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  <front>
    <journal-meta>
      <journal-id journal-id-type="nlm-ta">Arq Bras Cardiol</journal-id>
      <journal-title-group>
        <journal-title>Arquivos Brasileiros de Cardiologia</journal-title>
        <abbrev-journal-title abbrev-type="publisher">Arq. Bras. Cardiol.</abbrev-journal-title>
      </journal-title-group>
      <issn pub-type="ppub">0066-782X</issn>
      <issn pub-type="epub">1678-4170</issn>
      <publisher>
        <publisher-name>Sociedade Brasileira de Cardiologia</publisher-name>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id" specific-use="scielo-v3">KQjkRwP7PQDLyCKXvkpGPhP</article-id>
      <article-id pub-id-type="publisher-id" specific-use="scielo-v2">S0066-782X2014000300003</article-id>
      <article-id pub-id-type="other">00003</article-id>
      <article-id pub-id-type="publisher-id" specific-use="previous-pid">S0066-782X2014005040004</article-id>
      <article-id pub-id-type="doi">10.5935/abc.20140004</article-id>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Artigos Originais</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title xml:lang="pt">Procedimentos Minimamente Invasivos &#8211; Formas Direta e
               Videoassistida no Tratamento das Cardiopatias</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <name>
            <surname>Castro</surname>
            <given-names>Josu&#233; Viana</given-names>
            <suffix>Neto</suffix>
          </name>
          <xref ref-type="aff" rid="aff01">1</xref>
          <xref ref-type="aff" rid="aff02">2</xref>
          <xref ref-type="corresp" rid="c01"/>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Melo</surname>
            <given-names>Emanuel Carvalho</given-names>
          </name>
          <xref ref-type="aff" rid="aff01">1</xref>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Silva</surname>
            <given-names>Juliana Fernandes</given-names>
          </name>
          <xref ref-type="aff" rid="aff01">1</xref>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Rebou&#231;as</surname>
            <given-names>Leonardo Lemos</given-names>
          </name>
          <xref ref-type="aff" rid="aff02">2</xref>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Corr&#234;a</surname>
            <given-names>Larissa Chagas</given-names>
          </name>
          <xref ref-type="aff" rid="aff02">2</xref>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Germano</surname>
            <given-names>Amanda de Queiroz</given-names>
          </name>
          <xref ref-type="aff" rid="aff02">2</xref>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Machado</surname>
            <given-names>Jo&#227;o Jos&#233; Aquino</given-names>
          </name>
          <xref ref-type="aff" rid="aff01">1</xref>
        </contrib>
      </contrib-group>
      <aff id="aff01">
        <label>1</label>
        <institution content-type="orgname">Instituto do Cora&#231;&#227;o do Nordeste</institution>
        <addr-line>
          <named-content content-type="city">Fortaleza</named-content>
          <named-content content-type="state">CE</named-content>
        </addr-line>
        <country>Brasil</country>
        <institution content-type="original">Instituto do Cora&#231;&#227;o do Nordeste (INCONE),
               Fortaleza, CE - Brasil</institution>
      </aff>
      <aff id="aff02">
        <label>2</label>
        <institution content-type="orgname">Universidade de Fortaleza</institution>
        <addr-line>
          <named-content content-type="city">Fortaleza</named-content>
          <named-content content-type="state">CE</named-content>
        </addr-line>
        <country>Brasil</country>
        <institution content-type="original">Universidade de Fortaleza (UNIFOR), Fortaleza, CE -
               Brasil</institution>
      </aff>
      <author-notes>
        <corresp id="c01"><bold>Correspond&#234;ncia:</bold> Josu&#233; Viana Castro Neto, Avenida Santos Dumont,
               5.753/108, Papicu. CEP 60175-047, Fortaleza, CE - Brasil. E-mail:
                  <email>jvcn@uol.com.br</email>, <email>jvcn@cardiol.br</email>
				</corresp>
        <fn fn-type="con">
          <p>
            <bold>Contribui&#231;&#227;o dos autores</bold>
          </p>
          <p>Concep&#231;&#227;o e desenho da pesquisa: Castro Neto JV, Melo EC; Obten&#231;&#227;o de dados: Silva
                  JF, Rebou&#231;as LL, Correia LC, Queiroz AG; An&#225;lise e interpreta&#231;&#227;o dos dados: Castro
                  Neto JV, Melo EC, Silva JF; An&#225;lise estat&#237;stica:Rebou&#231;as LL, Correia LC; Reda&#231;&#227;o
                  do manuscrito: Castro Neto JV, Silva JF, Aquino JJM; Revis&#227;o cr&#237;tica do manuscrito
                  quanto ao conte&#250;do intelectual: Castro Neto JV.</p>
        </fn>
        <fn fn-type="conflict">
          <p>
            <bold>Potencial Conflito de Interesses</bold>
          </p>
          <p>Declaro n&#227;o haver conflito de interesses pertinentes.</p>
        </fn>
        <fn fn-type="other">
          <p>
            <bold>Vincula&#231;&#227;o Acad&#234;mica</bold>
          </p>
          <p>N&#227;o h&#225; vincula&#231;&#227;o deste estudo com disserta&#231;&#245;es e teses de p&#243;s-gradua&#231;&#227;o.</p>
        </fn>
      </author-notes>
      <pub-date pub-type="epub">
        <day>10</day>
        <month>02</month>
        <year>2014</year>
      </pub-date>
      <pub-date pub-type="collection">
        <month>04</month>
        <year>2014</year>
      </pub-date>
      <volume>102</volume>
      <issue>3</issue>
      <fpage>219</fpage>
      <lpage>225</lpage>
      <history>
        <date date-type="received">
          <day>10</day>
          <month>07</month>
          <year>2013</year>
        </date>
        <date date-type="rev-recd">
          <day>26</day>
          <month>08</month>
          <year>2013</year>
        </date>
        <date date-type="accepted">
          <day>26</day>
          <month>09</month>
          <year>2013</year>
        </date>
      </history>
      <permissions>
        <license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc/3.0/">
          <license-p>This is an Open Access article distributed under the terms of the Creative
                  Commons Attribution Non-Commercial License which permits unrestricted
                  non-commercial use, distribution, and reproduction in any medium, provided the
                  original work is properly cited. </license-p>
        </license>
      </permissions>
      <abstract xml:lang="pt">
        <sec>
          <title>Fundamento:</title>
          <p> Procedimentos cardiovasculares minimamente invasivos t&#234;m sido progressivamente
                  empregados no tratamento das cardiopatias. </p>
        </sec>
        <sec>
          <title>Objetivo:</title>
          <p> Descrever as t&#233;cnicas e os resultados imediatos dos procedimentos minimamente
                  invasivos ao longo de uma experi&#234;ncia de 5 anos. </p>
        </sec>
        <sec>
          <title>M&#233;todos:</title>
          <p> Estudo unic&#234;ntrico, descritivo e prospectivo, com abordagem quantitativa, no qual
                  102 pacientes foram submetidos a procedimentos minimamente invasivos de forma
                  direta e de forma videoassistida. Foram avaliadas vari&#225;veis cl&#237;nicas, operat&#243;rias
                  e evolu&#231;&#227;o imediata dos pacientes operados. </p>
        </sec>
        <sec>
          <title>Resultados:</title>
          <p> Quatorze pacientes foram submetidos a procedimentos minimamente invasivos diretos
                  e 88 a videoassistidos. Entre os submetidos a procedimentos minimamente invasivos
                  diretos, 13 tinham cardiopatia valvar a&#243;rtica. Entre os submetidos a procedimentos
                  minimamente invasivos videoassistidos, 43 tinham cardiopatia valvar mitral, 41
                  defeito do septo interatrial e quatro tumores. Entre os portadores de cardiopatia
                  valvar mitral, foram realizadas 26 trocas e 17 reconstru&#231;&#245;es valvares. As m&#233;dias
                  de tempo de clampeamento a&#243;rtico, de extracorp&#243;rea e do procedimento foram,
                  respectivamente, 91,6 &#177; 21,8, 112,7 &#177; 27,9 e 247,1 &#177; 20,3 minutos entre os
                  submetidos a procedimentos minimamente invasivos diretos. J&#225; entre os submetidos a
                  procedimentos minimamente invasivos videoassistidos, foram 71,6 &#177; 29, 99,7 &#177; 32,6
                  e 226,1 &#177; 42,7 minutos, respectivamente. Considerando os tempos de terapia
                  intensiva e de internamento, foram 41,1 &#177; 14,7 horas e 4,6 &#177; 2 dias entre os
                  submetidos a procedimentos minimamente invasivos diretos e 36,8 &#177; 16,3 horas e 4,3
                  &#177; 1,9 dias entre os videoassistidos. </p>
        </sec>
        <sec>
          <title>Conclus&#227;o:</title>
          <p> Procedimentos minimamente invasivos foram empregados de duas formas - direta e
                  videoassistida - com seguran&#231;a no tratamento das cardiopatias valvares, do defeito
                  do septo interatrial e das neoplasias do cora&#231;&#227;o. Constatamos tempos maiores das
                  vari&#225;veis operat&#243;rias nesses procedimentos. Contudo, a recupera&#231;&#227;o na fase
                  hospitalar foi r&#225;pida, independentemente do acesso e da doen&#231;a tratada.</p>
        </sec>
      </abstract>
      <kwd-group xml:lang="pt">
        <kwd>Cardiopatias</kwd>
        <kwd>Procedimentos cir&#250;rgicos minimamente invasivos</kwd>
        <kwd>Cirurgia videoassistida</kwd>
      </kwd-group>
      <counts>
        <fig-count count="3"/>
        <table-count count="2"/>
        <equation-count count="0"/>
        <ref-count count="24"/>
        <page-count count="7"/>
      </counts>
    </article-meta>
  </front>
  <body>
    <sec sec-type="intro">
      <title>Introdu&#231;&#227;o</title>
      <p>A reconfigura&#231;&#227;o da cirurgia trata de um processo por meio do qual essa especialidade
            m&#233;dica incorporou os avan&#231;os t&#233;cnicos e passou a ser praticada ao longo dos &#250;ltimos
               anos<xref ref-type="bibr" rid="B01">1</xref>. Esses avan&#231;os foram importantes para
            tornar os procedimentos cir&#250;rgicos mais seguros para os pacientes. Nesse contexto,
            procedimentos ditos Minimamente Invasivos (MI) t&#234;m sido alternativamente introduzidos em
            cirurgia card&#237;aca<xref ref-type="bibr" rid="B02">2</xref>.</p>
      <p>Com o intuito de universalizar o acesso em procedimentos cir&#250;rgicos cardiovasculares, a
            partir do in&#237;cio da d&#233;cada de 1960<xref ref-type="bibr" rid="B03">3</xref>, os
            cirurgi&#245;es adotaram a esternotomia mediana total como incis&#227;o preferencial, em
            detrimento das toracotomias iniciais<xref ref-type="bibr" rid="B04">4</xref>. Com a
            esternotomia, permitiu-se o acesso a todas as superf&#237;cies, compartimentos e grandes
            vasos do cora&#231;&#227;o, com canula&#231;&#245;es centrais. Esse acesso, que comunica amplamente o
            mediastino m&#233;dio com o ambiente operat&#243;rio, trouxe conforto para o cirurgi&#227;o.
            Entretanto, possivelmente pelo fato da ampla abertura e tamb&#233;m pela divis&#227;o &#243;ssea
            inerente, tem sido considerado um estigma para os pacientes a serem operados.</p>
      <p>A partir de 1997, com incentivo do trabalho previamente publicado por Laborde e
               cols.<xref ref-type="bibr" rid="B05">5</xref>, ficou clara a necessidade de
            envolvimento t&#233;cnico para o desenvolvimento de uma experi&#234;ncia inicial em procedimentos
               videocir&#250;rgicos<xref ref-type="bibr" rid="B06">6</xref>. Dando sequ&#234;ncia, em 1999,
            foi elaborado um projeto com foco em videocirurgia experimental que, por dificuldades
            estruturais, n&#227;o seguiu adiante. Somente a partir de 2006 &#233; que o time passou a
            desenvolver fortes a&#231;&#245;es focadas em cirurgia MI, com base na experi&#234;ncia inicial de
            outros autores<xref ref-type="bibr" rid="B07">7</xref>
				<sup>,</sup>
				<xref ref-type="bibr" rid="B08">8</xref>. Nessa fase, foram necess&#225;rios intensa capacita&#231;&#227;o e treinamento
            complementares; os primeiros procedimentos foram realizados a partir do final de 2007. O
            fato &#233; que o processo para atingir o m&#233;todo hoje empregado foi progressivo e
            graduado.</p>
      <p>Este trabalho teve como objetivo descrever a metodologia utilizada e os resultados
            imediatos obtidos ao longo de 5 anos de experi&#234;ncia em um total de 102 pacientes
            submetidos a procedimentos cir&#250;rgicos cardiovasculares MI.</p>
    </sec>
    <sec sec-type="methods">
      <title>M&#233;todos</title>
      <p>No per&#237;odo compreendido entre dezembro de 2007 e dezembro de 2012, 102 pacientes foram
            submetidos, ap&#243;s consentimento informado, a procedimentos MI. Esse estudo unic&#234;ntrico,
            descritivo, prospectivo, com abordagem quantitativa, avaliou as vari&#225;veis cl&#237;nicas e
            operat&#243;rias, al&#233;m da evolu&#231;&#227;o imediata na fase hospitalar dos pacientes operados, tendo
            sido aprovado pelo comit&#234; de &#233;tica da Universidade de Fortaleza.</p>
      <sec>
        <title>Sele&#231;&#227;o dos pacientes</title>
        <p>Foram selecionados pacientes sintom&#225;ticos portadores de cardiopatias valvares mitral,
               a&#243;rtica e tric&#250;spide, portadores de defeito do septo e portadores de tumor card&#237;aco
               que foram submetidos a procedimentos cir&#250;rgicos, com recomenda&#231;&#227;o da terap&#234;utica
               fundamentada nas diretrizes das sociedades de cardiologia<xref ref-type="bibr" rid="B09">9</xref>.</p>
        <p>Os crit&#233;rios de exclus&#227;o foram: idade superior a 70 anos; &#237;ndice de massa corp&#243;rea
               &gt; 32 kg/m<xref ref-type="bibr" rid="B02">2</xref>; serem portadores de doen&#231;a
               pulmonar obstrutiva cr&#244;nica (VEF<sub>1</sub>/CVF &lt; 0,7); pacientes submetidos &#224;
               cirurgia card&#237;aca pr&#233;via; portadores de insufici&#234;ncia renal; pacientes com
               procedimento cir&#250;rgico na cavidade pleural direita pr&#233;via ou doen&#231;a inflamat&#243;ria
               pulmonar com ader&#234;ncias pleuro-pulmonares significantes; pacientes com deformidades
               tor&#225;cicas e com calcifica&#231;&#227;o difusa da aorta ascendente; pacientes com calcifica&#231;&#227;o
               importante do anel valvar, press&#227;o sist&#243;lica em art&#233;ria pulmonar &gt; 80 mmHg, doen&#231;a
               arterial coronariana associada n&#227;o suscet&#237;vel a implante de endopr&#243;tese coronariana
                  (<italic>stent</italic>), insufici&#234;ncia tric&#250;spide grave, calcifica&#231;&#227;o de art&#233;rias
               il&#237;acas ou femorais, art&#233;rias femorais de di&#226;metro &lt; 5 mm e d&#250;vida na pun&#231;&#227;o
               direta do vaso femoral; pacientes com cardiopatia valvar mitral ou defeito septal com
               insufici&#234;ncia a&#243;rtica moderada ou grave associada; e pacientes que, em algum momento,
               decidissem n&#227;o participar do estudo.</p>
      </sec>
      <sec>
        <title>T&#233;cnica operat&#243;ria</title>
        <p>Todos os procedimentos foram realizados de forma MI. Estes foram categorizados em
               dois n&#237;veis:</p>
        <p>MI Direto (D): procedimento realizado por meio de uma incis&#227;o &lt; 8 cm e com uso
               preferencial da vis&#227;o direta;</p>
        <p>MI Videoassistido (VA): procedimento realizado por meio de quatro portais; portal ou
               incis&#227;o para trabalho (4 cm) e tr&#234;s portais auxiliares (0,5 cm), com uso preferencial
               da vis&#227;o da imagem obtida pela &#243;tica e em monitor.</p>
      </sec>
      <sec>
        <title>Procedimento MI D</title>
        <p>Foram submetidos a esse tipo de acesso cir&#250;rgico os portadores de cardiopatia valvar
               a&#243;rtica, cardiopatia valvar pulmonar, cardiopatia subvalvar a&#243;rtica, procedimentos na
               raiz a&#243;rtica e defeito septal do tipo seio venoso. </p>
        <p>O paciente foi posicionado em dec&#250;bito dorsal; foram realizadas pun&#231;&#245;es venosa e
               arterial perif&#233;rica no membro superior esquerdo. Foi realizada a indu&#231;&#227;o anest&#233;sica,
               e o paciente foi intubado com sonda endotraqueal usual. Foi posicionada a sonda
               esof&#225;gica de ecocardi&#243;grafo. A pun&#231;&#227;o venosa central foi realizada na veia subcl&#225;via
               direita; placas descart&#225;veis para cardiovers&#227;o externa foram posicionadas, e a sonda
               vesical foi introduzida.</p>
        <p>O acesso foi realizado por meio de uma incis&#227;o de aproximadamente 6 cm de
               comprimento. A divis&#227;o esternal foi parcial, desde a incisura jugular at&#233; o terceiro
               espa&#231;o intercostal direito (<xref ref-type="fig" rid="f01">Figura 1</xref>). A serra
               &#243;ssea foi mantida na mesa operat&#243;ria durante todo procedimento. </p>
        <fig id="f01" fig-type="other">
          <label>Figura 1</label>
          <caption>
            <title>Desenho descritivo do procedimento minimamente invasivo direto.</title>
          </caption>
          <graphic xlink:href="1678-4170-abc-102-03-0219-40004-gf01.jpg"/></fig>
        <p>O peric&#225;rdio foi parcialmente aberto e fixado aos campos, oferecendo amplo acesso ao
               mediastino superior. </p>
        <p>Ap&#243;s administra&#231;&#227;o de heparina na dose de 4 mg/kg, o suporte circulat&#243;rio foi
               estabelecido por meio da canula&#231;&#227;o arterial na aorta ascendente e da canula&#231;&#227;o venosa
               no tr&#237;gono femoral direito, por pun&#231;&#227;o da veia femoral. A oclus&#227;o a&#243;rtica foi
               realizada diretamente na aorta ascendente por meio de pin&#231;a articulada. A prote&#231;&#227;o
               mioc&#225;rdica foi obtida com solu&#231;&#227;o cristaloide gelada rica em pot&#225;ssio. O campo
               operat&#243;rio foi permeado com a infus&#227;o cont&#237;nua de CO<sub>2</sub> a 2 L/min. Quando
               necess&#225;rio, um aspirador foi introduzido na veia pulmonar superior esquerda para
               aspirar o sangue oriundo do retorno venoso pulmonar.</p>
        <p>O procedimento foi realizado preferencialmente sob vis&#227;o direta, com o uso do v&#237;deo
               apenas para clarificar qualquer d&#250;vida e para auxiliar a drenagem mediastinal.</p>
      </sec>
      <sec>
        <title>Procedimento MI VA</title>
        <p>Foram submetidas a procedimento videocir&#250;rgico com esse tipo de acesso as
               interven&#231;&#245;es intra-atriais esquerdas e direitas - ou seja: plastia e troca valvar,
               fechamento de defeito septal atrial, retirada de tumor card&#237;aco, e abla&#231;&#227;o de
               arritmia; todos por videotoracoscopia.</p>
        <p>O preparo inicial do paciente para esse tipo de acesso foi semelhante ao descrito
               para a forma MI direta. A &#250;nica modifica&#231;&#227;o foi o posicionamento do paciente. Um
               pequeno coxim subescapular direito deslocava entre 15 e 30&#186; o dec&#250;bito dorsal do
               paciente para a esquerda.</p>
        <p>O acesso era realizado por meio de quatro portais intercostais. O portal ou incis&#227;o
               de trabalho de 4 cm (sempre maximizado com afastador de tecidos moles
                  ALEXIS<sup>&#174;</sup>) e tr&#234;s portais auxiliares de 0,5 cm (<xref ref-type="fig" rid="f02">Figura 2</xref>). O local da incis&#227;o de trabalho variou conforme o sexo
               do paciente e a c&#226;mara card&#237;aca a ser abordada, por&#233;m sempre direcionada para o
               quarto espa&#231;o intercostal direito.</p>
        <fig id="f02" fig-type="other">
          <label>Figura 2</label>
          <caption>
            <title>Desenho descritivo do procedimento minimamente invasivo videoassistido
                     intra-atrial direito.</title>
          </caption>
          <graphic xlink:href="1678-4170-abc-102-03-0219-40004-gf02.jpg"/></fig>
        <p>Nos homens, a incis&#227;o era subareolar<xref ref-type="bibr" rid="B10">10</xref> e
               direcionada ao espa&#231;o intercostal por meio do m&#250;sculo peitoral maior (transpeitoral).
               Nas mulheres, a incis&#227;o era realizada no sulco inframam&#225;rio e direcionada ao espa&#231;o
               de forma subpeitoral. </p>
        <p>Para procedimentos intra-atriais esquerdos, a incis&#227;o na pele era localizada entre a
               linha mam&#225;ria e linha axilar anterior direita; para procedimentos intra-atriais
               direitos, o ponto m&#233;dio da incis&#227;o era a linha mam&#225;ria.</p>
        <p>O suporte circulat&#243;rio foi estabelecido por meio da canula&#231;&#227;o arterial e venosa,
               perif&#233;ricas, no tr&#237;gono femoral direito. Ambas as c&#226;nulas foram introduzidas por
               pun&#231;&#227;o dos vasos sob vis&#227;o direta, entre bolsas de polipropileno 6.0, com agulha de
               pun&#231;&#227;o, fio guia, dilatadores e com a introdu&#231;&#227;o e o correto posicionamento das
               c&#226;nulas confirmado por imagem obtida pelo ecocardiograma.</p>
        <p>A sele&#231;&#227;o da c&#226;nula arterial foi baseada em duas vari&#225;veis: o di&#226;metro interno
               pr&#233;-operat&#243;rio da arterial femoral direita e a superf&#237;cie corp&#243;rea do paciente.</p>
        <p>Por meio dos tr&#234;s portais auxiliares de 0,5 cm situados &#224; frente da linha axilar
               m&#233;dia direita, foram introduzidos: pin&#231;a transtor&#225;cica para oclus&#227;o a&#243;rtica no
               segundo espa&#231;o, &#243;tica de 0,5 cm no quarto ou quinto espa&#231;o e aspirador/insuflador de
                  CO<sub>2</sub> no s&#233;timo espa&#231;o.</p>
        <p>O campo operat&#243;rio foi permeado com a infus&#227;o cont&#237;nua de CO<sub>2</sub> a 2 L/min. </p>
        <p>A pericardiotomia era realizada desde a aorta at&#233; a veia cava inferior, sendo o
               peric&#225;rdio fixado com tr&#234;s pontos inferiores, exteriorizados pelos portais
               auxiliares, e dois pontos superiores, fixados internamente na parede tor&#225;cica. </p>
        <p>A oclus&#227;o da aorta ascendente foi realizada com a pin&#231;a transtor&#225;cica. A prote&#231;&#227;o
               mioc&#225;rdica foi obtida com solu&#231;&#227;o cristaloide gelada rica em pot&#225;ssio, administrada
               por pun&#231;&#227;o a&#243;rtica com longa agulha, por meio da incis&#227;o para trabalho. </p>
        <p>Para os procedimentos no &#225;trio esquerdo, era introduzido o afastador espec&#237;fico. Para
               procedimentos no &#225;trio direito, a exposi&#231;&#227;o era obtida com pontos na parede do &#225;trio,
               fixados no peric&#225;rdio.</p>
      </sec>
      <sec>
        <title>Demografia</title>
        <p>Entre os 102 pacientes, 64 (62,75%) eram mulheres. Os pacientes submetidos &#224;
               terap&#234;utica cir&#250;rgica de forma MI D (n = 14) apresentavam as seguintes doen&#231;as:
               cardiopatia valvar a&#243;rtica (n = 13), defeito do septo tipo seio venoso (n = 1). Os de
               forma MI VA (n = 88) apresentaram: cardiopatia valvar mitral (n = 43, sendo estenose
               - n = 18, insufici&#234;ncia - n = 17 e mista - n = 8); defeito do septo (n = 41, sendo
               &#243;stio secund&#225;rio - n = 37, &#243;stio prim&#225;rio - n = 1 e forame oval perme&#225;vel - n = 3);
               tumor card&#237;aco (n = 4) (<xref ref-type="table" rid="t01">Tabela 1</xref>).</p>
        <table-wrap id="t01">
          <label>Tabela 1</label>
          <caption>
            <title>Vari&#225;veis cl&#237;nicas</title>
          </caption>
          <table rules="rows" frame="hsides">
            <thead>
              <tr>
                <td rowspan="2">
                  <bold>Vari&#225;vel clinica</bold>
                </td>
                <td align="center">
                  <bold>MI D</bold>
                </td>
                <td align="center">
                  <bold>MI VA</bold>
                </td>
                <td align="center">
                  <bold>Total</bold>
                </td>
              </tr>
              <tr>
                <td>
                  <bold>(n = 14)</bold>
                </td>
                <td>
                  <bold>(n = 88)</bold>
                </td>
                <td>
                  <bold>(n = 102)</bold>
                </td>
              </tr>
            </thead>
            <tbody>
              <tr>
                <td>Idade (a)</td>
                <td align="center">39,7 &#177; 15,8</td>
                <td align="center">37,2 &#177; 12,5</td>
                <td align="center">37,6 &#177; 13</td>
              </tr>
              <tr>
                <td>Sexo (M/F)</td>
                <td align="center">9/5</td>
                <td align="center">29/59</td>
                <td align="center">38/64</td>
              </tr>
              <tr>
                <td>CV a&#243;rtica</td>
                <td align="center">13</td>
                <td align="center">-</td>
                <td align="center">13</td>
              </tr>
              <tr>
                <td>Defeito do septo</td>
                <td align="center">1</td>
                <td align="center">41</td>
                <td align="center">42</td>
              </tr>
              <tr>
                <td>CV mitral</td>
                <td align="center">-</td>
                <td align="center">43</td>
                <td align="center">43</td>
              </tr>
              <tr>
                <td>Tumor</td>
                <td align="center">-</td>
                <td align="center">4</td>
                <td align="center">4</td>
              </tr>
            </tbody>
          </table>
          <table-wrap-foot>
            <fn>
              <p>MI D: minimamente invasivo direto; MI VA: minimamente invasivo
                        videoassistido; M: masculino; F: feminino; CV: cardiopatia valvar.</p>
            </fn>
          </table-wrap-foot>
        </table-wrap>
      </sec>
    </sec>
    <sec sec-type="results">
      <title>Resultados</title>
      <p>Os procedimentos dos pacientes submetidos &#224; terap&#234;utica MI D inclu&#237;ram troca valvar
            a&#243;rtica (n = 11), reconstru&#231;&#227;o valvar (n = 1), troca valvar com amplia&#231;&#227;o do anel (n =
            1) e septoplastia com redirecionamento de fluxo pulmonar (n = 1). </p>
      <p>Os procedimentos dos 88 pacientes submetidos &#224; terap&#234;utica MI VA inclu&#237;ram reconstru&#231;&#227;o
            valvar (n = 17), troca valvar (n = 26), septorrrafia (n = 22), septoplastia com
            peric&#225;rdio (n = 19), ex&#233;rese de tumor (n = 4).</p>
      <p>No grupo de pacientes MI VA, vale ressaltar que as reconstru&#231;&#245;es mitrais consistiram em
            cinco comissurotomias (associadas com papilarotomia em tr&#234;s casos), 11 ressec&#231;&#245;es
            parciais da c&#250;spide com anuloplastias (anel semirr&#237;gido em sete casos e tira de
            peric&#225;rdio em quatro) e em um caso comissuroplastia com neocorda. Al&#233;m dos procedimentos
            mitrais, foram feitos quatro isolamentos ultrass&#244;nicos das veias pulmonares. </p>
      <p>As m&#233;dias de tempo de clampeamento a&#243;rtico foram 91,6 &#177; 21,8 minutos no grupo MI D e
            71,6 &#177; 29 minutos no grupo MI VA. As m&#233;dias de tempo de circula&#231;&#227;o extracorp&#243;rea foram
            112,7 &#177; 27,9 minutos no grupo MI D e 99,7 &#177; 32,6 minutos no grupo MI VA. Estas e outras
            vari&#225;veis temporais est&#227;o descritas na <xref ref-type="table" rid="t02">Tabela
            2</xref>.</p>
      <table-wrap id="t02">
        <label>Tabela 2</label>
        <caption>
          <title>Vari&#225;veis temporais</title>
        </caption>
        <table rules="rows" frame="hsides">
          <thead>
            <tr>
              <td rowspan="2">
                <bold>Vari&#225;vel</bold>
              </td>
              <td align="center">
                <bold>MI D</bold>
              </td>
              <td align="center">
                <bold>MI VA</bold>
              </td>
              <td align="center">
                <bold>Total</bold>
              </td>
            </tr>
            <tr>
              <td align="center">
                <bold>(n = 14)</bold>
              </td>
              <td align="center">
                <bold>(n = 88)</bold>
              </td>
              <td align="center">
                <bold>(n = 102)</bold>
              </td>
            </tr>
          </thead>
          <tbody>
            <tr>
              <td>Clampeamento (min)</td>
              <td align="center">91,6 &#177; 21,8</td>
              <td align="center">71,6 &#177; 29</td>
              <td align="center">74,4 &#177; 28,9</td>
            </tr>
            <tr>
              <td>CEC (min)</td>
              <td align="center">112,7 &#177; 27,9</td>
              <td align="center">99,6 &#177; 32,5</td>
              <td align="center">101,4 &#177; 32,2</td>
            </tr>
            <tr>
              <td>Procedimento (min)</td>
              <td align="center">247,1 &#177; 20,3</td>
              <td align="center">226,1 &#177; 42,7</td>
              <td align="center">228,1 &#177; 41,6</td>
            </tr>
            <tr>
              <td>Extubados em sala (%)</td>
              <td align="center">-</td>
              <td align="center">15 (17,04)</td>
              <td align="center">15 (17,04)</td>
            </tr>
            <tr>
              <td>UTI (horas)</td>
              <td align="center">41,1 &#177; 14,7</td>
              <td align="center">36,8 &#177; 16,3</td>
              <td align="center">37,3 &#177; 16,2</td>
            </tr>
            <tr>
              <td>Internamento (dias)</td>
              <td align="center">4,6 &#177; 2</td>
              <td align="center">4,3 &#177; 1,9</td>
              <td align="center">4,4 &#177; 1,9</td>
            </tr>
          </tbody>
        </table>
        <table-wrap-foot>
          <fn>
            <p>MI D: minimamente invasivo direto; MI VA: minimamente invasivo videoassistido;
                     CEC: circula&#231;&#227;o extracorp&#243;rea; UTI: unidade de terapia intensiva.</p>
          </fn>
        </table-wrap-foot>
      </table-wrap>
      <p>Houve um &#243;bito hospitalar (0,98%), no grupo MI D. Houve dois novos epis&#243;dios de
            fibrila&#231;&#227;o atrial que foram revertidos farmacologicamente. Houve uma drenagem
            peric&#225;rdica p&#243;s-operat&#243;ria no grupo MI D e duas revis&#245;es de hemostasia no grupo MI VA.
            Uma paciente do grupo MI VA relatou parestesia transit&#243;ria na coxa, sendo esta uma das
            primeiras pacientes da s&#233;rie. Um paciente apresentou pneumot&#243;rax, necessitando de
            redrenagem. Uma paciente, submetida &#224; septoplastia, apresentou hipertens&#227;o pulmonar
            revertida com vasodilatador. Entre os pacientes submetidos a procedimento MI VA, 15
            (17%) foram extubados em sala. O aspecto final dos portais em um paciente do grupo MI VA
            est&#225; demonstrado na <xref ref-type="fig" rid="f03">Figura 3</xref>.</p>
      <fig id="f03" fig-type="other">
        <label>Figura 3</label>
        <caption>
          <title>Resultado final dos quatro portais em paciente do grupo minimamente invasivo
                  videoassistido.</title>
        </caption>
        <graphic xlink:href="1678-4170-abc-102-03-0219-40004-gf03.jpg"/></fig>
    </sec>
    <sec sec-type="discussion">
      <title>Discuss&#227;o</title>
      <p>Um dos fundamentos dos procedimentos MI, independentemente da forma do acesso, consiste
            em um time equilibrado e bem capacitado. Suportando esse time, t&#234;m import&#226;ncia:
            conhecimento detalhado da anatomia de superf&#237;cie e interna do t&#243;rax; sele&#231;&#227;o criteriosa
            dos pacientes; utiliza&#231;&#227;o de instrumental adequado; desenvolvimento de habilidades e
            compet&#234;ncias em videocirurgia; al&#233;m disso, s&#227;o necess&#225;rias mudan&#231;a conceitual e
            filos&#243;fica, e extrema determina&#231;&#227;o.</p>
      <p>Na verdade, a cirurgia card&#237;aca brasileira, ap&#243;s uma experi&#234;ncia inicial, &#233; mais uma das
            especialidades cir&#250;rgicas que passa a incorporar, de uma forma mais definitiva, os
            procedimentos cir&#250;rgicos MI. Hoje, j&#225; s&#227;o realizadas a cirurgia valvar mitral e a
            corre&#231;&#227;o dos defeitos do septo interatrial com a mesma seguran&#231;a para o paciente,
            conforme demonstrado previamente<xref ref-type="bibr" rid="B11">11</xref>
				<sup>-</sup>
				<xref ref-type="bibr" rid="B15">15</xref>. Esse benef&#237;cio pode
            ser estendido a outros procedimentos: retirada de tumores card&#237;acos, cirurgia para
            abla&#231;&#227;o, arritmias, procedimentos peric&#225;rdicos e dissec&#231;&#227;o de enxertos. Isso impulsionou
            nossa experi&#234;ncia, de forma que esses procedimentos videocir&#250;rgicos representam 24% de
            nosso movimento cir&#250;rgico.</p>
      <p>O processo de incorpora&#231;&#227;o dessa metodologia pelo nosso time permitiu delinear algumas
            prioridades, como consultas cardiol&#243;gica cir&#250;rgica, cardiol&#243;gica cl&#237;nica e pr&#233;
            anest&#233;sica, somadas &#224; avalia&#231;&#227;o e orienta&#231;&#227;o fisioter&#225;pica e de enfermagem. Al&#233;m dos
            exames habituais necess&#225;rios - hemograma, coagulograma, bioqu&#237;mica, sum&#225;rio de urina,
            eletrocardiograma e radiografia do t&#243;rax em posteroanterior e perfil - solicitamos,
            especificamente, ultrassonografia arterial com <italic>Doppler</italic> de aorta,
            il&#237;acas e femorais com quantifica&#231;&#227;o do di&#226;metro interno desses vasos. A avalia&#231;&#227;o
            pr&#233;-operat&#243;ria da circula&#231;&#227;o coronariana &#233; realizada de forma bastante estratificada. Em
            pacientes sem fatores de risco maiores para doen&#231;a isqu&#234;mica do mioc&#225;rdio, preferimos
            uma avalia&#231;&#227;o da anatomia com angiotomografia das art&#233;rias coron&#225;rias, associada a um
            teste isqu&#234;mico provocativo, com cintilografia mioc&#225;rdica ou teste ergom&#233;trico. Qualquer
            altera&#231;&#227;o, d&#250;vida ou risco maior recomendou-se uma coronariografia invasiva via membro
            superior ou via femoral esquerda.</p>
      <p>Alguns autores reportaram ampla experi&#234;ncia com esse tipo de procedimento<xref ref-type="bibr" rid="B16">16</xref>
				<sup>-</sup>
				<xref ref-type="bibr" rid="B19">19</xref>. Isso tem demonstrado que, em centros especializados, certas doen&#231;as podem
            ser preferencialmente abordadas por acessos MI. Toda essa experi&#234;ncia acumulada tem
            revelado que os benef&#237;cios compreendem maior prote&#231;&#227;o da &#225;rea operada, menor incid&#234;ncia
            de sangramento, menor uso de hemocomponentes, melhor controle da dor, menor infec&#231;&#227;o,
            melhor cicatriza&#231;&#227;o, menor tempo de internamento, recupera&#231;&#227;o e reabilita&#231;&#227;o mais r&#225;pida
            do paciente a suas atividades di&#225;rias. Os benef&#237;cios podem ser estendidos para os
            membros do time: menor contamina&#231;&#227;o, melhor compartilhamento do campo operat&#243;rio e
            melhor qualidade de vida para o cirurgi&#227;o, com menor n&#250;mero de visitas e com divis&#227;o das
            responsabilidades. Por outro lado, algumas desvantagens podem ser apontadas: acesso a
            dois espa&#231;os no t&#243;rax, canula&#231;&#227;o perif&#233;rica, maior tempo do procedimento cir&#250;rgico na
            curva de adapta&#231;&#227;o ao m&#233;todo, maior custo para formata&#231;&#227;o do programa e adapta&#231;&#227;o a
            instrumental espec&#237;fico.</p>
      <p>Entre os pacientes operados, houve predom&#237;nio do sexo feminino. Na mulher submetida a
            procedimento MI VA, o portal para trabalho muito se assemelha &#224; incis&#227;o para implante de
            pr&#243;tese mam&#225;ria. Nessa situa&#231;&#227;o, a vantagem &#233; o acesso subpeitoral, sem divis&#227;o
            muscular. Por outro lado, Poffo e cols.<xref ref-type="bibr" rid="B10">10</xref>
            introduzem o acesso periareolar, o que maximiza o aspecto cosm&#233;tico, por&#233;m implica em
            divis&#227;o de gl&#226;ndulas mam&#225;rias e muscular.</p>
      <p>Nos procedimentos MI D prevaleceu a cardiopatia valvar a&#243;rtica. Uma abordagem MI j&#225; &#233;
            amplamente empregada por outros, em que a substitui&#231;&#227;o valvar a&#243;rtica &#233; realizada por
            minitoracotomia anterior direita<xref ref-type="bibr" rid="B20">20</xref>. Fica a
            observa&#231;&#227;o, nesses casos, da impossibilidade de compress&#227;o do cora&#231;&#227;o na fase de
            reperfus&#227;o, por vezes necess&#225;ria nos casos de hipertrofia mioc&#225;rdica significante. Vejo
            assim uma limita&#231;&#227;o desse m&#233;todo, o que pode ter contribu&#237;do para o &#250;nico &#243;bito da
            s&#233;rie.</p>
      <p>J&#225; entre os procedimentos MI VA, predominaram os procedimentos mitrais e procedimentos
            para fechamento do defeito do septo interatrial.</p>
      <p>Entre os mitrais, a troca valvar foi a mais comum. Entretanto, foram reconstru&#237;das 17
            valvas, o que representa 40% dos procedimentos videocir&#250;rgicos mitrais. Esse percentual
            pode ser considerado baixo se analisarmos os &#237;ndices para reconstru&#231;&#227;o valvar mitral na
            insufici&#234;ncia severa de etiologia degenerativa<xref ref-type="bibr" rid="B21">21</xref>.
            Por&#233;m, considerando que a les&#227;o valvar era insufici&#234;ncia isolada em apenas 17 pacientes
            e que a etiologia inflamat&#243;ria-reum&#225;tica foi muito frequente, esse &#237;ndice de
            reconstru&#231;&#227;o valvar videocir&#250;rgica pode ser aceit&#225;vel e compar&#225;vel ao reportado na
            literatura por acesso transesternal<xref ref-type="bibr" rid="B22">22</xref>.</p>
      <p>Considerando os procedimentos septais, houve um balanceamento entre os fechamentos por
            sutura e o fechamento com peric&#225;rdio. Nos fechamentos por sutura, modificamos nossa
            t&#233;cnica inicial, que era de dupla sutura cont&#237;nua para sutura com pontos separados em U,
            ancorados em almofadas de teflon. Outros autores tamb&#233;m demonstraram bons resultados,
            com fechamento videocir&#250;rgico do defeito septal<xref ref-type="bibr" rid="B23">23</xref>.</p>
      <p>Finalmente, quatro tumores foram retirados com o acesso MI VA. O resultado
            histopatol&#243;gico foi de mixoma em todos. Acreditamos que esse &#233; um excelente acesso para
            tratar essa doen&#231;a, inclusive para verificar, com detalhamento, o interior do ventr&#237;culo
            esquerdo. Essa impress&#227;o tamb&#233;m &#233; corroborada por outros autores<xref ref-type="bibr" rid="B20">20</xref>. Fica aqui registrada a aten&#231;&#227;o necess&#225;ria aos tumores s&#233;sseis de
            &#225;trio direito, quanto ao posicionamento da c&#226;nula proveniente da veia cava inferior e ao
            uso do v&#225;cuo, bem como a mixomas do tipo papilar ou viloso, que tendem a ser
            extremamente fri&#225;veis no &#225;trio esquerdo e de alto risco embolig&#234;nico.</p>
      <p>Considerando as vari&#225;veis temporais, percebemos que, apesar de longos tempos de
            clampeamento e de circula&#231;&#227;o extracorp&#243;rea, isso n&#227;o repercutiu na evolu&#231;&#227;o dos
            pacientes. Pelo contr&#225;rio, houve uma r&#225;pida recupera&#231;&#227;o na Unidade de Terapia Intensiva
            (UTI) e no internamento p&#243;s-operat&#243;rio. Esses achados confirmam os resultados j&#225;
            publicados na literatura que compararam o acesso MI e o acesso por esternotomia<xref ref-type="bibr" rid="B02">2</xref>
				<sup>,</sup>
				<xref ref-type="bibr" rid="B15">15</xref>
				<sup>,</sup>
				<xref ref-type="bibr" rid="B24">24</xref>. </p>
      <p>Nossa impress&#227;o &#233; de que os cirurgi&#245;es cardiovasculares vivem, hoje, um momento de
            transforma&#231;&#227;o na especialidade. As inova&#231;&#245;es e as modifica&#231;&#245;es t&#233;cnicas podem,
            progressivamente, ser incorporadas &#224; pr&#225;tica cir&#250;rgica, caso tornem o procedimento mais
            preciso e seguro.</p>
    </sec>
    <sec sec-type="conclusions">
      <title>Conclus&#227;o</title>
      <p>Procedimentos minimamente invasivos foram empregados de duas formas - Direta e
            Videoassistida - com seguran&#231;a no tratamento das cardiopatias valvares, do defeito do
            septo e das neoplasias do cora&#231;&#227;o. Constatamos tempos maiores das vari&#225;veis operat&#243;rias
            nesses procedimentos. Contudo, a recupera&#231;&#227;o na fase hospitalar foi r&#225;pida,
            independentemente do acesso e da doen&#231;a tratada. Em casos selecionados, essas formas de
            acesso poder&#227;o se tornar o m&#233;todo preferencial de abordagem cir&#250;rgica.</p>
    </sec>
  </body>
  <back>
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    <fn-group>
      <fn fn-type="supported-by">
        <p>
          <bold>Fontes de Financiamento</bold>
        </p>
        <p>O presente estudo n&#227;o teve fontes de financiamento externas.</p>
      </fn>
    </fn-group>
  </back>
  <sub-article article-type="translation" id="TR01" xml:lang="en">
    <front-stub>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Original Articles</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title xml:lang="en">Minimally Invasive Procedures - Direct and Video-Assisted
               Forms in the Treatment of Heart Diseases</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <name>
            <surname>Castro</surname>
            <given-names>Josu&#233; Viana</given-names>
            <suffix>Neto</suffix>
          </name>
          <xref ref-type="aff" rid="aff03">1</xref>
          <xref ref-type="aff" rid="aff04">2</xref>
          <xref ref-type="corresp" rid="c02"/>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Melo</surname>
            <given-names>Emanuel Carvalho</given-names>
          </name>
          <xref ref-type="aff" rid="aff03">1</xref>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Silva</surname>
            <given-names>Juliana Fernandes</given-names>
          </name>
          <xref ref-type="aff" rid="aff03">1</xref>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Rebou&#231;as</surname>
            <given-names>Leonardo Lemos</given-names>
          </name>
          <xref ref-type="aff" rid="aff04">2</xref>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Corr&#234;a</surname>
            <given-names>Larissa Chagas</given-names>
          </name>
          <xref ref-type="aff" rid="aff04">2</xref>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Germano</surname>
            <given-names>Amanda de Queiroz</given-names>
          </name>
          <xref ref-type="aff" rid="aff04">2</xref>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Machado</surname>
            <given-names>Jo&#227;o Jos&#233; Aquino</given-names>
          </name>
          <xref ref-type="aff" rid="aff03">1</xref>
        </contrib>
      </contrib-group>
      <aff id="aff03">
        <label>1</label>
        <institution content-type="orgname">Instituto do Cora&#231;&#227;o do Nordeste</institution>
        <addr-line>
          <named-content content-type="city">Fortaleza</named-content>
          <named-content content-type="state">CE</named-content>
        </addr-line>
        <country>Brazil</country>
        <institution content-type="original">Instituto do Cora&#231;&#227;o do Nordeste (INCONE),
               Fortaleza, CE - Brazil</institution>
      </aff>
      <aff id="aff04">
        <label>2</label>
        <institution content-type="orgname">Universidade de Fortaleza</institution>
        <addr-line>
          <named-content content-type="city">Fortaleza</named-content>
          <named-content content-type="state">CE</named-content>
        </addr-line>
        <country>Brazil</country>
        <institution content-type="original">Universidade de Fortaleza (UNIFOR), Fortaleza, CE -
               Brazil</institution>
      </aff>
      <author-notes>
        <corresp id="c02"><bold>Mailing Address:</bold> Josu&#233; Viana Castro Neto, Avenida Santos Dumont,
               5.753/108, Papicu. Postal Code 60175-047, Fortaleza, CE - Brazil. E-mail:
                  <email>jvcn@uol.com.br</email>, <email>jvcn@cardiol.br</email>
				</corresp>
        <fn fn-type="con">
          <p>
            <bold>Author contributions</bold>
          </p>
          <p>Conception and design of the research: Castro Neto JV, Melo EC; Acquisition of
                  data: Silva JF, Rebou&#231;as LL, Correia LC, Queiroz AG; Analysis and interpretation
                  of the data: Castro Neto JV, Melo EC, Silva JF; Statistical analysis: Rebou&#231;as LL,
                  Correia LC; Writing of the manuscript: Castro Neto JV, Silva JF, Aquino JJM;
                  Critical revision of the manuscript for intellectual content: Castro Neto JV. </p>
        </fn>
        <fn fn-type="conflict">
          <p>
            <bold>Potential Conflict of Interest</bold>
          </p>
          <p>No potential conflict of interest relevant to this article was reported.</p>
        </fn>
        <fn fn-type="other">
          <p>
            <bold>Study Association</bold>
          </p>
          <p>This study is not associated with any thesis or dissertation work.</p>
        </fn>
      </author-notes>
      <abstract xml:lang="en">
        <sec>
          <title>Background:</title>
          <p> Minimally invasive cardiovascular procedures have been progressively used in
                  heart surgery. </p>
        </sec>
        <sec>
          <title>Objective:</title>
          <p> To describe the techniques and immediate results of minimally invasive procedures
                  in 5 years. </p>
        </sec>
        <sec>
          <title>Methods:</title>
          <p> Prospective and descriptive study in which 102 patients were submitted to
                  minimally invasive procedures in direct and video-assisted forms. Clinical and
                  surgical variables were evaluated as well as the in hospital follow-up of the
                  patients. </p>
        </sec>
        <sec>
          <title>Results:</title>
          <p> Fourteen patients were operated through the direct form and 88 through the
                  video-assisted form. Between minimally invasive procedures in direct form, 13 had
                  aortic valve disease. Between minimally invasive procedures in video-assisted
                  forms, 43 had mitral valve disease, 41 atrial septal defect and four tumors. In
                  relation to mitral valve disease, we replaced 26 and reconstructed 17 valves.
                  Aortic clamp, extracorporeal and procedure times were, respectively, 91,6 &#177; 21,8,
                  112,7 &#177; 27,9 e 247,1 &#177; 20,3 minutes in minimally invasive procedures in direct
                  form. Between minimally invasive procedures in video-assisted forms, 71,6 &#177; 29,
                  99,7 &#177; 32,6 e 226,1 &#177; 42,7 minutes. Considering intensive care and hospitalization
                  times, these were 41,1 &#177; 14,7 hours and 4,6 &#177; 2 days in minimally invasive
                  procedures in direct and 36,8 &#177; 16,3 hours and 4,3 &#177; 1,9 days in minimally
                  invasive procedures in video-assisted forms procedures. </p>
        </sec>
        <sec>
          <title>Conclusion:</title>
          <p> Minimally invasive procedures were used in two forms - direct and video-assisted
                  - with safety in the surgical treatment of video-assisted, atrial septal defect
                  and tumors of the heart. These procedures seem to result in longer surgical
                  variables. However, hospital recuperation was faster, independent of the access or
                  pathology.</p>
        </sec>
      </abstract>
      <kwd-group xml:lang="en">
        <kwd>Heart Diseases</kwd>
        <kwd>Surgical Procedures, Minimally Invasive</kwd>
        <kwd>Video-Assisted Surgery</kwd>
      </kwd-group>
      <counts>
        <fig-count count="3"/>
        <table-count count="2"/>
        <equation-count count="0"/>
        <ref-count count="24"/>
        <page-count count="7"/>
      </counts>
    </front-stub>
    <body>
      <sec sec-type="intro">
        <title>Introducion</title>
        <p>The reconfiguration of the surgery is about a process through which this medical
               specialty incorporated the technical advances and became a practice over the past few
                  years<xref ref-type="bibr" rid="B01">1</xref>. These advances were important in
               making surgical procedures safer for patients. In this context, such said Minimally
               Invasive procedures (MI) has been introduced alternatively in heart surgery<xref ref-type="bibr" rid="B02">2</xref>.</p>
        <p>With the purpose of making universal the access in cardiovascular surgical
               procedures, from the beginning of 1960<xref ref-type="bibr" rid="B03">3</xref>,
               surgeons have adopted the total median sternotomy as the preferred incision, at the
               expense of initial thoracotomy<xref ref-type="bibr" rid="B04">4</xref>. With
               sternotomy it was enabled the access to all surfaces, compartments and great vessels
               of the heart, with central cannulations. This access, which communicates widely the
               middle mediastinum with the operative environment, brought comfort to the surgeon.
               However, possibly due to the wide opening and also due to the inherent bone division,
               it has been considered a stigma for the patients to be operated.</p>
        <p>In 1997, with incentives from previously published work by Laborde et al<xref ref-type="bibr" rid="B05">5</xref>, it was clear the necessity for a technical
               involvement for the development of an initial experience in video-assisted surgical
                  procedures<xref ref-type="bibr" rid="B06">6</xref>. Continuing, in 1999 a project
               was developed with a focus on experimental laparoscopic surgery, which due to
               structural problems, has not moved on. Only since 2006 is that the team started to
               develop strong actions oriented to MI surgery, based on the initial experience of
               other authors<xref ref-type="bibr" rid="B07">7</xref>
					<sup>,</sup>
					<xref ref-type="bibr" rid="B08">8</xref>. At this stage, it took intensive training and
               additional training of capabilities, the first procedures were performed from the end
               of 2007. The fact is that the process to achieve the method used nowadays was
               progressive and graduated.</p>
        <p>This paper had the purpose of describing the methodology used and the immediate
               results obtained over 5 years experience in a total of 102 patients undergoing MI
               cardiovascular surgeries.</p>
      </sec>
      <sec sec-type="methods">
        <title>Methods</title>
        <p>In the period between December 2007 and December 2012, 102 patients underwent, after
               informed consent form was obtained, MI procedures. This single-center, prospective,
               descriptive, quantitative approach study evaluated the clinical and operative
               variables, in addition to the immediate evolution during hospitalization of the
               patients, and was approved by the ethics committee of the University of
               Fortaleza.</p>
        <sec>
          <title>Selection of patients</title>
          <p>Symptomatic patients with mitral, aortic and tricuspid heart disease, patients
                  with septal defect and patients with cardiac tumor who underwent surgical
                  procedures, with a recommendation of therapy grounded on the guidelines of
                  cardiology societies<xref ref-type="bibr" rid="B09">9</xref>.</p>
          <p>Exclusion criteria were: age superior to 70 years, body mass index &gt; 32
                     kg/m<xref ref-type="bibr" rid="B02">2</xref>; patients with chronic obstructive
                  pulmonary disease ( FEV<sub>1</sub>/FVC &lt; 0.7); patients subjected to prior
                  heart surgery; patients with renal failure, patients with prior surgical procedure
                  in the right pleural cavity or inflammatory lung disease with significant
                  pleura-pulmonary adhesions; patients with chest deformities and diffuse
                  calcification of the ascending aorta, patients with important calcification of the
                  valvular annulus, systolic pressure in pulmonary artery of &gt; 80 mmHg,
                  associated coronary artery disease not susceptible to coronary stent implantation
                  (stent), severe tricuspid insufficiency, calcification of iliac or femoral artery,
                  femoral artery diameter of &lt; 5 mm and doubt in direct puncture of the femoral
                  vessel; patients with heart valve disease or mitral septal defect with moderate or
                  severe associated aortic insufficiency, and patients who, at some point, decided
                  not to participate in the study.</p>
        </sec>
        <sec>
          <title>Operative Technique</title>
          <p>All procedures have been carried out in the form of MI. These were categorized in
                  two levels:</p>
          <p>Direct MI (D): procedure carried out by means of a &lt; 8 cm incision and with
                  preferential use of direct view;</p>
          <p>Video-Assisted MI (VA): procedure carried out by means of four portals; working
                  port or incision (4 cm) and three auxiliary portals (0.5 cm), with preferential
                  use of imaging view obtained by optical and in monitor.</p>
        </sec>
        <sec>
          <title>MI D Procedure</title>
          <p>Individuals with aortic valvular heart disease, pulmonary valvular heart disease,
                  aortic subvalvular heart disease, individuals with procedures in the aortic root
                  and septal defect of venous sinus type were subjected to this type of surgical
                  access.</p>
          <p>The patient was positioned in supine position; peripheral venous and arterial
                  punctures in the left upper limb were performed. Anesthetic induction was
                  performed, and the patient was intubated with a usual endotracheal tube. The
                  echocardiography esophageal tube was positioned. The central venous puncture was
                  performed in the right subclavian vein, disposable plates for external
                  cardioversion were positioned, and the catheter was inserted.</p>
          <p>Access was made through an incision of approximately 6 cm in length. The sternal
                  division was partial, from the jugular notch until the third right intercostal
                  space (<xref ref-type="fig" rid="f04">Figure 1</xref>). A bone saw was kept on the
                  operating table during the procedure.</p>
          <fig id="f04" fig-type="other">
            <label>Figure 1</label>
            <caption>
              <title>Descriptive drawing of the direct minimally invasive procedure.</title>
            </caption>
            <graphic xlink:href="1678-4170-abc-102-03-0219-40004-gf01-en.jpg"/></fig>
          <p>The pericardium was partially open and fixed to the fields, offering broad access
                  to the upper mediastinum.</p>
          <p>After administration of heparin at a dose of 4 mg/kg, the circulatory support was
                  established by arterial cannulation in the ascending aorta and venous cannulation
                  of the right femoral triangle by femoral vein puncture. The aortic occlusion was
                  performed directly in the ascending aorta through hinged clamp. Myocardial
                  protection was achieved with cold crystalloid solution rich in potassium. The
                  operative field was flooded with continuous infusion of CO<sub>2</sub> at 2 L/min.
                  When necessary, a vent was introduced in the left superior pulmonary vein to drain
                  blood from the pulmonary venous return.</p>
          <p>The procedure was performed preferably under direct view with the use of v&#237;deo
                  reserved to clarify any questions and to assist the mediastinal drainage.</p>
        </sec>
        <sec>
          <title>MI VA Procedure</title>
          <p>Left and right intra-atrial interventions were subjected to the video-assisted
                  surgical procedure with this type of access, i.e., valvuloplasty and valve
                  replacement, closure of the atrial septal defect, removal of cardiac tumor, and
                  arrhythmia ablation, all though thoracoscopy.</p>
          <p>The initial preparation of the patient for this type of access was similar to that
                  described for the direct MI form. The only modification was the positioning of the
                  patient. A small right subscapularis cushion moved between 15 and 30&#176; the patient
                  in the supine position to the left.</p>
          <p>Access was made through four intercostals portals. The portal or work incision of
                  4 cm (always maximized with soft tissue retractor, ALEXIS<sup>&#174;</sup>) and three
                  auxiliary portals of 0.5 cm (<xref ref-type="fig" rid="f05">Figure 2</xref>). The
                  work incision site varied according to the gender of the patient and the cardiac
                  chamber to be addressed, but always directed to the fourth right intercostal
                  space.</p>
          <fig id="f05" fig-type="other">
            <label>Figure 2</label>
            <caption>
              <title>Descriptive drawing of the right intra-atrial video-assisted minimally
                        invasive procedure</title>
            </caption>
            <graphic xlink:href="1678-4170-abc-102-03-0219-40004-gf02-en.jpg"/></fig>
          <p>In men, the incision was subareola<xref ref-type="bibr" rid="B10">10</xref> and
                  oriented through the intercostal space of the pectoralis major muscle
                  (transpeitoral). In women, the incision was made in the inframammary fold and
                  oriented to the subpectoral space.</p>
          <p>For left intra-atrial procedures, the skin incision was located between the
                  mammary line and right anterior axillary line; for right intra-atrial procedures,
                  the midpoint of the incision was the mammary line.</p>
          <p>The support was provided through the peripheral arterial and venous cannulation in
                  the right femoral triangle. Both cannulas were introduced by puncturing the vessel
                  under direct view between 6.0 polypropylene sutures, with puncture needle,
                  guidewire, dilator and the introduction and the correct positioning of the cannula
                  confirmed by image obtained by echocardiography.</p>
          <p>The selection of the arterial cannula was based on two variables: pre-operative
                  internal diameter of the right femoral artery and the patient's body surface.</p>
          <p>Through the three auxiliary portals of 0.5 cm located at the front of the right
                  middle axillary line, the following was introduced: transthoracic clamp for aortic
                  occlusion in the second space, optical of 0.5cm in the fourth or fifth space and
                     CO<sub>2</sub> vacuum/blower in the seventh intercostal space.</p>
          <p>The operative field was permeated with continuous infusion of CO<sub>2</sub> at 2
                  L/min.</p>
          <p>The pericardiotomy was performed from the aorta until the inferior vena cava, and
                  pericardium fixed with three lower sutures, externalized through the auxiliary
                  portals and two upper points fixed internally on the thoracic wall.</p>
          <p>For the procedures in the left atrium, specific retractor was introduced. For
                  procedures in the right atrium, exposure was obtained with points in the atrial
                  wall, fixed in the pericardium.</p>
        </sec>
        <sec>
          <title>Demographics</title>
          <p>Among the 102 patients, 64 (62.75%) were women. Patients undergoing surgical
                  therapy in the MI D form (n = 14) presented the following diseases: aortic valve
                  heart disease (n = 13), septal sinus venosus defect (n = 1). The form of VA MI (n
                  = 88) presented: mitral valvular heart disease (n = 43, and stenosis - n = 18,
                  failure - n = 17 and mixed - n = 8); septal defect (n = 41, being ostium secondary
                  - n = 37, primary ostium - n = 1 and permeable foramen ovale - n = 3), cardiac
                  tumor (n = 4) (<xref ref-type="table" rid="t03">Table 1</xref>).</p>
          <table-wrap id="t03">
            <label>Table 1</label>
            <caption>
              <title>Clinical variables</title>
            </caption>
            <table rules="rows" frame="hsides">
              <thead>
                <tr>
                  <td rowspan="2">
                    <bold>Clinical variable</bold>
                  </td>
                  <td align="center">
                    <bold>MI D</bold>
                  </td>
                  <td align="center">
                    <bold>MI VA</bold>
                  </td>
                  <td align="center">
                    <bold>Total</bold>
                  </td>
                </tr>
              </thead>
              <tbody>
                <tr>
                  <td align="center">
                    <bold>(n = 14)</bold>
                  </td>
                  <td align="center">
                    <bold>(n = 88)</bold>
                  </td>
                  <td align="center">
                    <bold>(n = 102)</bold>
                  </td>
                </tr>
                <tr>
                  <td>Age (a)</td>
                  <td align="center">39.7 &#177; 15.8</td>
                  <td align="center">37.2 &#177; 12.5</td>
                  <td align="center">37.6 &#177; 13</td>
                </tr>
                <tr>
                  <td>Gender (M/F)</td>
                  <td align="center">9/5</td>
                  <td align="center">29/59</td>
                  <td align="center">38/64</td>
                </tr>
                <tr>
                  <td>Aortic CV</td>
                  <td align="center">13</td>
                  <td align="center">-</td>
                  <td align="center">13</td>
                </tr>
                <tr>
                  <td>Septum Deffect</td>
                  <td align="center">1</td>
                  <td align="center">41</td>
                  <td align="center">42</td>
                </tr>
                <tr>
                  <td>Mitral CV</td>
                  <td align="center">-</td>
                  <td align="center">43</td>
                  <td align="center">43</td>
                </tr>
                <tr>
                  <td>Tumor</td>
                  <td align="center">-</td>
                  <td align="center">4</td>
                  <td align="center">4</td>
                </tr>
              </tbody>
            </table>
            <table-wrap-foot>
              <fn>
                <p>MI D: direct minimally invasive; MI VA: video-assisted minimally
                           invasive; M: male; F: female; CV: valvular heart disease</p>
              </fn>
            </table-wrap-foot>
          </table-wrap>
        </sec>
      </sec>
      <sec sec-type="results">
        <title>Results</title>
        <p>The procedures of patients undergoing therapeutic MI D included aortic valve
               replacement (n = 11), valve repair (n = 1), valve replacement with annular
               enlargement (n = 1) and septoplasty with pulmonary flow redirection (n = 1).</p>
        <p>The procedures of 88 patients undergoing therapeutic MI VA included valve repair (n =
               17), valve replacement (n = 26), septorraphy (n = 22), septoplasty with pericardium
               (n = 19), tumor resection (n = 4).</p>
        <p>In the group of patients with MI VA, it is noteworthy that the mitral repair
               consisted of five commissurotomy (associated with papillectomy in three cases), 11
               partial resections of the leaflet with annuloplasty (semi-rigid ring in seven cases
               and pericardial strip in four) and in one case commissuroplasty with neochord. In
               addition to the mitral valve procedures, four ultrasonic isolation of the pulmonary
               veins were carried out.</p>
        <p>Mean aortic clamping time was 91.6 &#177; 21.8 minutes in the MI D group and 71.6 &#177; 29 min
               in the MI VA group. The mean cardiopulmonary bypass time was 112.7 &#177; 27.9 minutes in
               the MI D group and 99.7 &#177; 32.6 minutes in the MI VA group. These and other temporal
               variables are described in <xref ref-type="table" rid="t04">Table 2</xref>.</p>
        <table-wrap id="t04">
          <label>Table 2</label>
          <caption>
            <title>Time variables</title>
          </caption>
          <table rules="rows" frame="hsides">
            <thead>
              <tr>
                <td rowspan="2">
                  <bold>Variable</bold>
                </td>
                <td align="center">
                  <bold>MI D</bold>
                </td>
                <td align="center">
                  <bold>MI VA</bold>
                </td>
                <td align="center">
                  <bold>Total</bold>
                </td>
              </tr>
              <tr>
                <td align="center">
                  <bold>(n = 14)</bold>
                </td>
                <td align="center">
                  <bold>(n = 88)</bold>
                </td>
                <td align="center">
                  <bold>(n = 102)</bold>
                </td>
              </tr>
            </thead>
            <tbody>
              <tr>
                <td>Clamping (min)</td>
                <td align="center">91.6 &#177; 21.8</td>
                <td align="center">71.6 &#177; 29</td>
                <td align="center">74.4 &#177; 28.9</td>
              </tr>
              <tr>
                <td>CEC (min)</td>
                <td align="center">112.7 &#177; 27.9</td>
                <td align="center">99.6 &#177; 32.5</td>
                <td align="center">101.4 &#177; 32.2</td>
              </tr>
              <tr>
                <td>Procedure(min)</td>
                <td align="center">247.1 &#177; 20.3</td>
                <td align="center">226.1 &#177; 42.7</td>
                <td align="center">228.1 &#177; 41.6</td>
              </tr>
              <tr>
                <td>Tube removed in the room (%)</td>
                <td align="center">-</td>
                <td align="center">15 (17.04)</td>
                <td align="center">15 (17.04)</td>
              </tr>
              <tr>
                <td>ICU (hours)</td>
                <td align="center">41.1 &#177; 14.7</td>
                <td align="center">36.8 &#177; 16.3</td>
                <td align="center">37.3 &#177; 16.2</td>
              </tr>
              <tr>
                <td>Hospitalization (days)</td>
                <td align="center">4.6 &#177; 2</td>
                <td align="center">4.3 &#177; 1.9</td>
                <td align="center">4.4 &#177; 1.9</td>
              </tr>
            </tbody>
          </table>
          <table-wrap-foot>
            <fn>
              <p>MI D: direct minimally invasive; MI VA: video-assisted minimally invasive;
                        CEC: cardiopulmonary bypass; ICU: Intensive care unit.</p>
            </fn>
          </table-wrap-foot>
        </table-wrap>
        <p>There was one death (0.98%) in the MI D group. There were two new episodes of atrial
               fibrillation that was pharmacologically reversed. There was one post-operative
               pericardial drainage in the MI D group and two revisions of hemostasis in the MI VA
               group. One patient in MI VA group reported transient numbness in the thigh, this
               being one of the first patients in the series. One patient developed pneumothorax
               requiring redrainage. One female patient undergoing septoplasty presented reversed
               pulmonary hypertension with vasodilator. Among the patients submitted to VA MI, 15
               (17%) has tubes removed at the room. The final aspect of portals in one patient in MI
               VA group is shown in <xref ref-type="fig" rid="f06">Figure 3</xref>.</p>
        <fig id="f06" fig-type="other">
          <label>Figure 3</label>
          <caption>
            <title>Final result of the four portals in patient of the video-assisted minimally
                     invasive procedure.</title>
          </caption>
          <graphic xlink:href="1678-4170-abc-102-03-0219-40004-gf03-en.jpg"/></fig>
      </sec>
      <sec sec-type="discussion">
        <title>Discussion</title>
        <p>One of the foundations of the MI procedures, regardless of the form of access,
               consists of a well balanced and skilled team. Supporting this team, the following are
               important: Detailed knowledge of the inner and surface anatomy of the chest, careful
               selection of patients, use of proper equipment, development of skills and expertise
               in laparoscopic surgery; in addition, philosophical and conceptual change, and sheer
               determination are also necessary .</p>
        <p>In fact, the Brazilian cardiac surgery, after an initial experience, is another of
               the surgical specialties to incorporate, in a more definitive manner, the MI surgical
               procedures. Nowadays, mitral valve surgery and correction of atrial septal defects
               surgery are performed with the same safety for the patient, as previously
                  demonstrated<xref ref-type="bibr" rid="B11">11</xref>
					<sup>-</sup>
					<xref ref-type="bibr" rid="B15">15</xref>. This benefit could be extended to other
               procedures: removal of cardiac tumors, surgical ablation, arrhythmia, pericardial
               procedures and dissection of grafts. This has boosted our experience, so that these
               video-assisted surgical procedures represent 24% of our surgical movement.</p>
        <p>The process of incorporation of this methodology allowed our team to outline some
               priorities, such as heart surgery, clinical cardiology and pre-anesthetic
               consultation, this added to the assessment and guidance of physiotherapy and nursing.
               In addition to the usual tests needed - blood count, coagulation, biochemistry,
               urinalysis, electrocardiogram and chest radiograph in posteroanterior and profile
               views - we specifically ask for arterial ultrasound with doppler of the aortc, iliac
               and femoral arteries with quantification of the internal diameter of these vessels.
               The pre-operative evaluation of the coronary circulation is carried out in fairly
               stratified manner. In patients without major risk factors for myocardial ischemic
               disease, we prefer an assessment of the anatomy of the coronary arteries with CT
               angiography, associated with an ischemic provocative testing with myocardial
               scintigraphy and ergometric testing. Any changes, questions or greater risk
               recommended an invasive coronary angiography via the left femoral or upper limb.</p>
        <p>Some authors reported extensive experience with this procedure<xref ref-type="bibr" rid="B16">16</xref>
					<sup>-</sup>
					<xref ref-type="bibr" rid="B19">19</xref>. This has
               shown that, in specialized centers, certain diseases can be preferentially addressed
               by MI accesses. All this accumulated experience has shown that the benefits include
               greater protection of the operated area, lower incidence of bleeding, less use of
               blood products, better pain control, less infection, better healing, shorter hospital
               stay, faster recovery and rehabilitation of the patient to its daily activities. The
               benefits can be extended to the members of the team: less contamination, better
               sharing of the operative field and better quality of life for the surgeon, with fewer
               visits and sharing of responsibilities. Moreover, some disavantages can be indicated:
               access to two spaces in the chest, peripheral cannulation, increased surgical time in
               the adjustment curve of the method, higher cost for formatting the software and
               adaptation to specific instruments.</p>
        <p>Among surgical patients, there was a predominance of females. In women undergoing MI
               VA procedure, the portal to work is very similar to the incision for breast
               augmentation. In this situation, the advantage is the subpectoral access without
               muscle division. On the other hand, Poffo et al<xref ref-type="bibr" rid="B10">10</xref> introduce the periareolar access, which maximizes the cosmetic
               appearance, however implying in division of mammary glands and muscle division.</p>
        <p>In MI D procedures, aortic valve heart disease has prevailed. A MI approach is
               already widely employed by others, in which the aortic valve replacement is performed
               by anterior right minithoracotomy<xref ref-type="bibr" rid="B20">20</xref>. So there
               is an observation to be made, in those cases, about the impossibility of compression
               of the heart during reperfusion phase, sometimes necessary in cases of significant
               myocardial hypertrophy. Therefore, I see just one limitation of this method, which
               may have contributed to the single death in the series.</p>
        <p>Regarding MI VA procedures, mitral procedures and procedures for closure of atrial
               septal defect were predominant.</p>
        <p>Among the mitral, valve replacement was the most common. However, 17 valves were
               repaired, which represents 40% of video-assisted surgical mitral procedures. This
               percentage can be considered low if we analyze the indexes for mitral valve repair in
               severe impairment of degenerative etiology<xref ref-type="bibr" rid="B21">21</xref>.
               However, considering that the valve injury was an isolated failure in only 17
               patients and the inflammatory-rheumatic etiology was very common, this video-assisted
               surgical valve repair procedures index can be acceptable and comparable to the one
               reported in the literature for transternal access<xref ref-type="bibr" rid="B22">22</xref>.</p>
        <p>Considering the septal procedures, there was a balance between the closure by suture
               and closure with pericardium. In closure by suture, we have modified our initial
               technique, which consisted of double continuous suture to suture with stitches
               separated in U, anchored in a Teflon cushion. Other authors have also shown good
               results, with video-assisted surgical procedure for the closure of septal defect<xref ref-type="bibr" rid="B23">23</xref>.</p>
        <p>Finally, four tumors were removed with MI VA access. The histopathological result was
               myxoma in all of them. We believe this is an excellent access to treat this disease,
               including verifying in details the interior of the left ventricle. This impression is
               also supported by other authors<xref ref-type="bibr" rid="B20">20</xref>. It is here
               recorded the necessary attention to sessile tumors of the right atrium regarding the
               positioning of the cannula from the inferior vena cava and the use of vacuum, as well
               as the myxomas of papillary or villous type, which tend to be extremely friable in
               the left atrium and of high emboligenic risk.</p>
        <p>Considering the temporal variables, we have noticed that, although long clamping time
               and cardiopulmonary bypass, this did not influence the patients' evolution. Rather,
               there was a rapid recovery in the Intensive Care Unit (ICU) and post-operative
               hospitalization. These findings confirm those already published in the literature
               that compared MI access and access by sternotomy<xref ref-type="bibr" rid="B02">2</xref>
					<sup>,</sup>
					<xref ref-type="bibr" rid="B15">15</xref>
					<sup>,</sup>
					<xref ref-type="bibr" rid="B24">24</xref>.</p>
        <p>Our impression is that cardiovascular surgeons today live a time of transformation in
               the specialty. Innovations and technical modifications may progressively be
               incorporated into surgical practice, should they make the procedure more precise and
               safe.</p>
      </sec>
      <sec sec-type="conclusions">
        <title>Conclusion</title>
        <p>Minimally invasive procedures have been employed in two forms - Direct and
               Video-Assisted - safely in the treatment of valvular heart diseases, septum defect
               and heart neoplasia. We evidended longer times of operative variables in these
               procedures. However, the recovery in hospital was fast, regardless of access and
               disease treated. In selected cases, such forms of access may become the preferred
               method of surgical approach.</p>
      </sec>
    </body>
    <back>
      <fn-group>
        <fn fn-type="supported-by">
          <p>
            <bold>Sources of Funding</bold>
          </p>
          <p>There were no external funding sources for this study.</p>
        </fn>
      </fn-group>
    </back>
  </sub-article>
</article>
