<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.1 20151215//EN" "https://jats.nlm.nih.gov/publishing/1.1/JATS-journalpublishing1.dtd">
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" article-type="editorial" dtd-version="1.1" specific-use="sps-1.8" xml:lang="en">
  <front>
    <journal-meta>
      <journal-id journal-id-type="nlm-ta">Arq Bras Cardiol</journal-id>
      <journal-id journal-id-type="publisher-id">abc</journal-id>
      <journal-title-group>
        <journal-title>Arquivos Brasileiros de Cardiologia</journal-title>
        <abbrev-journal-title abbrev-type="publisher">Arq. Bras. Cardiol.</abbrev-journal-title>
      </journal-title-group>
      <issn pub-type="ppub">0066-782X</issn>
      <issn pub-type="epub">1678-4170</issn>
      <publisher>
        <publisher-name>Sociedade Brasileira de Cardiologia - SBC</publisher-name>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id" specific-use="scielo-v3">BDnTxBy8CcRqVTrVnkK6dmw</article-id>
      <article-id pub-id-type="publisher-id" specific-use="scielo-v2">S0066-782X2018001600605</article-id>
      <article-id pub-id-type="doi">10.5935/abc.20180186</article-id>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Short Editorial</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>From Journals to Bedside: We Must Improve the Compliance with Practice Guidelines</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <name>
            <surname>Kumagai</surname>
            <given-names>Barbara</given-names>
          </name>
          <xref ref-type="aff" rid="aff1"/>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Caramelli</surname>
            <given-names>Bruno</given-names>
          </name>
          <xref ref-type="aff" rid="aff1"/>
          <xref ref-type="corresp" rid="c1"/>
        </contrib>
        <aff id="aff1">
          <institution content-type="orgname">Universidade de S&#227;o Paulo</institution>
          <institution content-type="orgdiv1">Faculdade de Medicina</institution>
          <institution content-type="orgdiv2">Hospital das Cl&#237;nicas</institution>
          <addr-line>
            <city>S&#227;o Paulo</city>
            <state>SP</state>
          </addr-line>
          <country country="BR">Brazil</country>
          <institution content-type="original">Unidade de Medicina Interdisciplinar em Cardiologia, InCor, HCFMUSP, S&#227;o Paulo, SP - Brazil</institution>
        </aff>
      </contrib-group>
      <author-notes>
        <corresp id="c1"><bold>Mailing Address: Bruno Caramelli,</bold> Av. Dr. En&#233;as C. de Aguiar,44. Postal Code 05403-000, Pinheiros, S&#227;o Paulo, SP - Brazil. E-mail: <email>bcaramel@usp.br</email>
				</corresp>
      </author-notes>
      <pub-date pub-type="epub-ppub">
        <month>10</month>
        <year>2018</year>
      </pub-date>
      <volume>111</volume>
      <issue>4</issue>
      <fpage>605</fpage>
      <lpage>606</lpage>
      <permissions>
        <license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/" xml:lang="en">
          <license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
        </license>
      </permissions>
      <kwd-group xml:lang="en">
        <title>Keywords</title>
        <kwd>Practice Guidelines as Topic</kwd>
        <kwd>Myocardial Infarction</kwd>
        <kwd>Perioperative Care</kwd>
        <kwd>Platelet Aggregation Inhibitors/therapeutic use</kwd>
        <kwd>Medication Adherence</kwd>
        <kwd>Treatment Refusal</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <body>
    <p>In this issue of &#8220;Arquivos Brasileiros de Cardiologia&#8221;, Borges et al.<xref ref-type="bibr" rid="B1">1</xref> described the rate of non-compliance with practice guidelines in a Hospital-based study regarding the use of antiplatelet agents in the perioperative setting of non-cardiac surgery.<xref ref-type="bibr" rid="B1">1</xref> The authors found an extremely high non-compliance rate of 80.75%, and depicted a significant negative association among non-compliance, patient education level, and the presence of previous myocardial infarction. The authors concluded that local procedures and protocols must be urgently defined.</p>
    <p>Perioperative care underwent profound changes in the past decades. Initially, evaluation was limited to issues related to the anesthetic procedures, or to the cancellation of interventions for patients at high risk of complications. Eventually, population aging, the improvement in surgical techniques, and the development of less invasive procedures brought to operation theaters patients at an increased risk of complications, especially cardiovascular ones. Perioperative care specialists had to develop new and interdisciplinary skills to deal with several aspects of medicine, kindly deserving the nickname <italic>Chameleon doctor</italic>.<xref ref-type="bibr" rid="B2">2</xref><sup>-</sup><xref ref-type="bibr" rid="B4">4</xref>
		</p>
    <p>Among perioperative complications, cardiovascular are the most feared and strongly related to mortality and morbidity. Myocardial infarction complicating non-cardiac surgery represents a big challenge, especially after the elegant demonstration that almost half of the events involves coronary thrombosis in the pathophysiology, and are not a simple consequence of increased oxygen demand or decreased supply.<xref ref-type="bibr" rid="B5">5</xref> This latter issue, in a scenario of an increasing number of coronary Stenting procedures, requires recommendations for physicians working at the point-of-care. Elaborated by experts and frequently supported by medical associations, practice guidelines serve also as a reference for public and private health systems approval and reimbursement.<xref ref-type="bibr" rid="B6">6</xref> Previous authors have also found elevated non-compliance rates in different areas of medicine both at local and country level. However, the non-compliance rate regarding the management of antiplatelet agents in the perioperative setting, has not been previously studied. Despite analyzing a small sample size and one Hospital, the study by Borges et al. is very welcome, and stands out because of the astonishing high non-compliance rate of more than 80%.</p>
    <p>At a closer look, however, two other aspects came out and must be highlighted:</p>
    <p>
      <list list-type="order">
        <list-item>
          <p>
            <bold>Treatment delivered without evidence-based support</bold>
          </p>
          <p>The most worrying aspect is the finding that almost 30% of the patients were taking antiplatelet agents for primary prevention of cardiovascular diseases. Unfortunately, this treatment is not fully supported by clinical data, even for patients at high cardiovascular risk.</p>
        </list-item>
        <list-item>
          <p>
            <bold>Underrepresentation of some surgical specialties</bold>
          </p>
          <p>According to clinical practice guidelines, there are only two specific conditions where antiplatelet agents are not safe and must be suspended before non-cardiac surgery: intracranial and transurethral resection of the prostate because of the limited possibility for local compression in order to stop bleeding. In Borges et al.&#8217;s study, however, urological interventions represent only 6.8% of the group, and neurological interventions were not included. This finding leads us to conclude that observed interruptions (or not) of the antiplatelet agent refers, most of the times in the present study, to their use as a primary prevention drug. </p>
        </list-item>
        <list-item>
          <p>
            <bold>Is it correct to consider some aspects related to the use of non-evidence-based treatment as non-compliance?</bold>
          </p>
          <p>Taking in account aspects 1 and 2 above, one can depict that, indeed, most patients in the present study did not interrupt or incorrectly interrupt the antiplatelet drug that was incorrectly prescribed (18.6 + 26.1 + 13 = 57.7% on Table 2). Despite the importance of the finding in Borges et al.&#8217;s study, we think that their results could be contained in two major findings:</p>
          <list list-type="bullet">
            <list-item>
              <p>Antiplatelet agents are frequently overprescribed, and this issue can have consequences for patients that may be submitted to surgery in the future.</p>
            </list-item>
            <list-item>
              <p>Interrupting an antiplatelet agent, going against practical guidelines recommendations, is frequent and can have consequences for patients at an increased cardiovascular risk in the perioperative period.</p>
            </list-item>
          </list>
        </list-item>
      </list>
    </p>
    <p>In conclusion, the interesting study by Borges et al. tells us that training is urgently needed to improve perioperative care and cardiovascular primary prevention.</p>
  </body>
  <back>
    <fn-group>
      <fn fn-type="other">
        <p>Short Editorial regarding the article: Factors Associated with Inadequate Management of Antiplatelet Agents in Perioperative Period of Non-Cardiac Surgeries</p>
      </fn>
    </fn-group>
    <ref-list>
      <title>References</title>
      <ref id="B1">
        <label>1</label>
        <mixed-citation>1 Borges JMDM, Almeida PA, Nascimento MMG, Barreto Filho JAS, Rosa MB, Sousa ACS. Factors Associated with Inadequate Management of Antiplatelet Agents in Perioperative Period of Non- Cardiac Surgeries. Arq Bras Cardiol. 2018; 111(4):596-604.</mixed-citation>
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>Borges</surname>
              <given-names>JMDM</given-names>
            </name>
            <name>
              <surname>Almeida</surname>
              <given-names>PA</given-names>
            </name>
            <name>
              <surname>Nascimento</surname>
              <given-names>MMG</given-names>
            </name>
            <name>
              <surname>Barreto</surname>
              <given-names>JAS</given-names>
              <suffix>Filho</suffix>
            </name>
            <name>
              <surname>Rosa</surname>
              <given-names>MB</given-names>
            </name>
            <name>
              <surname>Sousa</surname>
              <given-names>ACS</given-names>
            </name>
          </person-group>
          <article-title>Factors Associated with Inadequate Management of Antiplatelet Agents in Perioperative Period of Non- Cardiac Surgeries</article-title>
          <source>Arq Bras Cardiol</source>
          <year>2018</year>
          <volume>111</volume>
          <issue>4</issue>
          <fpage>596</fpage>
          <lpage>604</lpage>
        </element-citation>
      </ref>
      <ref id="B2">
        <label>2</label>
        <mixed-citation>2 Caramelli B. Perioperative cardiology: an inspiring arena for the Chameleon doctor. Heart. 2016;102(20):1610-1.</mixed-citation>
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>Caramelli</surname>
              <given-names>B</given-names>
            </name>
          </person-group>
          <article-title>Perioperative cardiology: an inspiring arena for the Chameleon doctor</article-title>
          <source>Heart</source>
          <year>2016</year>
          <volume>102</volume>
          <issue>20</issue>
          <fpage>1610</fpage>
          <lpage>1611</lpage>
        </element-citation>
      </ref>
      <ref id="B3">
        <label>3</label>
        <mixed-citation>3 Carmo GA, Calderaro D, Gualandro DM, Pastana AF, Yu PC, Marques AC, Caramelli B. The Ankle-Brachial Index is Associated with Cardiovascular Complications After Noncardiac Surgery. Angiology. 2016;67(2):187-92.</mixed-citation>
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>Carmo</surname>
              <given-names>GA</given-names>
            </name>
            <name>
              <surname>Calderaro</surname>
              <given-names>D</given-names>
            </name>
            <name>
              <surname>Gualandro</surname>
              <given-names>DM</given-names>
            </name>
            <name>
              <surname>Pastana</surname>
              <given-names>AF</given-names>
            </name>
            <name>
              <surname>Yu</surname>
              <given-names>PC</given-names>
            </name>
            <name>
              <surname>Marques</surname>
              <given-names>AC</given-names>
            </name>
            <name>
              <surname>Caramelli</surname>
              <given-names>B</given-names>
            </name>
          </person-group>
          <article-title>The Ankle-Brachial Index is Associated with Cardiovascular Complications After Noncardiac Surgery</article-title>
          <source>Angiology</source>
          <year>2016</year>
          <volume>67</volume>
          <issue>2</issue>
          <fpage>187</fpage>
          <lpage>192</lpage>
        </element-citation>
      </ref>
      <ref id="B4">
        <label>4</label>
        <mixed-citation>4 Pinho C, Grandini PC, Gualandro DM, Calderaro D, Monachini M, Caramelli B. Multicenter study of perioperative evaluation for noncardiac surgeries in Brazil (EMAPO). Clinics (Sao Paulo). 2007 Feb;62(1):17-22.</mixed-citation>
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>Pinho</surname>
              <given-names>C</given-names>
            </name>
            <name>
              <surname>Grandini</surname>
              <given-names>PC</given-names>
            </name>
            <name>
              <surname>Gualandro</surname>
              <given-names>DM</given-names>
            </name>
            <name>
              <surname>Calderaro</surname>
              <given-names>D</given-names>
            </name>
            <name>
              <surname>Monachini</surname>
              <given-names>M</given-names>
            </name>
            <name>
              <surname>Caramelli</surname>
              <given-names>B</given-names>
            </name>
          </person-group>
          <article-title>Multicenter study of perioperative evaluation for noncardiac surgeries in Brazil (EMAPO)</article-title>
          <source>Clinics (Sao Paulo)</source>
          <month>02</month>
          <year>2007</year>
          <volume>62</volume>
          <issue>1</issue>
          <fpage>17</fpage>
          <lpage>22</lpage>
        </element-citation>
      </ref>
      <ref id="B5">
        <label>5</label>
        <mixed-citation>5 Gualandro DM, Campos CA, Calderaro D, Yu PC, Marques AC, Pastana AF, et al. Coronary plaque rupture in patients with myocardial infarction after noncardiac surgery: frequent and dangerous. Atherosclerosis. 2012;222(1):191-5.</mixed-citation>
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>Gualandro</surname>
              <given-names>DM</given-names>
            </name>
            <name>
              <surname>Campos</surname>
              <given-names>CA</given-names>
            </name>
            <name>
              <surname>Calderaro</surname>
              <given-names>D</given-names>
            </name>
            <name>
              <surname>Yu</surname>
              <given-names>PC</given-names>
            </name>
            <name>
              <surname>Marques</surname>
              <given-names>AC</given-names>
            </name>
            <name>
              <surname>Pastana</surname>
              <given-names>AF</given-names>
            </name>
            <etal/>
          </person-group>
          <article-title>Coronary plaque rupture in patients with myocardial infarction after noncardiac surgery: frequent and dangerous</article-title>
          <source>Atherosclerosis</source>
          <year>2012</year>
          <volume>222</volume>
          <issue>1</issue>
          <fpage>191</fpage>
          <lpage>195</lpage>
        </element-citation>
      </ref>
      <ref id="B6">
        <label>6</label>
        <mixed-citation>6 Gualandro DM, Yu PC, Caramelli B, Marques AC, Calderaro D, Fornay LS, et al. 3rd Guideline for Perioperative Cardiovascular Evaluation of the Brazilian Society of Cardiology. Arq Bras Cardiol. 2017;109(3 Supl 1):1-104.</mixed-citation>
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>Gualandro</surname>
              <given-names>DM</given-names>
            </name>
            <name>
              <surname>Yu</surname>
              <given-names>PC</given-names>
            </name>
            <name>
              <surname>Caramelli</surname>
              <given-names>B</given-names>
            </name>
            <name>
              <surname>Marques</surname>
              <given-names>AC</given-names>
            </name>
            <name>
              <surname>Calderaro</surname>
              <given-names>D</given-names>
            </name>
            <name>
              <surname>Fornay</surname>
              <given-names>LS</given-names>
            </name>
            <etal/>
          </person-group>
          <article-title>3rd Guideline for Perioperative Cardiovascular Evaluation of the Brazilian Society of Cardiology</article-title>
          <source>Arq Bras Cardiol</source>
          <year>2017</year>
          <volume>109</volume>
          <issue>3</issue>
          <supplement>Supl 1</supplement>
          <fpage>1</fpage>
          <lpage>104</lpage>
        </element-citation>
      </ref>
    </ref-list>
  </back>
  <sub-article article-type="translation" id="s1" xml:lang="pt">
    <front-stub>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Minieditorial</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>De Peri&#243;dicos &#224; Cabeceira: Devemos Melhorar a Ades&#227;o &#224;s Diretrizes Pr&#225;ticas</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <name>
            <surname>Kumagai</surname>
            <given-names>Barbara</given-names>
          </name>
          <xref ref-type="aff" rid="aff2"/>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Caramelli</surname>
            <given-names>Bruno</given-names>
          </name>
          <xref ref-type="aff" rid="aff2"/>
          <xref ref-type="corresp" rid="c2"/>
        </contrib>
        <aff id="aff2">
          <institution content-type="original">Unidade de Medicina Interdisciplinar em Cardiologia, InCor, HCFMUSP, S&#227;o Paulo, SP - Brasil</institution>
        </aff>
      </contrib-group>
      <author-notes>
        <corresp id="c2"><bold>Correspond&#234;ncia: Bruno Caramelli,</bold> Av. Dr. En&#233;as C. de Aguiar,44. CEP 05403-000, Pinheiros, S&#227;o Paulo, SP - Brasil. E-mail: <email>bcaramel@usp.br</email>
				</corresp>
      </author-notes>
      <kwd-group xml:lang="pt">
        <title>Palavras-chave</title>
        <kwd>Guias de Pr&#225;tica Cl&#237;nica como Assunto</kwd>
        <kwd>Infarto do Mioc&#225;rdio</kwd>
        <kwd>Assist&#234;ncia Perioperat&#243;ria</kwd>
        <kwd>Inibidores da Agrega&#231;&#227;o de Plaquetas/uso terap&#234;utico</kwd>
        <kwd>Ades&#227;o &#224; Medica&#231;&#227;o</kwd>
        <kwd>Recusa do Paciente ao Tratamento</kwd>
      </kwd-group>
    </front-stub>
    <body>
      <p>Nesta edi&#231;&#227;o dos &#8220;Arquivos Brasileiros de Cardiologia&#8221;, Borges et al.<xref ref-type="bibr" rid="B1">1</xref> descreveram a taxa de n&#227;o ades&#227;o &#224;s diretrizes pr&#225;ticas em um estudo de base hospitalar sobre o uso de antiagregantes plaquet&#225;rios no contexto perioperat&#243;rio de cirurgia n&#227;o card&#237;aca.<xref ref-type="bibr" rid="B1">1</xref> Os autores encontraram uma taxa de n&#227;o ades&#227;o extremamente alta de 80,75% e descreveram associa&#231;&#227;o negativa significativa entre a n&#227;o ades&#227;o, o n&#237;vel de escolaridade do paciente e a presen&#231;a de infarto do mioc&#225;rdio pr&#233;vio. Os autores conclu&#237;ram que os procedimentos e protocolos locais devem ser definidos com urg&#234;ncia.</p>
      <p>Os cuidados perioperat&#243;rios sofreram profundas mudan&#231;as nas &#250;ltimas d&#233;cadas. Inicialmente, a avalia&#231;&#227;o limitava-se a quest&#245;es relacionadas aos procedimentos anest&#233;sicos ou ao cancelamento de interven&#231;&#245;es para pacientes com alto risco de complica&#231;&#245;es. Eventualmente, o envelhecimento populacional, a melhora das t&#233;cnicas cir&#250;rgicas e o desenvolvimento de procedimentos menos invasivos trouxeram &#224; opera&#231;&#227;o pacientes com maior risco de complica&#231;&#245;es, principalmente cardiovasculares. Especialistas em cuidados perioperat&#243;rios tiveram que desenvolver habilidades novas e interdisciplinares para lidar com v&#225;rios aspectos da medicina, merecidamente recebendo o apelido de <italic>m&#233;dico camale&#227;o</italic>.<xref ref-type="bibr" rid="B2">2</xref><sup>-</sup><xref ref-type="bibr" rid="B4">4</xref>
			</p>
      <p>Dentre as complica&#231;&#245;es perioperat&#243;rias, as cardiovasculares s&#227;o as mais temidas e fortemente relacionadas a mortalidade e morbidade. O infarto do mioc&#225;rdio que complica a cirurgia n&#227;o card&#237;aca representa um grande desafio, especialmente ap&#243;s a sofisticada demonstra&#231;&#227;o de que quase metade dos eventos envolve trombose coronariana na fisiopatologia, e n&#227;o s&#227;o uma simples consequ&#234;ncia do aumento da demanda de oxig&#234;nio ou diminui&#231;&#227;o da oferta.<xref ref-type="bibr" rid="B5">5</xref> Em um cen&#225;rio de um n&#250;mero crescente de procedimentos de implante de stent coron&#225;rio, esta quest&#227;o requer recomenda&#231;&#245;es para m&#233;dicos que trabalham no ponto de atendimento. Elaborado por especialistas e frequentemente apoiado por associa&#231;&#245;es m&#233;dicas, as diretrizes pr&#225;ticas servem tamb&#233;m como refer&#234;ncia para aprova&#231;&#227;o e reembolso de sistemas p&#250;blicos e privados de sa&#250;de.<xref ref-type="bibr" rid="B6">6</xref> Os autores anteriores tamb&#233;m encontraram taxas elevadas de n&#227;o conformidade em diferentes &#225;reas da medicina, tanto no n&#237;vel local quanto nacional. No entanto, a taxa de n&#227;o ades&#227;o em rela&#231;&#227;o ao manejo de antiagregantes plaquet&#225;rios no contexto perioperat&#243;rio n&#227;o foi previamente estudada. Apesar de analisar um tamanho de amostra pequeno e um hospital, o estudo de Borges et al. &#233; muito bem-vindo e destaca-se por causa da taxa de n&#227;o ades&#227;o altamente surpreendente de mais de 80%.</p>
      <p>Olhando mais de perto, no entanto, dois outros aspectos surgiram e devem ser destacados:</p>
      <p>
        <list list-type="order">
          <list-item>
            <p>
              <bold>Tratamento prestado sem suporte baseado em evid&#234;ncias</bold>
            </p>
            <p>O aspecto mais preocupante &#233; a constata&#231;&#227;o de que quase 30% dos pacientes estavam em uso de antiagregantes plaquet&#225;rios para preven&#231;&#227;o prim&#225;ria de doen&#231;as cardiovasculares. Infelizmente, este tratamento n&#227;o &#233; totalmente sustentado por dados cl&#237;nicos, mesmo para pacientes com alto risco cardiovascular.</p>
          </list-item>
          <list-item>
            <p>
              <bold>Sub-representa&#231;&#227;o de algumas especialidades cir&#250;rgicas</bold>
            </p>
            <p>De acordo com as diretrizes de pr&#225;tica cl&#237;nica, existem apenas duas condi&#231;&#245;es espec&#237;ficas em que os agentes antiplaquet&#225;rios n&#227;o s&#227;o seguros e devem ser suspensos antes da cirurgia n&#227;o card&#237;aca: ressec&#231;&#227;o intracraniana e transuretral da pr&#243;stata devido &#224; possibilidade limitada de compress&#227;o local para interromper sangramento. No estudo de Borges et al., contudo, as interven&#231;&#245;es urol&#243;gicas representam apenas 6,8% do grupo e as interven&#231;&#245;es neurol&#243;gicas n&#227;o foram inclu&#237;das. Esse achado nos leva a concluir que as interrup&#231;&#245;es observadas (ou n&#227;o) do agente antiagregante plaquet&#225;rio referem-se, na maioria das vezes no presente estudo, ao seu uso como medicamento de preven&#231;&#227;o prim&#225;ria.</p>
          </list-item>
          <list-item>
            <p>
              <bold>&#201; correto considerar alguns aspectos relacionados ao uso de tratamento n&#227;o baseado em evid&#234;ncias como n&#227;o ades&#227;o?</bold>
            </p>
            <p>Considerando os aspectos 1 e 2 acima, pode-se concluir que, de fato, a maioria dos pacientes do presente estudo n&#227;o interrompeu ou interrompeu incorretamente o medicamento antiplaquet&#225;rio que foi prescrito incorretamente (18,6 + 26,1 + 13 = 57,7% na Tabela 2). Apesar da import&#226;ncia do achado no estudo de Borges et al., achamos que seus resultados poderiam estar contidos em dois achados principais:</p>
            <list list-type="bullet">
              <list-item>
                <p>Os agentes antiplaquet&#225;rios s&#227;o frequentemente prescritos em excesso, e essa quest&#227;o pode ter consequ&#234;ncias para os pacientes que podem ser submetidos &#224; cirurgia no futuro.</p>
              </list-item>
              <list-item>
                <p>A interrup&#231;&#227;o de um agente antiagregante plaquet&#225;rio, contrariando as recomenda&#231;&#245;es de diretrizes pr&#225;ticas, &#233; frequente e pode ter consequ&#234;ncias para os pacientes com risco cardiovascular aumentado no per&#237;odo perioperat&#243;rio.</p>
              </list-item>
            </list>
          </list-item>
        </list>
      </p>
      <p>Em conclus&#227;o, o interessante estudo de Borges et al. nos diz que o treinamento &#233; urgentemente necess&#225;rio para melhorar o cuidado perioperat&#243;rio e a preven&#231;&#227;o prim&#225;ria cardiovascular.</p>
    </body>
    <back>
      <fn-group>
        <fn fn-type="other">
          <p>Minieditorial referente ao artigo: Fatores Associados com o Manejo Inadequado de Antiagregantes Plaquet&#225;rios em Perioperat&#243;rio de Cirurgias n&#227;o Card&#237;acas</p>
        </fn>
      </fn-group>
    </back>
  </sub-article>
</article>
