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  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">abc</journal-id>
      <journal-title-group>
        <journal-title>Arquivos Brasileiros de Cardiologia</journal-title>
        <abbrev-journal-title abbrev-type="publisher">Arq. Bras. Cardiol.</abbrev-journal-title>
      </journal-title-group>
      <issn pub-type="ppub">0066-782X</issn>
      <issn pub-type="epub">1678-4170</issn>
      <publisher>
        <publisher-name>Sociedade Brasileira de Cardiologia - SBC</publisher-name>
        <publisher-loc>S&#227;o Paulo, SP, Brazil</publisher-loc>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id" specific-use="scielo-v3">TyKzBBjjTVbLqZ54kWtpjBn</article-id>
      <article-id pub-id-type="publisher-id" specific-use="scielo-v2">S0066-782X2013002800015</article-id>
      <article-id pub-id-type="publisher-id" specific-use="scielo-v1">S0066-782X(13)10100200015</article-id>
      <article-id pub-id-type="doi">10.5935/abc.20130155</article-id>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Carta ao Editor</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Disfun&#231;&#227;o mioc&#225;rdica relacionada &#224; cirrose</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <name>
            <surname>Silvestre</surname>
            <given-names>Odilson Marcos</given-names>
          </name>
          <xref ref-type="aff" rid="aff01"/>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Farias</surname>
            <given-names>Alberto Queiroz</given-names>
          </name>
          <xref ref-type="aff" rid="aff02"/>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Bacal</surname>
            <given-names>Fernando</given-names>
          </name>
          <xref ref-type="aff" rid="aff01"/>
        </contrib>
      </contrib-group>
      <aff id="aff01">
        <addr-line>
          <named-content content-type="state">S&#227;o Paulo</named-content>
        </addr-line>
        <institution content-type="orgname">Universidade de S&#227;o Paulo</institution>
        <institution content-type="orgdiv1">Faculdade de Medicina </institution>
        <institution content-type="orgdiv2">Hospital das Cl&#237;nicas</institution>
        <country country="BR">Brazil</country>
      </aff>
      <aff id="aff02">
        <addr-line>
          <named-content content-type="city">S&#227;o Paulo</named-content>
          <named-content content-type="state">S&#227;o Paulo</named-content>
        </addr-line>
        <institution content-type="orgname">Universidade de S&#227;o Paulo</institution>
        <institution content-type="orgdiv1">Faculdade de Medicina </institution>
        <institution content-type="orgdiv2">Hospital das Cl&#237;nicas</institution>
        <country country="BR">Brazil</country>
      </aff>
      <pub-date date-type="collection" publication-format="electronic">
        <month>08</month>
        <year>2013</year>
      </pub-date>
      <volume>101</volume>
      <issue>2</issue>
      <fpage>192</fpage>
      <lpage>192</lpage>
      <permissions>
        <license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc/4.0/" xml:lang="en">
          <license-p>This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.</license-p>
        </license>
      </permissions>
      <pub-date publication-format="electronic" date-type="pub">
        <day>09</day>
        <month>09</month>
        <year>2013</year>
      </pub-date>
    </article-meta>
  </front>
  <body>
    <p>
      <bold>CARTA AO EDITOR</bold>
    </p>
    <p>
      <bold>Disfun&#231;&#227;o mioc&#225;rdica relacionada &#224; cirrose</bold>
    </p>
    <p>
      <bold>Odilson Marcos Silvestre<sup>I</sup>; Alberto Queiroz Farias<sup>II</sup>; Fernando Bacal<sup>I</sup></bold>
    </p>
    <p><sup>I</sup>Instituto do Cora&#231;&#227;o do Hospital das Cl&#237;nicas da Faculdade de Medicina da Universidade de S&#227;o Paulo </p>
    <p><sup>II</sup>Hospital das Cl&#237;nicas da Faculdade de Medicina da Universidade de S&#227;o Paulo, S&#227;o Paulo, SP - Brasil</p>
    <p>
      <xref ref-type="corresp" rid="end">Correspond&#234;ncia</xref>
    </p>
    <p><bold>Palavras-chave:</bold> Cirrose Hep&#225;tica / complica&#231;&#245;es, Cirrose Hep&#225;tica / fisiopatologia, Cardiopatias / complica&#231;&#245;es, Cardiopatias / fisiopatologia, Ecocardiografia.</p>
    <p>
      <bold>Caro Editor,</bold>
    </p>
    <p>A revis&#227;o sistem&#225;tica de Mota e Markman Filho<sup>1</sup> demonstra que o ecodopplercardiograma est&#225; indicado, em casos de cirrose, para investiga&#231;&#227;o das complica&#231;&#245;es vasculares pulmonares e da cardiomiopatia cirr&#243;tica. Concordamos que esse exame pode demonstrar altera&#231;&#245;es card&#237;acas relacionadas &#224; cirrose. Em nossa experi&#234;ncia, 184 pacientes, prospectivamente avaliados, apresentaram altera&#231;&#245;es card&#237;acas estruturais em repouso, que se correlacionaram com a gravidade da cirrose<sup>2</sup>. Entretanto, a presen&#231;a dessas anormalidades n&#227;o &#233; suficiente para caracterizar a denominada cardiomiopatia cirr&#243;tica. Os crit&#233;rios para o diagn&#243;stico ainda n&#227;o est&#227;o estabelecidos ou validados internacionalmente. As manifesta&#231;&#245;es cl&#237;nicas surgem em condi&#231;&#245;es de estresse. Em repouso, o cora&#231;&#227;o &#233; funcionalmente normal. Dessa forma, o ecodopplercardiograma em repouso &#233; frequentemente insuficiente para caracterizar a cardiomiopatia cirr&#243;tica.</p>
    <p>
      <fn id="end" fn-type="corresp">
        <label>
          <bold>Correspond&#234;ncia:</bold>
        </label>
        <p> Odilson Marcos Silvestre </p>
        <p> Rua Oscar Freire, 1.967, apto. 10B, Pinheiros </p>
        <p> CEP 05409-011, S&#227;o Paulo - SP - Brasil </p>
        <p> E-mail: </p>
        <p><email xlink:href="odilsonsilvestre@yahoo.com.br">odilsonsilvestre@yahoo.com.br</email>, </p>
        <p>
          <email xlink:href="odilsonsilvestre@cardiol.br">odilsonsilvestre@cardiol.br</email>
        </p>
      </fn>
    </p>
    <p>Artigo recebido em 16/04/13; revisado em 16/04/13; aceito em 10/05/13.</p>
    <p>
      <bold>Carta-resposta</bold>
    </p>
    <p>Agradecemos as coloca&#231;&#245;es de Silvestre e cols.<sup>1</sup>, com as quais concordamos, fato este j&#225; citado na introdu&#231;&#227;o do nosso artigo. Revis&#245;es recentes<sup>2,3</sup> que abordam o tema descrevem uma s&#233;rie de anormalidades ao ecodopplercardiograma de repouso, caracterizando a cardiomiopatia cirr&#243;tica: rela&#231;&#227;o E/A &lt; 1, : tempo de desacelera&#231;&#227;o da onda E &gt; 200 ms, tempo de relaxamento isovolum&#233;trico &gt; 80ms, aumento do volume atrial esquerdo, diminui&#231;&#227;o da contratilidade do ventr&#237;culo esquerdo, presen&#231;a de hipocinesia e/ou acinesia de parede, aumento da massa mioc&#225;rdica, fra&#231;&#227;o de eje&#231;&#227;o rebaixada (&lt; 55%), entre outras.</p>
    <p>Atenciosamente, </p>
    <p>Vitor Gomes Mota </p>
    <p> Brivaldo Markman Filho</p>
    <p>
      <bold>Refer&#234;ncias</bold>
    </p>
  </body>
  <back>
    <ref-list>
      <ref id="B1">
        <mixed-citation>1. Mota VG, Markman Filho B. Echocardiography in chronic liver disease: systematic review. Arq Bras Cardiol. 2013 Mar 22. [Epub ahead of print]</mixed-citation>
        <element-citation publication-type="journal">
          <article-title>Echocardiography in chronic liver disease: systematic review</article-title>
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          <date>
            <year>2013</year>
            <day>22</day>
            <month>03</month>
          </date>
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            <name>
              <surname>Mota</surname>
              <given-names>VG</given-names>
            </name>
            <name>
              <surname>Markman Filho</surname>
              <given-names>B</given-names>
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        <mixed-citation>2. Silvestre OM, Bacal F, de Souza Ramos D, Andrade JL, Furtado M, Pugliese V, et al. Impact of the severity of end-stage liver disease in cardiac structure and function. Ann Hepatol. 2013;12(1):85-91.</mixed-citation>
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            <year>2013</year>
          </date>
          <fpage>85</fpage>
          <lpage>91</lpage>
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          <volume>12</volume>
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            </name>
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              <surname>de Souza Ramos</surname>
              <given-names>D</given-names>
            </name>
            <name>
              <surname>Andrade</surname>
              <given-names>JL</given-names>
            </name>
            <name>
              <surname>Furtado</surname>
              <given-names>M</given-names>
            </name>
            <name>
              <surname>Pugliese</surname>
              <given-names>V</given-names>
            </name>
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        <mixed-citation>1. Mota VG, Markman Filho B. O ecoDopplercardiograma na doen&#231;a hep&#225;tica cr&#244;nica: revis&#227;o sistem&#225;tica. Arq Bras Cardiol. 2013 Mar 22. [Epub ahead of print]</mixed-citation>
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            <year>2013</year>
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              <given-names>VG</given-names>
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  </back>
  <sub-article article-type="translation" id="TRen" xml:lang="en">
    <front-stub>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Letter to the Editor</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title xml:lang="en">Cardiac dysfunction related to cirrhosis</article-title>
      </title-group>
    </front-stub>
    <body>
      <p>
        <bold>LETTER TO THE EDITOR</bold>
      </p>
      <p>
        <bold>Cardiac dysfunction related to cirrhosis</bold>
      </p>
      <p>
        <bold>Odilson Marcos Silvestre<sup>I</sup>; Alberto Queiroz Farias<sup>II</sup>; Fernando Bacal<sup>I</sup></bold>
      </p>
      <p><sup>I</sup>Instituto do Cora&#231;&#227;o do Hospital das Cl&#237;nicas da Faculdade de Medicina da Universidade de S&#227;o Paulo</p>
      <p><sup>II</sup>Hospital das Cl&#237;nicas da Faculdade de Medicina da Universidade de S&#227;o Paulo, S&#227;o Paulo, SP - Brazil</p>
      <p>
        <xref ref-type="corresp" rid="end-body2">Mailing Address</xref>
      </p>
      <p><bold>Keywords:</bold> Heart Diseases / complications; Heart Disease / physiopathology; Liver Cirrhosis / complications; Liver Cirrhosis / physiopathology; Echocardiography.</p>
      <p>
        <bold>Dear Editor,</bold>
      </p>
      <p>A systematic review of Mota and Markman Filho<sup>1</sup> demonstrates that Doppler echocardiography is indicated in cases of cirrhosis, for investigation of pulmonary and vascular complications of cirrhotic cardiomyopathy. We agree that this test may show cardiac abnormalities related to cirrhosis. In our experience, 184 patients prospectively evaluated showed structural cardiac abnormalities at rest, which correlated with the severity of cirrhosis<sup>2</sup>. However, the presence of these abnormalities is not sufficient to characterize cirrhotic cardiomyopathy. The criteria for diagnosis are not yet established or validated internationally. Clinical manifestations occur in conditions of stress. At rest, the heart is functionally normal. Hence, Doppler echocardiography at rest is often insufficient to characterize cirrhotic cardiomyopathy.</p>
      <p>
        <bold>References</bold>
      </p>
      <p>
        <fn id="end-body2" fn-type="corresp">
          <label>
            <bold>Mailing address:</bold>
          </label>
          <p> Odilson Marcos Silvestre</p>
          <p> Rua Oscar Freire, 1.967, apto. 10B, Pinheiros</p>
          <p> Postal Code 05409-011, S&#227;o Paulo - SP - Brazil</p>
          <p> E-mail: </p>
          <p><email xlink:href="odilsonsilvestre@yahoo.com.br">odilsonsilvestre@yahoo.com.br</email>, </p>
          <p>
            <email xlink:href="odilsonsilvestre@cardiol.br">odilsonsilvestre@cardiol.br</email>
          </p>
        </fn>
      </p>
      <p>Manuscript received April 16, 2013; manuscript revised April 16, 2013; accepted May 10, 2013.</p>
      <p>
        <bold>Reply</bold>
      </p>
      <p>We are thankful to the statements of Silvestre et al<sup>1</sup>, with which we agree and have mentioned in the introduction to our manuscript. Recent reviews<sup>2,3</sup> that address this issue describe a number of abnormalities on Doppler echocardiography at rest, characterizing cirrhotic cardiomyopathy: E/A ratio &lt; 1; E wave deceleration time &gt; 200 ms, isovolumic relaxation time &gt; 80ms, increased left atrial volume, decreased left ventricular contractility, presence of wall hypokinesia and/or akinesia, increased myocardial mass, lowered ejection fraction (&lt; 55%), among others.</p>
      <p>Sincerely,</p>
      <p>Vitor Gomes Mota</p>
      <p> Brivaldo Markman Filho</p>
      <p>
        <bold>References</bold>
      </p>
      <p>
        <bold>Correspond&#234;ncia:</bold>
      </p>
      <p> Odilson Marcos Silvestre </p>
      <p> Rua Oscar Freire, 1.967, apto. 10B, Pinheiros </p>
      <p> CEP 05409-011, S&#227;o Paulo - SP - Brasil </p>
      <p> E-mail: <email xlink:href="odilsonsilvestre@yahoo.com.br">odilsonsilvestre@yahoo.com.br</email>, <email xlink:href="odilsonsilvestre@cardiol.br">odilsonsilvestre@cardiol.br</email></p>
      <p>Artigo recebido em 16/04/13; revisado em 16/04/13; aceito em 10/05/13.</p>
      <p>
        <bold>Carta-resposta</bold>
      </p>
      <p>Agradecemos as coloca&#231;&#245;es de Silvestre e cols.<sup>1</sup>, com as quais concordamos, fato este j&#225; citado na introdu&#231;&#227;o do nosso artigo. Revis&#245;es recentes<sup>2,3</sup> que abordam o tema descrevem uma s&#233;rie de anormalidades ao ecodopplercardiograma de repouso, caracterizando a cardiomiopatia cirr&#243;tica: rela&#231;&#227;o E/A &lt; 1, : tempo de desacelera&#231;&#227;o da onda E &gt; 200 ms, tempo de relaxamento isovolum&#233;trico &gt; 80ms, aumento do volume atrial esquerdo, diminui&#231;&#227;o da contratilidade do ventr&#237;culo esquerdo, presen&#231;a de hipocinesia e/ou acinesia de parede, aumento da massa mioc&#225;rdica, fra&#231;&#227;o de eje&#231;&#227;o rebaixada (&lt; 55%), entre outras.</p>
      <p>Atenciosamente, </p>
      <p>Vitor Gomes Mota </p>
      <p> Brivaldo Markman Filho</p>
      <p>
        <bold>Refer&#234;ncias</bold>
      </p>
    </body>
  </sub-article>
</article>
