<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.1 20151215//EN" "https://jats.nlm.nih.gov/publishing/1.1/JATS-journalpublishing1.dtd">
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  <front>
    <journal-meta>
      <journal-id journal-id-type="nlm-ta">Arq. Bras. Cardiol.</journal-id>
      <journal-title-group>
        <journal-title>Arquivos Brasileiros de Cardiologia</journal-title>
        <abbrev-journal-title abbrev-type="publisher">Arq. Bras. Cardiol.</abbrev-journal-title>
      </journal-title-group>
      <issn pub-type="ppub">0066-782X</issn>
      <issn pub-type="epub">1678-4170</issn>
      <publisher>
        <publisher-name>Sociedade Brasileira de Cardiologia</publisher-name>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id" specific-use="scielo-v3">VCcBvNBvp8Rq4VNnqwdgSJF</article-id>
      <article-id pub-id-type="publisher-id" specific-use="scielo-v2">S0066-782X2014000200033</article-id>
      <article-id pub-id-type="other">00033</article-id>
      <article-id pub-id-type="doi">10.5935/abc.20140007</article-id>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Carta Ao Editor</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title xml:lang="pt">Incompet&#234;ncia Cronotr&#243;pica em Idosos Diab&#233;ticos &#224;
               Ecocardiografia</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <name>
            <surname>Rosa</surname>
            <given-names>Eduardo Maffini da</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Wilhelms</surname>
            <given-names>Roberta Casanova</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Brand&#227;o</surname>
            <given-names>Rodrigo Borges</given-names>
          </name>
        </contrib>
        <aff>
          <institution content-type="orgname">Universidade de Caxias do Sul</institution>
          <addr-line>
            <named-content content-type="city">Caxias do Sul</named-content>
            <named-content content-type="state">RS</named-content>
          </addr-line>
          <country>Brasil</country>
          <institution content-type="original">Universidade de Caxias do Sul, Caxias do Sul, RS
                  - Brasil</institution>
        </aff>
      </contrib-group>
      <pub-date pub-type="epub-ppub">
        <day>25</day>
        <month>03</month>
        <year>2014</year>
      </pub-date>
      <volume>102</volume>
      <issue>2</issue>
      <fpage>199</fpage>
      <lpage>199</lpage>
      <permissions>
        <license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc/3.0/">
          <license-p>This is an Open Access article distributed under the terms of the Creative
                  Commons Attribution Non-Commercial License which permits unrestricted
                  non-commercial use, distribution, and reproduction in any medium, provided the
                  original work is properly cited. </license-p>
        </license>
      </permissions>
      <kwd-group xml:lang="pt">
        <kwd>Envelhecimento da Popula&#231;&#227;o</kwd>
        <kwd>Diabetes Mellitus</kwd>
        <kwd>Estresse Mecanico</kwd>
        <kwd>Ecocardiografia</kwd>
        <kwd>Frequ&#234;ncia Card&#237;aca</kwd>
      </kwd-group>
      <counts>
        <fig-count count="0"/>
        <table-count count="0"/>
        <equation-count count="0"/>
        <ref-count count="3"/>
        <page-count count="1"/>
      </counts>
    </article-meta>
  </front>
  <body>
    <p>
      <bold>Caro editor,</bold>
    </p>
    <p>Parabenizamos os autores do artigo que trata do progn&#243;stico da incompet&#234;ncia cronotr&#243;pica
         na popula&#231;&#227;o de idosos diab&#233;ticos submetidos a avalia&#231;&#227;o por ecocardiografia de estresse
         f&#237;sico, publicado nos Arq Bras Cardiol. 2013;100(5):429-43<xref ref-type="bibr" rid="B01">1</xref>.</p>
    <p>Quando observamos d&#233;fice cronotr&#243;pico no ecocardiograma de estresse farmacol&#243;gico, n&#227;o
         encontramos uma rela&#231;&#227;o com progn&#243;stico ou preval&#234;ncia de doen&#231;a coronariana, mas
         dist&#250;rbios do n&#243; sinusal, extrass&#237;stoles ou disautonomias; o que tamb&#233;m pode ser decorrente
         de para efeitos da dobutamina<xref ref-type="bibr" rid="B02">2</xref>
			<sup>,</sup>
			<xref ref-type="bibr" rid="B03">3</xref>. Gostar&#237;amos de saber se, na opini&#227;o dos autores, o
         d&#233;fice cronotr&#243;pico pode ser usado com algum papel progn&#243;stico na ecocardiografia de
         estresse farmacol&#243;gico.</p>
  </body>
  <back>
    <ref-list>
      <title>Refer&#234;ncias</title>
      <ref id="B01">
        <label>1</label>
        <mixed-citation>1. Santana JS, S&#225; Neto AA, Melo EV, Santana NO, Barreto AT, et al.
               Progn&#243;stico da incompet&#234;ncia cronotr&#243;pica em idosos diab&#233;ticos &#224; ecocardiografia sob
               estresse f&#237;sico. Arq Bras Cardiol. 2013;100(5):429-43.</mixed-citation>
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>Santana</surname>
              <given-names>JS</given-names>
            </name>
            <name>
              <surname>S&#225;</surname>
              <given-names>AA</given-names>
              <suffix>Neto</suffix>
            </name>
            <name>
              <surname>Melo</surname>
              <given-names>EV</given-names>
            </name>
            <name>
              <surname>Santana</surname>
              <given-names>NO</given-names>
            </name>
            <name>
              <surname>Barreto</surname>
              <given-names>AT</given-names>
            </name>
            <etal>et al</etal>
          </person-group>
          <article-title xml:lang="pt">Progn&#243;stico da incompet&#234;ncia cronotr&#243;pica em idosos
                  diab&#233;ticos &#224; ecocardiografia sob estresse f&#237;sico</article-title>
          <source>Arq Bras Cardiol</source>
          <year>2013</year>
          <volume>100</volume>
          <issue>5</issue>
          <fpage>429</fpage>
          <lpage>443</lpage>
        </element-citation>
      </ref>
      <ref id="B02">
        <label>2</label>
        <mixed-citation>2. Linhares RR, Gil MA, Ferreira LD, Monaco CG. Ecocardiografia sob
               estresse com dobutamina: revis&#227;o. Rev Bras Ecocardiogr Imagem Cardiovasc.
               2012;25(1):28-35</mixed-citation>
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>Linhares</surname>
              <given-names>RR</given-names>
            </name>
            <name>
              <surname>Gil</surname>
              <given-names>MA</given-names>
            </name>
            <name>
              <surname>Ferreira</surname>
              <given-names>LD</given-names>
            </name>
            <name>
              <surname>Monaco</surname>
              <given-names>CG</given-names>
            </name>
          </person-group>
          <article-title xml:lang="pt">Ecocardiografia sob estresse com dobutamina:
                  revis&#227;o</article-title>
          <source>Rev Bras Ecocardiogr Imagem Cardiovasc</source>
          <year>2012</year>
          <volume>25</volume>
          <issue>1</issue>
          <fpage>28</fpage>
          <lpage>35</lpage>
        </element-citation>
      </ref>
      <ref id="B03">
        <label>3</label>
        <mixed-citation>3. Bogaz FA, Saroute AN, Tsutsui, JM, Kowatsch I, Neto F, Francisco M,
               et al. Vasoespasmo coronariano induzido pela ecocardiografia sob estresse pela
               dobutamina-atropina. Arq Bras Cardiol. 2006;87(6):e250-3.</mixed-citation>
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>Bogaz</surname>
              <given-names>FA</given-names>
            </name>
            <name>
              <surname>Saroute</surname>
              <given-names>AN</given-names>
            </name>
            <name>
              <surname>Tsutsui</surname>
              <given-names>JM</given-names>
            </name>
            <name>
              <surname>Kowatsch</surname>
              <given-names>I</given-names>
            </name>
            <name>
              <surname>Neto</surname>
              <given-names>F</given-names>
            </name>
            <name>
              <surname>Francisco</surname>
              <given-names>M</given-names>
            </name>
            <etal>et al</etal>
          </person-group>
          <article-title xml:lang="pt">Vasoespasmo coronariano induzido pela ecocardiografia
                  sob estresse pela dobutamina-atropina</article-title>
          <source>Arq Bras Cardiol</source>
          <year>2006</year>
          <volume>87</volume>
          <issue>6</issue>
          <fpage>e250</fpage>
          <lpage>e253</lpage>
        </element-citation>
      </ref>
    </ref-list>
  </back>
  <sub-article article-type="reply" id="r01" xml:lang="pt">
    <front-stub>
      <title-group>
        <article-title xml:lang="pt">Carta-resposta</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <name>
            <surname>Santana</surname>
            <given-names>Juliana Silva</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Sousa</surname>
            <given-names>Ant&#244;nio Carlos Sobral</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Oliveira</surname>
            <given-names>Joselina Luzia Menezes</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Melo</surname>
            <given-names>Enaldo Vieira de</given-names>
          </name>
        </contrib>
      </contrib-group>
      <counts>
        <fig-count count="0"/>
        <table-count count="0"/>
        <equation-count count="0"/>
        <ref-count count="0"/>
        <page-count count="1"/>
      </counts>
    </front-stub>
    <body>
      <p>O grupo da pesquisa tem uma experi&#234;ncia em Incompet&#234;ncia Cronotr&#243;pica (IC) utilizando
            como m&#233;todo para diagn&#243;stico a ecocardiografia sob estresse pelo Esfor&#231;o F&#237;sico (EF) e,
            por meio das coortes j&#225; realizadas, evidenciou se que a IC confere valor progn&#243;stico.
            Este m&#233;todo &#233; preferido quando os indiv&#237;duos apresentam capacidade f&#237;sica
            preservada.</p>
      <p>Apesar das implica&#231;&#245;es cl&#237;nicas bem conhecidas, o mecanismo subjacente da IC n&#227;o est&#225;
            bem definido, mas a hip&#243;tese mais proposta nos estudos &#233; a da disfun&#231;&#227;o auton&#244;mica.
            Entende se que o uso da dobutamina permite o envolvimento de um participante do sistema
            auton&#244;mico, os receptores adren&#233;rgicos B1 do mioc&#225;rdio, sendo mais restrito do que o
            exerc&#237;cio f&#237;sico, que envolve toda a complexidade do sistema.</p>
      <p>Para utiliza&#231;&#227;o pr&#225;tica, a maioria dos estudos utiliza, como defini&#231;&#227;o de IC, a
            incapacidade de atingir 80% da Frequ&#234;ncia Card&#237;aca (FC) de reserva, conforme a f&#243;rmula:
            FC de reserva (FC pico - FC repouso) / (FC m&#225;xima - FC repouso) x 100.</p>
      <p>Sugere-se que a pr&#243;pria defini&#231;&#227;o da IC deva ser avaliada quando o m&#233;todo diagn&#243;stico
            utiliza drogas inotr&#243;picas positivas para indu&#231;&#227;o do aumento da FC. &#201; necess&#225;rio
            compreender melhor qual o conceito pr&#225;tico da IC que se aplica ao m&#233;todo de
            ecocardiografia sob estresse farmacol&#243;gico, para estudar o progn&#243;stico dos incompetentes
            cronotr&#243;picos utilizando esse m&#233;todo.</p>
      <p>Possivelmente, o valor progn&#243;stico da IC &#233; independente do m&#233;todo utilizado, por&#233;m &#233;
            sugerido que haja diagn&#243;stico bem estabelecido do paciente incompetente
            cronotr&#243;pico.</p>
      <p>Atenciosamente,</p>
      <p>
        <bold>Juliana Silva Santana</bold>
      </p>
      <p>
        <bold>Ant&#244;nio Carlos Sobral Sousa</bold>
      </p>
      <p>
        <bold>Joselina Luzia Menezes Oliveira</bold>
      </p>
      <p>
        <bold>Enaldo Vieira de Melo</bold>
      </p>
    </body>
  </sub-article>
  <sub-article article-type="translation" id="SA1" xml:lang="en">
    <front-stub>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Letter To The Editor</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title xml:lang="en">Chronotropic Incompetence in Diabetic Elderly on
               Echocardiography</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <name>
            <surname>Rosa</surname>
            <given-names>Eduardo Maffini da</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Wilhelms</surname>
            <given-names>Roberta Casanova</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Brand&#227;o</surname>
            <given-names>Rodrigo Borges</given-names>
          </name>
        </contrib>
        <aff>
          <institution content-type="orgname">Universidade de Caxias do Sul</institution>
          <addr-line>
            <named-content content-type="city">Caxias do Sul</named-content>
            <named-content content-type="state">RS</named-content>
          </addr-line>
          <country>Brazil</country>
          <institution content-type="original">Universidade de Caxias do Sul, Caxias do Sul, RS
                  - Brazil</institution>
        </aff>
      </contrib-group>
      <kwd-group xml:lang="en">
        <kwd>Ageing; Diabetes Mellitus</kwd>
        <kwd>Stress Mechanical</kwd>
        <kwd>Echocardiography, Heart Rate</kwd>
      </kwd-group>
    </front-stub>
    <body>
      <sec>
        <title>Dear editor,</title>
        <p>We congratulate the authors of the article on the prognosis of chronotropic
               incompetence in diabetic elderly undergoing physical stress echocardiography,
               published in the Arq Bras Cardiol. 2013;100(5):429-43<xref ref-type="bibr" rid="B01">1</xref>.</p>
        <p>When chronotropic deficit is observed on pharmacological stress echocardiography, a
               relationship is observed with neither prognosis nor prevalence of coronary artery
               disease, but with sinus node disorders, extrasystoles or dysautonomia, which might be
               due to dobutamine effects<xref ref-type="bibr" rid="B02">2</xref>
					<sup>,</sup>
					<xref ref-type="bibr" rid="B03">3</xref>. We would like to know whether, in those
               authors' opinion, the chronotropic deficit can play any prognostic role in
               pharmacological stress echocardiography.</p>
      </sec>
    </body>
  </sub-article>
  <sub-article article-type="translation" id="r02" xml:lang="en">
    <front-stub>
      <title-group>
        <article-title xml:lang="en">Reply</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <name>
            <surname>Santana</surname>
            <given-names>Juliana Silva</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Sousa</surname>
            <given-names>Ant&#244;nio Carlos Sobral</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Oliveira</surname>
            <given-names>Joselina Luzia Menezes</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Melo</surname>
            <given-names>Enaldo Vieira de</given-names>
          </name>
        </contrib>
      </contrib-group>
    </front-stub>
    <body>
      <p>Our group has experience with chronotropic incompetence (CI) by using physical stress
            echocardiography as the diagnostic method; according to already performed cohorts, CI
            has shown prognostic value. That is the preferred method for individuals with preserved
            physical capacity.</p>
      <p>Despite the well-known clinical implications, the underlying mechanism of CI has not
            been well clarified, autonomic dysfunction being the most frequently found hypothesis in
            the studies. The use of dobutamine is known to involve an autonomic system participant,
            the myocardial beta 1 adrenergic receptor, and is more restrictive than physical effort,
            which involves all the complexity of the system.</p>
      <p>For practical purpose, most studies define CI as the incapacity to reach 80% of heart
            rate (HR) reserve according to the formula: HR reserve = (peak HR - resting HR) /
            (maximum HR - resting HR) x 100.</p>
      <p>It has been suggested that the definition of CI should be assessed when the diagnostic
            method uses positive inotropic drugs to induce HR increase. It is necessary to better
            understand which practical concept of CI applies to the pharmacological stress
            echocardiography method to study the prognosis of those who have chronotropic
            incompetence according to that method.</p>
      <p>The prognostic value of CI probably does not depend on the method used; however, the
            diagnosis of patients with CI should be well established.</p>
      <p>Sincerely,</p>
      <p>
        <bold>Juliana Silva Santana</bold>
      </p>
      <p>
        <bold>Ant&#244;nio Carlos Sobral Sousa</bold>
      </p>
      <p>
        <bold>Joselina Luzia Menezes Oliveira</bold>
      </p>
      <p>
        <bold>Enaldo Vieira de Melo</bold>
      </p>
    </body>
  </sub-article>
</article>
