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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" article-type="case-report" dtd-version="1.1" specific-use="sps-1.7" xml:lang="en">
  <front>
    <journal-meta>
      <journal-id journal-id-type="nlm-ta">Arq Bras Cardiol</journal-id>
      <journal-id journal-id-type="publisher-id">abc</journal-id>
      <journal-title-group>
        <journal-title>Arquivos Brasileiros de Cardiologia</journal-title>
        <abbrev-journal-title abbrev-type="publisher">Arq. Bras. Cardiol.</abbrev-journal-title>
      </journal-title-group>
      <issn pub-type="ppub">0066-782X</issn>
      <issn pub-type="epub">1678-4170</issn>
      <publisher>
        <publisher-name>Sociedade Brasileira de Cardiologia - SBC</publisher-name>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id" specific-use="scielo-v3">kswTx7DGpjrssV4hCbMVy6t</article-id>
      <article-id pub-id-type="publisher-id" specific-use="scielo-v2">S0066-782X2018000500493</article-id>
      <article-id pub-id-type="doi">10.5935/abc.20180064</article-id>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Image</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Computed Tomography-Guided Core Needle Biopsy of Cardiac Angiosarcoma</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <name>
            <surname>Gorospe</surname>
            <given-names>Luis</given-names>
          </name>
          <xref ref-type="aff" rid="aff1"/>
          <xref ref-type="corresp" rid="c1"/>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Caba&#241;ero-S&#225;nchez</surname>
            <given-names>Alberto</given-names>
          </name>
          <xref ref-type="aff" rid="aff1"/>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Mu&#241;oz-Molina</surname>
            <given-names>Gemma Mar&#237;a</given-names>
          </name>
          <xref ref-type="aff" rid="aff1"/>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Ayala-Carbonero</surname>
            <given-names>Ana Mar&#237;a</given-names>
          </name>
          <xref ref-type="aff" rid="aff1"/>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Fern&#225;ndez-M&#233;ndez</surname>
            <given-names>Mar&#237;a &#193;ngeles</given-names>
          </name>
          <xref ref-type="aff" rid="aff1"/>
        </contrib>
        <aff id="aff1">
          <institution content-type="orgname">Ram&#243;n y Cajal University Hospital</institution>
          <addr-line>
            <city>Madrid</city>
          </addr-line>
          <country country="ES">Spain</country>
          <institution content-type="original">Ram&#243;n y Cajal University Hospital, Madrid - Spain</institution>
        </aff>
      </contrib-group>
      <author-notes>
        <corresp id="c1"><bold>Mailing Address: Luis Gorospe</bold>, Calle Tarragoa 28, Madrid - Spain. E-mail: <email>luisgorospe@yahoo.com</email>, <email>luisgorospe@yahoo.com</email></corresp>
        <fn fn-type="con">
          <p>
            <bold>Author contributions</bold>
          </p>
          <p>Acquisition of data: Caba&#241;ero-S&#225;nchez A, Mu&#241;oz-Molina GM, Fern&#225;ndez-M&#233;ndez MA; Analysis and interpretation of the data: Gorospe L, Ayala-Carbonero AM; Writing of the manuscript: Caba&#241;ero-S&#225;nchez A, Mu&#241;oz-Molina GM, Ayala-Carbonero AM, Fern&#225;ndez-M&#233;ndez MA; Critical revision of the manuscript for intellectual content: Gorospe L, Ayala-Carbonero AM, Fern&#225;ndez-M&#233;ndez MA.</p>
        </fn>
        <fn fn-type="conflict">
          <p>
            <bold>Potential Conflict of Interest</bold>
          </p>
          <p>No potential conflict of interest relevant to this article was reported.</p>
        </fn>
      </author-notes>
      <pub-date pub-type="epub-ppub">
        <month>05</month>
        <year>2018</year>
      </pub-date>
      <volume>110</volume>
      <issue>5</issue>
      <fpage>493</fpage>
      <lpage>494</lpage>
      <history>
        <date date-type="received">
          <day>29</day>
          <month>06</month>
          <year>2017</year>
        </date>
        <date date-type="rev-recd">
          <day>10</day>
          <month>08</month>
          <year>2017</year>
        </date>
        <date date-type="accepted">
          <day>10</day>
          <month>08</month>
          <year>2017</year>
        </date>
      </history>
      <permissions>
        <license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/" xml:lang="en">
          <license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited</license-p>
        </license>
      </permissions>
      <kwd-group xml:lang="en">
        <title>Keywords</title>
        <kwd>Hemangiosarcoma/diagnosis</kwd>
        <kwd>Hemangiosarcoma/pathology</kwd>
        <kwd>Biopsy, Large-Core Needle</kwd>
        <kwd>Tomography, X-Ray Computed</kwd>
        <kwd>Neoplasm Staging</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <body>
    <p>A 34-year-old man was referred to our institution after an echocardiography performed at another center because of tachycardia (atrial flutter), which showed heterogeneous pericardial mass infiltrating the right chambers. Thoracic computed tomography (CT) and cardiac magnetic resonance (MR) imaging were performed for more accurate assessment of the exact tumor location, size, and potential infiltration of other cardiac and mediastinal structures. CT (<xref ref-type="fig" rid="f1">Figure 1A</xref>) and MR imaging (<xref ref-type="fig" rid="f1">Figure 1B</xref>) confirmed an 8-cm ill-defined heterogeneous enhancing pericardial mass infiltrating the anterior and superior walls of the right atrium and extending to lateral and inferior walls of the right ventricle, consistent with cardiac angiosarcoma. The patient was deemed inoperable, as the mass also invaded the superior vena cava, aortic root, and epicardial fat. CT-guided core needle biopsy of the cardiac mass was the method of choice for histological verification of tentative diagnosis. Once the patient signed the informed consent and was put in supine position, an 18-gauge biopsy needle was driven between the left thoracic internal arteries and the left border of the sternal body (<xref ref-type="fig" rid="f1">Figure 1C</xref>) and a tissue specimen was safely obtained from the beating heart without adverse events. The procedure was performed by an experienced interventional thoracic radiologist under local anesthesia and in the presence of a thoracic surgeon. CT images obtained immediately after biopsy showed no post-procedural complications. Preliminary histological analysis performed on-site by a pathologist determined the adequacy of the tissue specimen. Final histopathologic diagnosis was high-grade cardiac angiosarcoma. To the best of our knowledge, only one case of a CT-guided core needle biopsy of a cardiac angiosarcoma involving the right chambers has been previously reported in English-language scientific literature.</p>
    <p>
      <fig id="f1">
        <label>Figure 1</label>
        <caption>
          <title>A) Axial contrast-enhanced CT image showing heterogeneous mass (asterisks) infiltrating the right atrium, the right atrioventricular groove, and the right ventricle; B) Axial T1-weighted MR cardiac image showing mass (asterisks) infiltrating the right cardiac chambers; C) Axial unenhanced CT MIP (maximum intensity projection) image showing core-needle biopsy, with the tip entering the cardiac mass.</title>
        </caption>
        <graphic xlink:href="1678-4170-abc-110-05-0493-80064-gf01.jpg"/></fig>
    </p>
  </body>
  <back>
    <fn-group>
      <fn fn-type="financial-disclosure">
        <p>
          <bold>Sources of Funding</bold>
        </p>
        <p>There were no external funding sources for this study.</p>
      </fn>
      <fn fn-type="other">
        <p>
          <bold>Study Association</bold>
        </p>
        <p>This study is not associated with any thesis or dissertation work.</p>
      </fn>
    </fn-group>
  </back>
  <sub-article article-type="translation" id="s1" xml:lang="pt">
    <front-stub>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Imagem</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Bi&#243;psia de Angiossarcoma Card&#237;aco por Agulha Grossa Guiada por Tomografia Computadorizada</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <name>
            <surname>Gorospe</surname>
            <given-names>Luis</given-names>
          </name>
          <xref ref-type="aff" rid="aff2"/>
          <xref ref-type="corresp" rid="c2"/>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Caba&#241;ero-S&#225;nchez</surname>
            <given-names>Alberto</given-names>
          </name>
          <xref ref-type="aff" rid="aff2"/>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Mu&#241;oz-Molina</surname>
            <given-names>Gemma Mar&#237;a</given-names>
          </name>
          <xref ref-type="aff" rid="aff2"/>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Ayala-Carbonero</surname>
            <given-names>Ana Mar&#237;a</given-names>
          </name>
          <xref ref-type="aff" rid="aff2"/>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Fern&#225;ndez-M&#233;ndez</surname>
            <given-names>Mar&#237;a &#193;ngeles</given-names>
          </name>
          <xref ref-type="aff" rid="aff2"/>
        </contrib>
        <aff id="aff2">
          <institution content-type="original">Ram&#243;n y Cajal University Hospital, Madrid - Espanha</institution>
        </aff>
      </contrib-group>
      <author-notes>
        <corresp id="c2"><bold>Correspond&#234;ncia: Luis Gorospe</bold>, Calle Tarragoa 28, Madrid, Espanha. E-mail: <email>luisgorospe@yahoo.com</email>, <email>luisgorospe@yahoo.com</email></corresp>
        <fn fn-type="con">
          <p>
            <bold>Contribui&#231;&#227;o dos autores</bold>
          </p>
          <p>Obten&#231;&#227;o de dados: Caba&#241;ero-S&#225;nchez A, Mu&#241;oz-Molina GM, Fern&#225;ndez-M&#233;ndez MA; An&#225;lise e interpreta&#231;&#227;o dos dados: Gorospe L, Ayala-Carbonero AM; Reda&#231;&#227;o do manuscrito: Caba&#241;ero-S&#225;nchez A, Mu&#241;oz-Molina GM, Ayala-Carbonero AM, Fern&#225;ndez-M&#233;ndez MA; Revis&#227;o cr&#237;tica do manuscrito quanto ao conte&#250;do intelectual importante: Gorospe L, Ayala-Carbonero AM, Fern&#225;ndez-M&#233;ndez MA.</p>
        </fn>
        <fn fn-type="conflict">
          <p>
            <bold>Potencial conflito de interesses</bold>
          </p>
          <p>Declaro n&#227;o haver conflito de interesses pertinentes.</p>
        </fn>
      </author-notes>
      <kwd-group xml:lang="pt">
        <title>Palavras-chave</title>
        <kwd>Hemangiossarcoma/diagn&#243;stico</kwd>
        <kwd>Hemangiomassarcoma/patologia</kwd>
        <kwd>Bi&#243;psia com Agulha de Grande Calibre</kwd>
        <kwd>Tomografia Computadorizada por Raios X</kwd>
        <kwd>Estadiamento de Neoplasias</kwd>
      </kwd-group>
    </front-stub>
    <body>
      <p>Um homem de 34 anos foi encaminhado &#224; nossa institui&#231;&#227;o ap&#243;s uma ecocardiografia realizada em outro centro devido a uma taquicardia (<italic>flutter</italic> atrial), que apresentou massa peric&#225;rdica heterog&#234;nea infiltrando-se nas c&#226;maras direitas. Foram realizadas tomografia computadorizada (TC) e resson&#226;ncia magn&#233;tica (RM) card&#237;acas para uma avalia&#231;&#227;o mais precisa sobre a localiza&#231;&#227;o exata do tumor, o seu tamanho, e outras potenciais infiltra&#231;&#245;es de outras estruturas card&#237;acas e mediastinais. As imagens de TC (<xref ref-type="fig" rid="f2">Figura 1A</xref>) e RM (<xref ref-type="fig" rid="f2">Figura 1B</xref>) confirmaram uma massa peric&#225;rdica heterog&#234;nea pouco definida de 8 cm infiltrando-se nas paredes anterior e superior do &#225;trio direito e estendendo-se &#224;s paredes lateral e inferior do ventr&#237;culo direito, consistente com o angiossarcoma card&#237;aco. O paciente foi considerado inoper&#225;vel, considerando que a massa tamb&#233;m invadiu a veia cava superior, a raiz a&#243;rtica, e a gordura epic&#225;rdica. A bi&#243;psia da massa card&#237;aca por agulha grossa guiada por TC foi o m&#233;todo escolhido para a verifica&#231;&#227;o histol&#243;gica de diagn&#243;stico de tentativa. Uma vez que o paciente assinou o termo de consentimento livre e esclarecido e foi colocado em posi&#231;&#227;o supinada, uma agulha calibre 18 foi conduzida entre as art&#233;rias internas tor&#225;cicas esquerdas e a borda esquerda do corpo esternal (<xref ref-type="fig" rid="f2">Figura 1C</xref>) e uma amostra de tecido do cora&#231;&#227;o em batimento foi obtida com seguran&#231;a e sem eventos adversos. O procedimento foi realizado por um radiologista tor&#225;cico intervencionista experiente sob anestesia local e na presen&#231;a de um cirurgi&#227;o tor&#225;cico. As imagens de TC obtidas imediatamente ap&#243;s a bi&#243;psia n&#227;o apresentaram complica&#231;&#245;es p&#243;s-procedimento. A an&#225;lise histol&#243;gica preliminar realizada no local pelo patologista determinou a adequa&#231;&#227;o da amostra de tecido. O diagn&#243;stico histopatol&#243;gico final foi angiossarcoma card&#237;aco de alto grau. At&#233; onde sabemos, apenas um caso de bi&#243;psia de angiossarcoma card&#237;aco por agulha grossa guiada por TC envolvendo as c&#226;maras direitas foi anteriormente relatado na literatura cient&#237;fica em l&#237;ngua inglesa.</p>
      <p>
        <fig id="f2">
          <label>Figura 1</label>
          <caption>
            <title>A) Imagem de TC axial com contraste mostrando massa heterog&#234;nea (asteriscos) infiltrando o &#225;trio direito, o sulco atrioventricular direito e o ventr&#237;culo direito; B) Imagem de RM axial card&#237;aca T1 mostrando massa (asteriscos) infiltrando as c&#226;maras card&#237;acas direitas; C) Imagem de TC de m&#225;xima intensidade de proje&#231;&#227;o sem contraste mostrando bi&#243;psia por agulha grossa, com a ponta da agulha adentrando o tecido card&#237;aco.</title>
          </caption>
          <graphic xlink:href="1678-4170-abc-110-05-0493-80064-gf01-pt.jpg"/></fig>
      </p>
    </body>
    <back>
      <fn-group>
        <fn fn-type="financial-disclosure">
          <p>
            <bold>Fontes de financiamento</bold>
          </p>
          <p>O presente estudo n&#227;o teve fontes de financiamento externas.</p>
        </fn>
        <fn fn-type="other">
          <p>
            <bold>Vincula&#231;&#227;o acad&#234;mica</bold>
          </p>
          <p>N&#227;o h&#225; vincula&#231;&#227;o deste estudo a programas de p&#243;s-gradua&#231;&#227;o.</p>
        </fn>
      </fn-group>
    </back>
  </sub-article>
</article>
