234;s <italic>Whole Body Vibration</italic>) &#233; um novo e intrigante programa de treinamento. &#201; importante ressaltar que, se a prote&#231;&#227;o induzida por vibra&#231;&#227;o for um m&#233;todo eficaz de exerc&#237;cio, ela pode ser uma alternativa ao treinamento f&#237;sico, especialmente para aqueles que n&#227;o conseguem realizar o exerc&#237;cio tradicional. Sendo assim, os efeitos da WBV em diferentes sistemas, incluindo o sistema cardiovascular, foram investigados nos &#250;ltimos anos.</p>
      <p>Considerando estudos cl&#237;nicos, os resultados que sugerem benef&#237;cios com essa estrat&#233;gia t&#234;m sido conflitantes. Por exemplo, os efeitos da WBV no desempenho neuromuscular, mobilidade, espasticidade e respostas cardiovasculares foram estudados ap&#243;s o AVC. Embora alguns resultados positivos tenham sido relatados, uma revis&#227;o sistem&#225;tica recente concluiu que n&#227;o h&#225; evid&#234;ncias s&#243;lidas confirmando os efeitos ben&#233;ficos da WBV em indiv&#237;duos com acidente vascular cerebral.<xref ref-type="bibr" rid="B3">3</xref> Por outro lado, em pacientes pedi&#225;tricos com c&#226;ncer, a WBV melhorou a massa muscular e a for&#231;a dos membros inferiores, controle de equil&#237;brio, marcha e capacidade de caminhada.<xref ref-type="bibr" rid="B4">4</xref> Da mesma forma, em pacientes com DPOC (doen&#231;a pulmonar obstrutiva cr&#244;nica) moderada, a WBV aumentou o desempenho f&#237;sico e a qualidade de vida. No entanto, n&#227;o houve efeitos sobre os biomarcadores inflamat&#243;rios e oxidativos.<xref ref-type="bibr" rid="B5">5</xref>
			</p>
      <p>Em modelos experimentais, a terapia com WBV ap&#243;s isquemia reduziu o dano cerebral em ratos senescentes.<xref ref-type="bibr" rid="B6">6</xref> Em outro modelo, a WBV atenua o estresse oxidativo, melhorando a esteatose hep&#225;tica e a resist&#234;ncia &#224; insulina em camundongos db/db.<xref ref-type="bibr" rid="B7">7</xref> Da mesma forma, a Plataforma Vibrat&#243;ria reverteu os aumentos no armazenamento de l&#237;pides hep&#225;ticos induzidos pelo envelhecimento em camundongos.<xref ref-type="bibr" rid="B8">8</xref>
			</p>
      <p>Nesta edi&#231;&#227;o dos Arquivos Brasileiros de Cardiologia, Autor et al. estudaram a seguran&#231;a e a efic&#225;cia da vibra&#231;&#227;o na les&#227;o de isquemia-reperfus&#227;o (I/R) mioc&#225;rdica.<xref ref-type="bibr" rid="B9">9</xref> Vinte e quatro ratos Wistar machos foram divididos em grupos controle e vibrat&#243;rio e todos os ratos foram submetidos &#224; les&#227;o de I/R do mioc&#225;rdio. O treinamento com vibra&#231;&#227;o consistiu no uso de um aparato vertical sinusoidal por 30 min por dia, 6 dias por semana. Os dados mostraram que o treinamento com WBV aumentou a toler&#226;ncia card&#237;aca &#224; les&#227;o de I/R em ratos, evidenciada pela redu&#231;&#227;o do tamanho do infarto e arritmias card&#237;acas, e pela facilita&#231;&#227;o da desfibrila&#231;&#227;o espont&#226;nea.</p>
      <p>Embora promissores, esses resultados devem ser interpretados com cautela, pois, com alguma frequ&#234;ncia, o sucesso dos tratamentos experimentais estudados n&#227;o se reproduz quando aplicado aos estudos cl&#237;nicos. Al&#233;m disso, estrat&#233;gias de cardioprote&#231;&#227;o em situa&#231;&#245;es de isquemia-reperfus&#227;o constituem o principal modelo utilizado para exemplificar as dificuldades da medicina translacional, uma vez que resultados positivos de estudos experimentais s&#227;o ofuscados pelo fato de que, at&#233; o momento, estrat&#233;gias de cardioprote&#231;&#227;o em estudos cl&#237;nicos t&#234;m mostrado resultados negativos.<xref ref-type="bibr" rid="B10">10</xref>
			</p>
      <p>Considerando o exposto acima, embora os dados n&#227;o sejam consistentes, h&#225; evid&#234;ncias do benef&#237;cio da WBV em diferentes modelos. No entanto, a grande maioria das evid&#234;ncias vem de pesquisas experimentais e estudos cl&#237;nicos de centro &#250;nico, com um pequeno n&#250;mero de pacientes, n&#227;o randomizados e sem eventos cardiovasculares como principais desfechos. Portanto, mais estudos s&#227;o necess&#225;rios para esclarecer o papel exato dessa nova modalidade de atividade f&#237;sica no manejo da doen&#231;a cardiovascular.</p>
    </body>
  </sub-article>
</article>
